LOCUS       NM_022144               1205 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tenomodulin (TNMD), mRNA.
ACCESSION   NM_022144
VERSION     NM_022144.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Song,W., Wang,H., Ma,L. and Chen,Y.
  TITLE     Associations between the TNMD rs4828038 and ACE2 rs879922
            polymorphisms and preeclampsia susceptibility: a case-control study
  JOURNAL   J Obstet Gynaecol 42 (5), 1132-1136 (2022)
   PUBMED   34996340
  REMARK    GeneRIF: Associations between the TNMD rs4828038 and ACE2 rs879922
            polymorphisms and preeclampsia susceptibility: a case-control
            study.
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1205)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1205)
  AUTHORS   Lin,D., Alberton,P., Delgado Caceres,M., Prein,C.,
            Clausen-Schaumann,H., Dong,J., Aszodi,A., Shukunami,C.,
            Iatridis,J.C. and Docheva,D.
  TITLE     Loss of tenomodulin expression is a risk factor for age-related
            intervertebral disc degeneration
  JOURNAL   Aging Cell 19 (3), e13091 (2020)
   PUBMED   32083813
  REMARK    GeneRIF: Loss of tenomodulin expression is a risk factor for
            age-related intervertebral disc degeneration.
REFERENCE   5  (bases 1 to 1205)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1205)
  AUTHORS   Shukunami,C., Oshima,Y. and Hiraki,Y.
  TITLE     Chondromodulin-I and tenomodulin: a new class of tissue-specific
            angiogenesis inhibitors found in hypovascular connective tissues
  JOURNAL   Biochem Biophys Res Commun 333 (2), 299-307 (2005)
   PUBMED   15950187
  REMARK    Review article
REFERENCE   7  (bases 1 to 1205)
  AUTHORS   Oshima,Y., Sato,K., Tashiro,F., Miyazaki,J., Nishida,K., Hiraki,Y.,
            Tano,Y. and Shukunami,C.
  TITLE     Anti-angiogenic action of the C-terminal domain of tenomodulin that
            shares homology with chondromodulin-I
  JOURNAL   J Cell Sci 117 (Pt 13), 2731-2744 (2004)
   PUBMED   15150318
REFERENCE   8  (bases 1 to 1205)
  AUTHORS   Brandau,O., Meindl,A., Fassler,R. and Aszodi,A.
  TITLE     A novel gene, tendin, is strongly expressed in tendons and
            ligaments and shows high homology with chondromodulin-I
  JOURNAL   Dev Dyn 221 (1), 72-80 (2001)
   PUBMED   11357195
REFERENCE   9  (bases 1 to 1205)
  AUTHORS   Shukunami,C., Oshima,Y. and Hiraki,Y.
  TITLE     Molecular cloning of tenomodulin, a novel chondromodulin-I related
            gene
  JOURNAL   Biochem Biophys Res Commun 280 (5), 1323-1327 (2001)
   PUBMED   11162673
REFERENCE   10 (bases 1 to 1205)
  AUTHORS   Yamana,K., Wada,H., Takahashi,Y., Sato,H., Kasahara,Y. and
            Kiyoki,M.
  TITLE     Molecular cloning and characterization of CHM1L, a novel membrane
            molecule similar to chondromodulin-I
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1101-1106 (2001)
   PUBMED   11162640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF191770.1, AF291656.1 and
            AB055421.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022144.2.
            
            Summary: This gene encodes a protein that is related to
            chondromodulin-I, which is a cartilage-specific glycoprotein that
            functions to stimulate chondrocyte growth and to inhibit tube
            formation of endothelial cells. This protein is also an
            angiogenesis inhibitor. Genetic variation in this gene is
            associated with a risk for type 2 diabetes, central obesity and
            serum levels of systemic immune mediators in a body size-dependent
            manner. This gene is also a candidate gene for age-related macular
            degeneration, though a direct link has yet to be demonstrated.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF234259.1, AF191770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373031.5/ ENSP00000362122.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AF191770.1         104-114
            12-1195             AF291656.1         1-1184
            1196-1205           AB055421.1         1119-1128
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1205
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /note="tenomodulin"
                     /db_xref="GeneID:64102"
                     /db_xref="HGNC:HGNC:17757"
                     /db_xref="MIM:300459"
     exon            1..131
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1037
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /note="BRICHOS domain containing 4; myodulin; tendin;
                     chondromodulin-IB; hTeM; hChM1L; chondromodulin-1-like
                     protein; chondromodulin-I-like protein"
                     /codon_start=1
                     /product="tenomodulin"
                     /protein_id="NP_071427.2"
                     /db_xref="CCDS:CCDS14469.1"
                     /db_xref="GeneID:64102"
                     /db_xref="HGNC:HGNC:17757"
                     /db_xref="MIM:300459"
                     /translation="MAKNPPENCEDCHILNAEAFKSKKICKSLKICGLVFGILALTLI
                     VLFWGSKHFWPEVPKKAYDMEHTFYSNGEKKKIYMEIDPVTRTEIFRSGNGTDETLEV
                     HDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAE
                     KPIENRDFLKNSKILEICDNVTMYWINPTLISVSELQDFEEEGEDLHFPANEKKGIEQ
                     NEQWVVPQVKVEKTRHARQASEEELPINDYTENGIEFDPMLDERGYCCIYCRRGNRYC
                     RRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV"
     exon            132..263
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     exon            264..404
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     exon            405..506
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     exon            507..660
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     exon            661..827
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1205
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="TNMD"
                     /gene_synonym="BRICD4; CHM1L; TEM"
                     /note="major polyA site"
ORIGIN      
        1 agccgactca cttgcaactc cacctcagca gtggtctctc agtcctctca aagcaaggaa
       61 agagtactgt gtgctgagag accatggcaa agaatcctcc agagaattgt gaagactgtc
      121 acattctaaa tgcagaagct tttaaatcca agaaaatatg taaatcactt aagatttgtg
      181 gactggtgtt tggtatcctg gccctaactc taattgtcct gttttggggg agcaagcact
      241 tctggccgga ggtacccaaa aaagcctatg acatggagca cactttctac agcaatggag
      301 agaagaagaa gatttacatg gaaattgatc ctgtgaccag aactgaaata ttcagaagcg
      361 gaaatggcac tgatgaaaca ttggaagtgc acgactttaa aaacggatac actggcatct
      421 acttcgtggg tcttcaaaaa tgttttatca aaactcagat taaagtgatt cctgaatttt
      481 ctgaaccaga agaggaaata gatgagaatg aagaaattac cacaactttc tttgaacagt
      541 cagtgatttg ggtcccagca gaaaagccta ttgaaaaccg agattttctt aaaaattcca
      601 aaattctgga gatttgtgat aacgtgacca tgtattggat caatcccact ctaatatcag
      661 tttctgagtt acaagacttt gaggaggagg gagaagatct tcactttcct gccaacgaaa
      721 aaaaagggat tgaacaaaat gaacagtggg tggtccctca agtgaaagta gagaagaccc
      781 gtcacgccag acaagcaagt gaggaagaac ttccaataaa tgactatact gaaaatggaa
      841 tagaatttga tcccatgctg gatgagagag gttattgttg tatttactgc cgtcgaggca
      901 accgctattg ccgccgcgtc tgtgaacctt tactaggcta ctacccatat ccatactgct
      961 accaaggagg acgagtcatc tgtcgtgtca tcatgccttg taactggtgg gtggcccgca
     1021 tgctggggag ggtctaatag gaggtttgag ctcaaatgct taaactgctg gcaacatata
     1081 ataaatgcat gctattcaat gaatttctgc ctatgaggca tctggcccct ggtagccagc
     1141 tctccagaat tacttgtagg taattcctct cttcatgttc taataaactt ctacattatc
     1201 accaa
//
