LOCUS       NM_014452               3595 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 21 (TNFRSF21), mRNA.
ACCESSION   NM_014452 NM_016629
VERSION     NM_014452.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Clay,S., Alladina,J., Smith,N.P., Visness,C.M., Wood,R.A.,
            O'Connor,G.T., Cohen,R.T., Khurana Hershey,G.K., Kercsmar,C.M.,
            Gruchalla,R.S., Gill,M.A., Liu,A.H., Kim,H., Kattan,M.,
            Bacharier,L.B., Rastogi,D., Rivera-Spoljaric,K., Robison,R.G.,
            Gergen,P.J., Busse,W.W., Villani,A.C., Cho,J.L., Medoff,B.D.,
            Gern,J.E., Jackson,D.J., Ober,C. and Dapas,M.
  TITLE     Gene-based association study of rare variants in children of
            diverse ancestries implicates TNFRSF21 in the development of
            allergic asthma
  JOURNAL   J Allergy Clin Immunol 153 (3), 809-820 (2024)
   PUBMED   37944567
  REMARK    GeneRIF: Gene-based association study of rare variants in children
            of diverse ancestries implicates TNFRSF21 in the development of
            allergic asthma.
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Cheng,J., Tang,Y., Cai,X. and Gong,J.
  TITLE     Long Noncoding RNAs Testis Development Related Gene 1 Aggravates
            Transforming Growth Factor-beta1-Induced Fibrogenesis and
            Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor
            Necrosis Factor Receptor Superfamily-21 Axis
  JOURNAL   J Cardiovasc Pharmacol 79 (3), 296-303 (2022)
   PUBMED   34775426
  REMARK    GeneRIF: Long Noncoding RNAs Testis Development Related Gene 1
            Aggravates Transforming Growth Factor-beta1-Induced Fibrogenesis
            and Inflammatory Response of Cardiac Fibroblasts Via
            miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis.
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Stegmann,S.K., Kuhl,S., Im,N.G., Diem-Dinh,D.T., Goertz,L.,
            Goldbrunner,R. and Timmer,M.
  TITLE     Death Receptor 6 as a Prognostic Marker in Low-grade Glioma
  JOURNAL   Anticancer Res 42 (3), 1237-1245 (2022)
   PUBMED   35220214
  REMARK    GeneRIF: Death Receptor 6 as a Prognostic Marker in Low-grade
            Glioma.
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Liu,Y., Chang,Y. and Cai,Y.
  TITLE     circTNFRSF21, a newly identified circular RNA promotes endometrial
            carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis
  JOURNAL   Aging (Albany NY) 12 (8), 6774-6792 (2020)
   PUBMED   32299063
  REMARK    GeneRIF: circTNFRSF21, a newly identified circular RNA promotes
            endometrial carcinoma pathogenesis through regulating
            miR-1227-MAPK13/ATF2 axis.
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3595)
  AUTHORS   Cho,S.M., Kim,J., Ryu,H.J., Kim,J.J., Kim,H.H., Park,J.H.,
            Kim,H.T., Kim,K.H., Cho,H.Y., Oh,B., Park,C., Kimm,K., Jo,I.,
            Lee,J.E., Shin,H.D. and Lee,J.K.
  TITLE     Identification of single nucleotide polymorphisms in the tumor
            necrosis factor (TNF) and TNF receptor superfamily in the Korean
            population
  JOURNAL   Hum Immunol 65 (7), 710-718 (2004)
   PUBMED   15301860
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3595)
  AUTHORS   Kasof,G.M., Lu,J.J., Liu,D., Speer,B., Mongan,K.N., Gomes,B.C. and
            Lorenzi,M.V.
  TITLE     Tumor necrosis factor-alpha induces the expression of DR6, a member
            of the TNF receptor family, through activation of NF-kappaB
  JOURNAL   Oncogene 20 (55), 7965-7975 (2001)
   PUBMED   11753679
REFERENCE   8  (bases 1 to 3595)
  AUTHORS   Zhao,H., Yan,M., Wang,H., Erickson,S., Grewal,I.S. and Dixit,V.M.
  TITLE     Impaired c-Jun amino terminal kinase activity and T cell
            differentiation in death receptor 6-deficient mice
  JOURNAL   J Exp Med 194 (10), 1441-1448 (2001)
   PUBMED   11714751
  REMARK    GeneRIF: DR6 knockout mice are viable and fertile, and show
            hyperproliferation of T cells when stimulated.
REFERENCE   9  (bases 1 to 3595)
  AUTHORS   Liu,J., Na,S., Glasebrook,A., Fox,N., Solenberg,P.J., Zhang,Q.,
            Song,H.Y. and Yang,D.D.
  TITLE     Enhanced CD4+ T cell proliferation and Th2 cytokine production in
            DR6-deficient mice
  JOURNAL   Immunity 15 (1), 23-34 (2001)
   PUBMED   11485735
  REMARK    GeneRIF: DR6 mediates T cell proliferation and differentiation in
            mice.
REFERENCE   10 (bases 1 to 3595)
  AUTHORS   Pan,G., Bauer,J.H., Haridas,V., Wang,S., Liu,D., Yu,G., Vincenz,C.,
            Aggarwal,B.B., Ni,J. and Dixit,V.M.
  TITLE     Identification and functional characterization of DR6, a novel
            death domain-containing TNF receptor
  JOURNAL   FEBS Lett 431 (3), 351-356 (1998)
   PUBMED   9714541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY007775.1 and AY358304.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014452.4.
            
            Summary: This gene encodes a member of the tumor necrosis factor
            receptor superfamily. The encoded protein activates nuclear factor
            kappa-B and mitogen-activated protein kinase 8 (also called c-Jun
            N-terminal kinase 1), and induces cell apoptosis. Through its death
            domain, the encoded receptor interacts with tumor necrosis factor
            receptor type 1-associated death domain (TRADD) protein, which is
            known to mediate signal transduction of tumor necrosis factor
            receptors. Knockout studies in mice suggest that this gene plays a
            role in T-helper cell activation, and may be involved in
            inflammation and immune regulation. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.910204.1,
                                           SRR1803617.15433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296861.2/ ENSP00000296861.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               HY007775.1         44-233
            191-3595            AY358304.1         121-3525
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..3595
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /note="TNF receptor superfamily member 21"
                     /db_xref="GeneID:27242"
                     /db_xref="HGNC:HGNC:13469"
                     /db_xref="MIM:605732"
     exon            1..490
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..2362
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /note="death receptor 6; TNFR-related death receptor 6;
                     tumor necrosis factor receptor superfamily member 21"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 21 precursor"
                     /protein_id="NP_055267.1"
                     /db_xref="CCDS:CCDS4921.1"
                     /db_xref="GeneID:27242"
                     /db_xref="HGNC:HGNC:13469"
                     /db_xref="MIM:605732"
                     /translation="MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPE
                     QKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENG
                     IEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKG
                     TETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFS
                     SSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVP
                     DNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRG
                     HPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKA
                     GLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSN
                     GYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDK
                     LALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSG
                     SSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDK
                     LDRLFEIIGVKSQEASQTLLDSVYSHLPDLL"
     exon            491..1142
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1637
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1903
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2132
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..3595
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3574..3579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="TNFRSF21"
                     /gene_synonym="BM-018; CD358; DR6"
                     /note="major polyA site"
ORIGIN      
        1 agtccctcgc cgaccagtct gggcagcgga ggagggtggt tggcagtggc tggaagcttc
       61 gctatgggaa gtcgttcctt tgctctctcg cgcccagtcc tcctccctgg ttctcctcag
      121 ccgctgtcgg aggagagcac ccggagacgc gggctgcagt cgcggcggct tctccccgcc
      181 tgggcggccg cgccgctggg caggtgctga gcgcccctag agcctccctt gccgcctccc
      241 tcctctgccc ggccgcagca gtgcacatgg ggtgttggag gtagatgggc tcccggcccg
      301 ggaggcggcg gtggatgcgg cgctgggcag aagcagccgc cgattccagc tgccccgcgc
      361 gccccgggcg cccctgcgag tccccggttc agccatgggg acctctccga gcagcagcac
      421 cgccctcgcc tcctgcagcc gcatcgcccg ccgagccaca gccacgatga tcgcgggctc
      481 ccttctcctg cttggattcc ttagcaccac cacagctcag ccagaacaga aggcctcgaa
      541 tctcattggc acataccgcc atgttgaccg tgccaccggc caggtgctaa cctgtgacaa
      601 gtgtccagca ggaacctatg tctctgagca ttgtaccaac acaagcctgc gcgtctgcag
      661 cagttgccct gtggggacct ttaccaggca tgagaatggc atagagaaat gccatgactg
      721 tagtcagcca tgcccatggc caatgattga gaaattacct tgtgctgcct tgactgaccg
      781 agaatgcact tgcccacctg gcatgttcca gtctaacgct acctgtgccc cccatacggt
      841 gtgtcctgtg ggttggggtg tgcggaagaa agggacagag actgaggatg tgcggtgtaa
      901 gcagtgtgct cggggtacct tctcagatgt gccttctagt gtgatgaaat gcaaagcata
      961 cacagactgt ctgagtcaga acctggtggt gatcaagccg gggaccaagg agacagacaa
     1021 cgtctgtggc acactcccgt ccttctccag ctccacctca ccttcccctg gcacagccat
     1081 ctttccacgc cctgagcaca tggaaaccca tgaagtccct tcctccactt atgttcccaa
     1141 aggcatgaac tcaacagaat ccaactcttc tgcctctgtt agaccaaagg tactgagtag
     1201 catccaggaa gggacagtcc ctgacaacac aagctcagca agggggaagg aagacgtgaa
     1261 caagaccctc ccaaaccttc aggtagtcaa ccaccagcaa ggcccccacc acagacacat
     1321 cctgaagctg ctgccgtcca tggaggccac tgggggcgag aagtccagca cgcccatcaa
     1381 gggccccaag aggggacatc ctagacagaa cctacacaag cattttgaca tcaatgagca
     1441 tttgccctgg atgattgtgc ttttcctgct gctggtgctt gtggtgattg tggtgtgcag
     1501 tatccggaaa agctcgagga ctctgaaaaa ggggccccgg caggatccca gtgccattgt
     1561 ggaaaaggca gggctgaaga aatccatgac tccaacccag aaccgggaga aatggatcta
     1621 ctactgcaat ggccatggta tcgatatcct gaagcttgta gcagcccaag tgggaagcca
     1681 gtggaaagat atctatcagt ttctttgcaa tgccagtgag agggaggttg ctgctttctc
     1741 caatgggtac acagccgacc acgagcgggc ctacgcagct ctgcagcact ggaccatccg
     1801 gggccccgag gccagcctcg cccagctaat tagcgccctg cgccagcacc ggagaaacga
     1861 tgttgtggag aagattcgtg ggctgatgga agacaccacc cagctggaaa ctgacaaact
     1921 agctctcccg atgagcccca gcccgcttag cccgagcccc atccccagcc ccaacgcgaa
     1981 acttgagaat tccgctctcc tgacggtgga gccttcccca caggacaaga acaagggctt
     2041 cttcgtggat gagtcggagc cccttctccg ctgtgactct acatccagcg gctcctccgc
     2101 gctgagcagg aacggttcct ttattaccaa agaaaagaag gacacagtgt tgcggcaggt
     2161 acgcctggac ccctgtgact tgcagcctat ctttgatgac atgctccact ttctaaatcc
     2221 tgaggagctg cgggtgattg aagagattcc ccaggctgag gacaaactag accggctatt
     2281 cgaaattatt ggagtcaaga gccaggaagc cagccagacc ctcctggact ctgtttatag
     2341 ccatcttcct gacctgctgt agaacatagg gatactgcat tctggaaatt actcaattta
     2401 gtggcagggt ggttttttaa ttttcttctg tttctgattt ttgttgtttg gggtgtgtgt
     2461 gtgtgtttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttaacaga gaatatggcc
     2521 agtgcttgag ttctttctcc ttctctctct ctcttttttt tttaaataac tcttctggga
     2581 agttggttta taagcctttg ccaggtgtaa ctgttgtgaa atacccacca ctaaagtttt
     2641 ttaagttcca tattttctcc attttgcctt cttatgtatt ttcaagatta ttctgtgcac
     2701 tttaaattta cttaacttac cataaatgca gtgtgacttt tcccacacac tggattgtga
     2761 ggctcttaac ttcttaaaag tataatggca tcttgtgaat cctataagca gtctttatgt
     2821 ctcttaacat tcacacctac tttttaaaaa caaatattat tactattttt attattgttt
     2881 gtcctttata aattttctta aagattaaga aaatttaaga ccccattgag ttactgtaat
     2941 gcaattcaac tttgagttat cttttaaata tgtcttgtat agttcatatt catggctgaa
     3001 acttgaccac actattgctg attgtatggt tttcacctgg acaccgtgta gaatgcttga
     3061 ttacttgtac tcttcttatg ctaatatgct ctgggctgga gaaatgaaat cctcaagcca
     3121 tcaggatttg ctatttaagt ggcttgacaa ctgggccacc aaagaacttg aacttcacct
     3181 tttaggattt gagctgttct ggaacacatt gctgcacttt ggaaagtcaa aatcaagtgc
     3241 cagtggcgcc ctttccatag agaatttgcc cagctttgct ttaaaagatg tcttgttttt
     3301 tatatacaca taatcaatag gtccaatctg ctctcaaggc cttggtcctg gtgggattcc
     3361 ttcaccaatt actttaatta aaaatggctg caactgtaag aacccttgtc tgatatattt
     3421 gcaactatgc tcccatttac aaatgtacct tctaatgctc agttgccagg ttccaatgca
     3481 aaggtggcgt ggactccctt tgtgtgggtg gggtttgtgg gtagtggtga aggaccgata
     3541 tcagaaaaat gccttcaagt gtactaattt attaataaac attaggtgtt tgtta
//
