LOCUS       NM_003747               9622 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tankyrase (TNKS), mRNA.
ACCESSION   NM_003747
VERSION     NM_003747.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9622)
  AUTHORS   Morino,S., Mashima,T., Shirai,F., Nagayama,S., Katayama,R. and
            Seimiya,H.
  TITLE     BET protein-dependent E2F pathway activity confers bell-shaped type
            resistance to tankyrase inhibitors in APC-mutated colorectal cancer
  JOURNAL   Cancer Lett 584, 216632 (2024)
   PUBMED   38216082
  REMARK    GeneRIF: BET protein-dependent E2F pathway activity confers
            bell-shaped type resistance to tankyrase inhibitors in APC-mutated
            colorectal cancer.
REFERENCE   2  (bases 1 to 9622)
  AUTHORS   Ma,N., Wibowo,Y.C., Wirtz,P., Baltus,D., Wieland,T. and Jansen,S.
  TITLE     Tankyrase inhibition interferes with junction remodeling, induces
            leakiness, and disturbs YAP1/TAZ signaling in the endothelium
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (3), 1763-1789 (2024)
   PUBMED   37741944
  REMARK    GeneRIF: Tankyrase inhibition interferes with junction remodeling,
            induces leakiness, and disturbs YAP1/TAZ signaling in the
            endothelium.
REFERENCE   3  (bases 1 to 9622)
  AUTHORS   Duan,X., Huang,T., Zhang,D., Wei,Y., Li,L., Yao,W., Cui,L.,
            Zhou,X., Yang,Y., Wang,W. and Zhao,J.
  TITLE     Effect and interaction of TNKS genetic polymorphisms and
            environmental factors on telomere damage in COEs-exposure workers
  JOURNAL   Ecotoxicol Environ Saf 250, 114489 (2023)
   PUBMED   36603485
  REMARK    GeneRIF: Effect and interaction of TNKS genetic polymorphisms and
            environmental factors on telomere damage in COEs-exposure workers.
REFERENCE   4  (bases 1 to 9622)
  AUTHORS   Xu,Y.R., Shi,M.L., Zhang,Y., Kong,N., Wang,C., Xiao,Y.F., Du,S.S.,
            Zhu,Q.Y. and Lei,C.Q.
  TITLE     Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2122805119 (2022)
   PUBMED   35733260
  REMARK    GeneRIF: Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation.
REFERENCE   5  (bases 1 to 9622)
  AUTHORS   Tang,B., Luo,H., Xie,S., Pan,C. and Fu,J.
  TITLE     Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the
            Expression of USP25 to Promote the Progression of Glioma
  JOURNAL   Dis Markers 2022, 9087190 (2022)
   PUBMED   35450028
  REMARK    GeneRIF: Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to
            Affect the Expression of USP25 to Promote the Progression of
            Glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9622)
  AUTHORS   Lyons,R.J., Deane,R., Lynch,D.K., Ye,Z.S., Sanderson,G.M.,
            Eyre,H.J., Sutherland,G.R. and Daly,R.J.
  TITLE     Identification of a novel human tankyrase through its interaction
            with the adaptor protein Grb14
  JOURNAL   J Biol Chem 276 (20), 17172-17180 (2001)
   PUBMED   11278563
REFERENCE   7  (bases 1 to 9622)
  AUTHORS   Chi,N.W. and Lodish,H.F.
  TITLE     Tankyrase is a golgi-associated mitogen-activated protein kinase
            substrate that interacts with IRAP in GLUT4 vesicles
  JOURNAL   J Biol Chem 275 (49), 38437-38444 (2000)
   PUBMED   10988299
REFERENCE   8  (bases 1 to 9622)
  AUTHORS   Smith,S. and de Lange,T.
  TITLE     Cell cycle dependent localization of the telomeric PARP, tankyrase,
            to nuclear pore complexes and centrosomes
  JOURNAL   J Cell Sci 112 (Pt 21), 3649-3656 (1999)
   PUBMED   10523501
REFERENCE   9  (bases 1 to 9622)
  AUTHORS   Zhu,L., Smith,S., de Lange,T. and Seldin,M.F.
  TITLE     Chromosomal mapping of the tankyrase gene in human and mouse
  JOURNAL   Genomics 57 (2), 320-321 (1999)
   PUBMED   10198177
REFERENCE   10 (bases 1 to 9622)
  AUTHORS   Smith,S., Giriat,I., Schmitt,A. and de Lange,T.
  TITLE     Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
  JOURNAL   Science 282 (5393), 1484-1487 (1998)
   PUBMED   9822378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021242.10, AC103877.2, AC103834.2 and AC104052.9.
            
            On Nov 23, 2018 this sequence version replaced NM_003747.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098394.1, SRR1803611.228164.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310430.11/ ENSP00000311579.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               AC021242.10        195244-195944
            702-926             AC103877.2         62656-62880
            927-1022            AC103834.2         39268-39363
            1023-1059           AC103834.2         103637-103673
            1060-1135           AC103834.2         104411-104486
            1136-1230           AC103834.2         128349-128443
            1231-1297           AC103834.2         129873-129939
            1298-1484           AC103834.2         130497-130683
            1485-1606           AC103834.2         132057-132178
            1607-1698           AC103834.2         133641-133732
            1699-1777           AC103834.2         133828-133906
            1778-1949           AC103834.2         144060-144231
            1950-2029           AC103834.2         150327-150406
            2030-2175           AC103834.2         154576-154721
            2176-2341           AC103834.2         156965-157130
            2342-2561           AC103834.2         158551-158770
            2562-2671           AC103834.2         159063-159172
            2672-2860           AC103834.2         171710-171898
            2861-3098           AC104052.9         41210-41447         c
            3099-3181           AC104052.9         40430-40512         c
            3182-3302           AC104052.9         31420-31540         c
            3303-3400           AC104052.9         29812-29909         c
            3401-3475           AC104052.9         28266-28340         c
            3476-3581           AC104052.9         27259-27364         c
            3582-3768           AC104052.9         26631-26817         c
            3769-3925           AC104052.9         22794-22950         c
            3926-9622           AC104052.9         10710-16406         c
FEATURES             Location/Qualifiers
     source          1..9622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..9622
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /note="tankyrase"
                     /db_xref="GeneID:8658"
                     /db_xref="HGNC:HGNC:11941"
                     /db_xref="MIM:603303"
     exon            1..701
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..4012
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /EC_number="2.4.2.30"
                     /note="tankyrase-1; TANK1; TNKS-1; tankyrase I; poly
                     [ADP-ribose] polymerase 5A; tankyrase, TRF1-interacting
                     ankyrin-related ADP-ribose polymerase;
                     ADP-ribosyltransferase diphtheria toxin-like 5;
                     TRF1-interacting ankyrin-related ADP-ribose polymerase 1;
                     protein poly-ADP-ribosyltransferase tankyrase-1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase tankyrase-1"
                     /protein_id="NP_003738.2"
                     /db_xref="CCDS:CCDS5974.1"
                     /db_xref="GeneID:8658"
                     /db_xref="HGNC:HGNC:11941"
                     /db_xref="MIM:603303"
                     /translation="MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTT
                     PASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAA
                     PVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVS
                     STAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSS
                     PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN
                     ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEY
                     KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG
                     ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEV
                     CSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKT
                     LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA
                     ERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG
                     FTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEG
                     RHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG
                     ASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQ
                     DLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL
                     LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG
                     RTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVV
                     SASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMN
                     ISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLG
                     GQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYN
                     VIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
                     GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQ
                     FSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTA
                     TAAEQKT"
     exon            702..926
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1022
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1059
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1135
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1230
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1297
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1484
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1606
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1698
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1777
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1949
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2029
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2175
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2341
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2561
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2671
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2860
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3098
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3181
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3302
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3400
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3475
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3581
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3768
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3925
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..9622
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9602..9607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /note="hexamer: AATAAA"
     polyA_site      9622
                     /gene="TNKS"
                     /gene_synonym="ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1;
                     TINF1; TNKS1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgacag tgctagggga gtccgaagat ggcggcgtcg cgtcgctctc agcatcatca
       61 ccaccatcat caacaacagc tccagcccgc cccaggggct tcagcgccgc cgccgccacc
      121 tcctccccca ctcagccctg gcctggcccc ggggaccacc ccagcctctc ccacggccag
      181 cggcctggcc cccttcgcct ccccgcggca cggcctagcg ctgccggagg gggatggcag
      241 tcgggatccg cccgacaggc cccgatcccc ggacccggtt gacggtacca gctgttgcag
      301 taccaccagc acaatctgta ccgtcgccgc cgctcccgtg gtcccagcgg tttctacttc
      361 atctgccgct ggggtcgctc ccaacccagc cggcagtggc agtaacaatt caccgtcgtc
      421 ctcttcttcc ccgacttctt cctcatcttc ctctccatcc tcccctggat cgagcttggc
      481 ggagagcccc gaggcggccg gagttagcag cacagcacca ctggggcctg gggcagcagg
      541 acctgggaca ggggtcccag cagtgagcgg ggccctacgg gaactgctgg aggcctgtcg
      601 caatggggac gtgtcccggg taaagaggct ggtggacgcg gcaaacgtaa atgcaaagga
      661 catggccggc cggaagtctt ctcccctgca cttcgctgca ggttttggaa ggaaggatgt
      721 tgtagaacac ttactacaga tgggtgctaa tgtccacgct cgtgatgatg gaggtctcat
      781 cccgcttcat aatgcctgtt cttttggcca tgctgaggtt gtgagtctgt tattgtgcca
      841 aggagctgat ccaaatgcca gggataactg gaactataca cctctgcatg aagctgctat
      901 taaagggaag atcgatgtgt gcattgtgct gctgcagcac ggagctgacc caaacattcg
      961 gaacactgat gggaaatcag ccctggacct ggcagatcct tcagcaaaag ctgtccttac
     1021 aggtgaatac aagaaagacg aactcctaga agctgctagg agtggtaatg aagaaaaact
     1081 aatggcttta ctgactcctc taaatgtgaa ttgccatgca agtgatgggc gaaagtcgac
     1141 tcctttacat ctagcagcgg gctacaacag agttcgaata gttcagcttc ttcttcagca
     1201 tggtgctgat gttcatgcaa aagacaaagg tggacttgtg cctcttcata atgcatgttc
     1261 atatggacat tatgaagtca cagaactgct actaaagcat ggagcttgtg ttaatgccat
     1321 ggatctctgg cagtttactc cactgcacga ggctgcttcc aagaaccgtg tagaagtctg
     1381 ctctttgtta cttagccatg gcgctgatcc tacattagtc aactgccatg gcaaaagtgc
     1441 tgtggatatg gctccaactc cggagcttag ggagagattg acttatgaat ttaaaggtca
     1501 ttctttacta caagcagcca gagaagcaga cttagctaaa gttaaaaaaa cactcgctct
     1561 ggaaatcatt aatttcaaac aaccgcagtc tcatgaaaca gcactgcact gtgctgtggc
     1621 ctctctgcat cccaaacgta aacaagtgac agaattgtta cttagaaaag gagcaaatgt
     1681 taatgaaaaa aataaagatt tcatgactcc cctgcatgtt gcagccgaaa gagcccataa
     1741 tgatgtcatg gaagttctgc ataagcatgg cgccaagatg aatgcactgg acacccttgg
     1801 tcagactgct ttgcatagag ccgccctagc aggtcacctg cagacctgcc gcctcctgct
     1861 gagttacggc tctgacccct ccatcatctc cttacaaggc ttcacagcag cacagatggg
     1921 caatgaagca gtgcagcaga ttctgagtga gagtacacct atacgtactt ctgatgttga
     1981 ttatcgactc ttagaggcat ctaaagctgg agacttggaa actgtgaagc aactttgcag
     2041 ctctcaaaat gtgaattgta gagacttaga gggccggcat tccacgccct tacacttcgc
     2101 agcaggctac aaccgcgtgt ctgttgtaga gtacctgcta caccacggtg ccgatgtcca
     2161 tgccaaagac aagggtggct tggtgcccct tcataatgcc tgttcatatg gacactatga
     2221 ggtggctgag cttttagtaa ggcatggggc ttctgtcaat gtggcggact tatggaaatt
     2281 tacccctctc catgaagcag cagctaaagg aaagtatgaa atctgcaagc tccttttaaa
     2341 acatggagca gatccaacta aaaagaacag agatggaaat acacctttgg atttggtaaa
     2401 ggaaggagac acagatattc aggacttact gagaggggat gctgctttgt tggatgctgc
     2461 caagaagggc tgcctggcaa gagtgcagaa gctctgtacc ccagagaata tcaactgcag
     2521 agacacccag ggcagaaatt caacccctct gcacctggca gcaggctata ataacctgga
     2581 agtagctgaa tatcttctag agcatggagc tgatgttaat gcccaggaca agggtggttt
     2641 aattcctctt cataatgcgg catcttatgg gcatgttgac atagcggctt tattgataaa
     2701 atacaacacg tgtgtaaatg caacagataa gtgggcgttt actcccctcc atgaagcagc
     2761 ccagaaagga aggacgcagc tgtgcgccct cctcctagcg catggtgcag accccaccat
     2821 gaagaaccag gaaggccaga cgcctctgga tctggcaaca gctgacgata tcagagcttt
     2881 gctgatagat gccatgcccc cagaggcctt acctacctgt tttaaacctc aggctactgt
     2941 agtgagtgcc tctctgatct caccagcatc caccccctcc tgcctctcgg ctgccagcag
     3001 catagacaac ctcactggcc ctttagcaga gttggccgta ggaggagcct ccaatgcagg
     3061 ggatggcgcc gcgggaacag aaaggaagga aggagaagtt gctggtcttg acatgaatat
     3121 cagccaattt ctaaaaagcc ttggccttga acaccttcgg gatatctttg aaacagaaca
     3181 gattacacta gatgtgttgg ctgatatggg tcatgaagag ttgaaagaaa taggcatcaa
     3241 tgcatatggg caccgccaca aattaatcaa aggagtagaa agactcttag gtggacaaca
     3301 aggcaccaat ccttatttga cttttcactg tgttaatcag ggaacgattt tgctggatct
     3361 tgctccagaa gataaagaat atcagtcagt ggaagaagag atgcaaagta ctattcgaga
     3421 acacagagat ggtggtaatg ctggcggcat cttcaacaga tacaatgtca ttcgaattca
     3481 aaaagttgtc aacaagaagt tgagggagcg gttctgccac cgacagaagg aagtgtctga
     3541 ggagaatcac aaccatcaca atgagcgcat gttgtttcat ggttctcctt tcattaatgc
     3601 cattattcat aaagggtttg atgagcgaca tgcatacata ggaggaatgt ttggggccgg
     3661 gatttatttt gctgaaaact cctcaaaaag caaccaatat gtttatggaa ttggaggagg
     3721 aacaggctgc cctacacaca aggacaggtc atgctatata tgtcacagac aaatgctctt
     3781 ctgtagagtg acccttggga aatcctttct gcagtttagc accatgaaaa tggcccacgc
     3841 gcctccaggg caccactcag tcattggtag accgagcgtc aatgggctgg catatgctga
     3901 atatgtcatc tacagaggag aacaggcata cccagagtat cttatcactt accagatcat
     3961 gaagccagaa gccccttccc agaccgcaac agccgcagag cagaagacct agtgaatgcc
     4021 tgctggtgaa ggccagatca gatttcaacc tgggactgga ttacagagga ttgtttctaa
     4081 taacaacatc aatattctag aagtccctga cagcctagaa ataagctgtt tgtcttctat
     4141 aaagcattgc tatagtgatg aatagtatga gtaactgata catactcaac tgctactgtt
     4201 ccctttgagg aaatgtttac aggggcggcc ttttaacata tctcaggctc attttcattg
     4261 caattatcca tttctaaaac aagattgctt cgatctagac ttggaaatgg aaaataagaa
     4321 aaccaatgct ttttcaaatg ttcacaattc acacactaca tttgttttgt tatgcatgac
     4381 gtgtctataa caaatataca catacgacag gcaacaagct tgtttttgat ttgccagaca
     4441 tgcatcattg gctattgttt gtttgttttt tgtttttttg tgttttttgg gttactttga
     4501 aaatgagcca gagccttctt gaggatattt tgcacaaagt cacgctgaca aaatcattag
     4561 cagtgcaacc caagcttctg gctgagcaag attcagtttc cactttttaa aattttttta
     4621 ttttgctctg tagctgcact tctcgttatc ataaattgag atgaaaagga aaaaacatca
     4681 agttttagta cctttttatg aattggccta tcttacaaga gaagggcaca aacaccaacc
     4741 tgacttagga acgcctaaat tcagagaagt caaagccggt gaaggccact tgctctttcc
     4801 aacacaagcc tgccacagag gtcttcggga cagtactgga gatgcaggtt gacacgggct
     4861 tgagttccaa ggtgaaaaaa ctggggaggc tgtgaaggaa gagctgcatt aaggagggtg
     4921 aggagcgtgt ggttctgtat catggcagcc ccaatggatc caggggatgc ctccaaaaaa
     4981 tacatgcttc ccttccctta atctgtactg ttgggattgt tacccctcca aattagctgc
     5041 cttatttcaa aagtcagtga aattactgca cttgatgagg gtcacaaaaa taccacttga
     5101 ttgtttcttt agttgagaat gctgggattc agactcgaat agtggataga tacacacaaa
     5161 tgcaaggact tttttgttta ctccagattt ggggtttatt ttgagtggca tgcttcaaat
     5221 agttcataaa gatccttgca ttaaatttct gaaccatttc ttcaaacttc ttagtgtgtt
     5281 tagacaagga gaacaaaaat tgaaaccaaa gccctttctg ttattttttc aatgaaggtg
     5341 agaaagaaat accatacaat tttctttgtg aaattactgt ttattttcat caacatttac
     5401 caagtgccat tgacatttat aaaaaaaaat gatcctttat agttcttaca cttgcccttt
     5461 tcaccttaac tgaatatgaa ttgagtgcac taacttattt acttgatata ctgtgcatct
     5521 actctgcttt gaagcgaaag aaatataaac acgaggagga ataggaaaga cagtgtgaca
     5581 caaacttgcc attgcaattc aaagccctga aaacgatggg tttaatgcaa ggtgattaag
     5641 ctgtgacctc ctttaatctc ctgaagcaaa ataaaatggt tacatgcaaa acttctagaa
     5701 atagactctt aaaatatata cattttgctt tgattttggc ttcaacccag tgctggaact
     5761 aggcatccag actagtttga atgtttgtag ctgaattttt atgggtcctc aaaattaaat
     5821 cgagaattag cctcagttgt tgcttctttt gaagtttcag tgacccaagc tgggtgtttg
     5881 tgtcttggct acttgtttaa tagcactaga attccaggtg aagctttgag agttgatatt
     5941 cattaagagg gctttttttc cccttctttc cttctctttt gctgtaacaa agggttgaag
     6001 aaattgccat ctgtgtagtt ttcagtagct gtcaagtgtg tcttacttac cttcccccag
     6061 acgtagttta aaatggtaaa cacagctgtg atttttagtt aagtaaaaga gttaatatga
     6121 tatagatatg gaaagcttta tggcttcatt aaaaagataa accactacct aactgtggtt
     6181 gtatgttgtt tccatcatac taactagatg aatggatgcg ccagttttca tcttggtcct
     6241 tacacttgag aagttaaact gtggttcagt atttaaactg ccagtgttat acgtctcatg
     6301 ctctgtgtgc caggtgaagg tactgtgtaa ggaagacatt tgcggtgctt cttgtcctat
     6361 aatgattcaa gtatatagta gttcttgaaa gagtgtgcat atattactca tctgcttaag
     6421 agagtgggtt aatggatata tcagaggagc caaatacatt tttttcagaa cttgaaaacc
     6481 aaaggtcatc atgagtgcac tcaaaagtta ggacaagttt attacatttg ggattttcat
     6541 ctgtagccgt atgaagaacc ctttccaata taaaagcatg gcattaaatt aggctgaagt
     6601 cttttatttt ttgtatatgt actatataga aatactagca agttaggatc atccaatatg
     6661 gcctaccccg aaatggcccc tctgtttccc taaccacatg gaagaaagaa tctgaacgtc
     6721 tccaccggct ctacccgagt tccaaaacta aagggcttct ccagacctga tggttccagt
     6781 ttacctgctg ttggcctgct ggatacttga ctcaggcata aattaagtgc cctggtcccg
     6841 aactttctcc ctgtatttga cctccttccc tctttcctaa attactagtc tggaattaaa
     6901 attagctcca gcaatgacct ttgactccat tcattttctc ctcatcttgg gtcttaaaaa
     6961 aggagaccag atacctccta gcttttgtat cacaaccagg aatgggtatt aggcctcatg
     7021 cgctttgctc agaacactgc cgctttgtta acaaatgaca gcatggaacc cagagttttg
     7081 attcgatgca aaataacagc agtgcaacca ggattcttgt tttccttttc cttcttggag
     7141 tttggaattt ctagcttttc aagcagcata agtagaatca acattaggat gttttcatga
     7201 aatagcatcc ttatacttct ttgagcttga tgttagtggc tagactgatt tccctttgct
     7261 ctcaaaatac aaagtgcatt gaagtataca gagaaatgcc tgaatatggc aagcaaataa
     7321 tgtagattaa cattctatta ttgtatccgt tttacaaaaa ataaaatttt gatatatgcc
     7381 ggagaacggc attagaatgc aataagttgt ctaggttttt ctgtttcagt gtctctccca
     7441 atggcacgaa gggttattgg gcattgtccc cacccccgcc tttttaacat gtgcactatc
     7501 tggattcctg taaatggcct tgcaaacaga agtggtgtgt attttcaagc acctttcccc
     7561 cattgtatcc gaatccctct tgtgtgatat ctgtgacaaa tagccttctt cttgtgtttt
     7621 ctgttggact aattgtctca cgtaaagcta tagaccttac taatttggca ggtattcaaa
     7681 actgccatta agataggatt tcatgtcaga tacgtattta aagagtaaag tcaaatttgt
     7741 ttaatgtcag atcagtgaca gaagtgaaaa gaaagtaatt gtgaaagtga tgtttgagct
     7801 attgtacaca tctagcatat ggaaagcaaa tgcactcgaa aactactatt ctagaacatg
     7861 aggcttcttc agcaacttgt gcactctgcc attaataaat taaatttttc ccctctagaa
     7921 agccttaact atggcggaaa ctttttaacc ttttatattt taataaataa aacattgtag
     7981 tcccatttct tagtgtttga aaggtgtgtc agtgagtcgg ccatgtctcc atgtgtttca
     8041 gacctgttca tcttatttta tgatggtata tttcataagt aatattccct tacatgcaat
     8101 ggagctgatt aaaattaatc catttcaatt tctccatatt ggaacttcct cagctaccag
     8161 atttctggtt tggagaagtg ctggaaagat ttcaaagcct attcagttgt gtatgtgggg
     8221 atacgacagc aactgtgata ccttgtagaa tatgagtgat atgcaagctg tgttttttaa
     8281 ttgttttaaa atgtaaatta tggttatgct aaagtgaaaa cctagaggaa gctaatgatt
     8341 ttatatactt tgcacgacca aatatggtcg tagtatgacg agttttatac attgccagag
     8401 agttctgcct cctctgaaat aacattcgca ctgtagattg catttcggct tttcctcctt
     8461 tcacattctt ttttgcttta cacttcacgt cttcgcacct gccctacctc ccatcctttc
     8521 aaagaggttt ctttcacgtt ccagaattca gattgttctg tgatttcttt tacatcagtc
     8581 tacccatttc tgcaggcagc cctgaaagcc cttgtgttga ttcagagtgt ttgcagagaa
     8641 atgcagttga accctggtag tggggtgtcc ctcacacacc cgcgcacccc tcccaaagtt
     8701 caggatgaaa ggctagaaaa cccattcaaa gttaggaaag aacacagatc tttgaggccg
     8761 atagcctaga cctagaagat gaccttgagt atgtaaacat tgtctccgtg acacaaaaca
     8821 ctgaaactct tcatgtgcat ataacacctg cttctgctcc cattgtttca agctcatctt
     8881 atctttgtag tagtaatgtt tgtctttgat acctacaaac taaaaaggta cttttatcaa
     8941 ggtttctcaa aacatttaca aaaccagctt tgagaaaatg ttatgttgcc tggcaacagc
     9001 actcggagta gtaattgtgt tttctcattg tgatgttggt ctgtgtgagc aaccagtgta
     9061 gtgactcttt ggttcattat tcgtgttgtt tttattttta gtctctgtgt gacccaacag
     9121 tggcaggggt tacaaccccc tctcctttct tttttgtatt tatctatttg taggattgtc
     9181 agatcaagta caagatgccc agttaagttt gaatttcaga gaaacaattt cacgttaaga
     9241 atgtttcatg caatatttgg catatattta cagtaaaagc attcattatt tgtctgaaat
     9301 tcaaatttaa ctgagcatgc tggtttttct cattgtttgg tttttctaaa tctggcaatc
     9361 ctacagctgt ggtcatggga aatcacctac agcatgttaa agtcctctag tcatcatctc
     9421 gtcacctgaa atggaagtcc tttttccctc accctccact tctttccaaa ggagggcatc
     9481 aaggaactta acctgcctgc ctggtgggtt tctatttaag acatctttgt gattatattt
     9541 aacctgcaat tgtgctttgg cttaatgtct agctcactgt acttgtaaat gattaatatt
     9601 caataaaacc atttttaaag ta
//
