LOCUS       NM_024309               1946 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TNFAIP3 interacting protein 2 (TNIP2), transcript
            variant 1, mRNA.
ACCESSION   NM_024309
VERSION     NM_024309.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Qian,X., Wang,Y., Li,X., Li,Y. and Li,L.
  TITLE     TNFAIP3 interacting protein 2 relieves lipopolysaccharide
            (LPS)-induced inflammatory injury in endometritis by inhibiting
            NF-kappaB activation
  JOURNAL   Immun Inflamm Dis 11 (10), e970 (2023)
   PUBMED   37904691
  REMARK    GeneRIF: TNFAIP3 interacting protein 2 relieves lipopolysaccharide
            (LPS)-induced inflammatory injury in endometritis by inhibiting
            NF-kappaB activation.
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Chen,L., Wang,L., Zhou,G.F., Liu,Y., Chen,X., Xie,X.Y., Wen,Q.X.,
            Li,C.L., Yang,J. and Chen,G.J.
  TITLE     TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An
            in vitro study
  JOURNAL   Neurosci Lett 808, 137265 (2023)
   PUBMED   37085111
  REMARK    GeneRIF: TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of
            BACE1: An in vitro study.
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Wang,P., Wang,Y. and Ma,B.
  TITLE     Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by
            targeting miR-8082/TNIP2 in osteoarthritis
  JOURNAL   Cell Cycle 22 (7), 796-807 (2023)
   PUBMED   36503346
  REMARK    GeneRIF: Long noncoding RNA NAV2-AS5 relieves chondrocyte
            inflammation by targeting miR-8082/TNIP2 in osteoarthritis.
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Liu,W.K., Chien,C.Y., Chou,C.K. and Su,J.Y.
  TITLE     An LKB1-interacting protein negatively regulates TNFalpha-induced
            NF-kappaB activation
  JOURNAL   J Biomed Sci 10 (2), 242-252 (2003)
   PUBMED   12595760
  REMARK    GeneRIF: FLIP1 has a role in the regulation of NF-kappaB activity
            related to the role of LKB1 in tumor suppression
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Wu,W.S., Xu,Z.X. and Chang,K.S.
  TITLE     The promyelocytic leukemia protein represses A20-mediated
            transcription
  JOURNAL   J Biol Chem 277 (35), 31734-31739 (2002)
   PUBMED   12080044
  REMARK    GeneRIF: transcription repressed by promyelocytic leukemia protein
            expression
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
  TITLE     Identification of a novel A20-binding inhibitor of nuclear
            factor-kappa B activation termed ABIN-2
  JOURNAL   J Biol Chem 276 (32), 30216-30223 (2001)
   PUBMED   11390377
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J Cell Biol 145 (7), 1471-1482 (1999)
   PUBMED   10385526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF372839.1, AL110117.3 and BC002740.2.
            
            On May 17, 2019 this sequence version replaced NM_024309.3.
            
            Summary: This gene encodes a protein which acts as an inhibitor of
            NFkappaB activation. The encoded protein is also involved in
            MAP/ERK signaling pathway in specific cell types. It may be
            involved in apoptosis of endothelial cells. Alternative splicing
            results in multiple transcript variants. A pseudogene related to
            this gene is located on the X chromosome.[provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.277087.1,
                                           SRR1660805.269720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315423.12/ ENSP00000321203.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1321              AF372839.1         41-1361
            1322-1322           AL110117.3         6761-6761
            1323-1934           BC002740.2         1321-1932
            1935-1946           AL110117.3         7374-7385
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1946
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="TNFAIP3 interacting protein 2"
                     /db_xref="GeneID:79155"
                     /db_xref="HGNC:HGNC:19118"
                     /db_xref="MIM:610669"
     exon            1..323
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1337
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A20-binding inhibitor of NF-kappaB activation-2; fetal
                     liver LKB1-interacting protein"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 2 isoform 1"
                     /protein_id="NP_077285.3"
                     /db_xref="CCDS:CCDS3362.1"
                     /db_xref="GeneID:79155"
                     /db_xref="HGNC:HGNC:19118"
                     /db_xref="MIM:610669"
                     /translation="MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDAL
                     IARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLE
                     EKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTA
                     TAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVT
                     HVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCA
                     EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASL
                     LHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGH
                     PGAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAECCQ"
     exon            324..614
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            615..704
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            705..953
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1073
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1946
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="hexamer: AATAAA"
     polyA_site      1930
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="major polyA site"
ORIGIN      
        1 gcggaagttg ccggcggccg cgcggcctcc cgggcgggcc tacagccatg tcccgggacc
       61 cggggtcggg cggctgggag gaggccccgc gcgcagctgc cgcgctctgc accctgtacc
      121 acgaggccgg acagcggctg cgccgcctgc aggaccagct cgctgcccgc gacgccctca
      181 tcgctcgcct ccgcgcccgc ctggccgcgc tggaggggga cgccgcgccg tccctagtgg
      241 acgcgctgct ggagcaggtt gcgcgcttcc gggagcagct gcgaaggcag gagggcggcg
      301 ccgccgaggc ccagatgcgc caggaaattg agaggctgac tgagcgacta gaagaaaaag
      361 agagggagat gcagcagctg ctgagccagc cccaacacga gcgagagaag gaagtcgtcc
      421 tgctacggag gagcatggca gaaggggagc gcgcccgggc cgccagtgac gtcctgtgcc
      481 gctccttggc caacgagacc catcagctgc ggaggacgct gaccgccacc gcccacatgt
      541 gtcagcatct ggccaagtgt ctggatgaac gacagcatgc acaaaggaat gtgggggaga
      601 gaagtcctga ccagtcggaa cacacagatg ggcacacctc tgtccagagt gttattgaga
      661 agttgcagga agaaaatcga ctgttaaaac agaaggtgac tcacgttgaa gacctcaatg
      721 ccaagtggca gcgctacaac gccagcaggg acgaatacgt gagggggctc catgcgcagc
      781 tcagggggct gcagatcccc cacgagcccg agctgatgag gaaggagatc tcccggctca
      841 acagacagtt ggaagagaaa ataaatgact gtgccgaagt gaagcaggag ctggcggcct
      901 ccaggacggc ccgggatgct gcgttggagc gggtgcagat gctggaacag cagattctcg
      961 cttacaagga tgacttcatg tcagaaaggg ccgatcggga acgggctcaa agtaggattc
     1021 aagaactgga ggaaaaggtc gcctctttgc tgcaccaggt gtcctggaga caggattctc
     1081 gagagccaga cgccggccgg attcacgctg ggagcaaaac tgccaagtat ttggccgccg
     1141 acgcattaga gcttatggtg cctggtggct ggaggcctgg gactgggtcc cagcagccag
     1201 aaccccctgc agagggcggg catcctggcg cggcccagag aggccagggg gaccttcagt
     1261 gccctcactg cctgcagtgc ttcagtgacg agcaagggga agagctcctc aggcatgtgg
     1321 ctgagtgctg ccagtgaccg agactcaccc gtgcccttgc ggcctcctgg cccggtgcag
     1381 ctgccctcag ggacagggtg ggtgctctca gatgccatgg gttgagctct actgagagcc
     1441 aaggccccta gaatagttgc ggggcactct gatcgttcac tttggtccct ttggctatgg
     1501 aacaggctgg gtcacaggga actgccagtg aggctggagg ctggaggtgg agatggggtc
     1561 aggaacatct ggcagaggga ggtcccagtc tgtgtctcca tcaggcttaa gccagagcta
     1621 tctggtgctg gtgtgccagc ccctccccca gcctgcctag aaaggggtgg ctgcctgagg
     1681 gagtcacttg tatggtcccc agggtgggag ccccatcctg ttctatggaa taaagcgtcg
     1741 cctctctgcc tcgaaccagt caaatggagt attgcggctg cacgtcacac tagggtggcc
     1801 acccccgcca ttgcgagcca catgtctgca ctgagaaact gcatttcagt agcatttgtc
     1861 atccagccgg aagttaaagc acacttactt tattcaccta tttttataat aaacgttctt
     1921 gctgctgtga ctgctctgag aatttg
//
