LOCUS       NM_006573               2576 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TNF superfamily member 13b (TNFSF13B), transcript
            variant 1, mRNA.
ACCESSION   NM_006573
VERSION     NM_006573.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Tagami,N., Yuda,J. and Goto,Y.
  TITLE     Current status of BAFF targeting immunotherapy in B-cell neoplasm
  JOURNAL   Int J Clin Oncol 29 (11), 1676-1683 (2024)
   PUBMED   39222149
  REMARK    GeneRIF: Current status of BAFF targeting immunotherapy in B-cell
            neoplasm.
            Review article
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   de Jong,M.M.E., Fokkema,C., Papazian,N., Czeti,A., Appelman,M.K.,
            Vermeulen,M., van Heusden,T., Hoogenboezem,R.M., van Beek,G.,
            Tahri,S., Sanders,M.A., van de Woestijne,P.C., Gay,F., Moreau,P.,
            Buttner-Herold,M., Bruns,H., van Duin,M., Broijl,A., Sonneveld,P.
            and Cupedo,T.
  TITLE     An IL-1beta-driven neutrophil-stromal cell axis fosters a BAFF-rich
            protumor microenvironment in individuals with multiple myeloma
  JOURNAL   Nat Immunol 25 (5), 820-833 (2024)
   PUBMED   38600356
  REMARK    GeneRIF: An IL-1beta-driven neutrophil-stromal cell axis fosters a
            BAFF-rich protumor microenvironment in individuals with multiple
            myeloma.
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Pang,J., Li,Y., Tao,R., Li,J., Wang,F. and Xu,H.
  TITLE     Correlation Between B-Cell Activating Factor of the Tumor Necrosis
            Factor Family Level in Serum and Immune Inflammation in Patients
            with Neuropsychiatric Systemic Lupus Erythematosus and its Clinical
            Value
  JOURNAL   Immunol Invest 53 (4), 559-573 (2024)
   PUBMED   38329469
  REMARK    GeneRIF: Correlation Between B-Cell Activating Factor of the Tumor
            Necrosis Factor Family Level in Serum and Immune Inflammation in
            Patients with Neuropsychiatric Systemic Lupus Erythematosus and its
            Clinical Value.
REFERENCE   4  (bases 1 to 2576)
  AUTHORS   Li,L., Liu,H.Y. and Wang,L.J.
  TITLE     [Research advances on B-cell activating factor and its targeted
            agents in inflammatory bowel disease]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 26 (3), 315-320 (2024)
   PUBMED   38557386
  REMARK    GeneRIF: [Research advances on B-cell activating factor and its
            targeted agents in inflammatory bowel disease].
            Review article
REFERENCE   5  (bases 1 to 2576)
  AUTHORS   Ullah,M.A., Garcillan,B., Whitlock,E., Figgett,W.A., Infantino,S.,
            Eslami,M., Yang,S., Rahman,M.A., Sheng,Y.H., Weber,N.,
            Schneider,P., Tam,C.S. and Mackay,F.
  TITLE     An unappreciated cell survival-independent role for BAFF initiating
            chronic lymphocytic leukemia
  JOURNAL   Front Immunol 15, 1345515 (2024)
   PUBMED   38469292
  REMARK    GeneRIF: An unappreciated cell survival-independent role for BAFF
            initiating chronic lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2576)
  AUTHORS   Tribouley,C., Wallroth,M., Chan,V., Paliard,X., Fang,E., Lamson,G.,
            Pot,D., Escobedo,J. and Williams,L.T.
  TITLE     Characterization of a new member of the TNF family expressed on
            antigen presenting cells
  JOURNAL   Biol Chem 380 (12), 1443-1447 (1999)
   PUBMED   10661873
REFERENCE   7  (bases 1 to 2576)
  AUTHORS   Moore,P.A., Belvedere,O., Orr,A., Pieri,K., LaFleur,D.W., Feng,P.,
            Soppet,D., Charters,M., Gentz,R., Parmelee,D., Li,Y., Galperina,O.,
            Giri,J., Roschke,V., Nardelli,B., Carrell,J., Sosnovtseva,S.,
            Greenfield,W., Ruben,S.M., Olsen,H.S., Fikes,J. and Hilbert,D.M.
  TITLE     BLyS: member of the tumor necrosis factor family and B lymphocyte
            stimulator
  JOURNAL   Science 285 (5425), 260-263 (1999)
   PUBMED   10398604
REFERENCE   8  (bases 1 to 2576)
  AUTHORS   Schneider,P., MacKay,F., Steiner,V., Hofmann,K., Bodmer,J.L.,
            Holler,N., Ambrose,C., Lawton,P., Bixler,S., Acha-Orbea,H.,
            Valmori,D., Romero,P., Werner-Favre,C., Zubler,R.H., Browning,J.L.
            and Tschopp,J.
  TITLE     BAFF, a novel ligand of the tumor necrosis factor family,
            stimulates B cell growth
  JOURNAL   J Exp Med 189 (11), 1747-1756 (1999)
   PUBMED   10359578
REFERENCE   9  (bases 1 to 2576)
  AUTHORS   Mukhopadhyay,A., Ni,J., Zhai,Y., Yu,G.L. and Aggarwal,B.B.
  TITLE     Identification and characterization of a novel cytokine, THANK, a
            TNF homologue that activates apoptosis, nuclear factor-kappaB, and
            c-Jun NH2-terminal kinase
  JOURNAL   J Biol Chem 274 (23), 15978-15981 (1999)
   PUBMED   10347144
REFERENCE   10 (bases 1 to 2576)
  AUTHORS   Shu,H.B., Hu,W.H. and Johnson,H.
  TITLE     TALL-1 is a novel member of the TNF family that is down-regulated
            by mitogens
  JOURNAL   J Leukoc Biol 65 (5), 680-683 (1999)
   PUBMED   10331498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157762.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 8, 2020 this sequence version replaced NM_006573.4.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA,
            and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage
            cells, and acts as a potent B cell activator. It has been also
            shown to play an important role in the proliferation and
            differentiation of B cells. Alternatively spliced transcript
            variants encoding distinct isoforms have been identified. [provided
            by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents a longer transcript
            and encodes the longer protein isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1164521.1, BC020674.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375887.9/ ENSP00000365048.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AL157762.13        67776-68292
            518-602             AL157762.13        68398-68482
            603-659             AL157762.13        84861-84917
            660-772             AL157762.13        101311-101423
            773-923             AL157762.13        101512-101662
            924-2576            AL157762.13        104884-106536
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.3"
     gene            1..2576
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /note="TNF superfamily member 13b"
                     /db_xref="GeneID:10673"
                     /db_xref="HGNC:HGNC:11929"
                     /db_xref="MIM:603969"
     exon            1..517
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1036
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     necrosis factor (ligand) superfamily, member 20;
                     B-lymphocyte stimulator; tumor necrosis factor-like
                     protein ZTNF4; ApoL related ligand TALL-1; TNF and
                     ApoL-related leukocyte expressed ligand 1; TNF homolog
                     that activates apoptosis; tumor necrosis factor
                     superfamily member 13b; dendritic cell-derived TNF-like
                     molecule; delta BAFF; Delta4 BAFF; B-cell-activating
                     factor; tumor necrosis factor (ligand) superfamily, member
                     13b; tumor necrosis factor ligand 7A; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     13B isoform 1"
                     /protein_id="NP_006564.1"
                     /db_xref="CCDS:CCDS9509.1"
                     /db_xref="GeneID:10673"
                     /db_xref="HGNC:HGNC:11929"
                     /db_xref="MIM:603969"
                     /translation="MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKD
                     GKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGL
                     EEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK
                     GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVH
                     VFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDV
                     TFFGALKLL"
     exon            518..602
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..659
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            660..772
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..923
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            924..2576
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /note="hexamer: AATAAA"
     polyA_site      2576
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /note="major polyA site"
ORIGIN      
        1 aggggtagag atgcagaaag gcagaaagga gaaaattcag gataactctc ctgaggggtg
       61 agccaagccc tgccatgtag tgcacgcagg acatcaacaa acacagataa caggaaatga
      121 tccattccct gtggtcactt attctaaagg ccccaacctt caaagttcaa gtagtgatat
      181 ggatgactcc acagaaaggg agcagtcacg ccttacttct tgccttaaga aaagagaaga
      241 aatgaaactg aaggagtgtg tttccatcct cccacggaag gaaagcccct ctgtccgatc
      301 ctccaaagac ggaaagctgc tggctgcaac cttgctgctg gcactgctgt cttgctgcct
      361 cacggtggtg tctttctacc aggtggccgc cctgcaaggg gacctggcca gcctccgggc
      421 agagctgcag ggccaccacg cggagaagct gccagcagga gcaggagccc ccaaggccgg
      481 cctggaggaa gctccagctg tcaccgcggg actgaaaatc tttgaaccac cagctccagg
      541 agaaggcaac tccagtcaga acagcagaaa taagcgtgcc gttcagggtc cagaagaaac
      601 agtcactcaa gactgcttgc aactgattgc agacagtgaa acaccaacta tacaaaaagg
      661 atcttacaca tttgttccat ggcttctcag ctttaaaagg ggaagtgccc tagaagaaaa
      721 agagaataaa atattggtca aagaaactgg ttactttttt atatatggtc aggttttata
      781 tactgataag acctacgcca tgggacatct aattcagagg aagaaggtcc atgtctttgg
      841 ggatgaattg agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc
      901 caataattcc tgctattcag ctggcattgc aaaactggaa gaaggagatg aactccaact
      961 tgcaatacca agagaaaatg cacaaatatc actggatgga gatgtcacat tttttggtgc
     1021 attgaaactg ctgtgaccta cttacaccat gtctgtagct attttcctcc ctttctctgt
     1081 acctctaaga agaaagaatc taactgaaaa taccaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aaaaagtagt taccattgcc ttttctgtga gctatttgtt ttggtttgct gaaactagtc
     1201 caaaacagga aatttaacag acagccacag ccaaagagtg tcatgtgaat tacaagaaat
     1261 agagcccatt tagggaaaga tagaactaga aaggcttttc attataattc catgttgaac
     1321 aattgagtca tagcttctta tcttggagga aggacacaat tcaaaggggc agtaaggatt
     1381 ttgtaaaacg tggcatccat aatttactat ggagcaagtg cccacatctc taggacatta
     1441 agacatttat gagaaatctc aggattcatc ttctgttttt atgttaaatg cactccctcc
     1501 ttttcagtta acattataaa aagtaaaaaa tgaaaatttt agaaatcttg cattagacac
     1561 atgaaaaaat aactaaaagt ttaaatttaa atatgaaaca attttgctga aaatagtatc
     1621 catatactat ttaagtcttt tatggttatt tcaagtatac aatttctatc tgtaatgtaa
     1681 tatattaccc acacattttt ttcacaggag agagagaata tcctcatttg tttatgctca
     1741 tgtgtatttt ctatagtgaa tttcagaaac ttttaatatc aggtaatttc aatttatgcc
     1801 tataaagcat tgattgaaaa ataactagaa ttgtgcatat ataacacata atctccaaca
     1861 gaagttactg aatacattca tactaatgta atgtaatttc cctttatttc ttgctcttct
     1921 gtttcaaact gctgctattg tagtttacat atcccaacct ttaaaaatat tcctcttatt
     1981 agctttatat tcactttata gaagttgagt tttaattaaa attcttggca tcctgaagta
     2041 tgtcacatag catgtgctcc ttataaatat gttgatatct cagaagacag catcccggtt
     2101 ttcattttat aaagtaccat acttaagaat gctgtaatac ttatctttta taacatgttt
     2161 ccttcgcttt gcttgtcttt tatgtcatca gttttaactg tttacttcat ttaacagttt
     2221 acatcattca acagtttact tcattaaaca gtaggtggaa aaatagatgc cagtctatga
     2281 aaatcttccc atctatatca aaatactttt caaggatata cttttcaaaa caaacgattt
     2341 aaattttatg tttaaaatat aaactttaga tttaaacttt atttaaatat ctggttccta
     2401 tgattttgac ttcagtaagt tcaaataaaa tatattttgc aattcatttt tacattataa
     2461 tttaaaaaga agaagcgata agtggagtca gtttcaatgc taggtggggt ggttaatgat
     2521 ttttctggtg ttgctgctaa tgtggattaa caaataaaaa cattcattgc cttttg
//
