LOCUS       NM_003790               1968 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 25 (TNFRSF25),
            transcript variant 2, mRNA.
ACCESSION   NM_003790
VERSION     NM_003790.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Al-Lamki,R.S., Wang,J., Pober,J.S. and Bradley,J.R.
  TITLE     Co-Expression and Functional Interactions of Death Receptor 3 and
            E-Selectin in Clear Cell Renal Cell Carcinoma
  JOURNAL   Am J Pathol 192 (4), 722-736 (2022)
   PUBMED   35063404
  REMARK    GeneRIF: Co-Expression and Functional Interactions of Death
            Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma.
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Charkiewicz,K., Goscik,J., Raba,G. and Laudanski,P.
  TITLE     Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel
            proteins in pathophysiology of preeclampsia
  JOURNAL   J Matern Fetal Neonatal Med 34 (18), 2965-2970 (2021)
   PUBMED   31608721
  REMARK    GeneRIF: Syndecan 4, galectin 2, and death receptor 3 (DR3) as
            novel proteins in pathophysiology of preeclampsia.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Oriol-Tordera,B., Olvera,A., Duran-Castells,C., Llano,A., Mothe,B.,
            Massanella,M., Dalmau,J., Ganoza,C., Sanchez,J., Calle,M.L.,
            Clotet,B., Martinez-Picado,J., Negredo,E., Blanco,J.,
            Hartigan-O'Connor,D., Brander,C. and Ruiz-Riol,M.
  TITLE     TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and
            DR3 Costimulation Boosts HIV-1-Specific T Cell Responses
  JOURNAL   J Immunol 205 (12), 3348-3357 (2020)
   PUBMED   33177161
  REMARK    GeneRIF: TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease
            Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell
            Responses.
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Rodriguez-Barbosa,J.I., Schneider,P., Graca,L., Buhler,L.,
            Perez-Simon,J.A. and Del Rio,M.L.
  TITLE     The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T
            Cell Depleting Transplantation Regimens
  JOURNAL   Int J Mol Sci 21 (9), 3347 (2020)
   PUBMED   32397343
  REMARK    GeneRIF: The Role of TNFR2 and DR3 in the In Vivo Expansion of
            Tregs in T Cell Depleting Transplantation Regimens.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Sattler,A., Thiel,L.G., Ruhm,A.H., Souidi,N., Seifert,M.,
            Herberth,G. and Kotsch,K.
  TITLE     The TL1A-DR3 Axis Selectively Drives Effector Functions in Human
            MAIT Cells
  JOURNAL   J Immunol 203 (11), 2970-2978 (2019)
   PUBMED   31628153
  REMARK    GeneRIF: The identifies a new inflammatory mechanism in
            Mucosal-associated invariant T cells linking the DR3/TL1A axis with
            amplification of TCR-dependent and -independent effector functions,
            particularly inducing excessive innate TNF-alpha production.
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Screaton,G.R., Xu,X.N., Olsen,A.L., Cowper,A.E., Tan,R.,
            McMichael,A.J. and Bell,J.I.
  TITLE     LARD: a new lymphoid-specific death domain containing receptor
            regulated by alternative pre-mRNA splicing
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4615-4619 (1997)
   PUBMED   9114039
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Bodmer,J.L., Burns,K., Schneider,P., Hofmann,K., Steiner,V.,
            Thome,M., Bornand,T., Hahne,M., Schroter,M., Becker,K., Wilson,A.,
            French,L.E., Browning,J.L., MacDonald,H.R. and Tschopp,J.
  TITLE     TRAMP, a novel apoptosis-mediating receptor with sequence homology
            to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)
  JOURNAL   Immunity 6 (1), 79-88 (1997)
   PUBMED   9052839
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Marsters,S.A., Sheridan,J.P., Donahue,C.J., Pitti,R.M., Gray,C.L.,
            Goddard,A.D., Bauer,K.D. and Ashkenazi,A.
  TITLE     Apo-3, a new member of the tumor necrosis factor receptor family,
            contains a death domain and activates apoptosis and NF-kappa B
  JOURNAL   Curr Biol 6 (12), 1669-1676 (1996)
   PUBMED   8994832
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Kitson,J., Raven,T., Jiang,Y.P., Goeddel,D.V., Giles,K.M.,
            Pun,K.T., Grinham,C.J., Brown,R. and Farrow,S.N.
  TITLE     A death-domain-containing receptor that mediates apoptosis
  JOURNAL   Nature 384 (6607), 372-375 (1996)
   PUBMED   8934525
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Chinnaiyan,A.M., O'Rourke,K., Yu,G.L., Lyons,R.H., Garg,M.,
            Duan,D.R., Xing,L., Gentz,R., Ni,J. and Dixit,V.M.
  TITLE     Signal transduction by DR3, a death domain-containing receptor
            related to TNFR-1 and CD95
  JOURNAL   Science 274 (5289), 990-992 (1996)
   PUBMED   8875942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U74611.1, BM666370.1 and
            AL158217.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_003790.2.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is expressed preferentially
            in the tissues enriched in lymphocytes, and it may play a role in
            regulating lymphocyte homeostasis. This receptor has been shown to
            stimulate NF-kappa B activity and regulate cell apoptosis. The
            signal transduction of this receptor is mediated by various death
            domain containing adaptor proteins. Knockout studies in mice
            suggested the role of this gene in the removal of self-reactive T
            cells in the thymus. Multiple alternatively spliced transcript
            variants of this gene encoding distinct isoforms have been
            reported, most of which are potentially secreted molecules. The
            alternative splicing of this gene in B and T cells encounters a
            programmed change upon T-cell activation, which predominantly
            produces full-length, membrane bound isoforms, and is thought to be
            involved in controlling lymphocyte proliferation induced by T-cell
            activation. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks two coding segments,
            both of which result in a frameshift, when compared to variant 1.
            The resulting isoform (2) has a shorter and distinct internal
            region, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U74611.1, BC117189.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356876.8/ ENSP00000349341.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1592              U74611.1           23-1614
            1593-1603           BM666370.1         14-24               c
            1604-1968           AL158217.25        9959-10323          c
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..1968
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /note="TNF receptor superfamily member 25"
                     /db_xref="GeneID:8718"
                     /db_xref="HGNC:HGNC:11910"
                     /db_xref="MIM:603366"
     exon            1..105
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1320
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; tumor necrosis factor receptor superfamily,
                     member 12 (translocating chain-association membrane
                     protein); tumor necrosis factor receptor superfamily
                     member 25; death domain receptor 3 soluble form; death
                     receptor beta; apoptosis inducing receptor; protein WSL-1;
                     apoptosis-inducing receptor AIR; apoptosis-mediating
                     receptor DR3; apoptosis-mediating receptor TRAMP;
                     lymphocyte-associated receptor of death; Pleckstrin
                     homology domain-containing family G member 5; PH
                     domain-containing family G member 5; Guanine nucleotide
                     exchange factor 720"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 25 isoform 2 precursor"
                     /protein_id="NP_003781.1"
                     /db_xref="CCDS:CCDS71.1"
                     /db_xref="GeneID:8718"
                     /db_xref="HGNC:HGNC:11910"
                     /db_xref="MIM:603366"
                     /translation="MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIG
                     LFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQV
                     ALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDT
                     DCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGA
                     TLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQL
                     VGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQ
                     LYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGA
                     VYAALERMGLDGCVEDLRSRLQRGP"
     exon            106..226
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            227..361
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            362..529
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            530..608
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            609..664
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            665..772
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            773..810
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            811..991
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1968
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /note="hexamer: AACAAA"
     polyA_site      1603
                     /gene="TNFRSF25"
                     /gene_synonym="APO-3; DDR3; DR3; GEF720; LARD; PLEKHG5;
                     TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcggaa ccacgacggg cagagagcac ggagccggga agcccctggg cgcccgtcgg
       61 agggctatgg agcagcggcc gcggggctgc gcggcggtgg cggcggcgct cctcctggtg
      121 ctgctggggg cccgggccca gggcggcact cgtagcccca ggtgtgactg tgccggtgac
      181 ttccacaaga agattggtct gttttgttgc agaggctgcc cagcggggca ctacctgaag
      241 gccccttgca cggagccctg cggcaactcc acctgccttg tgtgtcccca agacaccttc
      301 ttggcctggg agaaccacca taattctgaa tgtgcccgct gccaggcctg tgatgagcag
      361 gcctcccagg tggcgctgga gaactgttca gcagtggccg acacccgctg tggctgtaag
      421 ccaggctggt ttgtggagtg ccaggtcagc caatgtgtca gcagttcacc cttctactgc
      481 caaccatgcc tagactgcgg ggccctgcac cgccacacac ggctactctg ttcccgcaga
      541 gatactgact gtgggacctg cctgcctggc ttctatgaac atggcgatgg ctgcgtgtcc
      601 tgccccacga gcaccctggg gagctgtcca gagcgctgtg ccgctgtctg tggctggagg
      661 cagatgttct gggtccaggt gctcctggct ggccttgtgg tccccctcct gcttggggcc
      721 accctgacct acacataccg ccactgctgg cctcacaagc ccctggttac tgcagatgaa
      781 gctgggatgg aggctctgac cccaccaccg gccacccatc tgtcaccctt ggacagcgcc
      841 cacacccttc tagcacctcc tgacagcagt gagaagatct gcaccgtcca gttggtgggt
      901 aacagctgga cccctggcta ccccgagacc caggaggcgc tctgcccgca ggtgacatgg
      961 tcctgggacc agttgcccag cagagctctt ggccccgctg ctgcgcccac actctcgcca
     1021 gagtccccag ccggctcgcc agccatgatg ctgcagccgg gcccgcagct ctacgacgtg
     1081 atggacgcgg tcccagcgcg gcgctggaag gagttcgtgc gcacgctggg gctgcgcgag
     1141 gcagagatcg aagccgtgga ggtggagatc ggccgcttcc gagaccagca gtacgagatg
     1201 ctcaagcgct ggcgccagca gcagcccgcg ggcctcggag ccgtttacgc ggccctggag
     1261 cgcatggggc tggacggctg cgtggaagac ttgcgcagcc gcctgcagcg cggcccgtga
     1321 cacggcgccc acttgccacc taggcgctct ggtggccctt gcagaagccc taagtacggt
     1381 tacttatgcg tgtagacatt ttatgtcact tattaagccg ctggcacggc cctgcgtagc
     1441 agcaccagcc ggccccaccc ctgctcgccc ctatcgctcc agccaaggcg aagaagcacg
     1501 aacgaatgtc gagagggggt gaagacattt ctcaacttct cggccggagt ttggctgaga
     1561 tcgcggtatt aaatctgtga aagaaaacaa aacaaaacaa aaacggcttc ttggcgtttc
     1621 tgcggggctg gggtgttaag tggactggac ttttctcgag ggattcgaag gggacgggaa
     1681 tcttgtcacc ccgggatctg gcacccatgg tggagtccag tgtggcctta gctcccaagc
     1741 ctgcccctcc cgagtccact ctggctcaat taccccgaga aggagagagc aagtcgcggc
     1801 cacagcgagt gagtgaaccg gagcccagat gagagcgctt taatggggct gcgaggtggc
     1861 ggagacaggg tcgggatggg gtgcagcagt tggagacaca gggtcagggc ccctcatcct
     1921 ctattcactc caccggggca gtgaaagggt cccggcagcg agtgggtc
//
