LOCUS       NM_024873               2397 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TNFAIP3 interacting protein 3 (TNIP3), transcript
            variant 1, mRNA.
ACCESSION   NM_024873
VERSION     NM_024873.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2397)
  AUTHORS   Liu,D., Zhang,P., Zhou,J., Liao,R., Che,Y., Gao,M.M., Sun,J.,
            Cai,J., Cheng,X., Huang,Y., Chen,G., Nie,H., Ji,Y.X., Zhang,X.J.,
            Huang,Z., Xu,H., She,Z.G. and Li,H.
  TITLE     TNFAIP3 Interacting Protein 3 Overexpression Suppresses
            Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
  JOURNAL   Cell Metab 31 (4), 726-740 (2020)
   PUBMED   32268115
  REMARK    GeneRIF: TNFAIP3 Interacting Protein 3 Overexpression Suppresses
            Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.
REFERENCE   3  (bases 1 to 2397)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2397)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2397)
  AUTHORS   Huang,K.W., Wu,M.K. and Hung,Y.Y.
  TITLE     Elevated TNIP3 mRNA Expression in TNF-alpha-Secreting Cells from
            Patients with Major Depressive Disorder
  JOURNAL   Neuroimmunomodulation 26 (3), 153-158 (2019)
   PUBMED   31307045
  REMARK    GeneRIF: Elevated TNIP3 mRNA Expression in TNF-alpha-Secreting
            Cells from Patients with Major Depressive Disorder.
REFERENCE   6  (bases 1 to 2397)
  AUTHORS   Wagner,S., Carpentier,I., Rogov,V., Kreike,M., Ikeda,F., Lohr,F.,
            Wu,C.J., Ashwell,J.D., Dotsch,V., Dikic,I. and Beyaert,R.
  TITLE     Ubiquitin binding mediates the NF-kappaB inhibitory potential of
            ABIN proteins
  JOURNAL   Oncogene 27 (26), 3739-3745 (2008)
   PUBMED   18212736
REFERENCE   7  (bases 1 to 2397)
  AUTHORS   Verstrepen,L., Adib-Conquy,M., Kreike,M., Carpentier,I., Adrie,C.,
            Cavaillon,J.M. and Beyaert,R.
  TITLE     Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and
            toll-like receptor 4 stimulation is itself regulated by NF-kappaB
  JOURNAL   J Cell Mol Med 12 (1), 316-329 (2008)
   PUBMED   18081698
  REMARK    GeneRIF: Enhanced expression of ABIN-3 in monocytes is associated
            with sepsis
REFERENCE   8  (bases 1 to 2397)
  AUTHORS   Weaver,B.K., Bohn,E., Judd,B.A., Gil,M.P. and Schreiber,R.D.
  TITLE     ABIN-3: a molecular basis for species divergence in
            interleukin-10-induced anti-inflammatory actions
  JOURNAL   Mol Cell Biol 27 (13), 4603-4616 (2007)
   PUBMED   17485448
  REMARK    GeneRIF: ABIN-3 is, thus, an IL-10-induced gene product capable of
            attenuating NF-kappaB in human macrophages yet is inoperative in
            mice and represents a basis for species-specific differences in
            IL-10 actions.
REFERENCE   9  (bases 1 to 2397)
  AUTHORS   Wullaert,A., Verstrepen,L., Van Huffel,S., Adib-Conquy,M.,
            Cornelis,S., Kreike,M., Haegman,M., El Bakkouri,K., Sanders,M.,
            Verhelst,K., Carpentier,I., Cavaillon,J.M., Heyninck,K. and
            Beyaert,R.
  TITLE     LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of
            NF-kappaB activation
  JOURNAL   J Biol Chem 282 (1), 81-90 (2007)
   PUBMED   17088249
  REMARK    GeneRIF: ABIN-3 is a novel negative feedback regulator of
            LPS-induced NF-kappaB activation
REFERENCE   10 (bases 1 to 2397)
  AUTHORS   Staege,H., Brauchlin,A., Schoedon,G. and Schaffner,A.
  TITLE     Two novel genes FIND and LIND differentially expressed in
            deactivated and Listeria-infected human macrophages
  JOURNAL   Immunogenetics 53 (2), 105-113 (2001)
   PUBMED   11345586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290409.1, AK024815.1, CD367219.1 and AC105254.3.
            
            On Nov 22, 2018 this sequence version replaced NM_024873.5.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shortest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290409.1, AF277289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000057513.8/ ENSP00000057513.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1421              AK290409.1         1-1421
            1422-1583           AK024815.1         1042-1203
            1584-1765           CD367219.1         17-198              c
            1766-2198           AK024815.1         1378-1810
            2199-2397           AC105254.3         101322-101520       c
FEATURES             Location/Qualifiers
     source          1..2397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..2397
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="TNFAIP3 interacting protein 3"
                     /db_xref="GeneID:79931"
                     /db_xref="HGNC:HGNC:19315"
                     /db_xref="MIM:608019"
     exon            1..262
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1174
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Listeria induced; TNIP3 beta; ABIN-3 beta;
                     TNFAIP3-interacting protein 3 beta; listeria-induced gene
                     protein; A20-binding inhibitor of NF-kappa-B activation 3"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 3 isoform 1"
                     /protein_id="NP_079149.3"
                     /db_xref="CCDS:CCDS3718.1"
                     /db_xref="GeneID:79931"
                     /db_xref="HGNC:HGNC:19315"
                     /db_xref="MIM:608019"
                     /translation="MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLE
                     KQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDR
                     QREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIK
                     RLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDR
                     ERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHL
                     QDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP"
     exon            263..343
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            344..409
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            410..559
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            560..688
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            689..805
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            806..931
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            932..982
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1081
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1142
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..2397
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="hexamer: AATAAG"
     polyA_site      1765
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="major polyA site"
     regulatory      2370..2375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="hexamer: ATTAAA"
     regulatory      2375..2380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="hexamer: AATGAA"
     polyA_site      2387
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
     polyA_site      2397
                     /gene="TNIP3"
                     /gene_synonym="ABIN-3; LIND"
                     /note="major polyA site"
ORIGIN      
        1 attctgtgta attcctatcc acagtcactt ctgttcattt ttaatgaaaa cctattgctg
       61 ttattttcta ttatgagtta acggtgatgt gtgtttttta aattttgtat acttgctctc
      121 accctaaaat ataccttaag agacttttcc cctgtttttc tttctgcttt ccaagactcc
      181 aggaaaaaca gcttccatgg cacattttgt acagggcaca tctagaatga ttgccgcaga
      241 aagttctacg gagcataaag agtgtgctga accatcaaca agaaagaact tgatgaattc
      301 tcttgaacaa aagataaggt gtttggaaaa acaaagaaaa gagctcctgg aagttaacca
      361 gcaatgggat cagcaattta gaagtatgaa agagttatat gaaagaaagg tagcagagct
      421 gaagacgaaa ctggacgccg cggaaagatt cctcagcacg cgggagaagg atccgcatca
      481 gaggcagaga aaggacgaca ggcagagaga ggacgacagg cagcgcgacc tgacccggga
      541 ccggctgcag cgggaggaga aggaaaagga acgcctaaat gaagaattac atgaattgaa
      601 agaagagaat aaacttttaa agggaaaaaa tactcttgcg aacaaggaaa aggaacatta
      661 cgaatgtgaa ataaaacgcc tcaataaggc tcttcaggat gccttgaata tcaagtgttc
      721 attttccgag gactgtttga ggaagtctcg agtggaattc tgccatgagg agatgagaac
      781 agaaatggaa gttctgaagc agcaggtgca aatatacgaa gaagacttca aaaaggaacg
      841 atcggatcga gagagactta atcaagagaa agaggagcta cagcaaatta atgaaacttc
      901 ccaatcccag ttgaacaggc tgaattccca gataaaagct tgtcagatgg agaaagaaaa
      961 actagaaaag caattaaaac agatgtattg cccaccctgt aactgcggct tggttttcca
     1021 cctgcaagat ccatgggtac caacaggccc tggagctgtg cagaagcaac gggagcaccc
     1081 accagactat cagtggtatg ctcttgacca gcttccgcca gatgtacaac acaaggcaaa
     1141 tggtttatcc tcagtaaaga aagtccatcc gtagaagtac acactaacag agagagacaa
     1201 caggcaacga gggagcgtgg ctgaggaccc tcttctttgt ttatactgag gcttgtttct
     1261 gccacaaagg cacatcatct accctgttat ttgtgcctgg tcatgttttc ctttggtatg
     1321 aatacaggaa aaggcttctg acagctaaga tcctgatcaa attggaggag ccagttatta
     1381 tacaaccaaa tacaacttcc agtttccttg aaatgagact tggcagatgg atgatgcacg
     1441 actccctgaa aatctcttca gcatattgct gttggatgca caaaaatgat tctatgattt
     1501 aggcaactca gtgtttgctg cagggatatt gtatgttgat ttaaagtgca tatgtgtgtg
     1561 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttcctgggg taaaaatttc tgcagttgta
     1621 aacgtttaac attgctccca ttcttcttcc acagggcctt agttctttag ctatttgact
     1681 acatattgtt gacctcagtg atcctaaacg tagaattgaa gaggtgtata tacctcatta
     1741 aattaaataa gtggttcaat ctgaataaga tggttaattg gaagctattc cttagacaga
     1801 tcatttcttt aagatgatga gaaattgtgc gcctgcatca caagacttga ttatgaaaga
     1861 taaagtcttg ggctgggtgc agtggctcat gcctataatc ccagcacttt gggaggctga
     1921 ggcaggtgga ttgctttgag gccaggagtt ctagaccagc ctggccagca tggtgaaacc
     1981 ccatctctac tataaataca aaaattagcc aggctcgtgg cacacaccta taaacccagc
     2041 tactcaggag gcttgaggcg ggaggatcac ttgagcccag ggaggcagag gttgctgtaa
     2101 gttgagatcg ccactgcact ccagcctggg aaatagagtg agcaagactc agtgccccct
     2161 acccacccac tccacaccac caaaaaaaaa aaaaaaaaaa aaaggaagac aaagtcctga
     2221 tgggatgatg atggctatat ggctatgctg tgtccatata tacttacaga aatatttcag
     2281 acatatggat ttatagttaa atctgtgttt ttccttccct tggatttgat taattttaat
     2341 gaaaaactta attctgactt ctcaagccaa ttaaaatgaa aatggaattt attgaaa
//
