LOCUS       NM_025235               6242 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tankyrase 2 (TNKS2), mRNA.
ACCESSION   NM_025235
VERSION     NM_025235.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6242)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6242)
  AUTHORS   Xu,Y.R., Shi,M.L., Zhang,Y., Kong,N., Wang,C., Xiao,Y.F., Du,S.S.,
            Zhu,Q.Y. and Lei,C.Q.
  TITLE     Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2122805119 (2022)
   PUBMED   35733260
  REMARK    GeneRIF: Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation.
REFERENCE   3  (bases 1 to 6242)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   4  (bases 1 to 6242)
  AUTHORS   Wu,M., Liu,Z. and Zhang,S.
  TITLE     Down-regulation of hsa_circ_0045474 induces macrophage autophagy in
            tuberculosis via miR-582-5p/TNKS2 axis
  JOURNAL   Innate Immun 28 (1), 11-18 (2022)
   PUBMED   34861798
  REMARK    GeneRIF: Down-regulation of hsa_circ_0045474 induces macrophage
            autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
REFERENCE   5  (bases 1 to 6242)
  AUTHORS   Wu,J. and Crowe,D.L.
  TITLE     PARP5B is required for nonhomologous end joining during
            tumorigenesis in vivo
  JOURNAL   Mol Carcinog 61 (1), 85-98 (2022)
   PUBMED   34710250
  REMARK    GeneRIF: PARP5B is required for nonhomologous end joining during
            tumorigenesis in vivo.
REFERENCE   6  (bases 1 to 6242)
  AUTHORS   Cook,B.D., Dynek,J.N., Chang,W., Shostak,G. and Smith,S.
  TITLE     Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2
            at human telomeres
  JOURNAL   Mol Cell Biol 22 (1), 332-342 (2002)
   PUBMED   11739745
REFERENCE   7  (bases 1 to 6242)
  AUTHORS   Kaminker,P.G., Kim,S.H., Taylor,R.D., Zebarjadian,Y., Funk,W.D.,
            Morin,G.B., Yaswen,P. and Campisi,J.
  TITLE     TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes
            rapid induction of cell death upon overexpression
  JOURNAL   J Biol Chem 276 (38), 35891-35899 (2001)
   PUBMED   11454873
REFERENCE   8  (bases 1 to 6242)
  AUTHORS   Lyons,R.J., Deane,R., Lynch,D.K., Ye,Z.S., Sanderson,G.M.,
            Eyre,H.J., Sutherland,G.R. and Daly,R.J.
  TITLE     Identification of a novel human tankyrase through its interaction
            with the adaptor protein Grb14
  JOURNAL   J Biol Chem 276 (20), 17172-17180 (2001)
   PUBMED   11278563
REFERENCE   9  (bases 1 to 6242)
  AUTHORS   Kuimov,A.N., Kuprash,D.V., Petrov,V.N., Vdovichenko,K.K.,
            Scanlan,M.J., Jongeneel,C.V., Lagarkova,M.A. and Nedospasov,S.A.
  TITLE     Cloning and characterization of TNKL, a member of tankyrase gene
            family
  JOURNAL   Genes Immun 2 (1), 52-55 (2001)
   PUBMED   11294570
REFERENCE   10 (bases 1 to 6242)
  AUTHORS   Monz,D., Munnia,A., Comtesse,N., Fischer,U., Steudel,W.I.,
            Feiden,W., Glass,B. and Meese,E.U.
  TITLE     Novel tankyrase-related gene detected with meningioma-specific sera
  JOURNAL   Clin Cancer Res 7 (1), 113-119 (2001)
   PUBMED   11205898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF438201.1, AF309033.1 and BQ019749.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025235.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314612.1, AF438201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371627.5/ ENSP00000360689.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2625              AF438201.1         115-2739
            2626-6042           AF309033.1         2612-6028
            6043-6242           BQ019749.1         18-217              c
FEATURES             Location/Qualifiers
     source          1..6242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.32"
     gene            1..6242
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="tankyrase 2"
                     /db_xref="GeneID:80351"
                     /db_xref="HGNC:HGNC:15677"
                     /db_xref="MIM:607128"
     exon            1..464
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..3766
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /EC_number="2.4.2.30"
                     /note="TNKS-2; tankyrase II; tankyrase-like protein;
                     tankyrase-related protein; poly [ADP-ribose] polymerase
                     5B; TRF1-interacting ankyrin-related ADP-ribose polymerase
                     2; ADP-ribosyltransferase diphtheria toxin-like 6;
                     tankyrase, TRF1-interacting ankyrin-related ADP-ribose
                     polymerase 2; protein poly-ADP-ribosyltransferase
                     tankyrase-2"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase tankyrase-2"
                     /protein_id="NP_079511.1"
                     /db_xref="CCDS:CCDS7417.1"
                     /db_xref="GeneID:80351"
                     /db_xref="HGNC:HGNC:15677"
                     /db_xref="MIM:607128"
                     /translation="MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLV
                     TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFG
                     HAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTA
                     LDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLA
                     AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLW
                     QFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS
                     LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN
                     INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR
                     LLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETV
                     KKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA
                     CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD
                     GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTP
                     LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
                     TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAM
                     PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVS
                     SSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKE
                     IGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEM
                     QSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLF
                     HGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRS
                     CYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQ
                     AYPEYLITYQIMRPEGMVDG"
     exon            465..689
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            690..785
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            786..822
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            823..898
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            899..993
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1060
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1247
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1369
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1461
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1540
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1712
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1792
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1938
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2104
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2324
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2434
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2623
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2876
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2959
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3080
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3178
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3253
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3359
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3546
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3703
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..6242
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6024..6029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="hexamer: AATAAA"
     polyA_site      6043
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="major polyA site"
     regulatory      6119..6124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="hexamer: AATAAA"
     polyA_site      6141
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
     regulatory      6221..6226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="hexamer: ATTAAA"
     polyA_site      6242
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
ORIGIN      
        1 agcttccgcc gccgcgtcgt ttcaggaccc ggacggcgga ttcgcgctgc ctccgccgcc
       61 gcggggcagc cggggggcag ggagcccagc gaggggcgcg cgtgggcgcg gccatgggac
      121 tgcgccggat ccggtgacag cagggagcca agcggcccgg gccctgagcg cgtcttctcc
      181 ggggggcctc gccctcctgc tcgcggggcc ggggctcctg ctccggttgc tggcgctgtt
      241 gctggctgtg gcggcggcca ggatcatgtc gggtcgccgc tgcgccggcg ggggagcggc
      301 ctgcgcgagc gccgcggccg aggccgtgga gccggccgcc cgagagctgt tcgaggcgtg
      361 ccgcaacggg gacgtggaac gagtcaagag gctggtgacg cctgagaagg tgaacagccg
      421 cgacacggcg ggcaggaaat ccaccccgct gcacttcgcc gcaggttttg ggcggaaaga
      481 cgtagttgaa tatttgcttc agaatggtgc aaatgtccaa gcacgtgatg atgggggcct
      541 tattcctctt cataatgcat gctcttttgg tcatgctgaa gtagtcaatc tccttttgcg
      601 acatggtgca gaccccaatg ctcgagataa ttggaattat actcctctcc atgaagctgc
      661 aattaaagga aagattgatg tttgcattgt gctgttacag catggagctg agccaaccat
      721 ccgaaataca gatggaagga cagcattgga tttagcagat ccatctgcca aagcagtgct
      781 tactggtgaa tataagaaag atgaactctt agaaagtgcc aggagtggca atgaagaaaa
      841 aatgatggct ctactcacac cattaaatgt caactgccac gcaagtgatg gcagaaagtc
      901 aactccatta catttggcag caggatataa cagagtaaag attgtacagc tgttactgca
      961 acatggagct gatgtccatg ctaaagataa aggtgatctg gtaccattac acaatgcctg
     1021 ttcttatggt cattatgaag taactgaact tttggtcaag catggtgcct gtgtaaatgc
     1081 aatggacttg tggcaattca ctcctcttca tgaggcagct tctaagaaca gggttgaagt
     1141 atgttctctt ctcttaagtt atggtgcaga cccaacactg ctcaattgtc acaataaaag
     1201 tgctatagac ttggctccca caccacagtt aaaagaaaga ttagcatatg aatttaaagg
     1261 ccactcgttg ctgcaagctg cacgagaagc tgatgttact cgaatcaaaa aacatctctc
     1321 tctggaaatg gtgaatttca agcatcctca aacacatgaa acagcattgc attgtgctgc
     1381 tgcatctcca tatcccaaaa gaaagcaaat atgtgaactg ttgctaagaa aaggagcaaa
     1441 catcaatgaa aagactaaag aattcttgac tcctctgcac gtggcatctg agaaagctca
     1501 taatgatgtt gttgaagtag tggtgaaaca tgaagcaaag gttaatgctc tggataatct
     1561 tggtcagact tctctacaca gagctgcata ttgtggtcat ctacaaacct gccgcctact
     1621 cctgagctat gggtgtgatc ctaacattat atcccttcag ggctttactg ctttacagat
     1681 gggaaatgaa aatgtacagc aactcctcca agagggtatc tcattaggta attcagaggc
     1741 agacagacaa ttgctggaag ctgcaaaggc tggagatgtc gaaactgtaa aaaaactgtg
     1801 tactgttcag agtgtcaact gcagagacat tgaagggcgt cagtctacac cacttcattt
     1861 tgcagctggg tataacagag tgtccgtggt ggaatatctg ctacagcatg gagctgatgt
     1921 gcatgctaaa gataaaggag gccttgtacc tttgcacaat gcatgttctt atggacatta
     1981 tgaagttgca gaacttcttg ttaaacatgg agcagtagtt aatgtagctg atttatggaa
     2041 atttacacct ttacatgaag cagcagcaaa aggaaaatat gaaatttgca aacttctgct
     2101 ccagcatggt gcagacccta caaaaaaaaa cagggatgga aatactcctt tggatcttgt
     2161 taaagatgga gatacagata ttcaagatct gcttagggga gatgcagctt tgctagatgc
     2221 tgccaagaag ggttgtttag ccagagtgaa gaagttgtct tctcctgata atgtaaattg
     2281 ccgcgatacc caaggcagac attcaacacc tttacattta gcagctggtt ataataattt
     2341 agaagttgca gagtatttgt tacaacacgg agctgatgtg aatgcccaag acaaaggagg
     2401 acttattcct ttacataatg cagcatctta cgggcatgta gatgtagcag ctctactaat
     2461 aaagtataat gcatgtgtca atgccacgga caaatgggct ttcacacctt tgcacgaagc
     2521 agcccaaaag ggacgaacac agctttgtgc tttgttgcta gcccatggag ctgacccgac
     2581 tcttaaaaat caggaaggac aaacaccttt agatttagtt tcagcggatg atgtcagcgc
     2641 tcttctgaca gcagccatgc ccccatctgc tctgccctct tgttacaagc ctcaagtgct
     2701 caatggtgtg agaagcccag gagccactgc agatgctctc tcttcaggtc catctagccc
     2761 atcaagcctt tctgcagcca gcagtcttga caacttatct gggagttttt cagaactgtc
     2821 ttcagtagtt agttcaagtg gaacagaggg tgcttccagt ttggagaaaa aggaggttcc
     2881 aggagtagat tttagcataa ctcaattcgt aaggaatctt ggacttgagc acctaatgga
     2941 tatatttgag agagaacaga tcactttgga tgtattagtt gagatggggc acaaggagct
     3001 gaaggagatt ggaatcaatg cttatggaca taggcacaaa ctaattaaag gagtcgagag
     3061 acttatctcc ggacaacaag gtcttaaccc atatttaact ttgaacacct ctggtagtgg
     3121 aacaattctt atagatctgt ctcctgatga taaagagttt cagtctgtgg aggaagagat
     3181 gcaaagtaca gttcgagagc acagagatgg aggtcatgca ggtggaatct tcaacagata
     3241 caatattctc aagattcaga aggtttgtaa caagaaacta tgggaaagat acactcaccg
     3301 gagaaaagaa gtttctgaag aaaaccacaa ccatgccaat gaacgaatgc tatttcatgg
     3361 gtctcctttt gtgaatgcaa ttatccacaa aggctttgat gaaaggcatg cgtacatagg
     3421 tggtatgttt ggagctggca tttattttgc tgaaaactct tccaaaagca atcaatatgt
     3481 atatggaatt ggaggaggta ctgggtgtcc agttcacaaa gacagatctt gttacatttg
     3541 ccacaggcag ctgctctttt gccgggtaac cttgggaaag tctttcctgc agttcagtgc
     3601 aatgaaaatg gcacattctc ctccaggtca tcactcagtc actggtaggc ccagtgtaaa
     3661 tggcctagca ttagctgaat atgttattta cagaggagaa caggcttatc ctgagtattt
     3721 aattacttac cagattatga ggcctgaagg tatggtcgat ggataaatag ttattttaag
     3781 aaactaattc cactgaacct aaaatcatca aagcagcagt ggcctctacg ttttactcct
     3841 ttgctgaaaa aaaatcatct tgcccacagg cctgtggcaa aaggataaaa atgtgaacga
     3901 agtttaacat tctgacttga taaagcttta ataatgtaca gtgttttcta aatatttcct
     3961 gttttttcag cactttaaca gatgccattc caggttaaac tgggttgtct gtactaaatt
     4021 ataaacagag ttaacttgaa ccttttatat gttatgcatt gattctaaca aactgtaatg
     4081 ccctcaacag aactaatttt actaatacaa tactgtgttc tttaaaacac agcatttaca
     4141 ctgaatacaa tttcatttgt aaaactgtaa ataagagctt ttgtactagc ccagtattta
     4201 tttacattgc tttgtaatat aaatctgttt tagaactgca gcggtttaca aaattttttc
     4261 atatgtattg ttcatctata cttcatctta catcgtcatg attgagtgat ctttacattt
     4321 gattccagag gctatgttca gttgttagtt gggaaagatt gagttatcag atttaatttg
     4381 ccgatgggag cctttatctg tcattagaaa tctttctcat ttaagaactt atgaatatgc
     4441 tgaagattta atttgtgata cctttgtatg tatgagacac attccaaaga gctctaacta
     4501 tgataggtcc tgattactaa agaagcttct ttactggcct caatttctag ctttcatgtt
     4561 ggaaaatttt ctgcagtcct tctgtgaaaa ttagagcaaa gtgctcctgt tttttagaga
     4621 aactaaatct tgctgttgaa caattattgt gttcttttca tggaacataa gtaggatgtt
     4681 acatttccag ggtgggaagg gtaatcctaa atcatttccc aatctattct aattacctta
     4741 aatctaaagg ggaaaaaaaa aatcacaaac aggactgggt agttttttat cctaagtata
     4801 ttttttcctg ttctttttac ttggttttat tgctgtattt atagccaatc tatacatcat
     4861 gggtaaactt aacccagaac tataaaatgt agttgtctca gtcccctcca ggcctcctga
     4921 atgggcaagt gcagtgaaac aggtgcttct tgctcctggg ttttctctcc atgatgttat
     4981 gcccaattgg aaatatgctg tcagtttgtg caccatatgg tgaccacgcc tgtgctcagt
     5041 ttggcagcta tagaaggaaa tgctgtccca taaaatgcca ttcctatttt ctaatataaa
     5101 actcttttcc aggaagcatg cttaagcatc ttgttacaga gacatacatc cattatggct
     5161 tggcaatctc ttttatttgt tgactctagc tcccttcaaa gtcgaggaaa gatctttact
     5221 cacttaatga ggacattccc catcactgtc tgtaccagtt cacctttatt ttacgtttta
     5281 ttcagtctgt aaattaactg gccctttgca gtaacttgta cataaagtgc tagaaaatca
     5341 tgttccttgt cctgagtaag agttaatcag agtaaatgca tttctggagt tgtttctgtg
     5401 atgtaaatta tgatcattat ttaagaagtc aaatcctgat cttgaagtgc tttttataca
     5461 gctctctaat aattacaaat atccgaaagt catttcttgg aacacaagtg gagtatgcca
     5521 aattttatat gaatttttca gattatctaa gcttccaggt tttataatta gaagataatg
     5581 agagaattaa tggggtttat atttacatta tctctcaact atgtagccca tattactcac
     5641 cctatgagtg aatctggaat tgcttttcat gtgaaatcat tgtggtctat gagtttacaa
     5701 tactgcaaac tgtgttattt tatctaatcc attgcttaat gagtgtgttt ttccatgaat
     5761 gaatataccg tggttcatat gttagcatgg cagcattttc agatagcttt ttgtttgttg
     5821 ggaagttggg gttttggggg gagggggagt attagtacgt tgcatgaaat agcttacttt
     5881 ataatgatgg aattgctttt tcttttgtct tgtgattttt ttttttgaag tgaaatttaa
     5941 ctttttgtgc aagtagtact attataccca tcttcagtgt cttacttgta ctgtatcaca
     6001 ttccataccc tcatttaatt cttaataaaa ctgttcactt gtttttctgg gtagcatggt
     6061 aattactgga atagtataaa tgtgttgaat ggtctttgag aaaatgaatt aagattacaa
     6121 taaaccacaa ttgcaggaaa acaatgtagt tctgagtcta atagtgataa agaatgcagt
     6181 ttgaagtttg aaatattgaa tattgtagct gtacttgctc attaaaatga aagtagctgt
     6241 ga
//
