LOCUS       NM_001244               3779 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens TNF superfamily member 8 (TNFSF8), transcript variant
            1, mRNA.
ACCESSION   NM_001244
VERSION     NM_001244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Liu,C., Yan,S., Chen,H., Wu,Z., Li,L. and Li,Y.
  TITLE     Several genetic variants associated with systemic sclerosis in a
            Chinese Han population
  JOURNAL   Clin Rheumatol 42 (3), 773-781 (2023)
   PUBMED   36301368
  REMARK    GeneRIF: Several genetic variants associated with systemic
            sclerosis in a Chinese Han population.
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Sallin,M.A., Kauffman,K.D., Riou,C., Du Bruyn,E., Foreman,T.W.,
            Sakai,S., Hoft,S.G., Myers,T.G., Gardina,P.J., Sher,A., Moore,R.,
            Wilder-Kofie,T., Moore,I.N., Sette,A., Lindestam Arlehamn,C.S.,
            Wilkinson,R.J. and Barber,D.L.
  TITLE     Host resistance to pulmonary Mycobacterium tuberculosis infection
            requires CD153 expression
  JOURNAL   Nat Microbiol 3 (11), 1198-1205 (2018)
   PUBMED   30202016
  REMARK    GeneRIF: Polyfunctional CD153-expressing CD4 T cells are increased
            in latent Mycobacterium tuberculosis infection compared to active
            Tuberculosis.
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Hansen,H.P., Trad,A., Dams,M., Zigrino,P., Moss,M., Tator,M.,
            Schon,G., Grenzi,P.C., Bachurski,D., Aquino,B., Durkop,H.,
            Reiners,K.S., von Bergwelt-Baildon,M., Hallek,M., Grotzinger,J.,
            Engert,A., Paes Leme,A.F. and Pogge von Strandmann,E.
  TITLE     CD30 on extracellular vesicles from malignant Hodgkin cells
            supports damaging of CD30 ligand-expressing bystander cells with
            Brentuximab-Vedotin, in vitro
  JOURNAL   Oncotarget 7 (21), 30523-30535 (2016)
   PUBMED   27105521
  REMARK    GeneRIF: Data suggest that Brentuximab Vedotin (SGN-35) damaged
            CD30 ligand (CD30L)-immune cells through CD30 extracellular
            vesicles (EVs).
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian tumor necrosis factor
            ligand genes
  JOURNAL   Immunogenetics 68 (2), 125-132 (2016)
   PUBMED   26646413
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Pera,M.F., Bennett,W. and Cerretti,D.P.
  TITLE     CD30 and its ligand: possible role in regulation of teratoma stem
            cells
  JOURNAL   APMIS 106 (1), 169-72 (1998)
   PUBMED   9524575
  REMARK    Review article
REFERENCE   7  (bases 1 to 3779)
  AUTHORS   Croager,E.J. and Abraham,L.J.
  TITLE     Characterisation of the human CD30 ligand gene structure
  JOURNAL   Biochim Biophys Acta 1353 (3), 231-235 (1997)
   PUBMED   9349718
REFERENCE   8  (bases 1 to 3779)
  AUTHORS   Gruss,H.J., DaSilva,N., Hu,Z.B., Uphoff,C.C., Goodwin,R.G. and
            Drexler,H.G.
  TITLE     Expression and regulation of CD30 ligand and CD30 in human
            leukemia-lymphoma cell lines
  JOURNAL   Leukemia 8 (12), 2083-2094 (1994)
   PUBMED   7528856
REFERENCE   9  (bases 1 to 3779)
  AUTHORS   Gruss,H.J., Boiani,N., Williams,D.E., Armitage,R.J., Smith,C.A. and
            Goodwin,R.G.
  TITLE     Pleiotropic effects of the CD30 ligand on CD30-expressing cells and
            lymphoma cell lines
  JOURNAL   Blood 83 (8), 2045-2056 (1994)
   PUBMED   8161776
REFERENCE   10 (bases 1 to 3779)
  AUTHORS   Smith,C.A., Gruss,H.J., Davis,T., Anderson,D., Farrah,T., Baker,E.,
            Sutherland,G.R., Brannan,C.I., Copeland,N.G., Jenkins,N.A. et al.
  TITLE     CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose
            ligand defines an emerging family of cytokines with homology to TNF
  JOURNAL   Cell 73 (7), 1349-1360 (1993)
   PUBMED   8391931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313619.1, AL133412.7 and
            AA748015.1.
            
            On Jul 22, 2020 this sequence version replaced NM_001244.3.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            cytokine is a ligand for TNFRSF8/CD30, which is a cell surface
            antigen and a marker for Hodgkin lymphoma and related hematologic
            malignancies. The engagement of this cytokine expressed on B cell
            surface plays an inhibitory role in modulating Ig class switch.
            This cytokine was shown to enhance cell proliferation of some
            lymphoma cell lines, while to induce cell death and reduce cell
            proliferation of other lymphoma cell lines. The pleiotropic
            biologic activities of this cytokine on different CD30+ lymphoma
            cell lines may play a pathophysiologic role in Hodgkin's and some
            non-Hodgkin's lymphomas. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09753.1, SRR1803614.158217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223795.3/ ENSP00000223795.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-993               AK313619.1         5-997
            994-3589            AL133412.7         96066-98661         c
            3590-3779           AA748015.1         15-204              c
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32-q33.1"
     gene            1..3779
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /note="TNF superfamily member 8"
                     /db_xref="GeneID:944"
                     /db_xref="HGNC:HGNC:11938"
                     /db_xref="MIM:603875"
     exon            1..483
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..993
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /note="isoform 1 is encoded by transcript variant 1; CD30
                     antigen ligand; CD153 antigen; CD30 ligand; CD30-L; tumor
                     necrosis factor (ligand) superfamily, member 8; tumor
                     necrosis factor ligand 3A; tumor necrosis factor
                     superfamily member 8"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     8 isoform 1"
                     /protein_id="NP_001235.1"
                     /db_xref="CCDS:CCDS6810.1"
                     /db_xref="GeneID:944"
                     /db_xref="HGNC:HGNC:11938"
                     /db_xref="MIM:603875"
                     /translation="MDPGLQQALNGMAPPGDTAMHVPAGSVASHLGTTSRSYFYLTTA
                     TLALCLVFTVATIMVLVVQRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYL
                     QVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKL
                     ELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTST
                     FPLENVLSIFLYSNSD"
     exon            484..526
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /inference="alignment:Splign:2.1.0"
     exon            527..598
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /inference="alignment:Splign:2.1.0"
     exon            599..3779
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3134..3139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /note="hexamer: AGTAAA"
     polyA_site      3157
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /note="major polyA site"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
                     /note="hexamer: AATAAT"
     polyA_site      3779
                     /gene="TNFSF8"
                     /gene_synonym="CD153; CD30L; CD30LG; TNLG3A"
ORIGIN      
        1 gtcattttcc tacgcgccct ctgacatcag ccaccttctc tgtagctagt ttctctgcac
       61 acaacttaat ccctggcaat gaaaaatgaa cctctccccc acccttgctg ccgcctctcg
      121 cctcacgccc ccagagaaga gtttctccac caggcagcag gtgaaggttt ttttccaagt
      181 cacatgattc aggattcagg gggagaatcc ttcttggaac agagatgggc ccagaactga
      241 atcagatgaa gagagataag gtgtgatgtg gggaagacta tataaagaat ggacccaggg
      301 ctgcagcaag cactcaacgg aatggcccct cctggagaca cagccatgca tgtgccggcg
      361 ggctccgtgg ccagccacct ggggaccacg agccgcagct atttctattt gaccacagcc
      421 actctggctc tgtgccttgt cttcacggtg gccactatta tggtgttggt cgttcagagg
      481 acggactcca ttcccaactc acctgacaac gtccccctca aaggaggaaa ttgctcagaa
      541 gacctcttat gtatcctgaa aagggctcca ttcaagaagt catgggccta cctccaagtg
      601 gcaaagcatc taaacaaaac caagttgtct tggaacaaag atggcattct ccatggagtc
      661 agatatcagg atgggaatct ggtgatccaa ttccctggtt tgtacttcat catttgccaa
      721 ctgcagtttc ttgtacaatg cccaaataat tctgtcgatc tgaagttgga gcttctcatc
      781 aacaagcata tcaaaaaaca ggccctggtg acagtgtgtg agtctggaat gcaaacgaaa
      841 cacgtatacc agaatctctc tcaattcttg ctggattacc tgcaggtcaa caccaccata
      901 tcagtcaatg tggatacatt ccagtacata gatacaagca cctttcctct tgagaatgtg
      961 ttgtccatct tcttatacag taattcagac tgaacagttt ctcttggcct tcaggaagaa
     1021 agcgcctctc taccatacag tatttcatcc ctccaaacac ttgggcaaaa agaaaacttt
     1081 agaccaagac aaactacaca gggtattaaa tagtatactt ctccttctgt ctcttggaaa
     1141 gatacagctc cagggttaaa aagagagttt ttagtgaagt atctttcaga tagcaggcag
     1201 ggaagcaatg tagtgtggtg ggcagagccc cacacagaat cagaagggat gaatggatgt
     1261 cccagcccaa cctctaattc actgtatggt cttgatctat ttcttctgtt ttgagagcct
     1321 ccagttaaaa tggggctcca gtaccagagc agctagcaac tctgccctaa tgggaaatga
     1381 aggggagctg ggtgtgagtg tttacactgt gcccttcacg ggatacttct tttatctgca
     1441 gatggcctaa tacttagttg tccaagtcgc gatcaaggac tctctcacac aggaaacttc
     1501 cctatactgg cagatacact tgtgactgaa ccatgcccag tttatgcctg tctgactgtc
     1561 actctggcac taggaggctg atcttgtact ccatatgacc ccacccctag gaacccccag
     1621 ggaaaaccag gctgggacag ccccctgttc ctgagatgga aagcacaaat ttaatacacc
     1681 accacaatgg aaaacaagtt caaagacttt tacttacaga tcctggacag aaagggcata
     1741 atgagtctga agggcagtcc tccttctcta ggttacatga ggcaggaata agaagtcaga
     1801 cagagacagc aagacagtta acaatgtagg taaagaaata gggtgtggtc actctcaatt
     1861 cactggcaaa tgcctgaatg gtctgtctga aggaagcaac agagaagtgg ggaatccagt
     1921 ctgctaggca ggaaagatgc ctctaagttc ttgtctctgg ccagaggtgt ggtatagaac
     1981 cagaaaccca tatcaagggt gactaagccc ggcttctggt atgagaaatt aaacttgtat
     2041 acaaaatggt tgccaaggca acataaaatt ataagaattc actatacctt cccctccctg
     2101 gaactcagga tccaagtcta gaaaatgaaa ggactgggtt tgaattgctt caaaacctct
     2161 tccatctcag aagaccagac cctgggaact gagattccag acacaatttt ggaagctctc
     2221 caaccaaaat aaggcccccc taccccagta tataattgaa gacactagta acacctgact
     2281 gcatctcatc tcagcagagc cagaatatgg ggacaaggtt cagggtgccc tgctgaatgg
     2341 tgtgaacagc aggatctcaa ggatgtaatg gaaagaacta ccacactgac catccagaat
     2401 ctaagagacc atctgggtgt ttgggaaacc atctgacgag gcctgactct attccagtta
     2461 gattgacaat aattgagcag caggcatttt tcatttctgg tcaggaaagc attgtgcctt
     2521 tagcaaacaa tcagtgtgca acagtgatgt ggtcatctag ccagggaatg gctgctccat
     2581 cccctgcata atatattcct gcttcaaaca cctctcagaa aaccagttcc gcgagggttt
     2641 ttatatcccc acaaagttgt tgagagacaa tgatgaccct ggaagtgggg aggaggactt
     2701 ctgagaaaca gcaacctctc tcctgattgg ggtagccatg agatttctct agctatatcc
     2761 aacttggcat ctgtacatca tctttggagg aacatcttat ttgtggaagg accttgacaa
     2821 gccgtttgag atggaatgta ggccctgatg ttatgcttca gtaaaaaaag atggaagctt
     2881 ccctgctata ccaaaacatg gagcaaaatt tgcatttttc tcaagaagga gagaaaagga
     2941 gtaggactcc agcaaagttt gtcagaagga aagctagaaa agatttaaaa gaaaaaaaga
     3001 aagaacaaat cagcagtggt ggtatggatg aaagggactt gagagaacaa aaatggctaa
     3061 gggaaaattt taagtcatct gctgagcagt gtgctgtgtc aacctcctcc taggtctcct
     3121 ctatgaaata tttagtaaag tctacatttc tctttaactc tttctgtgag tagattcttt
     3181 gggagaagca ggcattggaa gaggtgttga attcagcaag ccaaatggtc tgtggtaaaa
     3241 aacaaaacag actttgagac tcaaggctaa aaaaacaggg aaatggctgg catttgagtc
     3301 acacactaac tgcataggac aaatgaatct tgcttaaacc aactcatgca ttcttgaaaa
     3361 ggtatatgca acccaactgt gtgttaacta agcaattttt ttgccatctc acattctaac
     3421 tcgagaaaga ttccattttc atttttcacc aactgttctc tgagcagagg tacctgactt
     3481 ttgcactgtg agtggtttct aatctcagtc tctgtcaagc aatgctaaga aagccaacac
     3541 ctaaagacac aaggggtaca tcatttaaat gaataatgta accaaacaaa caaaaaaaga
     3601 gaataatcat taataactca actgatagat atgtagggag taggcaaccc aggaagttta
     3661 aaactaaatt ctgttactct tgagggttaa ccagcccctg ggaatgttat gagcaaatga
     3721 tactccatga gtaaaatgat atctatgcaa gtaaaataaa taatttatct aactgggaa
//
