LOCUS       NM_003809               1377 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens TNF superfamily member 12 (TNFSF12), transcript
            variant 1, mRNA.
ACCESSION   NM_003809
VERSION     NM_003809.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Lei,H., Chen,X., Bai,R., Wang,Q., Xian,N., Zhao,X., Zhou,X.,
            Zheng,Y. and Wang,G.
  TITLE     Genetically predicted TWEAK mediates the association between
            lipidome and Keratinocyte Carcinomas
  JOURNAL   Skin Res Technol 30 (7), e13781 (2024)
   PUBMED   38932454
  REMARK    GeneRIF: Genetically predicted TWEAK mediates the association
            between lipidome and Keratinocyte Carcinomas.
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Xuekelati,S., Maimaitiwusiman,Z., Bai,X., Xiang,H., Li,Y. and
            Wang,H.
  TITLE     Sarcopenia is associated with hypomethylation of TWEAK and
            increased plasma levels of TWEAK and its downstream inflammatory
            factor TNF-alpha in older adults: A case-control study
  JOURNAL   Exp Gerontol 188, 112390 (2024)
   PUBMED   38437928
  REMARK    GeneRIF: Sarcopenia is associated with hypomethylation of TWEAK and
            increased plasma levels of TWEAK and its downstream inflammatory
            factor TNF-alpha in older adults: A case-control study.
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Turkmen,K., Baloglu,I., Aykut,T., Demir,S., Altin,E., Akguzel,Z.A.,
            Kocabas,M. and Yerlikaya,F.H.
  TITLE     The Relationship between Serum TWEAK Levels and Carotid
            Intima-media Thickness in Patients with Fabry Disease
  JOURNAL   Saudi J Kidney Dis Transpl 34 (5), 406-415 (2023)
   PUBMED   38995299
  REMARK    GeneRIF: The Relationship between Serum TWEAK Levels and Carotid
            Intima-media Thickness in Patients with Fabry Disease.
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Ozer,H., Baloglu,I., Aykut,T., Demirci,M.A., Aydemir,F.H.Y. and
            Turkmen,K.
  TITLE     Sclerostin and TNF-related weak inducer of apoptosis: can they be
            important in the patients with glomerulonephritis?
  JOURNAL   Rev Assoc Med Bras (1992) 69 (7), e20230239 (2023)
   PUBMED   37466605
  REMARK    GeneRIF: Sclerostin and TNF-related weak inducer of apoptosis: can
            they be important in the patients with glomerulonephritis?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Roos,C., Wicovsky,A., Muller,N., Salzmann,S., Rosenthal,T.,
            Kalthoff,H., Trauzold,A., Seher,A., Henkler,F., Kneitz,C. and
            Wajant,H.
  TITLE     Soluble and transmembrane TNF-like weak inducer of apoptosis
            differentially activate the classical and noncanonical NF-kappa B
            pathway
  JOURNAL   J Immunol 185 (3), 1593-1605 (2010)
   PUBMED   20610643
  REMARK    GeneRIF: Membrane TWEAK is superior to soluble TWEAK with respect
            to activation of the classical NF-kappa B pathway, whereas both
            TWEAK variants are potent inducers of TNFR-associated factor-2
            depletion, NF-kappaB-inducing kinase accumulation and p100
            processing.
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Brown,S.A., Ghosh,A. and Winkles,J.A.
  TITLE     Full-length, membrane-anchored TWEAK can function as a juxtacrine
            signaling molecule and activate the NF-kappaB pathway
  JOURNAL   J Biol Chem 285 (23), 17432-17441 (2010)
   PUBMED   20385556
  REMARK    GeneRIF: Full-length, membrane-anchored TWEAK can function as a
            juxtacrine signaling molecule and activate the NF-kappaB pathway
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Kaplan,M.J., Ray,D., Mo,R.R., Yung,R.L. and Richardson,B.C.
  TITLE     TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell
            killing of antigen-presenting macrophages
  JOURNAL   J Immunol 164 (6), 2897-2904 (2000)
   PUBMED   10706675
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   Lynch,C.N., Wang,Y.C., Lund,J.K., Chen,Y.W., Leal,J.A. and
            Wiley,S.R.
  TITLE     TWEAK induces angiogenesis and proliferation of endothelial cells
  JOURNAL   J Biol Chem 274 (13), 8455-8459 (1999)
   PUBMED   10085077
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Marsters,S.A., Sheridan,J.P., Pitti,R.M., Brush,J., Goddard,A. and
            Ashkenazi,A.
  TITLE     Identification of a ligand for the death-domain-containing receptor
            Apo3
  JOURNAL   Curr Biol 8 (9), 525-528 (1998)
   PUBMED   9560343
REFERENCE   10 (bases 1 to 1377)
  AUTHORS   Chicheportiche,Y., Bourdon,P.R., Xu,H., Hsu,Y.M., Scott,H.,
            Hession,C., Garcia,I. and Browning,J.L.
  TITLE     TWEAK, a new secreted ligand in the tumor necrosis factor family
            that weakly induces apoptosis
  JOURNAL   J Biol Chem 272 (51), 32401-32410 (1997)
   PUBMED   9405449
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI091441.1, BC104420.1 and
            AF030099.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003809.2.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            protein is a ligand for the FN14/TWEAKR receptor. This cytokine has
            overlapping signaling functions with TNF, but displays a much wider
            tissue distribution. This cytokine, which exists in both
            membrane-bound and secreted forms, can induce apoptosis via
            multiple pathways of cell death in a cell type-specific manner.
            This cytokine is also found to promote proliferation and migration
            of endothelial cells, and thus acts as a regulator of angiogenesis.
            Alternative splicing results in multiple transcript variants. Some
            transcripts skip the last exon of this gene and continue into the
            second exon of the neighboring TNFSF13 gene; such read-through
            transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
            [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055872.1, AY358870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293825.11/ ENSP00000293825.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AI091441.1         168-231
            65-1062             BC104420.1         1-998
            1063-1377           AF030099.1         984-1298
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1377
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /note="TNF superfamily member 12"
                     /db_xref="GeneID:8742"
                     /db_xref="HGNC:HGNC:11927"
                     /db_xref="MIM:602695"
     exon            1..255
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..846
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /note="proprotein is encoded by transcript variant 1;
                     APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis;
                     APO3 ligand; tumor necrosis factor (ligand) superfamily,
                     member 12; tumor necrosis factor ligand 4A; tumor necrosis
                     factor superfamily member 12"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     12 proprotein"
                     /protein_id="NP_003800.1"
                     /db_xref="CCDS:CCDS11109.1"
                     /db_xref="GeneID:8742"
                     /db_xref="HGNC:HGNC:11927"
                     /db_xref="MIM:602695"
                     /translation="MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSL
                     GSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTR
                     ARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGL
                     YYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLAL
                     RPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH"
     exon            256..303
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            304..379
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            380..433
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            434..469
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            470..594
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1377
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /note="hexamer: ATTAAA"
     polyA_site      1377
                     /gene="TNFSF12"
                     /gene_synonym="APO3L; DR3LG; TNF12; TNLG4A; TWEAK"
                     /note="major polyA site"
ORIGIN      
        1 ctctccccgg cccgatccgc ccgccggctc cccctccccc gatccctcgg gtcccgggat
       61 gggggggcgg tgaggcaggc acagcccccc gcccccatgg ccgcccgtcg gagccagagg
      121 cggagggggc gccgggggga gccgggcacc gccctgctgg tcccgctcgc gctgggcctg
      181 ggcctggcgc tggcctgcct cggcctcctg ctggccgtgg tcagtttggg gagccgggca
      241 tcgctgtccg cccaggagcc tgcccaggag gagctggtgg cagaggagga ccaggacccg
      301 tcggaactga atccccagac agaagaaagc caggatcctg cgcctttcct gaaccgacta
      361 gttcggcctc gcagaagtgc acctaaaggc cggaaaacac gggctcgaag agcgatcgca
      421 gcccattatg aagttcatcc acgacctgga caggacggag cgcaggcagg tgtggacggg
      481 acagtgagtg gctgggagga agccagaatc aacagctcca gccctctgcg ctacaaccgc
      541 cagatcgggg agtttatagt cacccgggct gggctctact acctgtactg tcaggtgcac
      601 tttgatgagg ggaaggctgt ctacctgaag ctggacttgc tggtggatgg tgtgctggcc
      661 ctgcgctgcc tggaggaatt ctcagccact gcggcgagtt ccctcgggcc ccagctccgc
      721 ctctgccagg tgtctgggct gttggccctg cggccagggt cctccctgcg gatccgcacc
      781 ctcccctggg cccatctcaa ggctgccccc ttcctcacct acttcggact cttccaggtt
      841 cactgagggg ccctggtctc cccgcagtcg tcccaggctg ccggctcccc tcgacagctc
      901 tctgggcacc cggtcccctc tgccccaccc tcagccgctc tttgctccag acctgcccct
      961 ccctctagag gctgcctggg cctgttcacg tgttttccat cccacataaa tacagtattc
     1021 ccactcttat cttacaactc ccccaccgcc cactctccac ctcactagct ccccaatccc
     1081 tgaccctttg aggcccccag tgatctcgac tcccccctgg ccacagaccc ccagggcatt
     1141 gtgttcactg tactctgtgg gcaaggatgg gtccagaaga ccccacttca ggcactaaga
     1201 ggggctggac ctggcggcag gaagccaaag agactgggcc taggccagga gttcccaaat
     1261 gtgaggggcg agaaacaaga caagctcctc ccttgagaat tccctgtgga tttttaaaac
     1321 agatattatt tttattatta ttgtgacaaa atgttgataa atggatatta aatagaa
//
