LOCUS       NM_003326               3492 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens TNF superfamily member 4 (TNFSF4), transcript variant
            1, mRNA.
ACCESSION   NM_003326
VERSION     NM_003326.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Jahromi,A.S., Erfanian,S. and Roustazadeh,A.
  TITLE     Association between OX40L polymorphism and type 2 diabetes mellitus
            in Iranians
  JOURNAL   BMC Med Genomics 17 (1), 184 (2024)
   PUBMED   38982447
  REMARK    GeneRIF: Association between OX40L polymorphism and type 2 diabetes
            mellitus in Iranians.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Sadrolashrafi,K., Guo,L., Kikuchi,R., Hao,A., Yamamoto,R.K.,
            Tolson,H.C., Bilimoria,S.N., Yee,D.K. and Armstrong,A.W.
  TITLE     An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic
            Dermatitis
  JOURNAL   Cells 13 (7), 587 (2024)
   PUBMED   38607026
  REMARK    GeneRIF: An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in
            Atopic Dermatitis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Qian,C., Pan,C., Liu,J., Wu,L., Pan,J., Liu,C. and Zhang,H.
  TITLE     Differential expression of immune checkpoints (OX40/OX40L and
            PD-1/PD-L1) in decidua of unexplained recurrent spontaneous
            abortion women
  JOURNAL   Hum Immunol 85 (1), 110745 (2024)
   PUBMED   38142184
  REMARK    GeneRIF: Differential expression of immune checkpoints (OX40/OX40L
            and PD-1/PD-L1) in decidua of unexplained recurrent spontaneous
            abortion women.
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Croft,M.
  TITLE     Control of immunity by the TNFR-related molecule OX40 (CD134)
  JOURNAL   Annu Rev Immunol 28, 57-78 (2010)
   PUBMED   20307208
  REMARK    Review article
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Ohshima,Y., Tanaka,Y., Tozawa,H., Takahashi,Y., Maliszewski,C. and
            Delespesse,G.
  TITLE     Expression and function of OX40 ligand on human dendritic cells
  JOURNAL   J Immunol 159 (8), 3838-3848 (1997)
   PUBMED   9378971
REFERENCE   6  (bases 1 to 3492)
  AUTHORS   Imura,A., Hori,T., Imada,K., Kawamata,S., Tanaka,Y., Imamura,S. and
            Uchiyama,T.
  TITLE     OX40 expressed on fresh leukemic cells from adult T-cell leukemia
            patients mediates cell adhesion to vascular endothelial cells:
            implication for the possible involvement of OX40 in leukemic cell
            infiltration
  JOURNAL   Blood 89 (8), 2951-2958 (1997)
   PUBMED   9108415
REFERENCE   7  (bases 1 to 3492)
  AUTHORS   Imura,A., Hori,T., Imada,K., Ishikawa,T., Tanaka,Y., Maeda,M.,
            Imamura,S. and Uchiyama,T.
  TITLE     The human OX40/gp34 system directly mediates adhesion of activated
            T cells to vascular endothelial cells
  JOURNAL   J Exp Med 183 (5), 2185-2195 (1996)
   PUBMED   8642328
REFERENCE   8  (bases 1 to 3492)
  AUTHORS   Baum,P.R., Gayle,R.B. 3rd, Ramsdell,F., Srinivasan,S.,
            Sorensen,R.A., Watson,M.L., Seldin,M.F., Baker,E., Sutherland,G.R.,
            Clifford,K.N. et al.
  TITLE     Molecular characterization of murine and human OX40/OX40 ligand
            systems: identification of a human OX40 ligand as the
            HTLV-1-regulated protein gp34
  JOURNAL   EMBO J 13 (17), 3992-4001 (1994)
   PUBMED   8076595
REFERENCE   9  (bases 1 to 3492)
  AUTHORS   Godfrey,W.R., Fagnoni,F.F., Harara,M.A., Buck,D. and Engleman,E.G.
  TITLE     Identification of a human OX-40 ligand, a costimulator of CD4+ T
            cells with homology to tumor necrosis factor
  JOURNAL   J Exp Med 180 (2), 757-762 (1994)
   PUBMED   7913952
REFERENCE   10 (bases 1 to 3492)
  AUTHORS   Miura,S., Ohtani,K., Numata,N., Niki,M., Ohbo,K., Ina,Y.,
            Gojobori,T., Tanaka,Y., Tozawa,H., Nakamura,M. et al.
  TITLE     Molecular cloning and characterization of a novel glycoprotein,
            gp34, that is specifically induced by the human T-cell leukemia
            virus type I transactivator p40tax
  JOURNAL   Mol Cell Biol 11 (3), 1313-1325 (1991)
   PUBMED   1996093
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022310.1, X79929.1,
            BC041663.1 and R45433.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003326.4.
            
            Summary: This gene encodes a cytokine of the tumor necrosis factor
            (TNF) ligand family. The encoded protein functions in T cell
            antigen-presenting cell (APC) interactions and mediates adhesion of
            activated T cells to endothelial cells. Polymorphisms in this gene
            have been associated with Sjogren's syndrome and systemic lupus
            erythematosus. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90224.1, X79929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281834.4/ ENSP00000281834.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL022310.1         72340-72357         c
            19-1066             X79929.1           1-1048
            1067-3489           BC041663.1         1007-3429
            3490-3492           R45433.1           11-13               c
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..3492
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="TNF superfamily member 4"
                     /db_xref="GeneID:7292"
                     /db_xref="HGNC:HGNC:11934"
                     /db_xref="MIM:603594"
     exon            1..308
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..707
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tax-transcriptionally activated glycoprotein 1 (34kD);
                     tumor necrosis factor (ligand) superfamily member 4; tumor
                     necrosis factor superfamily member 4; OX40 antigen ligand;
                     CD134 ligand; glycoprotein Gp34; tumor necrosis factor
                     ligand 2B"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     4 isoform 1"
                     /protein_id="NP_003317.1"
                     /db_xref="CCDS:CCDS1306.1"
                     /db_xref="GeneID:7292"
                     /db_xref="HGNC:HGNC:11934"
                     /db_xref="MIM:603594"
                     /translation="MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYIC
                     LHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYL
                     ISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSL
                     DDFHVNGGELILIHQNPGEFCVL"
     exon            309..357
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..3492
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3430..3435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="hexamer: AATATA"
     polyA_site      3466
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="major polyA site"
     regulatory      3469..3474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="hexamer: AATAAA"
     polyA_site      3492
                     /gene="TNFSF4"
                     /gene_synonym="CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B;
                     TXGP1"
                     /note="major polyA site"
ORIGIN      
        1 caatcgcctt ttatctctgg ccctgggacc tttgcctatt ttctgattga taggctttgt
       61 tttgtcttta cctccttctt tctggggaaa acttcagttt tatcgcacgt tccccttttc
      121 catatcttca tcttccctct acccagattg tgaagatgga aagggtccaa cccctggaag
      181 agaatgtggg aaatgcagcc aggccaagat tcgagaggaa caagctattg ctggtggcct
      241 ctgtaattca gggactgggg ctgctcctgt gcttcaccta catctgcctg cacttctctg
      301 ctcttcaggt atcacatcgg tatcctcgaa ttcaaagtat caaagtacaa tttaccgaat
      361 ataagaagga gaaaggtttc atcctcactt cccaaaagga ggatgaaatc atgaaggtgc
      421 agaacaactc agtcatcatc aactgtgatg ggttttatct catctccctg aagggctact
      481 tctcccagga agtcaacatt agccttcatt accagaagga tgaggagccc ctcttccaac
      541 tgaagaaggt caggtctgtc aactccttga tggtggcctc tctgacttac aaagacaaag
      601 tctacttgaa tgtgaccact gacaatacct ccctggatga cttccatgtg aatggcggag
      661 aactgattct tatccatcaa aatcctggtg aattctgtgt cctttgaggg gctgatggca
      721 atatctaaaa ccaggcacca gcatgaacac caagctgggg gtggacaggg catggattct
      781 tcattgcaag tgaaggagcc tcccagctca gccacgtggg atgtgacaag aagcagatcc
      841 tggccctccc gcccccaccc ctcagggata tttaaaactt attttatata ccagttaatc
      901 ttatttatcc ttatattttc taaattgcct agccgtcaca ccccaagatt gccttgagcc
      961 tactaggcac ctttgtgaga aagaaaaaat agatgcctct tcttcaagat gcattgtttc
     1021 tattggtcag gcaattgtca taataaactt atgtcattga aaacggtacc tgactaccat
     1081 ttgctggaaa tttgacatgt gtgtggcatt atcaaaatga agaggagcaa ggagtgaagg
     1141 agtggggtta tgaatctgcc aaaggtggta tgaaccaacc cctggaagcc aaagcggcct
     1201 ctccaaggtt aaattgattg cagtttgcat attgcctaaa tttaaacttt ctcatttggt
     1261 gggggttcaa aagaagaatc agcttgtgaa aaatcaggac ttgaagagag ccgtctaaga
     1321 aataccacgt gctttttttc tttaccattt tgctttccca gcctccaaac atagttaata
     1381 gaaatttccc ttcaaagaac tgtctgggga tgtgatgctt tgaaaaatct aatcagtgac
     1441 ttaagagaga ttttcttgta tacagggaga gtgagataac ttattgtgaa gggttagctt
     1501 tactgtacag gatagcaggg aactggacat ctcagggtaa aagtcagtac ggattttaat
     1561 agcctgggga ggaaaacaca ttctttgcca cagacaggca aagcaacaca tgctcatcct
     1621 cctgcctatg ctgagatacg cactcagctc catgtcttgt acacacagaa acattgctgg
     1681 tttcaagaaa tgaggtgatc ctattatcaa attcaatctg atgtcaaata gcactaagaa
     1741 gttattgtgc cttatgaaaa ataatgatct ctgtctagaa ataccataga ccatatatag
     1801 tctcacattg ataattgaaa ctagaagggt ctataatcag cctatgccag ggcttcaatg
     1861 gaatagtatc cccttatgtt tagttgaaat gtccccttaa cttgatataa tgtgttatgc
     1921 ttatggcgct gtggacaatc tgatttttca tgtcaacttt ccagatgatt tgtaacttct
     1981 ctgtgccaaa ccttttataa acataaattt ttgagatatg tattttaaaa ttgtagcaca
     2041 tgtttccctg acattttcaa tagaggatac aacatcacag aatctttctg gatgattctg
     2101 tgttatcaag gaattgtact gtgctacaat tatctctaga atctccagaa aggtggaggg
     2161 ctgttcgccc ttacactaaa tggtctcagt tggatttttt tttcctgttt tctatttcct
     2221 cttaagtaca ccttcaacta tattcccatc cctctatttt aatctgttat gaaggaaggt
     2281 aaataaaaat gctaaataga agaaattgta ggtaaggtaa gaggaatcaa gttctgagtg
     2341 gctgccaagg cactcacaga atcataatca tggctaaata tttatggagg gcctactgtg
     2401 gaccaggcac tgggctaaat acttacattt acaagaatca ttctgagaca gatattcaat
     2461 gatatctggc ttcactactc agaagattgt gtgtgtgttt gtgtgtgtgt gtgtgtgtgt
     2521 atttcacttt ttgttattga ccatgttctg caaaattgca gttactcagt gagtgatatc
     2581 cgaaaaagta aacgtttatg actataggta atatttaaga aaatgcatgg ttcattttta
     2641 agtttggaat ttttatctat atttctcaca gatgtgcagt gcacatgcag gcctaagtat
     2701 atgttgtgtg tgttgtttgt ctttgatgtc atggtcccct ctcttaggtg ctcactcgct
     2761 ttgggtgcac ctggcctgct cttcccatgt tggcctctgc aaccacacag ggatatttct
     2821 gctatgcacc agcctcactc caccttcctt ccatcaaaaa tatgtgtgtg tgtctcagtc
     2881 cctgtaagtc atgtccttca cagggagaat taacccttcg atatacatgg cagagttttg
     2941 tgggaaaaga attgaatgaa aagtcaggag atcagaattt taaatttgac ttagccacta
     3001 actagccatg taaccttggg aaagtcattt cccatttctg ggtcttgctt ttctttctgt
     3061 taaatgagag gaatgttaaa tatctaacag tttagaatct tatgcttaca gtgttatctg
     3121 tgaatgcaca tattaaatgt ctatgttctt gttgctatga gtcaaggagt gtaaccttct
     3181 cctttactat gttgaatgta tttttttctg gacaagctta catcttcctc agccatcttt
     3241 gtgagtcctt caagagcagt tatcaattgt tagttagata ttttctattt agagaatgct
     3301 taagggattc caatcccgat ccaaatcata atttgttctt aagtatactg ggcaggtccc
     3361 ctattttaag tcataatttt gtatttagtg ctttcctggc tctcagagag tattaatatt
     3421 gatattaata atatagttaa tagtaatatt gctatttaca tggaaacaaa taaaagatct
     3481 cagaattcac ta
//
