LOCUS       NM_005118               6583 bp    mRNA    linear   PRI 27-NOV-2024
DEFINITION  Homo sapiens TNF superfamily member 15 (TNFSF15), transcript
            variant 1, mRNA.
ACCESSION   NM_005118
VERSION     NM_005118.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6583)
  AUTHORS   Liu,X., Zhang,J., Zhang,D., Pan,Y., Zeng,R., Xu,C., Shi,S., Xu,J.,
            Qi,Q., Dong,X., Wang,J., Liu,T. and Dong,L.
  TITLE     Necroptosis plays a role in TL1A-induced airway inflammation and
            barrier damage in asthma
  JOURNAL   Respir Res 25 (1), 271 (2024)
   PUBMED   38987753
  REMARK    GeneRIF: Necroptosis plays a role in TL1A-induced airway
            inflammation and barrier damage in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6583)
  AUTHORS   Awad,A.M., Dabous,E., Alalem,M., Alalem,N., Nasr,M.E.,
            Elawdan,K.A., Nasr,G.M., Said,W., El Khashab,K., Basiouny,M.S.,
            Guirgis,A.A. and Khalil,H.
  TITLE     MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in
            hepatoblastoma cells as a novel mechanism in liver carcinogenesis
  JOURNAL   Sci Rep 14 (1), 13492 (2024)
   PUBMED   38866875
  REMARK    GeneRIF: MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression
            in hepatoblastoma cells as a novel mechanism in liver
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6583)
  AUTHORS   Schmitt,P., Duval,A., Camus,M., Lefrancais,E., Roga,S., Dedieu,C.,
            Ortega,N., Bellard,E., Mirey,E., Mouton-Barbosa,E.,
            Burlet-Schiltz,O., Gonzalez-de-Peredo,A., Cayrol,C. and Girard,J.P.
  TITLE     TL1A is an epithelial alarmin that cooperates with IL-33 for
            initiation of allergic airway inflammation
  JOURNAL   J Exp Med 221 (6) (2024)
   PUBMED   38597952
  REMARK    GeneRIF: TL1A is an epithelial alarmin that cooperates with IL-33
            for initiation of allergic airway inflammation.
REFERENCE   4  (bases 1 to 6583)
  AUTHORS   Abdelgalil,A.A., Monir,R., Elmetwally,M., Ghattas,M.H.,
            Bazeed,F.B., Mesbah,N.M., Abo-Elmatty,D.M. and Mehanna,E.T.
  TITLE     The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and
            Their Serum Protein Levels with Breast Cancer in Egyptian Patients
  JOURNAL   Biochem Genet 62 (1), 547-573 (2024)
   PUBMED   37392242
  REMARK    GeneRIF: The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic
            Variants and Their Serum Protein Levels with Breast Cancer in
            Egyptian Patients.
REFERENCE   5  (bases 1 to 6583)
  AUTHORS   Liu,Z., Liu,R., Gao,H., Jung,S., Gao,X., Sun,R., Liu,X., Kim,Y.,
            Lee,H.S., Kawai,Y., Nagasaki,M., Umeno,J., Tokunaga,K.,
            Kinouchi,Y., Masamune,A., Shi,W., Shen,C., Guo,Z., Yuan,K., Zhu,S.,
            Li,D., Liu,J., Ge,T., Cho,J., Daly,M.J., McGovern,D.P.B., Ye,B.D.,
            Song,K., Kakuta,Y., Li,M. and Huang,H.
  CONSRTM   FinnGen; International Inflammatory Bowel Disease Genetics
            Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium
  TITLE     Genetic architecture of the inflammatory bowel diseases across East
            Asian and European ancestries
  JOURNAL   Nat Genet 55 (5), 796-806 (2023)
   PUBMED   37156999
  REMARK    GeneRIF: Genetic architecture of the inflammatory bowel diseases
            across East Asian and European ancestries.
REFERENCE   6  (bases 1 to 6583)
  AUTHORS   Haridas,V., Shrivastava,A., Su,J., Yu,G.L., Ni,J., Liu,D.,
            Chen,S.F., Ni,Y., Ruben,S.M., Gentz,R. and Aggarwal,B.B.
  TITLE     VEGI, a new member of the TNF family activates nuclear factor-kappa
            B and c-Jun N-terminal kinase and modulates cell growth
  JOURNAL   Oncogene 18 (47), 6496-6504 (1999)
   PUBMED   10597252
REFERENCE   7  (bases 1 to 6583)
  AUTHORS   Yue,T.L., Ni,J., Romanic,A.M., Gu,J.L., Keller,P., Wang,C.,
            Kumar,S., Yu,G.L., Hart,T.K., Wang,X., Xia,Z., DeWolf,W.E. Jr. and
            Feuerstein,G.Z.
  TITLE     TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis
            in endothelial cells. Involvement of activation of stress protein
            kinases (stress-activated protein kinase and p38 mitogen-activated
            protein kinase) and caspase-3-like protease
  JOURNAL   J Biol Chem 274 (3), 1479-1486 (1999)
   PUBMED   9880523
REFERENCE   8  (bases 1 to 6583)
  AUTHORS   Zhai,Y., Ni,J., Jiang,G.W., Lu,J., Xing,L., Lincoln,C.,
            Carter,K.C., Janat,F., Kozak,D., Xu,S., Rojas,L., Aggarwal,B.B.,
            Ruben,S., Li,L.Y., Gentz,R. and Yu,G.L.
  TITLE     VEGI, a novel cytokine of the tumor necrosis factor family, is an
            angiogenesis inhibitor that suppresses the growth of colon
            carcinomas in vivo
  JOURNAL   FASEB J 13 (1), 181-189 (1999)
   PUBMED   9872942
REFERENCE   9  (bases 1 to 6583)
  AUTHORS   Tan,K.B., Harrop,J., Reddy,M., Young,P., Terrett,J., Emery,J.,
            Moore,G. and Truneh,A.
  TITLE     Characterization of a novel TNF-like ligand and recently described
            TNF ligand and TNF receptor superfamily genes and their
            constitutive and inducible expression in hematopoietic and
            non-hematopoietic cells
  JOURNAL   Gene 204 (1-2), 35-46 (1997)
   PUBMED   9434163
REFERENCE   10 (bases 1 to 6583)
  AUTHORS   Rubinstein,M.H.
  TITLE     A new granulation method for compressed tablets [proceedings]
  JOURNAL   J Pharm Pharmacol 28 Suppl, 67P (1976)
   PUBMED   12345
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC104463.1 and AL390240.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005118.3.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            protein is abundantly expressed in endothelial cells, but is not
            expressed in either B or T cells. The expression of this protein is
            inducible by TNF and IL-1 alpha. This cytokine is a ligand for
            receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate
            NF-kappaB and MAP kinases, and acts as an autocrine factor to
            induce apoptosis in endothelial cells. This cytokine is also found
            to inhibit endothelial cell proliferation, and thus may function as
            an angiogenesis inhibitor. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (VEGI-251).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291642.1, AF520785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374045.5/ ENSP00000363157.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               BC104463.1         90-718
            630-6583            AL390240.18        71259-77212         c
FEATURES             Location/Qualifiers
     source          1..6583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..6583
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /note="TNF superfamily member 15"
                     /db_xref="GeneID:9966"
                     /db_xref="HGNC:HGNC:11931"
                     /db_xref="MIM:604052"
     exon            1..237
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..783
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /note="isoform VEGI-251 precursor is encoded by transcript
                     variant 1; vascular endothelial cell growth inhibitor; TNF
                     superfamily ligand TL1A; TNF ligand-related molecule 1;
                     vascular endothelial growth inhibitor-192A; tumor necrosis
                     factor (ligand) superfamily, member 15; tumor necrosis
                     factor ligand 1B; tumor necrosis factor superfamily member
                     15"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     15 isoform VEGI-251 precursor"
                     /protein_id="NP_005109.2"
                     /db_xref="CCDS:CCDS6809.1"
                     /db_xref="GeneID:9966"
                     /db_xref="HGNC:HGNC:11931"
                     /db_xref="MIM:604052"
                     /translation="MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLL
                     PFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVV
                     RQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTS
                     ECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMF
                     SLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL"
     exon            238..280
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /inference="alignment:Splign:2.1.0"
     exon            281..328
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /inference="alignment:Splign:2.1.0"
     exon            329..6583
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6560..6565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /note="hexamer: AATAAA"
     polyA_site      6583
                     /gene="TNFSF15"
                     /gene_synonym="TL1; TL1A; TNLG1B; VEGI; VEGI192A"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgcct ccaggagcag caggagcatg gccgaggatc tgggactgag ctttggggaa
       61 acagccagtg tggaaatgct gccagagcac ggcagctgca ggcccaaggc caggagcagc
      121 agcgcacgct gggctctcac ctgctgcctg gtgttgctcc ccttccttgc aggactcacc
      181 acatacctgc ttgtcagcca gctccgggcc cagggagagg cctgtgtgca gttccaggct
      241 ctaaaaggac aggagtttgc accttcacat cagcaagttt atgcacctct tagagcagac
      301 ggagataagc caagggcaca cctgacagtt gtgagacaaa ctcccacaca gcactttaaa
      361 aatcagttcc cagctctgca ctgggaacat gaactaggcc tggccttcac caagaaccga
      421 atgaactata ccaacaaatt cctgctgatc ccagagtcgg gagactactt catttactcc
      481 caggtcacat tccgtgggat gacctctgag tgcagtgaaa tcagacaagc aggccgacca
      541 aacaagccag actccatcac tgtggtcatc accaaggtaa cagacagcta ccctgagcca
      601 acccagctcc tcatggggac caagtctgta tgcgaagtag gtagcaactg gttccagccc
      661 atctacctcg gagccatgtt ctccttgcaa gaaggggaca agctaatggt gaacgtcagt
      721 gacatctctt tggtggatta cacaaaagaa gataaaacct tctttggagc cttcttacta
      781 taggaggaga gcaaatatca ttatatgaaa gtcctctgcc accgagttcc taattttctt
      841 tgttcaaatg taattataac caggggtttt cttggggccg ggagtagggg gcattccaca
      901 gggacaacgg tttagctatg aaatttgggg cccaaaattt cacacttcat gtgccttact
      961 gatgagagta ctaactggaa aaaggctgaa gagagcaaat atattattaa gatgggttgg
     1021 aggattggcg agtttctaaa tattaagaca ctgatcacta aatgaatgga tgatctactc
     1081 gggtcaggat tgaaagagaa atatttcaac accttcctgc tatacaatgg tcaccagtgg
     1141 tccagttatt gttcaatttg atcataaatt tgcttcaatt caggagcttt gaaggaagtc
     1201 caaggaaagc tctagaaaac agtataaact ttcagaggca aaatccttca ccaatttttc
     1261 cacatacttt catgccttgc ctaaaaaaaa tgaaaagaga gttggtatgt ctcatgaatg
     1321 ttcacacaga aggagttggt tttcatgtca tctacagcat atgagaaaag ctacctttct
     1381 tttgattatg tacacagata tctaaataag gaagtatgag tttcacatgt atatcaaaaa
     1441 tacaacagtt gcttgtattc agtagagttt tcttgcccac ctattttgtg ctgggttcta
     1501 ccttaaccca gaagacacta tgaaaaacaa gacagactcc actcaaaatt tatatgaaca
     1561 ccactagata cttcctgatc aaacatcagt caacatactc taaagaataa ctccaagtct
     1621 tggccaggcg cagtggctca cacctgtaat cccaacactt tgggaggcca aggtgggtgg
     1681 atcatctaag gccgggagtt caagaccagc ctgaccaacg tggagaaacc ccatctctac
     1741 taaaaataca aaattagccg ggcgtggtag cgcatggctg taatcctggc tactcaggag
     1801 gccgaggcag aagaattgct tgaactgggg aggcagaggt tgcggtgagc ccagatcgcg
     1861 ccattgcact ccagcctggg taacaagagc aaaactctgt ccaaaaaaaa aaaaataaaa
     1921 taataactcc aagcctttaa aaaatatcat ctgaaactgt tacatcagat ttctggcact
     1981 ctactgactg tggaagatag ccagctgact ggaagatagc cagctgatta gttccctgaa
     2041 gaaacctgaa gacagatacc tggttaacta gatcaactac actgccaact tgtttgatgc
     2101 tgagagacaa tggacttatt ccatggggga agggaaaaaa gaagtcaatc accaaatctg
     2161 aagaagttaa cctagatctt tgaggtttga tttgcaactt tatatgcaga gtattatgtg
     2221 ggtattttcc cttaaaatat tcaaagggat ttacatatgg gattagctaa tgagcctagc
     2281 caagaccttc cctggaggac aggctggtca ttgcggaggt cccttctgtg cttcagtggg
     2341 ttcatatcct ctagtccgta tgattttcct acgctaatat gtcaagggca ggagaggcag
     2401 ctctgttctc ctagcctttg ttgacttgtc tgcaaagcag gaatctgccc atttgtttcc
     2461 aaggagcaaa tgagctcatg agaatgaaag atgttaactt catgcattct gtgccatctg
     2521 agcatttcgg tattatatga ctggtgaccc ttggcccgta ttataaatgc ttcctatcct
     2581 gggagacctc atggatgagt ctgagaggaa atttggcacc aaaatcactc tcactctggt
     2641 ttccagtaga ctatagaggc agagaggcat ttgagaggct cctgagcaaa gtgtccagtg
     2701 tagcaggagc acttcattaa tatttattga gttataatta aataaaaatt aatttctgat
     2761 ttctcagttt ggaggttaag gctctaaata tattttctaa cctctgctag gctaacttaa
     2821 gccaggcctt tttcttgcct tccctttctc aaaacagtca gcacagactc agtgggagca
     2881 cagaggagtg tggtcacctc cacctggctc accagagtct tcatagagga agtgaagcct
     2941 ggaagaaact gggcgggccc cagatgacca cagggaaagg gcatctcaga tggaggaatt
     3001 acccttgact taaagcagaa aagaaagatt tctcagtaac tccaaaactt gcttgatagg
     3061 agaatattcc ctcaaccaat tcctaggaca atatttattg gtagatcaag aatgtttcct
     3121 caataactct agtctagctc catgatcaga actaacaccc attaaaaaca taaaatgttc
     3181 tttctgaacc ggtcttcatg gtgcgtgaga gcaccaagca gctttggtat gcaggaggag
     3241 ttttgcacag aagagtggcc tgctcaaacc tgcccactgt tctgtaggtg atctggtgga
     3301 tctggaaatt tatcccaaga caggaatttc ctaatattcg aagacatttg aggctttggg
     3361 aaattctctg ctgtgcattt atttggctcc tgtcataagc ttgtttttta aagaatgtat
     3421 catagctcaa gtttttactg ctgattttgt taaattctgt atagtatatt ttttacggaa
     3481 aggcacagtc agacattcct aatagggctc atgtcagaac ttctgttccc aaggcattat
     3541 ctccatagca aaaattagtg cactgttttc aaaagtgagg tgggaaaatg cttttaagat
     3601 catgtgatgt tcccctaaaa ggggttaatg gggtgtattc agggtttggg agggaggaag
     3661 aagcatgctt tagaaaacag taaatttagg gagaaaatgc tttgttggtt aaatgtcact
     3721 caaaaggctg aattcaaatc aattccacaa acatttactg agtacctact gcccctgggg
     3781 acacagagat aaattattta gtctcagaca cactcattct aacttcccag cacctctact
     3841 gtctgcagat tctttaattt attttggttg tattagctaa ttaattcgta aactttaggc
     3901 acatggatct attctcatta tgaaaatgga tgccatttga ttaaggctga tgactaacaa
     3961 aatgatttgt gtttactcga agtgtttttt taaaaatagc tactcaagga tagttttcca
     4021 taaatcaaga aggtaaaaaa gttcccattt tttattgtag aatccattat ttaaactaca
     4081 tgtagagaca ggttattatt tgctatattc aagtttggtc atcaataccc ttaaaaatat
     4141 tagaatttta tggatgaccc agaaatgctt tgaaaatctg tgttcctcag caaatacaga
     4201 gaccatgatc aaaatgcaca gaatcactaa cattttgatg ctagcatggt ttcagtctat
     4261 ttggcagaac agaattgatt atgctactaa aatttctttt tctttttttt tttttttttt
     4321 tttgagacag agtcttgctt tgtcacccag gctgaagtgc agtggcagga tctcagttca
     4381 ctgcaacctc tgcctcccag gttcacgcca ttctcctgct tcagcctccc gagtagctgg
     4441 gactacaggc tcccaccacc atgcccggct aattttttgc atttttagta gagacggggt
     4501 ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccgcc cgcctcagcc
     4561 ttccaaagtg ctgggattac aggcgtgagc cactgtgccc ggactctgat ttttttttta
     4621 ctaaggtaca gtaagaaaag ggaaaagtgt acgttttcac ttcctgaaat atgtcaggtt
     4681 gaatcaataa tagagcacac cagaactctt ggctccattt caacctaaac tattcagttc
     4741 tcatcacccc agaggaaatt ccgcctctgt gctggtcagt aatccccctg gattataaaa
     4801 gtttaactaa ctcactgtgc acaaggcacg gccattgcca acattctctt gcaaggtatt
     4861 ttcccaagcc cttacccaat tctgtttcca tgattgtgac attggggatt aattctgcaa
     4921 gacagaactg tttatattct gtaccttaaa aacacatgca aacatctctt gccttaagat
     4981 ttctggcttt cctatggccc agagtcctag aagtgttttg atatttgtag cagaattttc
     5041 aagtgtacat ccttatcctg gatattaaca tttttgcatc atattggcag ctggacctac
     5101 agagaattta gtagactgtt aacctaataa gccttgaatc cttttgcacc agtggtgaga
     5161 gaatgtggat cagagccatc acctccatgc cccgtcaccc tctaacaacc acatttacaa
     5221 cttccccagc tctgagacac acttgcctcc accccttcca tcaccccatt ttaagatgaa
     5281 aataccacac cagcctggaa ggaagaagtt acttgcccag ggccacatag tgagttaagg
     5341 gctgatctag agctaggaag ctgtcttcct gaaccataat cctggactct tctaacctct
     5401 ctactcatcg caaatagagt tcattttagt gatttgaagg aagatgggac aagtattttc
     5461 aaacacctgt aggacaacat ggaagtggga ggagacttct actgtagctc cccagagaag
     5521 agagctaggg ctacagagtt gcagttacaa ggttgccctc tctggcttga tccccaaagg
     5581 aattttctac tccaaaatag aatttttcta ggatgctatt tctcagtccc tggagatact
     5641 caaacaaagg gcttgtcaca agggtttttg tagaagctat tcttcacaga ggttggggga
     5701 gagattaagc caaaggatct ctgaggtctt tttcaaatct ataattatgt ggccttttgt
     5761 tcattgactt ccatgtgttc tagttgatca ttacaaacct ggcaggcctt ctcaagggtt
     5821 cagtaattag ctgtcatttc ccatttgtcc agagagtgtc caacacaaaa tacccctaag
     5881 atcttggcca atagagaaat gtcatggaat tttagaaatg acagtatctg cggagtttat
     5941 tccaagttat atcatttcaa agatgaagaa acccaggctc agagggagcc atcacatcca
     6001 caccctgtca cccttcgtgg ccagtgccag acagtagcta gttggatgct aaaagtagaa
     6061 tttagatatc ttaacaataa gcccagcagt ctttcaactt cattcgtaaa tcatttttgt
     6121 tttgagcatc tgtcacgtgg cagcacttgc ctggatactg gagagctgag aaggaatgcg
     6181 acaggcaagt cctactctca cagtgtatac attcaggagg aacaagacac acagtgccaa
     6241 gtaaataaag tagctgaact tcatcaaatg attttattct taaagtcatt aaagcatgta
     6301 atgttcccct ttttttgttt caggggtgta cagattgaag aagtgtaggt gtttatgtgg
     6361 ttttagtgac aaaccccatg tgctttcatt gattttatgt tttatgttaa aacatcaacc
     6421 gcaaggtaaa atgcatattg tatgttgttg gatacgtact taactggtat gcatcccatg
     6481 tctttgggta ctagtgtatg aattctaatc tctgtaaatg aaatgttgta tgtgttaata
     6541 tatttaatag atgtaactta ataaactggc attgaagact gaa
//
