LOCUS       NM_033396               5820 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tankyrase 1 binding protein 1 (TNKS1BP1), mRNA.
ACCESSION   NM_033396
VERSION     NM_033396.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5820)
  AUTHORS   He,H., Wang,S., Zhang,W., Gao,S., Guan,H. and Zhou,P.
  TITLE     Downregulation of TAB182 promotes cancer stem-like cell properties
            and therapeutic resistance in triple-negative breast cancer cells
  JOURNAL   BMC Cancer 23 (1), 1101 (2023)
   PUBMED   37953246
  REMARK    GeneRIF: Downregulation of TAB182 promotes cancer stem-like cell
            properties and therapeutic resistance in triple-negative breast
            cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5820)
  AUTHORS   Wang,S., Guo,H., Jia,J., Zhang,W., Gao,S., Guan,H., He,H. and
            Zhou,P.
  TITLE     Silencing TAB182 inhibits cell EMT, migration and invasion by
            downregulating EGFR in A549 NSCLC cells
  JOURNAL   Mol Biol Rep 50 (4), 3073-3083 (2023)
   PUBMED   36689051
  REMARK    GeneRIF: Silencing TAB182 inhibits cell EMT, migration and invasion
            by downregulating EGFR in A549 NSCLC cells.
REFERENCE   3  (bases 1 to 5820)
  AUTHORS   Gao,A., Su,Z., Shang,Z., He,C., Miao,D., Li,X., Zou,S., Ding,W.,
            Zhou,Y., Sun,M. and Zhou,J.
  TITLE     TAB182 aggravates progression of esophageal squamous cell carcinoma
            by enhancing beta-catenin nuclear translocation through FHL2
            dependent manner
  JOURNAL   Cell Death Dis 13 (10), 900 (2022)
   PUBMED   36289198
  REMARK    GeneRIF: TAB182 aggravates progression of esophageal squamous cell
            carcinoma by enhancing beta-catenin nuclear translocation through
            FHL2 dependent manner.
            Erratum:[Cell Death Dis. 2023 Apr 14;14(4):270. doi:
            10.1038/s41419-023-05799-9.. PMID: 37059707]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5820)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5820)
  AUTHORS   Cao,Y., Gao,A., Li,X., Min,H., He,C., Sun,X., Ding,W.Q. and Zhou,J.
  TITLE     Elevated TAB182 enhances the radioresistance of esophageal squamous
            cell carcinoma through G2-M checkpoint modulation
  JOURNAL   Cancer Med 10 (9), 3101-3112 (2021)
   PUBMED   33787085
REFERENCE   6  (bases 1 to 5820)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 5820)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 5820)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
REFERENCE   9  (bases 1 to 5820)
  AUTHORS   Sbodio,J.I. and Chi,N.W.
  TITLE     Identification of a tankyrase-binding motif shared by IRAP, TAB182,
            and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif
            and is a novel tankyrase partner
  JOURNAL   J Biol Chem 277 (35), 31887-31892 (2002)
   PUBMED   12080061
  REMARK    GeneRIF: Identification of a tankyrase-binding motif in this
            protein.
REFERENCE   10 (bases 1 to 5820)
  AUTHORS   Seimiya,H. and Smith,S.
  TITLE     The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains
            multiple binding sites for telomeric repeat binding factor 1 (TRF1)
            and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
  JOURNAL   J Biol Chem 277 (16), 14116-14126 (2002)
   PUBMED   11854288
  REMARK    GeneRIF: The telomeric poly(ADP-ribose) polymerase, tankyrase 1,
            contains multiple binding sites for telomeric repeat binding factor
            1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein
            (TAB182).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000781.6, CT003184.1, AB051528.2, AF441771.1 and AA614752.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033396.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150333.1, HM005619.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358252.8/ ENSP00000350990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AP000781.6         80257-80269         c
            14-545              CT003184.1         1-532
            546-2898            AB051528.2         513-2865
            2899-4526           AF441771.1         3028-4655
            4527-5818           AB051528.2         4494-5785
            5819-5820           AA614752.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..5820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..5820
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /note="tankyrase 1 binding protein 1"
                     /db_xref="GeneID:85456"
                     /db_xref="HGNC:HGNC:19081"
                     /db_xref="MIM:607104"
     exon            1..113
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            114..272
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..5368
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /note="tankyrase 1-binding protein of 182 kDa; tankyrase 1
                     binding protein 1, 182kDa; testis secretory sperm-binding
                     protein Li 206a"
                     /codon_start=1
                     /product="182 kDa tankyrase-1-binding protein"
                     /protein_id="NP_203754.2"
                     /db_xref="CCDS:CCDS7951.1"
                     /db_xref="GeneID:85456"
                     /db_xref="HGNC:HGNC:19081"
                     /db_xref="MIM:607104"
                     /translation="MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKP
                     RALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPR
                     PAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATT
                     VEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFR
                     GWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSP
                     APSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAV
                     TPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLI
                     EVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAAL
                     PQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAE
                     AAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPA
                     VPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQP
                     AAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSS
                     RWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQP
                     SSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQ
                     EEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYS
                     SRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDH
                     HGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDA
                     QDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSP
                     STAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVG
                     EFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGG
                     HFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMN
                     LTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSG
                     VEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDL
                     EVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGL
                     RHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSF
                     GASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQE
                     EVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARS
                     PSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDS
                     TEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAE
                     EGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKK
                     KKV"
     exon            273..906
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            907..976
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            977..2332
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..4494
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4861
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            4862..5012
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            5013..5149
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            5150..5307
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            5308..5380
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..5820
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5803..5808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /note="hexamer: AATAAA"
     polyA_site      5820
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggctt cgtcccgcgg tgacggcggc ggcggcggcg gtagcagcgg cggcggcggc
       61 ggggactggc atcggggccc cgagccgagc ggagccggac cccgggcgag cgcgtctgca
      121 gccaccccag ctcatacctc tctgcctccc cgctctcaag gagggtctgc cgcatgtgat
      181 gaaagtgtct actctcaggg aaagctcagc catggcttcc ccactgcccc gggagatgga
      241 ggaggagctg gtgcctactg gctctgagcc aggtgacact cgggccaaac cccctgtcaa
      301 gcccaaaccc cgggccctgc ctgccaagcc agccctgcct gccaaaccca gcctgctggt
      361 gcctgttggg cctcggcctc cccggggtcc cctggctgag ttgccttctg ccaggaagat
      421 gaacatgctg gcaggacccc agccctatgg tggcagcaag cgcccccttc cctttgcacc
      481 aaggcctgcg gttgaggcct ccactggagg agaagccacc caagagactg ggaaagagga
      541 ggctgggaaa gaggagccac cccctttgac acccccagct cgatgtgcag ccccaggggg
      601 tgtacggaag gcccctgccc ctttccgccc agcctcagag cgcttcgcgg ccaccacggt
      661 ggaagagatc ctggccaaga tggagcagcc tcggaaggag gtccttgcca gccccgaccg
      721 cctgtggggt tcccgcctca cctttaacca cgatggcagc tcgcgatatg gccccaggac
      781 ctatggcacg accactgctc ccagggatga ggatggcagc accctcttca ggggatggtc
      841 ccaggagggg ccagtaaagt ctccagcaga gtgccgggaa gagcacagca agacccctga
      901 ggagaggagc cttccttccg acctggcctt caacggggac ctggctaagg cagccagctc
      961 ggagctacct gctgatattt ccaagccctg gattccctca agtccagccc cctcctcaga
     1021 gaatggaggc cctgccagcc caggcctccc cgcagaagcc tcaggctcag gccctggctc
     1081 tccccatctt cacccgcctg ataagagttc tccctgccac tcacagcttc tggaagccca
     1141 gactcctgaa gcttcccagg cttctccctg ccccgctgtg actccatcag ctccaagtgc
     1201 agccctgcct gacgagggct cccgccacac ccccagcccg gggctccctg ccgagggggc
     1261 tccagaggcc cccagaccca gcagcccacc ccctgaggtc ttggagcccc atagcctgga
     1321 tcagccccct gccacctcac cccggcccct gatcgaggtg ggtgagttgc tggatctcac
     1381 tcggacgttt ccatctggcg gggaggagga ggccaagggt gacgcacacc tccgccccac
     1441 cagcctggtt cagcgccgat tctctgaagg tgtgctccag tcacccagtc aggaccagga
     1501 gaagctgggg ggctcgctgg ctgccctgcc ccaaggccag gggagccagt tggccctgga
     1561 tcgtcccttt ggggcagagt ccaactggag cttatcacag tccttcgaat ggaccttccc
     1621 cacgaggccc tcgggtctgg gcgtgtggcg gctggactcc ccgcctccct cccccatcac
     1681 tgaagccagt gaggccgccg aggctgctga ggctggcaac ttggccgttt ccagcaggga
     1741 agaaggagtg tctcagcagg ggcaaggggc tgggtcagct ccaagtgggt caggaagttc
     1801 ctgggtgcag ggggatgatc caagcatgtc cctcacccag aagggcgatg gggagagtca
     1861 acctcaattc ccagctgttc cccttgagcc cctgcctaca actgagggca cacctggatt
     1921 acctttgcag caggcagagg agagatacga gtcgcaggag cccttggctg gacaggagtc
     1981 ccctctcccc ctggctacca gggaggcagc cttgcccatc ctggagccag tcctggggca
     2041 ggagcagcca gcagcccctg accagccctg tgttctcttt gctgatgccc ctgagcctgg
     2101 acaggcactg cctgttgagg aggaggccgt gaccctagcc cgggctgaga ccacccaagc
     2161 caggacagag gctcaagact tgtgtagggc atcccccgag cctccaggcc ctgaaagcag
     2221 ctcccgctgg ctggacgacc tcctggcttc accaccaccc agtggtggcg gtgcaaggcg
     2281 gggagctgga gctgagctga aggacacaca gtccccaagt acctgctctg agggactcct
     2341 tggctggtcc cagaaagatc tgcagagtga atttgggatc acaggagacc cacagcccag
     2401 cagtttcagt ccttccagct ggtgtcaagg tgcttctcag gactatggcc ttgggggtgc
     2461 aagccctaga ggagacccag gtctcggaga gagggactgg accagcaagt atgggcaagg
     2521 agcaggggaa gggagcacca gggagtgggc cagcaggtgt ggcatcggcc aggaggagat
     2581 ggaggccagc agcagccaag accagagtaa agtgtctgcc ccaggggtgc tcacagccca
     2641 ggaccgggta gttggaaagc cagcccagct tggcactcag cggagccagg aggcagatgt
     2701 tcaggactgg gagttcagaa agagggattc ccagggcact tactccagcc gggatgcaga
     2761 actccaggac caggaattcg gaaagagaga ttcactgggt acctacagta gtcgagatgt
     2821 aagccttggg gactgggaat ttgggaagag agattctctg ggtgcttatg ccagccaaga
     2881 tgccaacgag cagggccaag atttggggaa gagggaccac catggtaggt acagcagcca
     2941 ggatgccgat gagcaggact gggagtttca gaagagagat gtgtcactcg gcacctatgg
     3001 cagccgggct gcggagccac aggaacagga gtttgggaag agcgcttgga taagggacta
     3061 cagcagtggt ggcagctcca ggacccttga cgcccaggac agaagctttg gaacgagacc
     3121 cctgagctct gggttcagcc ccgaggaagc ccagcaacag gatgaggaat ttgagaagaa
     3181 gattccaagt gtggaagaca gccttggaga gggcagcagg gatgctggcc ggccaggaga
     3241 gagaggatcc gggggcttgt tcagtcctag cactgcccac gtgccggatg gggcactcgg
     3301 gcagagagac cagagcagct ggcaaaacag tgatgctagc caggaggtgg gagggcatca
     3361 ggagagacag caggcagggg ctcagggccc tggcagtgct gacctggaag atggggagat
     3421 gggaaagcga ggctgggtcg gtgagtttag cctcagtgtt ggcccccagc gagaggcagc
     3481 atttagccca gggcagcagg actggagccg ggacttctgc atcgaggcca gtgagaggag
     3541 ctatcagttt ggcatcattg gcaacgacag agtgagtggt gctggcttta gcccttctag
     3601 caagatggaa ggtggtcact ttgtgcctcc tgggaagacc acagctggct cggtggactg
     3661 gactgaccag ctgggtctca ggaacttgga agtgtccagc tgtgtgggtt ctgggggctc
     3721 gagcgaggcc agggagagtg ccgtgggaca gatgggctgg tcaggtggcc tgagcttgag
     3781 agacatgaac ctgaccggct gtttggaaag tggagggtct gaagagccgg ggggaatcgg
     3841 agttggggag aaggactgga cttctgatgt taatgtgaag agcaaagatt tggctgaggt
     3901 cggggaggga ggaggccaca gccaggccag agagagtggc gtggggcaga ctgactggtc
     3961 aggtgtggag gccggagagt tccttaaatc aagggagcgt ggagttggac aggcagactg
     4021 gacacctgac cttgggctga gaaacatggc cccaggggca gtctgcagtc ctggagagtc
     4081 caaagagctt ggggtgggcc agatggactg gggtaacaat ctgggcctga gggatttgga
     4141 ggtgacctgt gacccagact ctggaggttc tcaggggcta cggggatgtg gagtggggca
     4201 gatggactgg acccaggact tggcgcccca gaatgtggag ctctttgggg ctccaagtga
     4261 agccagggag catggggtgg gcggggtgag ccagtgccca gagcccggcc tgaggcacaa
     4321 tggcagcttg tctcctggcc tggaggccag agaccccttg gaggccaggg agctgggggt
     4381 tggtgagaca agtgggccag agacccaggg tgaagattac tcctcgtctt ccttggagcc
     4441 acaccctgca gaccctggaa tggagacagg agaagccctc agcttcggag caagccctgg
     4501 caggtgcccg gcccgccccc caccctccgg ctcccagggc ctgctggagg agatgctggc
     4561 agccagcagc tccaaggcgg tggctcggag ggagtcagcg gcctcgggcc ttgggggcct
     4621 gttggaggag gaaggagccg gggcaggtgc tgcccaagag gaggtgctgg agcctggcag
     4681 ggactctcca ccctcctgga ggccgcagcc tgatggtgag gccagccaga cagaagacgt
     4741 ggatggcacc tggggctctt cagcagccag gtggagcgat caggggccag cacagacttc
     4801 tcggcgaccc tcccaaggcc ctcctgccag atcccccagt caggacttct ccttcattga
     4861 ggacaccgag atcctcgaca gtgccatgta tcggagccgt gccaacttgg ggcgcaagcg
     4921 tgggcaccgg gccccggtca ttcggcctgg gggtaccttg ggcctgtcgg aggcagcaga
     4981 ctcggatgca cacctgttcc aggactctac agagccacgg gcatctcggg tgccatcttc
     5041 agatgaagag gtagtggagg aacctcagag ccgccggaca cggatgtcgt tgggcaccaa
     5101 ggggctgaaa gtcaacctct ttcctggcct gagcccctca gccctgaagg ccaagctgcg
     5161 cccccggaat cgctcagctg aggagggaga gctggctgag agcaagtcga gccagaagga
     5221 gtccgcggtc cagcgttcga aatcctgcaa ggtcccagga ctgggaaagc ccctcacgtt
     5281 acctcccaag ccagagaaat cctcagggtc agaaggatcg tcgcccaact ggcttcaagc
     5341 cctgaaactg aagaagaaga aggtctgaga agtcactgag gttcttccca cctggcagtc
     5401 tcaggcagtg cccattcctg tggggtccct gggtgaggag acggctggag ccccaccatg
     5461 ccccaggctg cagcctctgt cccctccacc tctgaggagc gtctggggag gcacatttat
     5521 gcactttgta tcaccctccg aactcccccc acaccttccc ttccctggat ttcatcacta
     5581 gtggttgaag gttttgtccc ttcctctcct ccttccctct ccctctctgc ttcctcctcc
     5641 agcctccctt gggttttctt ttgataccaa tttatagcat tttttataaa agcctttgat
     5701 ttttataatg ggtgggactg tatccctgcc tcaccccagg tctccgtctg ccccgccagg
     5761 taccccacag agaccaatga cattttgcca cttgaaacaa taaataaagt tttttgggaa
//
