LOCUS       NM_001561               5872 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 9 (TNFRSF9), mRNA.
ACCESSION   NM_001561 XM_011541386
VERSION     NM_001561.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Ji,X., Huang,G., Peng,Y., Wang,J., Cai,X., Yang,E., Zhu,L., Wu,Y.,
            Sha,W., Wang,F., Shen,L. and Shen,H.
  TITLE     CD137 expression and signal function drive pleiotropic gammadelta
            T-cell effector functions that inhibit intracellular M.
            tuberculosis growth
  JOURNAL   Clin Immunol 266, 110331 (2024)
   PUBMED   39067675
  REMARK    GeneRIF: CD137 expression and signal function drive pleiotropic
            gammadelta T-cell effector functions that inhibit intracellular M.
            tuberculosis growth.
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Solorzano,J.L., Menendez,V., Parra,E., Solis,L., Salazar,R.,
            Garcia-Cosio,M., Climent,F., Fernandez,S., Diaz,E.,
            Francisco-Cruz,A., Khoury,J., Jiang,M., Tamegnon,A., Montalban,C.,
            Melero,I., Wistuba,I., De Andrea,C. and F Garcia,J.
  TITLE     Multiplex spatial analysis reveals increased CD137 expression and
            m-MDSC neighboring tumor cells in refractory classical Hodgkin
            Lymphoma
  JOURNAL   Oncoimmunology 13 (1), 2388304 (2024)
   PUBMED   39135889
  REMARK    GeneRIF: Multiplex spatial analysis reveals increased CD137
            expression and m-MDSC neighboring tumor cells in refractory
            classical Hodgkin Lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Rath,U., Mester,P., Schwarz,H., Schmid,S., Muller,M., Buechler,C.
            and Pavel,V.
  TITLE     Soluble CD137: A Potential Prognostic Biomarker in Critically Ill
            Patients
  JOURNAL   Int J Mol Sci 24 (24), 17518 (2023)
   PUBMED   38139346
  REMARK    GeneRIF: Soluble CD137: A Potential Prognostic Biomarker in
            Critically Ill Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   Wu,Q., Pan,C., Zhou,Y., Wang,S., Xie,L., Zhou,W., Ding,L., Chen,T.,
            Qian,J., Su,R., Gao,X., Mei,Z., Qiao,Y., Yin,S., Wu,Y., Wang,J.,
            Zhou,L. and Zheng,S.
  TITLE     Targeting neuropilin-1 abolishes anti-PD-1-upregulated regulatory T
            cells and synergizes with 4-1BB agonist for liver cancer treatment
  JOURNAL   Hepatology 78 (5), 1402-1417 (2023)
   PUBMED   36811396
  REMARK    GeneRIF: Targeting neuropilin-1 abolishes anti-PD-1-upregulated
            regulatory T cells and synergizes with 4-1BB agonist for liver
            cancer treatment.
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Nielsen,M.A., Juul-Madsen,K., Stegmayr,J., Gao,C., Mehta,A.Y.,
            Greisen,S.R., Kragstrup,T.W., Hvid,M., Vorup-Jensen,T.,
            Cummings,R.D., Leffler,H. and Deleuran,B.W.
  TITLE     Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and
            Membrane Expressed 4-1BB
  JOURNAL   Front Immunol 13, 915890 (2022)
   PUBMED   35812455
  REMARK    GeneRIF: Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking
            Soluble and Membrane Expressed 4-1BB.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Schwarz,H., Blanco,F.J., von Kempis,J., Valbracht,J. and Lotz,M.
  TITLE     ILA, a member of the human nerve growth factor/tumor necrosis
            factor receptor family, regulates T-lymphocyte proliferation and
            survival
  JOURNAL   Blood 87 (7), 2839-2845 (1996)
   PUBMED   8639902
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Zhou,Z., Kim,S., Hurtado,J., Lee,Z.H., Kim,K.K., Pollok,K.E. and
            Kwon,B.S.
  TITLE     Characterization of human homologue of 4-1BB and its ligand
  JOURNAL   Immunol Lett 45 (1-2), 67-73 (1995)
   PUBMED   7622190
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Alderson,M.R., Smith,C.A., Tough,T.W., Davis-Smith,T.,
            Armitage,R.J., Falk,B., Roux,E., Baker,E., Sutherland,G.R. and
            Din,W.S.
  TITLE     Molecular and biological characterization of human 4-1BB and its
            ligand
  JOURNAL   Eur J Immunol 24 (9), 2219-2227 (1994)
   PUBMED   8088337
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Schwarz,H., Tuckwell,J. and Lotz,M.
  TITLE     A receptor induced by lymphocyte activation (ILA): a new member of
            the human nerve-growth-factor/tumor-necrosis-factor receptor family
  JOURNAL   Gene 134 (2), 295-298 (1993)
   PUBMED   8262389
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Kwon,B.S. and Weissman,S.M.
  TITLE     cDNA sequences of two inducible T-cell genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1963-1967 (1989)
   PUBMED   2784565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP381234.1, BC006196.2 and
            AL009183.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Aug 13, 2019 this sequence version replaced
            XM_011541386.2, NM_001561.5.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor contributes to the clonal
            expansion, survival, and development of T cells. It can also induce
            proliferation in peripheral monocytes, enhance T cell apoptosis
            induced by TCR/CD3 triggered activation, and regulate CD28
            co-stimulation to promote Th1 cell responses. The expression of
            this receptor is induced by lymphocyte activation. TRAF adaptor
            proteins have been shown to bind to this receptor and transduce the
            signals leading to activation of NF-kappaB. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.146.1, SRR11853564.132.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377507.8/ ENSP00000366729.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BP381234.1         122-140
            20-1896             BC006196.2         1-1877
            1897-5872           AL009183.10        30463-34438         c
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..5872
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="TNF receptor superfamily member 9"
                     /db_xref="GeneID:3604"
                     /db_xref="HGNC:HGNC:11924"
                     /db_xref="MIM:602250"
     exon            1..56
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            57..240
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..908
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="interleukin-activated receptor, homolog of mouse
                     Ly63; receptor protein 4-1BB; induced by lymphocyte
                     activation (ILA); CD137 antigen; homolog of mouse 4-1BB; T
                     cell antigen ILA; 4-1BB ligand receptor; T-cell antigen
                     4-1BB homolog; tumor necrosis factor receptor superfamily
                     member 9"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 9 precursor"
                     /protein_id="NP_001552.2"
                     /db_xref="CCDS:CCDS92.1"
                     /db_xref="GeneID:3604"
                     /db_xref="HGNC:HGNC:11924"
                     /db_xref="MIM:602250"
                     /translation="MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQI
                     CSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMC
                     EQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGP
                     SPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRK
                     KLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL"
     exon            241..348
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            349..486
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            487..553
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            554..684
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            685..819
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     exon            820..5872
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="hexamer: TATAAA"
     polyA_site      4160
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="major polyA site"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="hexamer: TATAAA"
     polyA_site      4876
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="major polyA site"
     regulatory      4895..4900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="hexamer: ATTAAA"
     polyA_site      4916
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
     regulatory      5357..5362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
                     /note="hexamer: AATGAA"
     polyA_site      5373
                     /gene="TNFRSF9"
                     /gene_synonym="4-1BB; CD137; CDw137; ILA; IMD109"
ORIGIN      
        1 gcagaagcct gaagaccaag gagtggaaag ttctccggca gccctgagat ctcaagagtg
       61 acatttgtga gaccagctaa tttgattaaa attctcttgg aatcagcttt gctagtatca
      121 tacctgtgcc agatttcatc atgggaaaca gctgttacaa catagtagcc actctgttgc
      181 tggtcctcaa ctttgagagg acaagatcat tgcaggatcc ttgtagtaac tgcccagctg
      241 gtacattctg tgataataac aggaatcaga tttgcagtcc ctgtcctcca aatagtttct
      301 ccagcgcagg tggacaaagg acctgtgaca tatgcaggca gtgtaaaggt gttttcagga
      361 ccaggaagga gtgttcctcc accagcaatg cagagtgtga ctgcactcca gggtttcact
      421 gcctgggggc aggatgcagc atgtgtgaac aggattgtaa acaaggtcaa gaactgacaa
      481 aaaaaggttg taaagactgt tgctttggga catttaacga tcagaaacgt ggcatctgtc
      541 gaccctggac aaactgttct ttggatggaa agtctgtgct tgtgaatggg acgaaggaga
      601 gggacgtggt ctgtggacca tctccagccg acctctctcc gggagcatcc tctgtgaccc
      661 cgcctgcccc tgcgagagag ccaggacact ctccgcagat catctccttc tttcttgcgc
      721 tgacgtcgac tgcgttgctc ttcctgctgt tcttcctcac gctccgtttc tctgttgtta
      781 aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa
      841 ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg
      901 aactgtgaaa tggaagtcaa tagggctgtt gggactttct tgaaaagaag caaggaaata
      961 tgagtcatcc gctatcacag ctttcaaaag caagaacacc atcctacata atacccagga
     1021 ttcccccaac acacgttctt ttctaaatgc caatgagttg gcctttaaaa atgcaccact
     1081 tttttttttt ttttgacagg gtctcactct gtcacccagg ctggagtgca gtggcaccac
     1141 catggctctc tgcagccttg acctctggga gctcaagtga tcctcctgcc tcagtctcct
     1201 gagtagctgg aactacaagg aagggccacc acacctgact aacttttttg ttttttgttt
     1261 ggtaaagatg gcatttcacc atgttgtaca ggctggtctc aaactcctag gttcactttg
     1321 gcctcccaaa gtgctgggat tacagacatg aactgccagg cccggccaaa ataatgcacc
     1381 acttttaaca gaacagacag atgaggacag agctggtgat aaaaaaaaaa aaaaaaaagc
     1441 attttctaga taccacttaa caggtttgag ctagtttttt tgaaatccaa agaaaattat
     1501 agtttaaatt caattacata gtccagtggt ccaactataa ttataatcaa aatcaatgca
     1561 ggtttgtttt ttggtgctaa tatgacatat gacaataagc cacgaggtgc agtaagtacc
     1621 cgactaaagt ttccgtgggt tctgtcatgt aacacgacat gctccaccgt caggggggag
     1681 tatgagcaga gtgcctgagt ttagggtcaa ggacaaaaaa cctcaggcct ggaggaagtt
     1741 ttggaaagag ttcaagtgtc tgtatatcct atggtcttct ccatcctcac accttctgcc
     1801 tttgtcctgc tcccttttaa gccaggttac attctaaaaa ttcttaactt ttaacataat
     1861 attttatacc aaagccaata aatgaactgc atatgatagg tatgaagtac agtgagaaaa
     1921 ttaacacctg tgagctcatt gtcctaccac agcactagag tgggggccgc caaactccca
     1981 tggccaaacc tggtgcacca tttgcctttg tttgtctgtt ggtttgcttg agacagtctt
     2041 gctctgttgc ccaggctgga atggagtggc tattcacagg cacaatcata gcacacttta
     2101 gccttaaact cctgggctca agtgatccac ccgcctcagt ctcccaagta gctgggatta
     2161 caggtgcaaa cctggcatgc ctgccattgt ttggcttatg atctaaggat agctttttaa
     2221 attttattca ttttattttt ttttgagaca gtgtctcact ctgtctccca ggctggagta
     2281 cagtggtaca atcttggatc accgcctccc agtttcaagt gatctccctg cctcagcctc
     2341 ctaagtagct gggactacag gtatgtgcca ccacgcctgg ctaattttta tatttttagt
     2401 agagacgggg tttcaccatg ttgtccaggc tggtctcaaa ctcctgacct caggtgatct
     2461 gcccacctct gcctcccaaa gtgctgggat tacaggcatg agccaccatg cctggccatt
     2521 tcttacactt ttgtatgaca tgcctattgc aagcttgcgt gcctctgtcc catgttattt
     2581 tactctggga tttaggtgga gggagcagct tctatttgga acattggcca tcgcatggca
     2641 aatgggtatc tgtcacttct gctcctattt agttggttct actataacct ttagagcaaa
     2701 tcctgcagcc aagccaggca tcaatagggc agaaaagtat attctgtaaa taggggtgag
     2761 gagaagatat ttctgaacaa tagtctactg cagtaccaaa ttgcttttca aagtggctgt
     2821 tctaatgtac tcccgtcagt catataagtg tcatgtaagt atcccattga tccacatcct
     2881 tgctaccctc tggtactatc aggtgccctt aattttgcca agccagtggg tatagaatga
     2941 gatctcactg tggtcttagt ttgcatttgc ttggttactg atgagcacct tgtcaaatat
     3001 ttatatacca tttgtgttta tttttttaaa taaaatgctt gctcatgctt ttttgcccat
     3061 ttgcaaaaaa acttggggcc gggtgcagtg gctcatgcct gtagtcccag ctctttggga
     3121 ggccaaggtg ggcagatcgc ttgagcccag gagttcgaga ccagccttgg caacatggcg
     3181 aaaccctgtc tttacaaaaa atacaaaaat tagccgggtg tggtggtgtg cacctgaagt
     3241 cccagctact cagtaggttc gctttgagcc tgggaggcag aggttgcagt gagctgggac
     3301 cgcatcacta cacttcagcc tgggcaacag agaaaaacct tttctcagaa acaaacaaac
     3361 ccaaatgtgg ttgtttgtcc tgattcctaa aaggtcttta tgtattctag ataataatct
     3421 ttggtcagtt atatgtgtta aaaaatatct tctttgtggc caggcacggt agctcacacc
     3481 tgtaatccca gcactttgcg gggctgaggt gggtggatca tctgaggtca agagttcaag
     3541 atcagcctgg ccaacacagt gaaaccccat ctctactaaa catgtacaaa acttagctgg
     3601 gtatggtggc gggtgcctgt aaccccagct gctccagagg ctgtggcaga agaatcgctt
     3661 gaacccagga ggcagaggtt gcagcgagcc aagattgtgc cattgcactc cagactgggt
     3721 gacaagagtg aaattctgcc tatctatcta tctatctatc tatatctata tatatatata
     3781 tatatatcct ttgtaattta tttttccctt tttaaaattt tttataaaat tcttttttat
     3841 ttttattttt agcagaggtg aggtttctga ggtttcatta tgttgcccag gctggtcttg
     3901 aactcctgag ctcaagtgat cctcccacct cagccttcca aagtgctgga attgcagaca
     3961 tgagccaccg cgcccctcct gtttttctct aattaatggt gtctttcttt gtctttctgg
     4021 taataagcaa aaagttcttc atttgatttg gttaaattta taactgtttt ctcatatggt
     4081 taacattttt tcttgcctgg ctaaagaaat ccttttctgc ccaatactat aaagaggttt
     4141 gcccacattt tattccaaaa gttttaagtt ttgtctttca tcttgaagtc taatgtatca
     4201 ggaactggct tttgtgcctg ttgggaggta gtgatccaat tccatgtctt gcatgtaggt
     4261 aaccactggt ccctgcgcca tgtattcaat acgtcgtctt tctcctgcgg gtctgcaatc
     4321 tcacctacca tccatcaagt ttccataggg ccatgggtct gcttctgggc tccctgttct
     4381 gttccattgt caatttgtct atcctgtgcc agtatcacac tgtgtttatt acaatagctt
     4441 tgtaacagct ctcgatatcc ggtaggacat ctccctccac cttctttttc tacttcagaa
     4501 gtgtcttagc taggtcaggc acggtggctc acgcctgtaa tcccagcact ttgggaggcc
     4561 gacgcggatg gatcacctga ggtcaggagt tttgagacag cctggccaac atggtgaaac
     4621 cccatctcta ctaaaaaata caaaaattag tcaggcatgg tggcatgtgc ctgtaatccc
     4681 agctatttgg gaggctgagg ccggagaatt gcttgaaccc ggggggcgga ggttgcagtg
     4741 agccgagatc gtaccattgc actccagcct gggtgacaga gcgaaactct gtctcaggaa
     4801 aaaaaagaaa agagatgtct tggttattct tggttcttta ttattcaata taaattttag
     4861 aagctgaatt tgaaaagatt tggattggaa tttcattaaa tctacaggtc aatttaggga
     4921 gagttgataa ttttacagaa ttgagtcatc tggtgttcca ataagaataa gagaacaatt
     4981 attggctgta caattcttgc caaatagtag gcaaagcaaa gcttaggaag tatactggtg
     5041 ccatttcagg aacaaagcta ggtgcgaata tttttgtctt tctgaatcat gatgctgtaa
     5101 gttctaaagt gatttctcct cttggctttg gacacatggt gtttaattac ctactgctga
     5161 ctatccacaa acagaaagag actggtcatg ccccacaggg ttggggtatc caagataatg
     5221 gagcgaggct ctcatgtgtc ctaggttaca caccgaaaat ccacagttta ttctgtgaag
     5281 aaaggaggct atgtttatga tacagactgt gatattttta tcatagccta ttctggtatc
     5341 atgtgcaaaa gctataaatg aaaaacacag gaacttggca tgtgagtcat tgctccccct
     5401 aaatgacaat taataaggaa ggaacattga gacagaataa aatgatcccc ttctgggttt
     5461 aatttagaaa gttccataat taggtttaat agaaataaat gtaaatttct atgattaaaa
     5521 ataaattagc acatttaggg atacacaaat tataaatcat tttctaaatg ctaaaaacaa
     5581 gctcaggttt ttttcagaag aaagttttaa ttttttttct ttagtggaag atatcactct
     5641 gacggaaagt tttgatgtga ggggcggatg actataaagt gggcatcttc ccccacagga
     5701 agatgtttcc atctgtgggt gagaggtgcc caccgcagct agggcaggtt acatgtgccc
     5761 tgtgtgtggt aggacttgga gagtgatctt tatcaacgtt tttatttaaa agactatcta
     5821 ataaaacaca aaactatgat gttcacagga aaaaaagaat aagaaaaaaa ga
//
