LOCUS       NM_003823               1140 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 6b (TNFRSF6B), mRNA.
ACCESSION   NM_003823
VERSION     NM_003823.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Guan,J., Huang,X., Zhou,Z., Li,S., Wang,F., Han,Y. and Yin,N.
  TITLE     HIF-1alpha regulates DcR3 to promote the development of
            endometriosis
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 296, 185-193 (2024)
   PUBMED   38458034
  REMARK    GeneRIF: HIF-1alpha regulates DcR3 to promote the development of
            endometriosis.
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Yang,L.Y., Lou,X.L., Wang,Y. and Hou,Y.Q.
  TITLE     [miR-148b inhibits M2 polarization of LPS-stimulated macrophages by
            targeting DcR3]
  JOURNAL   Zhonghua Yu Fang Yi Xue Za Zhi 57 (8), 1231-1237 (2023)
   PUBMED   37574317
  REMARK    GeneRIF: [miR-148b inhibits M2 polarization of LPS-stimulated
            macrophages by targeting DcR3].
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Wu,N.L., Huang,D.Y., Hsieh,S.L., Dai,Y.S. and Lin,W.W.
  TITLE     Decoy receptor 3 is involved in epidermal keratinocyte commitment
            to terminal differentiation via EGFR and PKC activation
  JOURNAL   Exp Mol Med 54 (4), 542-551 (2022)
   PUBMED   35478210
  REMARK    GeneRIF: Decoy receptor 3 is involved in epidermal keratinocyte
            commitment to terminal differentiation via EGFR and PKC activation.
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Lin,S., Wu,B., Lin,Y., Wang,M., Zhu,Y., Jiang,J., Zhang,L. and
            Lin,J.
  TITLE     Expression and Clinical Significance of Decoy Receptor 3 in
            Acute-on-Chronic Liver Failure
  JOURNAL   Biomed Res Int 2019, 9145736 (2019)
   PUBMED   31317042
  REMARK    GeneRIF: DcR3 was highly expressed in patients with
            acute-on-chronic liver failure and correlated with several clinical
            indices. Dynamic change of DcR3 might predict the prognosis of
            acute-on-chronic liver failure .
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Soliman,M.H. and Ebaid,A.M.
  TITLE     Association of Tumor Necrosis Like factor 1 A (TL1A) and its Decoy
            Receptor (DcR3) with The Disease Activity and Autoantibody
            Production in Rheumatoid Arthritis Patients
  JOURNAL   Egypt J Immunol 26 (1), 43-54 (2019)
   PUBMED   31332995
  REMARK    GeneRIF: significantly higher levels of TL1A and its decoy receptor
            DcR3 in RA patients than in controls; TL1A is significantly related
            to the disease activity and enhances IL-17 production
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Hsu,T.L., Chang,Y.C., Chen,S.J., Liu,Y.J., Chiu,A.W., Chio,C.C.,
            Chen,L. and Hsieh,S.L.
  TITLE     Modulation of dendritic cell differentiation and maturation by
            decoy receptor 3
  JOURNAL   J Immunol 168 (10), 4846-4853 (2002)
   PUBMED   11994433
  REMARK    GeneRIF: As a soluble receptor.Fc fusion protein, DcR3 modulates
            dendritic cell differentiation and maturation from CD14+ monocytes
            by up-regulation of CD86/B7.2 and down-regulation of CD40,
            CD54/ICAM-1, CD80/B7.1, CD1a, and HLA-DR.
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Migone,T.S., Zhang,J., Luo,X., Zhuang,L., Chen,C., Hu,B.,
            Hong,J.S., Perry,J.W., Chen,S.F., Zhou,J.X., Cho,Y.H., Ullrich,S.,
            Kanakaraj,P., Carrell,J., Boyd,E., Olsen,H.S., Hu,G., Pukac,L.,
            Liu,D., Ni,J., Kim,S., Gentz,R., Feng,P., Moore,P.A., Ruben,S.M.
            and Wei,P.
  TITLE     TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T
            cell costimulator
  JOURNAL   Immunity 16 (3), 479-492 (2002)
   PUBMED   11911831
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Bai,C., Connolly,B., Metzker,M.L., Hilliard,C.A., Liu,X.,
            Sandig,V., Soderman,A., Galloway,S.M., Liu,Q., Austin,C.P. and
            Caskey,C.T.
  TITLE     Overexpression of M68/DcR3 in human gastrointestinal tract tumors
            independent of gene amplification and its location in a four-gene
            cluster
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1230-1235 (2000)
   PUBMED   10655513
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Yu,K.Y., Kwon,B., Ni,J., Zhai,Y., Ebner,R. and Kwon,B.S.
  TITLE     A newly identified member of tumor necrosis factor receptor
            superfamily (TR6) suppresses LIGHT-mediated apoptosis
  JOURNAL   J Biol Chem 274 (20), 13733-13736 (1999)
   PUBMED   10318773
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Pitti,R.M., Marsters,S.A., Lawrence,D.A., Roy,M., Kischkel,F.C.,
            Dowd,P., Huang,A., Donahue,C.J., Sherwood,S.W., Baldwin,D.T.,
            Godowski,P.J., Wood,W.I., Gurney,A.L., Hillan,K.J., Cohen,R.L.,
            Goddard,A.D., Botstein,D. and Ashkenazi,A.
  TITLE     Genomic amplification of a decoy receptor for Fas ligand in lung
            and colon cancer
  JOURNAL   Nature 396 (6712), 699-703 (1998)
   PUBMED   9872321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM759033.1, BC034349.1 and
            AW204999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003823.3.
            
            Summary: This gene belongs to the tumor necrosis factor receptor
            superfamily. The encoded protein is postulated to play a regulatory
            role in suppressing FasL- and LIGHT-mediated cell death. It acts as
            a decoy receptor that competes with death receptors for ligand
            binding. Over-expression of this gene has been noted in
            gastrointestinal tract tumors. Read-through transcription into this
            gene from the neighboring upstream gene, which encodes regulator of
            telomere elongation helicase 1 (RTEL1), generates a non-coding
            transcript. [provided by RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.398972.1, AF104419.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369996.3/ ENSP00000359013.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BM759033.1         4-54
            52-1111             BC034349.1         44-1103
            1112-1140           AW204999.1         14-42               c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1140
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /note="TNF receptor superfamily member 6b"
                     /db_xref="GeneID:8771"
                     /db_xref="HGNC:HGNC:11921"
                     /db_xref="MIM:603361"
     exon            1..540
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1019
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /EC_number="3.6.4.12"
                     /note="decoy receptor for Fas ligand; tumor necrosis
                     factor receptor superfamily, member 6b, decoy; tumor
                     necrosis factor receptor superfamily member 6b"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 6B precursor"
                     /protein_id="NP_003814.1"
                     /db_xref="CCDS:CCDS13532.1"
                     /db_xref="GeneID:8771"
                     /db_xref="HGNC:HGNC:11921"
                     /db_xref="MIM:603361"
                     /translation="MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETG
                     ERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEA
                     RACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSA
                     SSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDF
                     VAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRL
                     LQALRVARMPGLERSVRERFLPVH"
     exon            541..735
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1140
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /note="hexamer: AAGAAA"
     polyA_site      1111
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /note="major polyA site"
     regulatory      1121..1126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /note="hexamer: TATAAA"
     polyA_site      1140
                     /gene="TNFRSF6B"
                     /gene_synonym="DCR3; DJ583P15.1.1; M68; M68E; TR6"
                     /note="major polyA site"
ORIGIN      
        1 ggacttgggc ggcccctccg caggcggacc gggggcaaag gaggtggcat gtcggtcagg
       61 cacagcaggg tcctgtgtcc gcgctgagcc gcgctctccc tgctccagca aggaccatga
      121 gggcgctgga ggggccaggc ctgtcgctgc tgtgcctggt gttggcgctg cctgccctgc
      181 tgccggtgcc ggctgtacgc ggagtggcag aaacacccac ctacccctgg cgggacgcag
      241 agacagggga gcggctggtg tgcgcccagt gccccccagg cacctttgtg cagcggccgt
      301 gccgccgaga cagccccacg acgtgtggcc cgtgtccacc gcgccactac acgcagttct
      361 ggaactacct agagcgctgc cgctactgca acgtcctctg cggggagcgt gaggaggagg
      421 cacgggcttg ccacgccacc cacaaccgtg cctgccgctg ccgcaccggc ttcttcgcgc
      481 acgctggttt ctgcttggag cacgcatcgt gtccacctgg tgccggcgtg attgccccgg
      541 gcacccccag ccagaacacg cagtgccagc cgtgcccccc aggcaccttc tcagccagca
      601 gctccagctc agagcagtgc cagccccacc gcaactgcac ggccctgggc ctggccctca
      661 atgtgccagg ctcttcctcc catgacaccc tgtgcaccag ctgcactggc ttccccctca
      721 gcaccagggt accaggagct gaggagtgtg agcgtgccgt catcgacttt gtggctttcc
      781 aggacatctc catcaagagg ctgcagcggc tgctgcaggc cctcgaggcc ccggagggct
      841 ggggtccgac accaagggcg ggccgcgcgg ccttgcagct gaagctgcgt cggcggctca
      901 cggagctcct gggggcgcag gacggggcgc tgctggtgcg gctgctgcag gcgctgcgcg
      961 tggccaggat gcccgggctg gagcggagcg tccgtgagcg cttcctccct gtgcactgat
     1021 cctggccccc tcttatttat tctacatcct tggcacccca cttgcactga aagaggcttt
     1081 tttttaaata gaagaaatga ggtttcttaa agcttatttt tataaagctt tttcataaaa
//
