LOCUS       NM_003810               1876 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens TNF superfamily member 10 (TNFSF10), transcript
            variant 1, mRNA.
ACCESSION   NM_003810
VERSION     NM_003810.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Cartland,S.P., Patil,M.S., Kelland,E., Le,N., Boccanfuso,L.,
            Stanley,C.P., Cholan,P.M., Dona,M.I., Patrick,R., McGrath,J.,
            Su,Q.P., Alwis,I., Ganss,R., Powell,J.E., Harvey,R.P., Pinto,A.R.,
            Griffith,T.S., Loa,J., Aitken,S.J., Robinson,D.A., Patel,S. and
            Kavurma,M.M.
  TITLE     The generation of stable microvessels in ischemia is mediated by
            endothelial cell derived TRAIL
  JOURNAL   Sci Adv 10 (40), eadn8760 (2024)
   PUBMED   39365855
  REMARK    GeneRIF: The generation of stable microvessels in ischemia is
            mediated by endothelial cell derived TRAIL.
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Kim,S.L., Shin,M., Jin,B.C., Seo,S., Ha,G.W. and Kim,S.W.
  TITLE     Acquired Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand
            (TRAIL) Resistance of Human Colorectal Cancer Cells Is Linked to
            Histone Acetylation and Is Synergistically Ameliorated by
            Combination with HDAC Inhibitors
  JOURNAL   Dig Dis Sci 69 (9), 3305-3317 (2024)
   PUBMED   39090444
  REMARK    GeneRIF: Acquired Tumor Necrosis Factor-Related Apoptosis-Inducing
            Ligand (TRAIL) Resistance of Human Colorectal Cancer Cells Is
            Linked to Histone Acetylation and Is Synergistically Ameliorated by
            Combination with HDAC Inhibitors.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Ghosal,N., Tapadar,P., Biswas,D. and Pal,R.
  TITLE     ELF3 plays an important role in defining TRAIL sensitivity in
            breast cancer by modulating the expression of decoy receptor 2
            (DCR2)
  JOURNAL   Mol Biol Rep 51 (1), 671 (2024)
   PUBMED   38787503
  REMARK    GeneRIF: ELF3 plays an important role in defining TRAIL sensitivity
            in breast cancer by modulating the expression of decoy receptor 2
            (DCR2).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Liphaus,B.L., Silva,S.C., Palmeira,P., Silva,C.A.,
            Goldenstein-Schainberg,C. and Carneiro-Sampaio,M.
  TITLE     Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and
            TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus
            patients: relations with disease activity, nephritis, and
            neuropsychiatric involvement
  JOURNAL   Front Immunol 15, 1327255 (2024)
   PUBMED   38562920
  REMARK    GeneRIF: Reduced expressions of apoptosis-related proteins TRAIL,
            Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus
            erythematosus patients: relations with disease activity, nephritis,
            and neuropsychiatric involvement.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Maji,A., Paul,A., Sarkar,A., Nahar,S., Bhowmik,R., Samanta,A.,
            Nahata,P., Ghosh,B., Karmakar,S. and Kumar Maity,T.
  TITLE     Significance of TRAIL/Apo-2 ligand and its death receptors in
            apoptosis and necroptosis signalling: Implications for
            cancer-targeted therapeutics
  JOURNAL   Biochem Pharmacol 221, 116041 (2024)
   PUBMED   38316367
  REMARK    GeneRIF: Significance of TRAIL/Apo-2 ligand and its death receptors
            in apoptosis and necroptosis signalling: Implications for
            cancer-targeted therapeutics.
            Review article
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Pan,G., O'Rourke,K., Chinnaiyan,A.M., Gentz,R., Ebner,R., Ni,J. and
            Dixit,V.M.
  TITLE     The receptor for the cytotoxic ligand TRAIL
  JOURNAL   Science 276 (5309), 111-113 (1997)
   PUBMED   9082980
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Marsters,S.A., Pitti,R.M., Donahue,C.J., Ruppert,S., Bauer,K.D. and
            Ashkenazi,A.
  TITLE     Activation of apoptosis by Apo-2 ligand is independent of FADD but
            blocked by CrmA
  JOURNAL   Curr Biol 6 (6), 750-752 (1996)
   PUBMED   8793301
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Pitti,R.M., Marsters,S.A., Ruppert,S., Donahue,C.J., Moore,A. and
            Ashkenazi,A.
  TITLE     Induction of apoptosis by Apo-2 ligand, a new member of the tumor
            necrosis factor cytokine family
  JOURNAL   J Biol Chem 271 (22), 12687-12690 (1996)
   PUBMED   8663110
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007919.18 and AC016938.24.
            
            On Nov 23, 2018 this sequence version replaced NM_003810.3.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            protein preferentially induces apoptosis in transformed and tumor
            cells, but does not appear to kill normal cells although it is
            expressed at a significant level in most normal tissues. This
            protein binds to several members of TNF receptor superfamily
            including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,
            TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity
            of this protein may be modulated by binding to the decoy receptors
            TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot
            induce apoptosis. The binding of this protein to its receptors has
            been shown to trigger the activation of MAPK8/JNK, caspase 8, and
            caspase 3. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.224519.1,
                                           SRR5189664.80318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2162328
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241261.7/ ENSP00000241261.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC007919.18        4049-4226           c
            179-316             AC016938.24        35112-35249         c
            317-359             AC016938.24        31868-31910         c
            360-464             AC016938.24        29468-29572         c
            465-1876            AC016938.24        25759-27170         c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.31"
     gene            1..1876
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /note="TNF superfamily member 10"
                     /db_xref="GeneID:8743"
                     /db_xref="HGNC:HGNC:11925"
                     /db_xref="MIM:603598"
     exon            1..178
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..892
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /note="isoform 1 is encoded by transcript variant 1; Apo-2
                     ligand; TNF-related apoptosis inducing ligand TRAIL; tumor
                     necrosis factor (ligand) family, member 10; chemokine
                     tumor necrosis factor ligand superfamily member 10; tumor
                     necrosis factor superfamily member 10; tumor necrosis
                     factor (ligand) superfamily, member 10; tumor necrosis
                     factor ligand 6A"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     10 isoform 1"
                     /protein_id="NP_003801.1"
                     /db_xref="CCDS:CCDS3219.1"
                     /db_xref="GeneID:8743"
                     /db_xref="HGNC:HGNC:11925"
                     /db_xref="MIM:603598"
                     /translation="MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQ
                     MQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETIST
                     VQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSG
                     HSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPD
                     PILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFG
                     AFLVG"
     exon            179..316
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            317..359
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            360..464
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1876
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /note="hexamer: AATAAA"
     polyA_site      1705
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /note="major polyA site"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TANCR; TL2; TNLG6A;
                     TRAIL"
ORIGIN      
        1 gaccggctgc ctggctgact tacagcagtc agactctgac aggatcatgg ctatgatgga
       61 ggtccagggg ggacccagcc tgggacagac ctgcgtgctg atcgtgatct tcacagtgct
      121 cctgcagtct ctctgtgtgg ctgtaactta cgtgtacttt accaacgagc tgaagcagat
      181 gcaggacaag tactccaaaa gtggcattgc ttgtttctta aaagaagatg acagttattg
      241 ggaccccaat gacgaagaga gtatgaacag cccctgctgg caagtcaagt ggcaactccg
      301 tcagctcgtt agaaagatga ttttgagaac ctctgaggaa accatttcta cagttcaaga
      361 aaagcaacaa aatatttctc ccctagtgag agaaagaggt cctcagagag tagcagctca
      421 cataactggg accagaggaa gaagcaacac attgtcttct ccaaactcca agaatgaaaa
      481 ggctctgggc cgcaaaataa actcctggga atcatcaagg agtgggcatt cattcctgag
      541 caacttgcac ttgaggaatg gtgaactggt catccatgaa aaagggtttt actacatcta
      601 ttcccaaaca tactttcgat ttcaggagga aataaaagaa aacacaaaga acgacaaaca
      661 aatggtccaa tatatttaca aatacacaag ttatcctgac cctatattgt tgatgaaaag
      721 tgctagaaat agttgttggt ctaaagatgc agaatatgga ctctattcca tctatcaagg
      781 gggaatattt gagcttaagg aaaatgacag aatttttgtt tctgtaacaa atgagcactt
      841 gatagacatg gaccatgaag ccagtttttt tggggccttt ttagttggct aactgacctg
      901 gaaagaaaaa gcaataacct caaagtgact attcagtttt caggatgata cactatgaag
      961 atgtttcaaa aaatctgacc aaaacaaaca aacagaaaac agaaaacaaa aaaacctcta
     1021 tgcaatctga gtagagcagc cacaaccaaa aaattctaca acacacactg ttctgaaagt
     1081 gactcactta tcccaagaga atgaaattgc tgaaagatct ttcaggactc tacctcatat
     1141 cagtttgcta gcagaaatct agaagactgt cagcttccaa acattaatgc aatggttaac
     1201 atcttctgtc tttataatct actccttgta aagactgtag aagaaagagc aacaatccat
     1261 ctctcaagta gtgtatcaca gtagtagcct ccaggtttcc ttaagggaca acatccttaa
     1321 gtcaaaagag agaagaggca ccactaaaag atcgcagttt gcctggtgca gtggctcaca
     1381 cctgtaatcc caacattttg ggaacccaag gtgggtagat cacgagatca agagatcaag
     1441 accatagtga ccaacatagt gaaaccccat ctctactgaa agtacaaaaa ttagctgggt
     1501 gtgttggcac atgcctgtag tcccagctac ttgagaggct gaggcaagag aattgtttga
     1561 acccgggagg cagaggttgc agtgtggtga gatcatgcca ctacactcca gcctggcgac
     1621 agagcgagac ttggtttcaa aaaaaaaaaa aaaaaaaact tcagtaagta cgtgttattt
     1681 ttttcaataa aattctatta cagtatgtca tgtttgctgt agtgctcata tttattgttg
     1741 tttttgtttt agtactcact tgtttcataa tatcaagatt actaaaaatg ggggaaaaga
     1801 cttctaatct ttttttcata atatctttga cacatattac agaagaaata aatttcttac
     1861 ttttaattta atatga
//
