LOCUS       NM_001376887            4487 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TNF superfamily member 14 (TNFSF14), transcript
            variant 3, mRNA.
ACCESSION   NM_001376887 XM_017027417
VERSION     NM_001376887.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Kanai,S., Fujiwara,H., Mizuno,S., Kishikawa,T., Nakatsuka,T.,
            Hamada,T., Tanaka,M., Arita,J., Nakai,Y., Isayama,H., Kasuga,M.,
            Tateishi,R., Tateishi,K., Ushiku,T., Hasegawa,K., Koike,K. and
            Fujishiro,M.
  TITLE     Increased expression of TNFRSF14 and LIGHT in biliary epithelial
            cells of patients with primary sclerosing cholangitis
  JOURNAL   Dig Liver Dis 56 (2), 305-311 (2024)
   PUBMED   37722959
  REMARK    GeneRIF: Increased expression of TNFRSF14 and LIGHT in biliary
            epithelial cells of patients with primary sclerosing cholangitis.
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Huang,X.W., Pang,S.W., Yang,L.Z., Han,T., Chen,J.M., Huang,C.W.,
            Liao,L. and Xie,P.J.
  TITLE     TNFSF14 mediates the impact of docosahexaenoic acid on atopic
            dermatitis: a Mendelian randomization study
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (1), 107-117 (2024)
   PUBMED   38235898
  REMARK    GeneRIF: TNFSF14 mediates the impact of docosahexaenoic acid on
            atopic dermatitis: a Mendelian randomization study.
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Zhang,N., Liu,X., Qin,J., Sun,Y., Xiong,H., Lin,B., Liu,K., Tan,B.,
            Zhang,C., Huang,C., Ren,S., Liu,M. and Du,B.
  TITLE     LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity
            through reversing immunosuppressive tumor microenvironment
  JOURNAL   Mol Ther 31 (9), 2575-2590 (2023)
   PUBMED   37408308
  REMARK    GeneRIF: LIGHT/TNFSF14 promotes CAR-T cell trafficking and
            cytotoxicity through reversing immunosuppressive tumor
            microenvironment.
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Faienza,M.F., Brunetti,G., Fintini,D., Grugni,G., Wasniewska,M.G.,
            Crino,A., D'Amato,G., Piacente,L., Oranger,A., Dicarlo,M.,
            Colucci,S. and Grano,M.
  TITLE     High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome
  JOURNAL   J Endocrinol Invest 46 (9), 1901-1909 (2023)
   PUBMED   36917420
  REMARK    GeneRIF: High levels of LIGHT/TNFSF14 in patients with Prader-Willi
            syndrome.
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Heo,S.K., Yu,H.M., Kim,D.K., Seo,H.J., Shin,Y., Kim,S.A., Kim,M.,
            Kim,Y., Lee,Y.J., Noh,E.K. and Jo,J.C.
  TITLE     LIGHT (TNFSF14) promotes the differentiation of human bone
            marrow-derived mesenchymal stem cells into functional
            hepatocyte-like cells
  JOURNAL   PLoS One 18 (8), e0289798 (2023)
   PUBMED   37552689
  REMARK    GeneRIF: LIGHT (TNFSF14) promotes the differentiation of human bone
            marrow-derived mesenchymal stem cells into functional
            hepatocyte-like cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Yu,K.Y., Kwon,B., Ni,J., Zhai,Y., Ebner,R. and Kwon,B.S.
  TITLE     A newly identified member of tumor necrosis factor receptor
            superfamily (TR6) suppresses LIGHT-mediated apoptosis
  JOURNAL   J Biol Chem 274 (20), 13733-13736 (1999)
   PUBMED   10318773
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Harrop,J.A., McDonnell,P.C., Brigham-Burke,M., Lyn,S.D., Minton,J.,
            Tan,K.B., Dede,K., Spampanato,J., Silverman,C., Hensley,P.,
            DiPrinzio,R., Emery,J.G., Deen,K., Eichman,C., Chabot-Fletcher,M.,
            Truneh,A. and Young,P.R.
  TITLE     Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for
            HVEM/TR2, stimulates proliferation of T cells and inhibits HT29
            cell growth
  JOURNAL   J Biol Chem 273 (42), 27548-27556 (1998)
   PUBMED   9765287
REFERENCE   8  (bases 1 to 4487)
  AUTHORS   Zhai,Y., Guo,R., Hsu,T.L., Yu,G.L., Ni,J., Kwon,B.S., Jiang,G.W.,
            Lu,J., Tan,J., Ugustus,M., Carter,K., Rojas,L., Zhu,F., Lincoln,C.,
            Endress,G., Xing,L., Wang,S., Oh,K.O., Gentz,R., Ruben,S.,
            Lippman,M.E., Hsieh,S.L. and Yang,D.
  TITLE     LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM
            induces apoptosis and suppresses in vivo tumor formation via gene
            transfer
  JOURNAL   J Clin Invest 102 (6), 1142-1151 (1998)
   PUBMED   9739048
REFERENCE   9  (bases 1 to 4487)
  AUTHORS   Marsters,S.A., Sheridan,J.P., Pitti,R.M., Brush,J., Goddard,A. and
            Ashkenazi,A.
  TITLE     Identification of a ligand for the death-domain-containing receptor
            Apo3
  JOURNAL   Curr Biol 8 (9), 525-528 (1998)
   PUBMED   9560343
REFERENCE   10 (bases 1 to 4487)
  AUTHORS   Mauri,D.N., Ebner,R., Montgomery,R.I., Kochel,K.D., Cheung,T.C.,
            Yu,G.L., Ruben,S., Murphy,M., Eisenberg,R.J., Cohen,G.H.,
            Spear,P.G. and Ware,C.F.
  TITLE     LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha
            are ligands for herpesvirus entry mediator
  JOURNAL   Immunity 8 (1), 21-30 (1998)
   PUBMED   9462508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008760.7, BC018058.1 and
            AF064090.1.
            
            On Nov 20, 2019 this sequence version replaced XM_017027417.1.
            
            Summary: The protein encoded by this gene is a member of the tumor
            necrosis factor (TNF) ligand family. This protein is a ligand for
            TNFRSF14, which is a member of the tumor necrosis factor receptor
            superfamily, and which is also known as a herpesvirus entry
            mediator (HVEM). This protein may function as a costimulatory
            factor for the activation of lymphoid cells and as a deterrent to
            infection by herpesvirus. This protein has been shown to stimulate
            the proliferation of T cells, and trigger apoptosis of various
            tumor cells. This protein is also reported to prevent tumor
            necrosis factor alpha mediated apoptosis in primary hepatocyte. Two
            alternatively spliced transcript variant encoding distinct isoforms
            have been reported. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292037.1, SRR14038194.3250868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675206.1/ ENSP00000502837.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC008760.7         105844-105846       c
            4-448               BC018058.1         2-446
            449-1191            AF064090.1         740-1482
            1192-4487           AC008760.7         96939-100234        c
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4487
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /note="TNF superfamily member 14"
                     /db_xref="GeneID:8740"
                     /db_xref="HGNC:HGNC:11930"
                     /db_xref="MIM:604520"
     exon            1..310
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..814
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /note="isoform 1 is encoded by transcript variant 3; tumor
                     necrosis factor ligand 1D; herpesvirus entry mediator
                     ligand; tumor necrosis factor (ligand) superfamily, member
                     14; tumor necrosis factor superfamily member 14"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     14 isoform 1"
                     /protein_id="NP_001363816.1"
                     /db_xref="CCDS:CCDS12171.1"
                     /db_xref="GeneID:8740"
                     /db_xref="HGNC:HGNC:11930"
                     /db_xref="MIM:604520"
                     /translation="MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLL
                     LLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGAN
                     SSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLAS
                     TITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVR
                     VLDERLVRLRDGTRSYFGAFMV"
     exon            311..347
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /inference="alignment:Splign:2.1.0"
     exon            348..389
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /inference="alignment:Splign:2.1.0"
     exon            390..4487
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2577..2582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /note="hexamer: AATAAA"
     polyA_site      2603
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /note="major polyA site"
     regulatory      4462..4467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
                     /note="hexamer: AATAAA"
     polyA_site      4487
                     /gene="TNFSF14"
                     /gene_synonym="CD258; HVEML; LIGHT; LTg"
ORIGIN      
        1 agcgtgcaca gcccaggagt gttgagcaat ttcggtttcc tctgaggttg aaggacccag
       61 gcgtgtcagc cctgctccag acaccttggg catggaggag agtgtcgtac ggccctcagt
      121 gtttgtggtg gatggacaga ccgacatccc attcacgagg ctgggacgaa gccaccggag
      181 acagtcgtgc agtgtggccc gggtgggtct gggtctcttg ctgttgctga tgggggccgg
      241 gctggccgtc caaggctggt tcctcctgca gctgcactgg cgtctaggag agatggtcac
      301 ccgcctgcct gacggacctg caggctcctg ggagcagctg atacaagagc gaaggtctca
      361 cgaggtcaac ccagcagcgc atctcacagg ggccaactcc agcttgaccg gcagcggggg
      421 gccgctgtta tgggagactc agctgggcct ggccttcctg aggggcctca gctaccacga
      481 tggggccctt gtggtcacca aagctggcta ctactacatc tactccaagg tgcagctggg
      541 cggtgtgggc tgcccgctgg gcctggccag caccatcacc cacggcctct acaagcgcac
      601 accccgctac cccgaggagc tggagctgtt ggtcagccag cagtcaccct gcggacgggc
      661 caccagcagc tcccgggtct ggtgggacag cagcttcctg ggtggtgtgg tacacctgga
      721 ggctggggag aaggtggtcg tccgtgtgct ggatgaacgc ctggttcgac tgcgtgatgg
      781 tacccggtct tacttcgggg ctttcatggt gtgaaggaag gagcgtggtg cattggacat
      841 gggtctgaca cgtggagaac tcagagggtg cctcagggga aagaaaactc acgaagcaga
      901 ggctgggcgt ggtggctctc gcctgtaatc ccagcacttt gggaggccaa ggcaggcgga
      961 tcacctgagg tcaggagttc gagaccagcc tggctaacat ggcaaaaccc catctctact
     1021 aaaaatacaa aaattagccg gacgtggtgg tgcctgcctg taatccagct actcaggagg
     1081 ctgaggcagg ataattttgc ttaaacccgg gaggcggagg ttgcagtgag ccgagatcac
     1141 accactgcac tccaacctgg gaaacgcagt gagactgtgc ctcaaaaaaa agaaaggaag
     1201 aaaaaagaaa actcaggaaa cagatcttgg gggacactcc agggaaccca aaactcaaag
     1261 gcggagagct cagtgggcac caccaaggcg agatgaagcc ccagcaggca ccttcagaag
     1321 acccacgtag actgcagacc ctgccacgga caatactaag gacaaaaacc cagagacttg
     1381 gggtctgtgg gcccccaaac atggggtaaa gttgatttgc ctgatattca ggaagaaggg
     1441 gtgaggggtg ggtatttatg cttttgattc agaagaaagt ggggcttggg attccaggga
     1501 cttggctggg ggtgggaaac ttcatccact tccctactct catcatgagt acggacaggg
     1561 tgggcgggag actgatcatc gggactcatc atgaagagcc cagccccacc ccacatactc
     1621 agatcccacc cacagactgg tggccacacc tcagcctggt cacaaagagt tacactcaga
     1681 tacatgagca cggcagcgtg ctcataactg tttaacaacc agctgtcctg ggagggggac
     1741 agctttgtaa tgtttgccaa tttccatggt gtaaatgcta ccaccatggc tgatttcatc
     1801 actgccaagc atagacatcc ctaataggac accacggatc tgtccccggc atccggccca
     1861 gggcctggca caaagcatgc tctagggaaa tgcttgctga ttgaaaggaa ggaagaatga
     1921 ctctacagtc acacctatgg catcccacaa aatctgtcac atggctgcat aatctcagcc
     1981 actctttcac aactatagac tcatacacgc gaagtgccag attcatgcac aaccacacaa
     2041 tcacatggaa gtcacagacg gcatcacaga cagtcacagc actgtgtgta tgttataaca
     2101 caagcacaca aaactcagac agcatcccag ctacacagcc actcccagag gtgtcaccgt
     2161 cacacttggt aattaatact cattacatta gacacagaca gaccaagtta tagtcagacc
     2221 tggttacaca catacacaca cacaatatca ccatgacaaa tacacattac acacacacaa
     2281 catcacaatg acaaacacac attacacaca caacatcacg atgacaaaca cacattacac
     2341 acacaacatc acgatgacaa acacacatta cacacacatc acaatgacaa acacaacatt
     2401 acacacacac aacatcacaa tgacacacac atcacacaca catcacaatg acaaacacac
     2461 aacattacac acatatacac acagcctgag ggccctcccc agcccagact aacacatctc
     2521 ggggtgagga ccagaccttg ttcataaccc tgggcctctt aaccactgat ctttgaaata
     2581 aatggcaaat agttgtacct ggatctgtct agttcttagg ggaacaaact gaagaagggt
     2641 ggagaggaat tgtcaggcct aaagagcccc acagggaaag ggaggagtcg gatggggggc
     2701 aaccatcagc aacaagtggt ggctcctaga ggcagaggga tggaggtaat gacccatgga
     2761 ggtcattcta cagatgagga acctggaccc agttggctca agtccatgca ggaaatgtgg
     2821 gggaaaccag agacctcacg tctggatctg gcttcctctc caatccacaa ttcctgagga
     2881 agtagaggct acatcccgca agacgccctt attagacaca tccaggacag aatgacaatc
     2941 cgccaagcca gctggaagca taaaacacag ggagctggtg ggttgggtgg gggcagataa
     3001 tgatatgcat acaaattaga gggtctatgc aaatgagcat tgctgcagtg tggctggagg
     3061 gaatccttag ttcctaggat tctaggatat gggtttcgac cccagaggtg aatgtattgt
     3121 tattattgtt ttgttgttgt tgtgaatgac aagtcaaaat ttgtgggtta ttgttgttat
     3181 cgccaatagt attcttgtca ttgttgcaca gtacagagat gaaggaaaca gattttgcaa
     3241 tcagatgatc ctgggttctg agtccactct gccactcacc agctatatga cctccagcaa
     3301 tttccatcac ctctcaatgc ttcagtttcc ccatcggcaa gatggttgtg gggggagagg
     3361 aacaacagta cagattcacc atcccaaatt caaaatgctc caaaatctag gccgggcgtg
     3421 gtggctcata cctgtaatcc cagcactttg ggaggtcaaa gtggacggat aacctgaggt
     3481 caggagctcc agaccagcct ggccaacatg gcgaaacccc atctctacta aaaatacaaa
     3541 aaattacctg ggtgtggtgg ggggcacctg taaccccagc tactcgggag gctgaggcag
     3601 gaaccctgga ggttgaggtt gcagtgagct gagatcacac cactgcactc cagcctgggt
     3661 gacagagcaa ggctcccatc tcaaaaaaca aaaaaacatg ctccaaaatc tgaaactctt
     3721 tgagccccag tgtgatgcca caagtgggaa attccacaac tcatcacatg tgatagattg
     3781 cagtggaaat gcaggcacac accacgaagt ttactcagca tcctcaaagg aaatccccgt
     3841 cagtagctat atatcatttt ctcacatgcc agataggtat ctctcatctt ttactgttag
     3901 gtacttctgt gttgaatagg tggaggaaaa tgattgctgg ttagtagtat ataaattcag
     3961 agtcaggaag gatggtgatg tcggctgggt gcagtggctc atgcctgtaa ttccaatgtg
     4021 ataccctacc ttgtgtttaa cgtgattgac tctcccttag ctgagagggc caggcagact
     4081 ctattttggc ttcttcgctt gcagtctctc acccaccccc cttcctcaag gacttaagct
     4141 gactcccagc acatccaaga atgcgattac tgataagata ctgtgacaag ctatatccac
     4201 aattcccagg aattcgtccg gttgatagca cccaaagccc ccgcgtctat caccttgtga
     4261 tagatttaaa gcccctgcac ctggaactgt ttgtttttct gttaccattt atctttttca
     4321 ctttcttgcc tgttttgctt ctgtaaaatt gcttcagctc ggctccctct tccccttcta
     4381 aaccaaggta taaaaagaaa cctagcccct tctttggggt ggagagaatt ttgagcgcta
     4441 gccgtctctc agtcgccggc taataaagga ctcctgaatt agtctaa
//
