LOCUS       NM_001243               3760 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 8 (TNFRSF8),
            transcript variant 1, mRNA.
ACCESSION   NM_001243
VERSION     NM_001243.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3760)
  AUTHORS   Yu,F., Wang,J., Ke,Z., Zhang,Y., Xu,L., Zhang,H., Huang,K.,
            Cheng,F., Yang,H., Wang,L., Wang,Z., Shou,L., Yu,W., Fang,H.,
            Medeiros,L.J. and Wang,W.
  TITLE     EBV-positive Nodal T-Cell and NK-Cell Lymphoma: A Study of 26 Cases
            Including a Subset With Strong CD30 Expression Mimicking Anaplastic
            Large Cell Lymphoma
  JOURNAL   Am J Surg Pathol 48 (4), 406-416 (2024)
   PUBMED   38287746
  REMARK    GeneRIF: EBV-positive Nodal T-Cell and NK-Cell Lymphoma: A Study of
            26 Cases Including a Subset With Strong CD30 Expression Mimicking
            Anaplastic Large Cell Lymphoma.
REFERENCE   2  (bases 1 to 3760)
  AUTHORS   Li,S., Zheng,S., Huang,X., Zhang,W., Liu,F. and Cao,Q.
  TITLE     Expression and Clinical Significance of CD30 and CD56 in
            Lymphoblastic Lymphoma: A Retrospective Analysis on
            Paraffin-Embedded Tissues by Immunohistochemistry
  JOURNAL   Fetal Pediatr Pathol 43 (2), 111-122 (2024)
   PUBMED   38213180
  REMARK    GeneRIF: Expression and Clinical Significance of CD30 and CD56 in
            Lymphoblastic Lymphoma: A Retrospective Analysis on
            Paraffin-Embedded Tissues by Immunohistochemistry.
REFERENCE   3  (bases 1 to 3760)
  AUTHORS   Wang,W.T., Xing,T.Y., Du,K.X., Hua,W., Guo,J.R., Duan,Z.W.,
            Wu,Y.F., Wu,J.Z., Li,Y., Yin,H., Shen,H.R., Wang,L., Li,J.Y.,
            Liang,J.H. and Xu,W.
  TITLE     CD30 protects EBV-positive diffuse large B-cell lymphoma cells
            against mitochondrial dysfunction through BNIP3-mediated mitophagy
  JOURNAL   Cancer Lett 583, 216616 (2024)
   PUBMED   38211650
  REMARK    GeneRIF: CD30 protects EBV-positive diffuse large B-cell lymphoma
            cells against mitochondrial dysfunction through BNIP3-mediated
            mitophagy.
REFERENCE   4  (bases 1 to 3760)
  AUTHORS   Wang,Y., Zhang,F., Gao,N., Bu,P., Cui,W. and Xi,Y.
  TITLE     Differential expression of BCL11b and CDKN2A in CD30-positive
            peripheral T cell lymphoma: Retrospective study
  JOURNAL   Medicine (Baltimore) 102 (46), e35531 (2023)
   PUBMED   37986346
  REMARK    GeneRIF: Differential expression of BCL11b and CDKN2A in
            CD30-positive peripheral T cell lymphoma: Retrospective study.
REFERENCE   5  (bases 1 to 3760)
  AUTHORS   Ali,N., Moussa,E., Khorshed,E., Zaghloul,M.S., Elnashar,A. and
            Abdalla,A.
  TITLE     Variant histology of pediatric nodular lymphocyte-predominant
            Hodgkin lymphoma with IgD and CD30 expression
  JOURNAL   Pediatr Blood Cancer 70 (11), e30647 (2023)
   PUBMED   37638819
  REMARK    GeneRIF: Variant histology of pediatric nodular
            lymphocyte-predominant Hodgkin lymphoma with IgD and CD30
            expression.
REFERENCE   6  (bases 1 to 3760)
  AUTHORS   Jung,W., Krueger,S., Renner,C., Gause,A., Sahin,U., Trumper,L. and
            Pfreundschuh,M.
  TITLE     Opposite effects of the CD30 ligand are not due to CD30 mutations:
            results from cDNA cloning and sequence comparison of the CD30
            antigen from different sources
  JOURNAL   Mol Immunol 31 (17), 1329-1334 (1994)
   PUBMED   7527901
REFERENCE   7  (bases 1 to 3760)
  AUTHORS   Shiota,M., Fujimoto,J., Semba,T., Satoh,H., Yamamoto,T. and Mori,S.
  TITLE     Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase
            similar to Ltk in a human Ki-1 lymphoma cell line, AMS3
  JOURNAL   Oncogene 9 (6), 1567-1574 (1994)
   PUBMED   8183550
REFERENCE   8  (bases 1 to 3760)
  AUTHORS   Fonatsch,C., Latza,U., Durkop,H., Rieder,H. and Stein,H.
  TITLE     Assignment of the human CD30 (Ki-1) gene to 1p36
  JOURNAL   Genomics 14 (3), 825-826 (1992)
   PUBMED   1330892
REFERENCE   9  (bases 1 to 3760)
  AUTHORS   Durkop,H., Latza,U., Hummel,M., Eitelbach,F., Seed,B. and Stein,H.
  TITLE     Molecular cloning and expression of a new member of the nerve
            growth factor receptor family that is characteristic for Hodgkin's
            disease
  JOURNAL   Cell 68 (3), 421-427 (1992)
   PUBMED   1310894
REFERENCE   10 (bases 1 to 3760)
  AUTHORS   Josimovic-Alasevic,O., Durkop,H., Schwarting,R., Backe,E., Stein,H.
            and Diamantstein,T.
  TITLE     Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in
            vitro and in vivo. I. Partial characterization of soluble Ki-1
            antigen and detection of the antigen in cell culture supernatants
            and in serum by an enzyme-linked immunosorbent assay
  JOURNAL   Eur J Immunol 19 (1), 157-162 (1989)
   PUBMED   2537734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357835.11, M83554.1,
            BC136400.1 and BC141804.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001243.4.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is expressed by activated,
            but not by resting, T and B cells. TRAF2 and TRAF5 can interact
            with this receptor, and mediate the signal transduction that leads
            to the activation of NF-kappaB. This receptor is a positive
            regulator of apoptosis, and also has been shown to limit the
            proliferative potential of autoreactive CD8 effector T cells and
            protect the body against autoimmunity. Two alternatively spliced
            transcript variants of this gene encoding distinct isoforms have
            been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83554.1, SRR1163658.402972.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263932.7/ ENSP00000263932.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AL357835.11        16789-16862
            75-161              M83554.1           1-87
            162-162             AL357835.11        16950-16950
            163-565             M83554.1           89-491
            566-1631            BC136400.1         311-1376
            1632-2785           M83554.1           1558-2711
            2786-3760           BC141804.1         1267-2241
FEATURES             Location/Qualifiers
     source          1..3760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3760
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /note="TNF receptor superfamily member 8"
                     /db_xref="GeneID:943"
                     /db_xref="HGNC:HGNC:11923"
                     /db_xref="MIM:153243"
     exon            1..359
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2084
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytokine receptor CD30; lymphocyte activation
                     antigen CD30; CD30L receptor; Ki-1 antigen; tumor necrosis
                     factor receptor superfamily member 8"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 8 isoform 1 precursor"
                     /protein_id="NP_001234.3"
                     /db_xref="CCDS:CCDS144.1"
                     /db_xref="GeneID:943"
                     /db_xref="HGNC:HGNC:11923"
                     /db_xref="MIM:153243"
                     /translation="MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRC
                     CYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNS
                     SRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPAC
                     ASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSV
                     GRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWN
                     SSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPD
                     CNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVI
                     LVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSG
                     ASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTE
                     HTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETE
                     PPLGSCSDVMLSVEEEGKEDPLPTAASGK"
     exon            360..447
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..564
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..717
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..808
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..972
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1089
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1242
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1336
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1449
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1551
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1605
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1631
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1839
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..3760
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /note="hexamer: CATAAA"
     polyA_site      3760
                     /gene="TNFRSF8"
                     /gene_synonym="CD30; D1S166E; Ki-1"
                     /note="major polyA site"
ORIGIN      
        1 ctgagtcatc tctgcacgtg tttgccccct tttttcttcg ctgcttgtag ctaagtgttc
       61 ctggaaccaa tttgatacgg gagaactaag gctgaaacct cggaggaaca accacttttg
      121 aagtgacttc gcggcgtgcg ttgggtgcgg actaggtggc cgcggcggga gtgtgctgga
      181 gcctgaagtc cacgcgcgcg gctgagaacc gccgggaccg cacgtgggcg ccgcgcgctt
      241 cccccgcttc ccaggtgggc gccggccgcc aggccacctc acgtccggcc ccggggatgc
      301 gcgtcctcct cgccgcgctg ggactgctgt tcctgggggc gctacgagcc ttcccacagg
      361 atcgaccctt cgaggacacc tgtcatggaa accccagcca ctactatgac aaggctgtca
      421 ggaggtgctg ttaccgctgc cccatggggc tgttcccgac acagcagtgc ccacagaggc
      481 ctactgactg caggaagcag tgtgagcctg actactacct ggatgaggcc gaccgctgta
      541 cagcctgcgt gacttgttct cgagacgacc tcgtggagaa gacgccgtgt gcatggaact
      601 cctcccgtgt ctgcgaatgt cgacccggca tgttctgttc cacgtctgcc gtcaactcct
      661 gtgcccgctg cttcttccat tctgtctgtc cggcagggat gattgtcaag ttcccaggca
      721 cggcgcagaa gaacacggtc tgtgagccgg cttccccagg ggtcagccct gcctgtgcca
      781 gcccagagaa ctgcaaggaa ccctccagtg gcaccatccc ccaggccaag cccaccccgg
      841 tgtccccagc aacctccagt gccagcacca tgcctgtaag agggggcacc cgcctcgccc
      901 aggaagctgc ttctaaactg acgagggctc ccgactctcc ctcctctgtg ggaaggccta
      961 gttcagatcc aggtctgtcc ccaacacagc catgcccaga ggggtctggt gattgcagaa
     1021 agcagtgtga gcccgactac tacctggacg aggccggccg ctgcacggcc tgcgtgagct
     1081 gttctcgaga tgaccttgtg gagaagacgc catgtgcatg gaactcctcc cgcacctgcg
     1141 aatgtcgacc tggcatgatc tgtgccacat cagccaccaa ctcctgtgcc cgctgtgtcc
     1201 cctacccaat ctgtgcagca gagacggtca ccaagcccca ggatatggct gagaaggaca
     1261 ccacctttga ggcgccaccc ctggggaccc agccggactg caaccccacc ccagagaatg
     1321 gcgaggcgcc tgccagcacc agccccactc agagcttgct ggtggactcc caggccagta
     1381 agacgctgcc catcccaacc agcgctcccg tcgctctctc ctccacgggg aagcccgttc
     1441 tggatgcagg gccagtgctc ttctgggtga tcctggtgtt ggttgtggtg gtcggctcca
     1501 gcgccttcct cctgtgccac cggagggcct gcaggaagcg aattcggcag aagctccacc
     1561 tgtgctaccc ggtccagacc tcccagccca agctagagct tgtggattcc agacccagga
     1621 ggagctcaac gcagctgagg agtggtgcgt cggtgacaga acccgtcgcg gaagagcgag
     1681 ggttaatgag ccagccactg atggagacct gccacagcgt gggggcagcc tacctggaga
     1741 gcctgccgct gcaggatgcc agcccggccg ggggcccctc gtcccccagg gaccttcctg
     1801 agccccgggt gtccacggag cacaccaata acaagattga gaaaatctac atcatgaagg
     1861 ctgacaccgt gatcgtgggg accgtgaagg ctgagctgcc ggagggccgg ggcctggcgg
     1921 ggccagcaga gcccgagttg gaggaggagc tggaggcgga ccataccccc cactaccccg
     1981 agcaggagac agaaccgcct ctgggcagct gcagcgatgt catgctctca gtggaagagg
     2041 aagggaaaga agaccccttg cccacagctg cctctggaaa gtgaggcctg ggctgggctg
     2101 gggctaggag ggcagcaggg tggcctctgg gaggccagga tggcactgtt ggcaccgagg
     2161 ttgggggcag aggcccatct ggcctgaact gaggctccag catctagtgg tggaccggcc
     2221 ggtcactgca ggggtctggt ggtctctgct tgcatcccca acttagctgt cccctgaccc
     2281 agagcctagg ggatccgggg cttgtacaga agagacagtc caaggggact ggatcccagc
     2341 agtgatgttg gttgaggcag caaacagatg gcaggatggg cactgccgag aacagcattg
     2401 gtcccagagc cctgggcatc agaccttaac caccaggccc acagcccagc gagggagagg
     2461 tcgtgaggcc agctcccggg gcccctgtaa ccctactctc ctctctccct ggacctcaga
     2521 ggtgacaccc attgggccct tccggcatgc ccccagttac tgtaaatgtg gcccccagtg
     2581 ggcatggagc cagtgcctgt ggttgtttct ccagagtcaa aagggaagtc gagggatggg
     2641 gcgtcgtcag ctggcactgt ctctgctgca gcggccacac tgtactctgc actggtgtga
     2701 gggcccctgc ctggactgtg ggaccctcct ggtgctgccc accttccctg tcctgtagcc
     2761 ccctcggtgg gcccagggcc tagggcccag gatcaagtca ctcatctcag aatgtcccca
     2821 ccaatccccg ccacagcagg cgcctcgggt cccagatgtc tgcagccctc agcagctgca
     2881 gaccgcccct caccaaccca gagaacctgc tttactttgc ccagggactt cctccccatg
     2941 tgaacatggg gaacttcggg ccctgcctgg agtccttgac cgctctctgt gggccccacc
     3001 cactctgtcc tgggaaatga agaagcatct tccttaggtc tgccctgctt gcaaatccac
     3061 tagcaccgac cccaccacct ggttccggct ctgcacgctt tggggtgtgg atgtcgagag
     3121 gcaccacggc ctcacccagg catctgcttt actctggacc ataggaaaca agaccgtttg
     3181 gaggtttcat caggattttg ggtttttcac atttcacgct aaggagtagt ggccctgact
     3241 tccggtcggc tggccagctg actccctagg gccttcagac gtgtatgcaa atgagtgatg
     3301 gataaggatg agtcttggag ttgcgggcag cctggagact cgtggactta ccgcctggag
     3361 gcaggcccgg gaaggctgct gtttactcat cgggcagcca cgtgctctct ggaggaagtg
     3421 atagtttctg aaaccgctca gatgttttgg ggaaagttgg agaagccgtg gccttgcgag
     3481 aggtggttac accagaacct ggacattggc cagaagaagc ttaagtgggc agacactgtt
     3541 tgcccagtgt ttgtgcaagg atggagtggg tgtctctgca tcacccacag ccgcagctgt
     3601 aaggcacgct ggaaggcaca cgcctgccag gcagggcagt ctggcgccca tgatgggagg
     3661 gattgacatg tttcaacaaa ataatgcact tccttaccta gtggcccttc acacaacttt
     3721 tgaatctcta aaaatccata aaatccttaa agaactgtaa
//
