LOCUS       NM_172089               1857 bp    mRNA    linear   PRI 10-JUL-2022
DEFINITION  Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.
ACCESSION   NM_172089
VERSION     NM_172089.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Yang C, Jie W, Yanlong Y, Xuefeng G, Aihua T, Yong G, Zheng L,
            Youjie Z, Haiying Z, Xue Q, Min Q, Linjian M, Xiaobo Y, Yanling H
            and Zengnan M.
  TITLE     Genome-wide association study identifies TNFSF13 as a
            susceptibility gene for IgA in a South Chinese population in
            smokers
  JOURNAL   Immunogenetics 64 (10), 747-753 (2012)
   PUBMED   22864923
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Yang M, Wu Y, Lu Y, Liu C, Sun J, Liao M, Qin M, Mo L, Gao Y, Lu Z,
            Wu C, Zhang Y, Zhang H, Qin X, Hu Y, Zhang S, Li J, Dong M, Zheng
            SL, Xu J, Yang X, Tan A and Mo Z.
  TITLE     Genome-wide scan identifies variant in TNFSF13 associated with
            serum IgM in a healthy Chinese male population
  JOURNAL   PLoS One 7 (10), e47990 (2012)
   PUBMED   23118916
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Osman W, Okada Y, Kamatani Y, Kubo M, Matsuda K and Nakamura Y.
  TITLE     Association of common variants in TNFRSF13B, TNFSF13, and ANXA3
            with serum levels of non-albumin protein and immunoglobulin
            isotypes in Japanese
  JOURNAL   PLoS One 7 (4), e32683 (2012)
   PUBMED   22558069
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y,
            Foo JN, Wang W, Li ZJ, Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan
            JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH and Liu JJ.
  TITLE     A genome-wide association study in Han Chinese identifies multiple
            susceptibility loci for IgA nephropathy
  JOURNAL   Nat Genet 44 (2), 178-182 (2011)
   PUBMED   22197929
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Pradet-Balade B, Medema JP, Lopez-Fraga M, Lozano JC, Kolfschoten
            GM, Picard A, Martinez-A C, Garcia-Sanz JA and Hahne M.
  TITLE     An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell
            surface TWEAK-APRIL fusion protein
  JOURNAL   EMBO J 21 (21), 5711-5720 (2002)
   PUBMED   12411489
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y,
            Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS,
            Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P,
            Moore PA and Baker KP.
  TITLE     Tumor necrosis factor (TNF) receptor superfamily member TACI is a
            high affinity receptor for TNF family members APRIL and BLyS
  JOURNAL   J Biol Chem 275 (45), 35478-35485 (2000)
   PUBMED   10956646
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Kelly K, Manos E, Jensen G, Nadauld L and Jones DA.
  TITLE     APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell
            death
  JOURNAL   Cancer Res 60 (4), 1021-1027 (2000)
   PUBMED   10706119
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Hahne M, Kataoka T, Schroter M, Hofmann K, Irmler M, Bodmer JL,
            Schneider P, Bornand T, Holler N, French LE, Sordat B, Rimoldi D
            and Tschopp J.
  TITLE     APRIL, a new ligand of the tumor necrosis factor family, stimulates
            tumor cell growth
  JOURNAL   J Exp Med 188 (6), 1185-1190 (1998)
   PUBMED   9743536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016876.10 and AY081051.1.
            
            On Jun 2, 2019 this sequence version replaced NM_172089.3.
            
            Summary: This gene encodes a member of the tumor necrosis factor
            superfamily. It encodes a hybrid protein composed of the
            cytoplasmic and transmembrane domains of family member 12 fused to
            the C-terminal domain of family member 13. The hybrid protein is
            membrane anchored and presents the receptor-binding domain of
            family member 13 at the cell surface. It stimulates cycling in T-
            and B-lymphoma cell lines. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY081051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8741, 8742
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC016876.10        45276-45316         c
            42-1196             AY081051.1         1-1155
            1197-1352           AC016876.10        33278-33433         c
            1353-1857           AY081051.1         1312-1816
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1857
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /note="TNFSF12-TNFSF13 readthrough"
                     /db_xref="GeneID:407977"
                     /db_xref="HGNC:HGNC:33537"
     exon            1..255
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1089
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     12-member 13"
                     /codon_start=1
                     /product="TNFSF12-TNFSF13 protein"
                     /protein_id="NP_742086.1"
                     /db_xref="GeneID:407977"
                     /db_xref="HGNC:HGNC:33537"
                     /translation="MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSL
                     GSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTR
                     ARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGL
                     YYLYCQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMW
                     QPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRC
                     IRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL"
     exon            256..303
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            304..379
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            380..433
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            434..469
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            470..594
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            595..673
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            674..721
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            722..840
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            841..979
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1857
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="TNFSF12-TNFSF13"
                     /gene_synonym="TWE-PRIL"
                     /note="major polyA site"
ORIGIN      
        1 ctctccccgg cccgatccgc ccgccggctc cccctccccc gatccctcgg gtcccgggat
       61 gggggggcgg tgaggcaggc acagcccccc gcccccatgg ccgcccgtcg gagccagagg
      121 cggagggggc gccgggggga gccgggcacc gccctgctgg tcccgctcgc gctgggcctg
      181 ggcctggcgc tggcctgcct cggcctcctg ctggccgtgg tcagtttggg gagccgggca
      241 tcgctgtccg cccaggagcc tgcccaggag gagctggtgg cagaggagga ccaggacccg
      301 tcggaactga atccccagac agaagaaagc caggatcctg cgcctttcct gaaccgacta
      361 gttcggcctc gcagaagtgc acctaaaggc cggaaaacac gggctcgaag agcgatcgca
      421 gcccattatg aagttcatcc acgacctgga caggacggag cgcaggcagg tgtggacggg
      481 acagtgagtg gctgggagga agccagaatc aacagctcca gccctctgcg ctacaaccgc
      541 cagatcgggg agtttatagt cacccgggct gggctctact acctgtactg tcagagttcc
      601 gatgccctgg aagcctggga gaatggggag agatcccgga aaaggagagc agtgctcacc
      661 caaaaacaga agaagcagca ctctgtcctg cacctggttc ccattaacgc cacctccaag
      721 gatgactccg atgtgacaga ggtgatgtgg caaccagctc ttaggcgtgg gagaggccta
      781 caggcccaag gatatggtgt ccgaatccag gatgctggag tttatctgct gtatagccag
      841 gtcctgtttc aagacgtgac tttcaccatg ggtcaggtgg tgtctcgaga aggccaagga
      901 aggcaggaga ctctattccg atgtataaga agtatgccct cccacccgga ccgggcctac
      961 aacagctgct atagcgcagg tgtcttccat ttacaccaag gggatattct gagtgtcata
     1021 attccccggg caagggcgaa acttaacctc tctccacatg gaaccttcct ggggtttgtg
     1081 aaactgtgat tgtgttataa aaagtggctc ccagcttgga agaccagggt gggtacatac
     1141 tggagacagc caagagctga gtatataaag gagagggaat gtgcaggaac agaggcgtct
     1201 tcctgggttt ggctccccgt tcctcacttt tcccttttca ttcccacccc ctagactttg
     1261 attttacgga tatcttgctt ctgttcccca tggagctccg aattcttgcg tgtgtgtaga
     1321 tgaggggcgg gggacgggcg ccaggcattg tccagacctg gtcggggccc actggaagca
     1381 tccagaacag caccaccatc tagcggccgc tcgagggaag cacccgccgg ttggccgaag
     1441 tccacgaagc cgccctctgc tagggaaaac ccctggttct ccatgccaca cctctctcca
     1501 ggtgccctct gcctcttcac cccacaagaa gccttatcct acgtccttct ctccatctat
     1561 cggaccccag tttccatcac tatctccaga gatgtagcta ttatgcgccc gtctacaggg
     1621 ggtgcccgac gatgacggtg ccttcgcagt caaattactc ttcgggtccc aaggtttggc
     1681 tttcacgcgc tccattgccc cggcgtggca ggccattcca agcccttccg ggctggaact
     1741 ggtgtcggag gagcctcggg tgtatcgtac gccctggtgt tggtgttgcc tcactcctct
     1801 gagctcttct ttctgatcaa gccctgctta aagttaaata aaatagaatg aatgata
//
