LOCUS       NM_006058               2870 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens TNFAIP3 interacting protein 1 (TNIP1), transcript
            variant 5, mRNA.
ACCESSION   NM_006058
VERSION     NM_006058.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Panyard,D.J., Reus,L.M., Ali,M., Liu,J., Deming,Y.K., Lu,Q.,
            Kollmorgen,G., Carboni,M., Wild,N., Visser,P.J., Bertram,L.,
            Zetterberg,H., Blennow,K., Gobom,J., Western,D., Sung,Y.J.,
            Carlsson,C.M., Johnson,S.C., Asthana,S., Cruchaga,C., Tijms,B.M.,
            Engelman,C.D. and Snyder,M.P.
  TITLE     Post-GWAS multiomic functional investigation of the TNIP1 locus in
            Alzheimer's disease highlights a potential role for GPX3
  JOURNAL   Alzheimers Dement 20 (7), 5044-5053 (2024)
   PUBMED   38809917
  REMARK    GeneRIF: Post-GWAS multiomic functional investigation of the TNIP1
            locus in Alzheimer's disease highlights a potential role for GPX3.
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Martin-Vicente,M., Mthiyane,H., Jimenez-Sousa,M.A., Subramoney,K.,
            Hellferscee,O., Wolter,N., Walaza,S., Fernandez-Rodriguez,A.,
            Cohen,C., von Gottberg,A., Resino,S., Martinez,I. and
            Treurnicht,F.K.
  TITLE     TNFAIP3-interacting protein 1 polymorphisms and their association
            with symptomatic human respiratory syncytial virus infection and
            bronchiolitis in infants younger than one year from South Africa: A
            case-control study
  JOURNAL   Int J Infect Dis 136, 107-110 (2023)
   PUBMED   37751795
  REMARK    GeneRIF: TNFAIP3-interacting protein 1 polymorphisms and their
            association with symptomatic human respiratory syncytial virus
            infection and bronchiolitis in infants younger than one year from
            South Africa: A case-control study.
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Rasmussen,N.L., Zhou,J., Olsvik,H., Kaeser-Pebernard,S., Lamark,T.,
            Dengjel,J. and Johansen,T.
  TITLE     The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy
            following TBK1 phosphorylation of its LIR
  JOURNAL   Autophagy 19 (10), 2819-2820 (2023)
   PUBMED   36847414
  REMARK    GeneRIF: The inflammation repressor TNIP1/ABIN-1 is degraded by
            autophagy following TBK1 phosphorylation of its LIR.
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Le Guerroue,F., Bunker,E.N., Rosencrans,W.M., Nguyen,J.T.,
            Basar,M.A., Werner,A., Chou,T.F., Wang,C. and Youle,R.J.
  TITLE     TNIP1 inhibits selective autophagy via bipartite interaction with
            LC3/GABARAP and TAX1BP1
  JOURNAL   Mol Cell 83 (6), 927-941 (2023)
   PUBMED   36898370
  REMARK    GeneRIF: TNIP1 inhibits selective autophagy via bipartite
            interaction with LC3/GABARAP and TAX1BP1.
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Zhou,J., Rasmussen,N.L., Olsvik,H.L., Akimov,V., Hu,Z., Evjen,G.,
            Kaeser-Pebernard,S., Sankar,D.S., Roubaty,C., Verlhac,P., van de
            Beek,N., Reggiori,F., Abudu,Y.P., Blagoev,B., Lamark,T.,
            Johansen,T. and Dengjel,J.
  TITLE     TBK1 phosphorylation activates LIR-dependent degradation of the
            inflammation repressor TNIP1
  JOURNAL   J Cell Biol 222 (2) (2023)
   PUBMED   36574265
  REMARK    GeneRIF: TBK1 phosphorylation activates LIR-dependent degradation
            of the inflammation repressor TNIP1.
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Gupta,K., Ott,D., Hope,T.J., Siliciano,R.F. and Boeke,J.D.
  TITLE     A human nuclear shuttling protein that interacts with human
            immunodeficiency virus type 1 matrix is packaged into virions
  JOURNAL   J Virol 74 (24), 11811-11824 (2000)
   PUBMED   11090181
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J Cell Biol 145 (7), 1471-1482 (1999)
   PUBMED   10385526
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Fukushi,M., Dixon,J., Kimura,T., Tsurutani,N., Dixon,M.J. and
            Yamamoto,N.
  TITLE     Identification and cloning of a novel cellular protein Naf1,
            Nef-associated factor 1, that increases cell surface CD4 expression
  JOURNAL   FEBS Lett 442 (1), 83-88 (1999)
   PUBMED   9923610
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Jakel,S. and Gorlich,D.
  TITLE     Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear
            import of ribosomal proteins in mammalian cells
  JOURNAL   EMBO J 17 (15), 4491-4502 (1998)
   PUBMED   9687515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB252972.1, AK074400.1 and
            AW589284.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_006058.4.
            
            Summary: This gene encodes an A20-binding protein which plays a
            role in autoimmunity and tissue homeostasis through the regulation
            of nuclear factor kappa-B activation. Mutations in this gene have
            been associated with psoriatic arthritis, rheumatoid arthritis, and
            systemic lupus erythematosus. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (3) is longer and contains a distinct Cz-terminus, compared
            to isoform 1. Variants 3, 4, 5 and 8 encode the same protein
            (isoform 3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012133.1, AK074400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521591.6/ ENSP00000430760.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2234              AB252972.1         41-2274
            2235-2866           AK074400.1         2216-2847
            2867-2870           AW589284.1         14-17               c
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2870
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /note="TNFAIP3 interacting protein 1"
                     /db_xref="GeneID:10318"
                     /db_xref="HGNC:HGNC:16903"
                     /db_xref="MIM:607714"
     exon            1..155
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            156..327
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2102
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /note="isoform 3 is encoded by transcript variant 5;
                     Nef-associated factor 1 SNP; HIV-1 Nef-interacting
                     protein; virion-associated nuclear shuttling protein;
                     A20-binding inhibitor of NF-kappa-B activation 1"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 1 isoform 3"
                     /protein_id="NP_006049.3"
                     /db_xref="CCDS:CCDS34280.1"
                     /db_xref="GeneID:10318"
                     /db_xref="HGNC:HGNC:16903"
                     /db_xref="MIM:607714"
                     /translation="MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKM
                     LGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTA
                     PACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLH
                     LQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKE
                     NEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKA
                     VAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQK
                     ITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELR
                     QKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALL
                     RKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQL
                     KAFKDEEKAREALRQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHGFED
                     WSQIRYPPPPMAMEHPPPLPNSRLFHLPEYTWRLPCGGVRNPNQSSQVMDPPTARPTE
                     PESPKNDREGPQ"
     exon            328..462
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            463..548
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            549..626
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            627..818
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            819..913
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1037
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1127
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1193
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1325
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1454
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1586
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1712
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1778
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1970
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2067
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2870
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /note="hexamer: CATAAA"
     polyA_site      2870
                     /gene="TNIP1"
                     /gene_synonym="ABIN-1; NAF1; nip40-1; VAN"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcgt cctcggcccg ggtgccctgc ccccgtccag gagccctagg agtgctacgg
       61 ggggccggag ccttgcccgg gccgctgccc cgtccctgga ttcggggctg gacgcagcaa
      121 gcggggcgct gtgtccccaa gctccccgtc ctcggccagg cgggcaccac ggcaggggct
      181 gagctaccct catggaaggg agaggaccgt accggatcta cgaccctggg ggcagcgtgc
      241 cctcaggaga ggcatccgca gcttttgagc gcctagtgaa ggagaattcc cggctgaagg
      301 aaaaaatgca agggataaag atgttagggg agcttttgga agagtcccag atggaagcga
      361 ccaggctccg gcagaaggca gaggagctag tgaaggacaa cgagctgctc ccaccacctt
      421 ctccctcctt gggctccttc gaccccctgg ctgagctcac aggaaaggac tcaaatgtca
      481 cagcatctcc cacagcccct gcatgcccca gtgacaagcc agcaccagtc cagaagcctc
      541 catccagtgg cacctcctct gaatttgaag tggtcactcc tgaggagcag aattcaccag
      601 agagcagcag ccatgccaat gcgatggcgc tgggccccct gccccgtgag gacggcaacc
      661 tgatgctgca cctgcagcgc ctggagacca cgctgagtgt gtgtgccgag gagccggacc
      721 acggccagct cttcacccac ctgggccgca tggccctgga gttcaaccga ctggcatcca
      781 aggtgcacaa gaatgagcag cgcacctcca ttctgcagac cctgtgtgag cagcttcgga
      841 aggagaacga ggctctgaag gccaagttgg ataagggcct ggaacagcgg gatcaggctg
      901 ccgagaggct gcgggaggaa aatttggagc tcaagaagtt gttgatgagc aatggcaaca
      961 aagagggtgc gtctgggcgg ccaggctcac cgaagatgga agggacaggc aagaaggcag
     1021 tggctggaca gcagcaggct agtgtgacgg caggtaaggt cccagaggtg gtggccttgg
     1081 gcgcagccga gaagaaggtg aagatgctgg agcagcagcg cagtgagctg ctggaagtga
     1141 acaagcagtg ggaccagcat ttccggtcca tgaagcagca gtatgagcag aagatcactg
     1201 agctgcgtca gaagctggct gatttgcaga agcaggtgac tgacctggag gccgagcggg
     1261 agcagaagca gcgtgacttt gaccgcaagc tcctcctggc caagtccaag attgaaatgg
     1321 aggagaccga caaggagcag ctgacagcag aggccaagga gctgcgccaa aaggtcaagt
     1381 acctgcagga tcagctgagc ccactcaccc gacagcgtga gtaccaggaa aaggagatcc
     1441 agcggctcaa caaggccctg gaggaagcac tgagcatcca aaccccgcca tcatctccac
     1501 caacagcatt tgggagccca gaaggagcag gggccctcct aaggaaacag gagctggtca
     1561 cgcagaatga gttgctgaaa cagcaggtga agatcttcga ggaggacttc cagagggagc
     1621 gcagtgatcg tgagcgcatg aatgaggaga aggaagagct gaagaagcaa gtggagaagc
     1681 tgcaggccca ggtcaccctg tcaaatgccc agctaaaagc attcaaagat gaggagaagg
     1741 caagagaagc cctcagacag cagaagagga aagcaaaggc ctcaggagag cgttaccatg
     1801 tggagcccca cccagaacat ctctgcgggg cctaccccta cgcctacccg cccatgccag
     1861 ccatggtgcc acaccatggc ttcgaggact ggtcccagat ccgctacccc cctcccccca
     1921 tggccatgga gcacccgccc ccactcccca actcgcgcct cttccatctg ccggaataca
     1981 cctggcgtct accctgtgga ggggttcgaa atccaaatca gagctcccaa gtgatggacc
     2041 ctcccacagc caggcctaca gaaccagagt ctccaaaaaa tgaccgtgag gggcctcagt
     2101 gagaccagat tgtgtcattt ggctccacct tcatcttgca gagccagctg atctcagatt
     2161 gccaagaaac tagaagccac ttgcacggtg tggccagagc ctcagctgga tgagaggctg
     2221 agatgggtgg ccagcttgta caccagtccc tgaactgagc tgtttacagg actggggagg
     2281 ctccacccag aaggctttca tttgtactct gctgggagtg actgggaaaa actccttccc
     2341 tgctgctgag tggagagagg cctcatccgg ctttgaccca ccatccgttg cagaagcctc
     2401 caggagcagc aatcctaaga gtgggaggca gccaagaccc ccttccttca aaacctcccg
     2461 gaagtggttt caggccctct agttgccatg accaatttgt gtgtgtgttt aatttttgct
     2521 tcaagctctg tagcaggacc tgccccacgc acacccctac ccctctgtga ggagctgtgg
     2581 gaagtgtggg tttgtctcca gaacagaaga gaatgatgga tattctggct ctggggccct
     2641 ctccaccacc actcacagta gccttgctga agccatcaca gatgggagaa ggccatgcca
     2701 gccacgtccg ccgaggggcg ccagcctgaa gctgccaggc cctgaggttc agaccctgga
     2761 ccccatagct ggaggcctgt ggtgccagaa gcccagatta gggtggctgt ccatccctgg
     2821 atagctattt gcacgaatca tggacataaa tccaagttga agaagatcaa
//
