LOCUS       NM_003327               1075 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 4 (TNFRSF4),
            transcript variant 1, mRNA.
ACCESSION   NM_003327
VERSION     NM_003327.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Sadrolashrafi,K., Guo,L., Kikuchi,R., Hao,A., Yamamoto,R.K.,
            Tolson,H.C., Bilimoria,S.N., Yee,D.K. and Armstrong,A.W.
  TITLE     An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic
            Dermatitis
  JOURNAL   Cells 13 (7), 587 (2024)
   PUBMED   38607026
  REMARK    GeneRIF: An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in
            Atopic Dermatitis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Kim,M., Renert-Yuval,Y., Stepensky,P., Even-Or,E., Zaidman,I.,
            Fachler,T., Neumark,M., Zamir,M., NandyMazumdar,M., Gour,D.,
            Facheris,P., Carroll,B., Liu,Y., Yu Ekey,M.L., Andrews,E.,
            Meariman,M., Angelov,M., Bose,S., Estrada,Y.D., Molho-Pessach,V.
            and Guttman-Yassky,E.
  TITLE     Sclerotic-Type Cutaneous Chronic Graft-Versus-Host Disease Exhibits
            Activation of T Helper 1 and OX40 Cytokines
  JOURNAL   J Invest Dermatol 144 (3), 563-572 (2024)
   PUBMED   37742913
  REMARK    GeneRIF: Sclerotic-Type Cutaneous Chronic Graft-Versus-Host Disease
            Exhibits Activation of T Helper 1 and OX40 Cytokines.
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Qian,C., Pan,C., Liu,J., Wu,L., Pan,J., Liu,C. and Zhang,H.
  TITLE     Differential expression of immune checkpoints (OX40/OX40L and
            PD-1/PD-L1) in decidua of unexplained recurrent spontaneous
            abortion women
  JOURNAL   Hum Immunol 85 (1), 110745 (2024)
   PUBMED   38142184
  REMARK    GeneRIF: Differential expression of immune checkpoints (OX40/OX40L
            and PD-1/PD-L1) in decidua of unexplained recurrent spontaneous
            abortion women.
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Yu,J., Cui,J., Zhang,X., Xu,H., Chen,Z., Li,Y., Niu,Y., Wang,S.,
            Ran,S., Zou,Y., Ye,W., Zhang,D., Zhou,C., Xia,J. and Wu,J.
  TITLE     The OX40-TRAF6 axis promotes CTLA-4 degradation to augment
            antitumor CD8+ T-cell immunity
  JOURNAL   Cell Mol Immunol 20 (12), 1445-1456 (2023)
   PUBMED   37932534
  REMARK    GeneRIF: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment
            antitumor CD8[+] T-cell immunity.
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Wang,D., Hu,H., Ding,H., Zhao,H., Tian,F. and Chi,Q.
  TITLE     Elevated expression of TNFRSF4 impacts immune cell infiltration and
            gene mutation in hepatocellular carcinoma
  JOURNAL   Cancer Biomark 36 (2), 147-159 (2023)
   PUBMED   36591653
  REMARK    GeneRIF: Elevated expression of TNFRSF4 impacts immune cell
            infiltration and gene mutation in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Kopf,M., Ruedl,C., Schmitz,N., Gallimore,A., Lefrang,K.,
            Ecabert,B., Odermatt,B. and Bachmann,M.F.
  TITLE     OX40-deficient mice are defective in Th cell proliferation but are
            competent in generating B cell and CTL Responses after virus
            infection
  JOURNAL   Immunity 11 (6), 699-708 (1999)
   PUBMED   10626892
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Kawamata,S., Hori,T., Imura,A., Takaori-Kondo,A. and Uchiyama,T.
  TITLE     Activation of OX40 signal transduction pathways leads to tumor
            necrosis factor receptor-associated factor (TRAF) 2- and
            TRAF5-mediated NF-kappaB activation
  JOURNAL   J Biol Chem 273 (10), 5808-5814 (1998)
   PUBMED   9488716
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Arch,R.H. and Thompson,C.B.
  TITLE     4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve
            growth factor receptor subfamily that bind TNF receptor-associated
            factors and activate nuclear factor kappaB
  JOURNAL   Mol Cell Biol 18 (1), 558-565 (1998)
   PUBMED   9418902
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Latza,U., Durkop,H., Schnittger,S., Ringeling,J., Eitelbach,F.,
            Hummel,M., Fonatsch,C. and Stein,H.
  TITLE     The human OX40 homolog: cDNA structure, expression and chromosomal
            assignment of the ACT35 antigen
  JOURNAL   Eur J Immunol 24 (3), 677-683 (1994)
   PUBMED   7510240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC105070.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003327.3.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor has been shown to activate
            NF-kappaB through its interaction with adaptor proteins TRAF2 and
            TRAF5. Knockout studies in mice suggested that this receptor
            promotes the expression of apoptosis inhibitors BCL2 and
            BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout
            studies also suggested the roles of this receptor in CD4+ T cell
            response, as well as in T cell-dependent B cell proliferation and
            differentiation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105070.1, SRR1163657.366819.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379236.4/ ENSP00000368538.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1075              BC105070.1         16-1090
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..1075
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /note="TNF receptor superfamily member 4"
                     /db_xref="GeneID:7293"
                     /db_xref="HGNC:HGNC:11918"
                     /db_xref="MIM:600315"
     exon            1..171
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..860
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD134 antigen; ATC35 antigen; OX40 antigen;
                     OX40 homologue; lymphoid activation antigene ACT35; OX40
                     cell surface antigen; tax-transcriptionally activated
                     glycoprotein 1 receptor; ACT35 antigen; OX40L receptor;
                     TAX transcriptionally-activated glycoprotein 1 receptor;
                     tumor necrosis factor receptor superfamily member 4"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 4 isoform 1 precursor"
                     /protein_id="NP_003318.1"
                     /db_xref="CCDS:CCDS11.1"
                     /db_xref="GeneID:7293"
                     /db_xref="HGNC:HGNC:11918"
                     /db_xref="MIM:600315"
                     /translation="MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCH
                     ECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTAT
                     QDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASN
                     SSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAI
                     LGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAK
                     I"
     exon            172..294
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            295..396
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            397..463
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            464..660
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            661..789
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1075
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /note="hexamer: AATAAA"
     polyA_site      1075
                     /gene="TNFRSF4"
                     /gene_synonym="ACT35; CD134; IMD16; OX40; TXGP1L"
                     /note="major polyA site"
ORIGIN      
        1 agactctggc gacagcagag acgaggatgt gcgtgggggc tcggcggctg ggccgcgggc
       61 cgtgtgcggc tctgctcctc ctgggcctgg ggctgagcac cgtgacgggg ctccactgtg
      121 tcggggacac ctaccccagc aacgaccggt gctgccacga gtgcaggcca ggcaacggga
      181 tggtgagccg ctgcagccgc tcccagaaca cggtgtgccg tccgtgcggg ccgggcttct
      241 acaacgacgt ggtcagctcc aagccgtgca agccctgcac gtggtgtaac ctcagaagtg
      301 ggagtgagcg gaagcagctg tgcacggcca cacaggacac agtctgccgc tgccgggcgg
      361 gcacccagcc cctggacagc tacaagcctg gagttgactg tgccccctgc cctccagggc
      421 acttctcccc aggcgacaac caggcctgca agccctggac caactgcacc ttggctggga
      481 agcacaccct gcagccggcc agcaatagct cggacgcaat ctgtgaggac agggaccccc
      541 cagccacgca gccccaggag acccagggcc ccccggccag gcccatcact gtccagccca
      601 ctgaagcctg gcccagaacc tcacagggac cctccacccg gcccgtggag gtccccgggg
      661 gccgtgcggt tgccgccatc ctgggcctgg gcctggtgct ggggctgctg ggccccctgg
      721 ccatcctgct ggccctgtac ctgctccgga gggaccagag gctgcccccc gatgcccaca
      781 agccccctgg gggaggcagt ttccggaccc ccatccaaga ggagcaggcc gacgcccact
      841 ccaccctggc caagatctga cctgggccca ccaaggtgga cgctgggccc cgccaggctg
      901 gagcccggag ggtctgctgg gcgagcaggg caggtgcagg ccgcctgccc cgccacgctc
      961 ctgggccaac tctgcaccgt tctaggtgcc gatggctgcc tccggctctc tgcttacgta
     1021 tgccatgcat acctcctgcc ccgcgggacc acaataaaaa ccttggcaga cggga
//
