LOCUS       NM_001066               3687 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 1B (TNFRSF1B), mRNA.
ACCESSION   NM_001066
VERSION     NM_001066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3687)
  AUTHORS   Hu,Y., Lou,X., Zhang,K., Pan,L., Bai,Y., Wang,L., Wang,M., Yan,Y.,
            Wan,J., Yao,X., Duan,X., Ni,C. and Qin,Z.
  TITLE     Tumor necrosis factor receptor 2 promotes endothelial cell-mediated
            suppression of CD8+ T cells through tuning glycolysis in
            chemoresistance of breast cancer
  JOURNAL   J Transl Med 22 (1), 672 (2024)
   PUBMED   39033271
  REMARK    GeneRIF: Tumor necrosis factor receptor 2 promotes endothelial
            cell-mediated suppression of CD8+ T cells through tuning glycolysis
            in chemoresistance of breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3687)
  AUTHORS   Al-Lamki,R.S., Tolkovsky,A.M., Alawwami,M., Lu,W., Field,S.F.,
            Wang,J., Pober,J.S. and Bradley,J.R.
  TITLE     Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma
            Proliferation via Phosphorylated 4E Binding Protein-1 and
            Mitochondrial Gene Translation
  JOURNAL   Am J Pathol 194 (7), 1374-1387 (2024)
   PUBMED   38537932
  REMARK    GeneRIF: Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal
            Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and
            Mitochondrial Gene Translation.
REFERENCE   3  (bases 1 to 3687)
  AUTHORS   Montoya-Buelna,M., Alvarado-Navarro,A., Munoz-Valle,J.F.,
            Lopez-Roa,R.I., Guerrero-Velazquez,C. and Fafutis-Morris,M.
  TITLE     Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B
            genes with lepromatous leprosy in Western Mexican patients
  JOURNAL   J Infect Dev Ctries 18 (5), 770-778 (2024)
   PUBMED   38865403
  REMARK    GeneRIF: Association of polymorphisms in the TNFA, TNFRSF1A and
            TNFRSF1B genes with lepromatous leprosy in Western Mexican
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3687)
  AUTHORS   da Silva,P.B., Romao-Veiga,M., Ribeiro-Vasques,V.R., Peracoli,J.C.,
            Peracoli,M.T.S. and Amaral,L.M.
  TITLE     Progesterone modulates TNF receptors expression by Jurkat cells
            cultured with plasma from pregnant women with preeclampsia
  JOURNAL   Int Immunopharmacol 130, 111701 (2024)
   PUBMED   38382266
  REMARK    GeneRIF: Progesterone modulates TNF receptors expression by Jurkat
            cells cultured with plasma from pregnant women with preeclampsia.
REFERENCE   5  (bases 1 to 3687)
  AUTHORS   Carvalho,B.F., Gomez,G.V.B., Carron,J., Macedo,L.T.,
            Goncalves,G.M., Vazquez,V.L., Serrano,S.V., Lourenco,G.J. and
            Lima,C.S.P.
  TITLE     TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis
            of Patients with Cutaneous Melanoma
  JOURNAL   Int J Mol Sci 25 (5), 2868 (2024)
   PUBMED   38474115
  REMARK    GeneRIF: TNFRSF1B Gene Variants in Clinicopathological Aspects and
            Prognosis of Patients with Cutaneous Melanoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3687)
  AUTHORS   Pocsik,E., Higuchi,M. and Aggarwal,B.B.
  TITLE     Down-modulation of cell surface expression of p80 form of the tumor
            necrosis factor receptor by human immunodeficiency virus-1 tat gene
  JOURNAL   Lymphokine Cytokine Res 11 (6), 317-325 (1992)
   PUBMED   1335762
REFERENCE   7  (bases 1 to 3687)
  AUTHORS   Pennica,D., Lam,V.T., Mize,N.K., Weber,R.F., Lewis,M., Fendly,B.M.,
            Lipari,M.T. and Goeddel,D.V.
  TITLE     Biochemical properties of the 75-kDa tumor necrosis factor
            receptor. Characterization of ligand binding, internalization, and
            receptor phosphorylation
  JOURNAL   J Biol Chem 267 (29), 21172-21178 (1992)
   PUBMED   1328224
REFERENCE   8  (bases 1 to 3687)
  AUTHORS   Ryffel,B., Brockhaus,M., Greiner,B., Mihatsch,M.J. and Gudat,F.
  TITLE     Tumour necrosis factor receptor distribution in human lymphoid
            tissue
  JOURNAL   Immunology 74 (3), 446-452 (1991)
   PUBMED   1663076
REFERENCE   9  (bases 1 to 3687)
  AUTHORS   Kemper,O., Derre,J., Cherif,D., Engelmann,H., Wallach,D. and
            Berger,R.
  TITLE     The gene for the type II (p75) tumor necrosis factor receptor
            (TNF-RII) is localized on band 1p36.2-p36.3
  JOURNAL   Hum Genet 87 (5), 623-624 (1991)
   PUBMED   1655619
REFERENCE   10 (bases 1 to 3687)
  AUTHORS   Bost,R. and Hostein,J.
  TITLE     [Gastroduodenal reflux and non-ulcerous dyspepsia. Is it an
            accidental association?]
  JOURNAL   Ann Gastroenterol Hepatol (Paris) 27 (4), 191-192 (1991)
   PUBMED   1929203
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357835.11 and AL031276.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_001066.2.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This protein and TNF-receptor 1 form a
            heterocomplex that mediates the recruitment of two anti-apoptotic
            proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase
            activity. The function of IAPs in TNF-receptor signalling is
            unknown, however, c-IAP1 is thought to potentiate TNF-induced
            apoptosis by the ubiquitination and degradation of
            TNF-receptor-associated factor 2, which mediates anti-apoptotic
            signals. Knockout studies in mice also suggest a role of this
            protein in protecting neurons from apoptosis by stimulating
            antioxidative pathways. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M32315.1, SRR1803617.222840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376259.7/ ENSP00000365435.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL357835.11        120477-120655
            180-279             AL357835.11        142282-142381
            280-408             AL357835.11        144443-144571
            409-558             AL357835.11        145260-145409
            559-652             AL357835.11        145917-146010
            653-888             AL357835.11        146349-146584
            889-966             AL357835.11        147441-147518
            967-1001            AL357835.11        148070-148104
            1002-1206           AL031276.1         109444-109648       c
            1207-3687           AL031276.1         102395-104875       c
FEATURES             Location/Qualifiers
     source          1..3687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3687
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /note="TNF receptor superfamily member 1B"
                     /db_xref="GeneID:7133"
                     /db_xref="HGNC:HGNC:11917"
                     /db_xref="MIM:191191"
     exon            1..179
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1487
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /note="tumor necrosis factor beta receptor; tumor necrosis
                     factor binding protein 2; p75 TNF receptor; TNF-R2;
                     TNF-RII; p80 TNF-alpha receptor; tumor necrosis factor
                     receptor 2; tumor necrosis factor receptor type II; tumor
                     necrosis factor receptor superfamily member 1B"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 1B precursor"
                     /protein_id="NP_001057.1"
                     /db_xref="CCDS:CCDS145.1"
                     /db_xref="GeneID:7133"
                     /db_xref="HGNC:HGNC:11917"
                     /db_xref="MIM:191191"
                     /translation="MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLRE
                     YYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSS
                     DQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVV
                     CKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQ
                     PVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLII
                     GVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESS
                     ASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSD
                     HSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLP
                     LGVPDAGMKPS"
     exon            180..279
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            280..408
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            409..558
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            559..652
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            653..888
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            889..966
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1001
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1206
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..3687
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /note="hexamer: AATAAA"
     polyA_site      3687
                     /gene="TNFRSF1B"
                     /gene_synonym="CD120b; p75; p75TNFR; TBPII; TNF-R-II;
                     TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80"
                     /note="major polyA site"
ORIGIN      
        1 agtcgagggc tagcgagcgc agcggagcct ggagagaagg cgctgggctg cgagggcgcg
       61 agggcgcgag ggcagggggc aaccggaccc cgcccgcacc catggcgccc gtcgccgtct
      121 gggccgcgct ggccgtcgga ctggagctct gggctgcggc gcacgccttg cccgcccagg
      181 tggcatttac accctacgcc ccggagcccg ggagcacatg ccggctcaga gaatactatg
      241 accagacagc tcagatgtgc tgcagcaaat gctcgccggg ccaacatgca aaagtcttct
      301 gtaccaagac ctcggacacc gtgtgtgact cctgtgagga cagcacatac acccagctct
      361 ggaactgggt tcccgagtgc ttgagctgtg gctcccgctg tagctctgac caggtggaaa
      421 ctcaagcctg cactcgggaa cagaaccgca tctgcacctg caggcccggc tggtactgcg
      481 cgctgagcaa gcaggagggg tgccggctgt gcgcgccgct gcgcaagtgc cgcccgggct
      541 tcggcgtggc cagaccagga actgaaacat cagacgtggt gtgcaagccc tgtgccccgg
      601 ggacgttctc caacacgact tcatccacgg atatttgcag gccccaccag atctgtaacg
      661 tggtggccat ccctgggaat gcaagcatgg atgcagtctg cacgtccacg tcccccaccc
      721 ggagtatggc cccaggggca gtacacttac cccagccagt gtccacacga tcccaacaca
      781 cgcagccaac tccagaaccc agcactgctc caagcacctc cttcctgctc ccaatgggcc
      841 ccagcccccc agctgaaggg agcactggcg acttcgctct tccagttgga ctgattgtgg
      901 gtgtgacagc cttgggtcta ctaataatag gagtggtgaa ctgtgtcatc atgacccagg
      961 tgaaaaagaa gcccttgtgc ctgcagagag aagccaaggt gcctcacttg cctgccgata
     1021 aggcccgggg tacacagggc cccgagcagc agcacctgct gatcacagcg ccgagctcca
     1081 gcagcagctc cctggagagc tcggccagtg cgttggacag aagggcgccc actcggaacc
     1141 agccacaggc accaggcgtg gaggccagtg gggccgggga ggcccgggcc agcaccggga
     1201 gctcagattc ttcccctggt ggccatggga cccaggtcaa tgtcacctgc atcgtgaacg
     1261 tctgtagcag ctctgaccac agctcacagt gctcctccca agccagctcc acaatgggag
     1321 acacagattc cagcccctcg gagtccccga aggacgagca ggtccccttc tccaaggagg
     1381 aatgtgcctt tcggtcacag ctggagacgc cagagaccct gctggggagc accgaagaga
     1441 agcccctgcc ccttggagtg cctgatgctg ggatgaagcc cagttaacca ggccggtgtg
     1501 ggctgtgtcg tagccaaggt gggctgagcc ctggcaggat gaccctgcga aggggccctg
     1561 gtccttccag gcccccacca ctaggactct gaggctcttt ctgggccaag ttcctctagt
     1621 gccctccaca gccgcagcct ccctctgacc tgcaggccaa gagcagaggc agcgagttgt
     1681 ggaaagcctc tgctgccatg gcgtgtccct ctcggaaggc tggctgggca tggacgttcg
     1741 gggcatgctg gggcaagtcc ctgactctct gtgacctgcc ccgcccagct gcacctgcca
     1801 gcctggcttc tggagccctt gggttttttg tttgtttgtt tgtttgtttg tttgtttctc
     1861 cccctgggct ctgccccagc tctggcttcc agaaaacccc agcatccttt tctgcagagg
     1921 ggctttctgg agaggaggga tgctgcctga gtcacccatg aagacaggac agtgcttcag
     1981 cctgaggctg agactgcggg atggtcctgg ggctctgtgc agggaggagg tggcagccct
     2041 gtagggaacg gggtccttca agttagctca ggaggcttgg aaagcatcac ctcaggccag
     2101 gtgcagtggc tcacgcctat gatcccagca ctttgggagg ctgaggcggg tggatcacct
     2161 gaggttagga gttcgagacc agcctggcca acatggtaaa accccatctc tactaaaaat
     2221 acagaaatta gccgggcgtg gtggcgggca cctatagtcc cagctactca gaagcctgag
     2281 gctgggaaat cgtttgaacc cgggaagcgg aggttgcagg gagccgagat cacgccactg
     2341 cactccagcc tgggcgacag agcgagagtc tgtctcaaaa gaaaaaaaaa agcaccgcct
     2401 ccaaatgcca acttgtcctt ttgtaccatg gtgtgaaagt cagatgccca gagggcccag
     2461 gcaggccacc atattcagtg ctgtggcctg ggcaagataa cgcacttcta actagaaatc
     2521 tgccaatttt ttaaaaaagt aagtaccact caggccaaca agccaacgac aaagccaaac
     2581 tctgccagcc acatccaacc ccccacctgc catttgcacc ctccgccttc actccggtgt
     2641 gcctgcagcc ccgcgcctcc ttccttgctg tcctaggcca caccatctcc tttcagggaa
     2701 tttcaggaac tagagatgac tgagtcctcg tagccatctc tctactccta cctcagccta
     2761 gaccctcctc ctcccccaga ggggtgggtt cctcttcccc actccccacc ttcaattcct
     2821 gggccccaaa cgggctgccc tgccactttg gtacatggcc agtgtgatcc caagtgccag
     2881 tcttgtgtct gcgtctgtgt tgcgtgtcgt gggtgtgtgt agccaaggtc ggtaagttga
     2941 atggcctgcc ttgaagccac tgaagctggg attcctcccc attagagtca gccttccccc
     3001 tcccagggcc agggccctgc agaggggaaa ccagtgtagc cttgcccgga ttctgggagg
     3061 aagcaggttg aggggctcct ggaaaggctc agtctcagga gcatggggat aaaggagaag
     3121 gcatgaaatt gtctagcaga gcaggggcag ggtgataaat tgttgataaa ttccactgga
     3181 cttgagcttg gcagctgaac tattggaggg tgggagagcc cagccattac catggagaca
     3241 agaagggttt tccaccctgg aatcaagatg tcagactggc tggctgcagt gacgtgcacc
     3301 tgtactcagg aggctgaggg gaggatcact ggagcccagg agtttgaggc tgcagcgagc
     3361 tatgatcgcg ccactacact ccagcctgag caacagagtg agaccctgtc tcttaaagaa
     3421 aaaaaaagtc agactgctgg gactggccag gtttctgccc acattggacc cacatgagga
     3481 catgatggag cgcacctgcc ccctggtgga cagtcctggg agaacctcag gcttccttgg
     3541 catcacaggg cagagccggg aagcgatgaa tttggagact ctgtggggcc ttggttccct
     3601 tgtgtgtgtg tgttgatccc aagacaatga aagtttgcac tgtatgctgg acggcattcc
     3661 tgcttatcaa taaacctgtt tgtttta
//
