LOCUS       NM_003811               1634 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens TNF superfamily member 9 (TNFSF9), mRNA.
ACCESSION   NM_003811
VERSION     NM_003811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Li,Z., Gao,T., Wang,J., Zhang,X., Zhang,Y., Zhang,L., Yang,P. and
            Liu,J.
  TITLE     Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke
            reperfusion injury with the progression of acute ischaemic stroke
  JOURNAL   J Neurochem 168 (6), 1030-1044 (2024)
   PUBMED   38344886
  REMARK    GeneRIF: Ferroptosis mediated by TNFSF9 interferes in acute
            ischaemic stroke reperfusion injury with the progression of acute
            ischaemic stroke.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Wu,J. and Wang,Y.
  TITLE     Role of TNFSF9 bidirectional signal transduction in antitumor
            immunotherapy
  JOURNAL   Eur J Pharmacol 928, 175097 (2022)
   PUBMED   35714694
  REMARK    GeneRIF: Role of TNFSF9 bidirectional signal transduction in
            antitumor immunotherapy.
            Review article
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Nielsen,M.A., Juul-Madsen,K., Stegmayr,J., Gao,C., Mehta,A.Y.,
            Greisen,S.R., Kragstrup,T.W., Hvid,M., Vorup-Jensen,T.,
            Cummings,R.D., Leffler,H. and Deleuran,B.W.
  TITLE     Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and
            Membrane Expressed 4-1BB
  JOURNAL   Front Immunol 13, 915890 (2022)
   PUBMED   35812455
  REMARK    GeneRIF: Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking
            Soluble and Membrane Expressed 4-1BB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Qiu,L., Ning,H., Zhu,Y., Yang,Q., Liu,L., Luo,L., Gao,Y. and
            Xing,Y.
  TITLE     Feedback regulation of antioxidant transcription factor NFE2L1 and
            immunostimulatory factor 41BBL mediates the crosstalk between
            oxidative stress and tumor immunity
  JOURNAL   Mol Immunol 141, 265-272 (2022)
   PUBMED   34902807
  REMARK    GeneRIF: Feedback regulation of antioxidant transcription factor
            NFE2L1 and immunostimulatory factor 41BBL mediates the crosstalk
            between oxidative stress and tumor immunity.
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Wu,J., Wang,Y., Yang,Y., Liu,F., Chen,J., Jiang,Z. and Jiang,Z.
  TITLE     TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail
            signaling and M2 polarization of macrophages
  JOURNAL   Aging (Albany NY) 13 (17), 21571-21586 (2021)
   PUBMED   34517345
  REMARK    GeneRIF: TNFSF9 promotes metastasis of pancreatic cancer through
            Wnt/Snail signaling and M2 polarization of macrophages.
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Saoulli,K., Lee,S.Y., Cannons,J.L., Yeh,W.C., Santana,A.,
            Goldstein,M.D., Bangia,N., DeBenedette,M.A., Mak,T.W., Choi,Y. and
            Watts,T.H.
  TITLE     CD28-independent, TRAF2-dependent costimulation of resting T cells
            by 4-1BB ligand
  JOURNAL   J Exp Med 187 (11), 1849-1862 (1998)
   PUBMED   9607925
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Arch,R.H. and Thompson,C.B.
  TITLE     4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve
            growth factor receptor subfamily that bind TNF receptor-associated
            factors and activate nuclear factor kappaB
  JOURNAL   Mol Cell Biol 18 (1), 558-565 (1998)
   PUBMED   9418902
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Loo,D.T., Chalupny,N.J., Bajorath,J., Shuford,W.W., Mittler,R.S.
            and Aruffo,A.
  TITLE     Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of
            the tumor necrosis factor receptor superfamily, and comparison with
            human 4-1BB
  JOURNAL   J Biol Chem 272 (10), 6448-6456 (1997)
   PUBMED   9045669
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Alderson,M.R., Smith,C.A., Tough,T.W., Davis-Smith,T.,
            Armitage,R.J., Falk,B., Roux,E., Baker,E., Sutherland,G.R. and
            Din,W.S.
  TITLE     Molecular and biological characterization of human 4-1BB and its
            ligand
  JOURNAL   Eur J Immunol 24 (9), 2219-2227 (1994)
   PUBMED   8088337
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Goodwin,R.G., Din,W.S., Davis-Smith,T., Anderson,D.M., Gimpel,S.D.,
            Sato,T.A., Maliszewski,C.R., Brannan,C.I., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Molecular cloning of a ligand for the inducible T cell gene 4-1BB:
            a member of an emerging family of cytokines with homology to tumor
            necrosis factor
  JOURNAL   Eur J Immunol 23 (10), 2631-2641 (1993)
   PUBMED   8405064
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010503.8 and BX107825.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003811.3.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            transmembrane cytokine is a bidirectional signal transducer that
            acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory
            receptor molecule in T lymphocytes. This cytokine and its receptor
            are involved in the antigen presentation process and in the
            generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is
            absent from resting T lymphocytes but rapidly expressed upon
            antigenic stimulation. The ligand encoded by this gene,
            TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes
            in addition to promoting T lymphocyte proliferation. This cytokine
            has also been shown to be required for the optimal CD8 responses in
            CD8 T cells. This cytokine is expressed in carcinoma cell lines,
            and is thought to be involved in T cell-tumor cell
            interaction.[provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.187091.1, U03398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245817.5/ ENSP00000245817.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC010503.8         94716-94993
            279-309             AC010503.8         96476-96506
            310-1571            AC010503.8         98290-99551
            1572-1634           BX107825.1         341-403
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1634
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /note="TNF superfamily member 9"
                     /db_xref="GeneID:8744"
                     /db_xref="HGNC:HGNC:11939"
                     /db_xref="MIM:606182"
     exon            1..278
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..776
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /note="receptor 4-1BB ligand; tumor necrosis factor
                     superfamily member 9; homolog of mouse 4-1BB-L; 4-1BBL;
                     tumor necrosis factor (ligand) superfamily, member 9;
                     tumor necrosis factor ligand 5A; CD137 ligand"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     9"
                     /protein_id="NP_003802.1"
                     /db_xref="CCDS:CCDS12169.1"
                     /db_xref="GeneID:8744"
                     /db_xref="HGNC:HGNC:11939"
                     /db_xref="MIM:606182"
                     /translation="MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAA
                     CAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLL
                     IDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGS
                     VSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHT
                     EARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE"
     exon            279..309
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /inference="alignment:Splign:2.1.0"
     exon            310..1634
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      996..1001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /note="hexamer: ATTATA"
     polyA_site      1030
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
     regulatory      1612..1617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="TNFSF9"
                     /gene_synonym="4-1BB-L; CD137L; TNLG5A"
                     /note="major polyA site"
ORIGIN      
        1 agtctctcgt catggaatac gcctctgacg cttcactgga ccccgaagcc ccgtggcctc
       61 ccgcgccccg cgctcgcgcc tgccgcgtac tgccttgggc cctggtcgcg gggctgctgc
      121 tgctgctgct gctcgctgcc gcctgcgccg tcttcctcgc ctgcccctgg gccgtgtccg
      181 gggctcgcgc ctcgcccggc tccgcggcca gcccgagact ccgcgagggt cccgagcttt
      241 cgcccgacga tcccgccggc ctcttggacc tgcggcaggg catgtttgcg cagctggtgg
      301 cccaaaatgt tctgctgatc gatgggcccc tgagctggta cagtgaccca ggcctggcag
      361 gcgtgtccct gacggggggc ctgagctaca aagaggacac gaaggagctg gtggtggcca
      421 aggctggagt ctactatgtc ttctttcaac tagagctgcg gcgcgtggtg gccggcgagg
      481 gctcaggctc cgtttcactt gcgctgcacc tgcagccact gcgctctgct gctggggccg
      541 ccgccctggc tttgaccgtg gacctgccac ccgcctcctc cgaggctcgg aactcggcct
      601 tcggtttcca gggccgcttg ctgcacctga gtgccggcca gcgcctgggc gtccatcttc
      661 acactgaggc cagggcacgc catgcctggc agcttaccca gggcgccaca gtcttgggac
      721 tcttccgggt gacccccgaa atcccagccg gactcccttc accgaggtcg gaataacgtc
      781 cagcctgggt gcagcccacc tggacagagt ccgaatccta ctccatcctt catggagacc
      841 cctggtgctg ggtccctgct gctttctcta cctcaagggg cttggcaggg gtccctgctg
      901 ctgacctccc cttgaggacc ctcctcaccc actccttccc caagttggac cttgatattt
      961 attctgagcc tgagctcaga taatatatta tatatattat atatatatat atatttctat
     1021 ttaaagagga tcctgagttt gtgaatggac ttttttagag gagttgtttt gggggggggg
     1081 gggtcttcga cattgccgag gctggtcttg aactcctgga cttagacgat cctcctgcct
     1141 cagcctccca agcaactggg attcatcctt tctattaatt cattgtactt atttgcttat
     1201 ttgtgtgtat tgagcatctg taatgtgcca gcattgtgcc caggctaggg ggctatagaa
     1261 acatctagaa atagactgaa agaaaatctg agttatggta atacgtgagg aatttaaaga
     1321 ctcatcccca gcctccacct cctgtgtgat acttgggggc tagctttttt ctttctttct
     1381 tttttttgag atggtcttgt tctgtcaacc aggctagaat gcagcggtgc aatcatgagt
     1441 caatgcagcc tccagcctcg acctcccgag gctcaggtga tcctcccatc tcagcctctc
     1501 gagtagctgg gaccacagtt gtgtgccacc acacttggct aactttttaa tttttttgcg
     1561 gagacggtat tgctatgttg ccaaggttgt ttacatgcca gtacaattta taataaacac
     1621 tcatttttcc tccc
//
