LOCUS       NM_003808               1811 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens TNF superfamily member 13 (TNFSF13), transcript
            variant alpha, mRNA.
ACCESSION   NM_003808
VERSION     NM_003808.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Tian,H., Zhai,Y., Sun,S., Zhang,W. and Zhao,Z.
  TITLE     The transcription factor HMGB2 indirectly regulates APRIL
            expression and Gd-IgA1 production in patients with IgA nephropathy
  JOURNAL   Ren Fail 46 (1), 2338931 (2024)
   PUBMED   38622929
  REMARK    GeneRIF: The transcription factor HMGB2 indirectly regulates APRIL
            expression and Gd-IgA1 production in patients with IgA nephropathy.
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Tan,X., Wang,J., Liu,X., Xie,G. and Ouyang,F.
  TITLE     M2 macrophage-derived paracrine factor TNFSF13 affects the
            fibrogenic alterations in endothelial cells and cardiac fibroblasts
            by mediating the NF-kappaB and Akt pathway
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23707 (2024)
   PUBMED   38622979
  REMARK    GeneRIF: M2 macrophage-derived paracrine factor TNFSF13 affects the
            fibrogenic alterations in endothelial cells and cardiac fibroblasts
            by mediating the NF-kappaB and Akt pathway.
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Amezcua-Guerra,L.M., Sanchez-Munoz,F., Guzman-Garcia,S.,
            Marquez-Velasco,R., Becerril-Villanueva,E., Vazquez-Panchos,Y. and
            Juarez-Vicuna,Y.
  TITLE     Mononuclear cells from patients with rhupus are influenced by TNF
            in their production of gp130/sIL-6Rb and APRIL
  JOURNAL   Lupus Sci Med 10 (2) (2023)
   PUBMED   37880158
  REMARK    GeneRIF: Mononuclear cells from patients with rhupus are influenced
            by TNF in their production of gp130/sIL-6Rb and APRIL.
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Sturm,N., Roger-Margueritat,M., Pierrel,F., Lehours,P., Genevay,M.
            and Huard,B.
  TITLE     Spatial heterogeneity for APRIL production by eosinophils in the
            small intestine
  JOURNAL   J Leukoc Biol 113 (4), 376-382 (2023)
   PUBMED   36808499
  REMARK    GeneRIF: Spatial heterogeneity for APRIL production by eosinophils
            in the small intestine.
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Stephenson,S., Care,M.A., Doody,G.M. and Tooze,R.M.
  TITLE     APRIL Drives a Coordinated but Diverse Response as a Foundation for
            Plasma Cell Longevity
  JOURNAL   J Immunol 209 (5), 926-937 (2022)
   PUBMED   36130130
  REMARK    GeneRIF: APRIL Drives a Coordinated but Diverse Response as a
            Foundation for Plasma Cell Longevity.
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Wu,Y., Bressette,D., Carrell,J.A., Kaufman,T., Feng,P., Taylor,K.,
            Gan,Y., Cho,Y.H., Garcia,A.D., Gollatz,E., Dimke,D., LaFleur,D.,
            Migone,T.S., Nardelli,B., Wei,P., Ruben,S.M., Ullrich,S.J.,
            Olsen,H.S., Kanakaraj,P., Moore,P.A. and Baker,K.P.
  TITLE     Tumor necrosis factor (TNF) receptor superfamily member TACI is a
            high affinity receptor for TNF family members APRIL and BLyS
  JOURNAL   J Biol Chem 275 (45), 35478-35485 (2000)
   PUBMED   10956646
REFERENCE   7  (bases 1 to 1811)
  AUTHORS   Kelly,K., Manos,E., Jensen,G., Nadauld,L. and Jones,D.A.
  TITLE     APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell
            death
  JOURNAL   Cancer Res 60 (4), 1021-1027 (2000)
   PUBMED   10706119
REFERENCE   8  (bases 1 to 1811)
  AUTHORS   Cousin,P., Billotte,J., Chaubert,P. and Shaw,P.
  TITLE     Physical map of 17p13 and the genes adjacent to p53
  JOURNAL   Genomics 63 (1), 60-68 (2000)
   PUBMED   10662545
REFERENCE   9  (bases 1 to 1811)
  AUTHORS   Shu,H.B., Hu,W.H. and Johnson,H.
  TITLE     TALL-1 is a novel member of the TNF family that is down-regulated
            by mitogens
  JOURNAL   J Leukoc Biol 65 (5), 680-683 (1999)
   PUBMED   10331498
REFERENCE   10 (bases 1 to 1811)
  AUTHORS   Hahne,M., Kataoka,T., Schroter,M., Hofmann,K., Irmler,M.,
            Bodmer,J.L., Schneider,P., Bornand,T., Holler,N., French,L.E.,
            Sordat,B., Rimoldi,D. and Tschopp,J.
  TITLE     APRIL, a new ligand of the tumor necrosis factor family, stimulates
            tumor cell growth
  JOURNAL   J Exp Med 188 (6), 1185-1190 (1998)
   PUBMED   9743536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI764562.1, AF046888.1,
            AK225556.1 and AI828515.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 19, 2020 this sequence version replaced NM_003808.3.
            
            Summary: The protein encoded by this gene is a member of the tumor
            necrosis factor (TNF) ligand family. This protein is a ligand for
            TNFRSF17/BCMA, a member of the TNF receptor family. This protein
            and its receptor are both found to be important for B cell
            development. In vitro experiments suggested that this protein may
            be able to induce apoptosis through its interaction with other TNF
            receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.
            Alternative splicing results in multiple transcript variants. Some
            transcripts that skip the last exon of the upstream gene (TNFSF12)
            and continue into the second exon of this gene have been
            identified; such read-through transcripts are contained in GeneID
            407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (alpha) represents the longest
            transcript and encodes the longest isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225556.1, AY081050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338784.9/ ENSP00000343505.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BI764562.1         459-476
            19-1150             AF046888.1         10-1141
            1151-1810           AK225556.1         1153-1812
            1811-1811           AI828515.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1811
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /note="TNF superfamily member 13"
                     /db_xref="GeneID:8741"
                     /db_xref="HGNC:HGNC:11928"
                     /db_xref="MIM:604472"
     exon            1..548
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1043
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /note="isoform alpha precursor is encoded by transcript
                     variant alpha; tumor necrosis factor-related death
                     ligand-1; tumor necrosis factor superfamily member 13;
                     TNF- and APOL-related leukocyte expressed ligand 2; tumor
                     necrosis factor-like protein ZTNF2; tumor necrosis factor
                     ligand 7B; a proliferation-inducing ligand; tumor necrosis
                     factor (ligand) superfamily, member 13"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     13 isoform alpha precursor"
                     /protein_id="NP_003799.1"
                     /db_xref="CCDS:CCDS11111.1"
                     /db_xref="GeneID:8741"
                     /db_xref="HGNC:HGNC:11928"
                     /db_xref="MIM:604472"
                     /translation="MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVAC
                     AMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRK
                     RRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDA
                     GVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFH
                     LHQGDILSVIIPRARAKLNLSPHGTFLGFVKL"
     exon            549..627
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..675
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..794
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..933
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1811
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="TNFSF13"
                     /gene_synonym="APRIL; CD256; TALL-2; TALL2; TNLG7B;
                     TRDL-1; UNQ383/PRO715; ZTNF2"
                     /note="major polyA site"
ORIGIN      
        1 gtcactggca gccctgtcct tcctagaggg actggaacct aattctcctg aggctgaggg
       61 agggtggagg gtctcaaggc aacgctggcc ccacgacgga gtgccaggag cactaacagt
      121 acccttagct tgctttcctc ctccctcctt tttattttca agttcctttt tatttctcct
      181 tgcgtaacaa ccttcttccc ttctgcacca ctgcccgtac ccttacccgc cccgccacct
      241 ccttgctacc ccactcttga aaccacagct gttggcaggg tccccagctc atgccagcct
      301 catctccttt cttgctagcc cccaaagggc ctccaggcaa catggggggc ccagtcagag
      361 agccggcact ctcagttgcc ctctggttga gttggggggc agctctgggg gccgtggctt
      421 gtgccatggc tctgctgacc caacaaacag agctgcagag cctcaggaga gaggtgagcc
      481 ggctgcaggg gacaggaggc ccctcccaga atggggaagg gtatccctgg cagagtctcc
      541 cggagcagag ttccgatgcc ctggaagcct gggagaatgg ggagagatcc cggaaaagga
      601 gagcagtgct cacccaaaaa cagaagaagc agcactctgt cctgcacctg gttcccatta
      661 acgccacctc caaggatgac tccgatgtga cagaggtgat gtggcaacca gctcttaggc
      721 gtgggagagg cctacaggcc caaggatatg gtgtccgaat ccaggatgct ggagtttatc
      781 tgctgtatag ccaggtcctg tttcaagacg tgactttcac catgggtcag gtggtgtctc
      841 gagaaggcca aggaaggcag gagactctat tccgatgtat aagaagtatg ccctcccacc
      901 cggaccgggc ctacaacagc tgctatagcg caggtgtctt ccatttacac caaggggata
      961 ttctgagtgt cataattccc cgggcaaggg cgaaacttaa cctctctcca catggaacct
     1021 tcctggggtt tgtgaaactg tgattgtgtt ataaaaagtg gctcccagct tggaagacca
     1081 gggtgggtac atactggaga cagccaagag ctgagtatat aaaggagagg gaatgtgcag
     1141 gaacagaggc gtcttcctgg gtttggctcc ccgttcctca cttttccctt ttcattccca
     1201 ccccctagac tttgatttta cggatatctt gcttctgttc cccatggagc tccgaattct
     1261 tgcgtgtgtg tagatgaggg gcgggggacg ggcgccaggc attgtccaga cctggtcggg
     1321 gcccactgga agcatccaga acagcaccac catctagcgg ccgctcgagg gaagcacccg
     1381 ccggttggcc gaagtccacg aagccgccct ctgctaggga aaacccctgg ttctccatgc
     1441 cacacctctc tccaggtgcc ctctgcctct tcaccccaca agaagcctta tcctacgtcc
     1501 ttctctccat ctatcggacc ccagtttcca tcactatctc cagagatgta gctattatgc
     1561 gcccgtctac agggggtgcc cgacgatgac ggtgccttcg cagtcaaatt actcttcggg
     1621 tcccaaggtt tggctttcac gcgctccatt gccccggcgt ggcaggccat tccaagccct
     1681 tccgggctgg aactggtgtc ggaggagcct cgggtgtatc gtacgccctg gtgttggtgt
     1741 tgcctcactc ctctgagctc ttctttctga tcaagccctg cttaaagtta aataaaatag
     1801 aatgaatgat a
//
