LOCUS       NM_001065               2171 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 1A (TNFRSF1A),
            transcript variant 1, mRNA.
ACCESSION   NM_001065
VERSION     NM_001065.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Alam,M.S., Gaida,M.M., Witzel,H.R., Otsuka,S., Abbasi,A.,
            Guerin,T., Abdelmaksoud,A., Wong,N., Cam,M.C., Kozlov,S. and
            Ashwell,J.D.
  TITLE     TNFR1 signaling promotes pancreatic tumor growth by limiting
            dendritic cell number and function
  JOURNAL   Cell Rep Med 5 (9), 101696 (2024)
   PUBMED   39178856
  REMARK    GeneRIF: TNFR1 signaling promotes pancreatic tumor growth by
            limiting dendritic cell number and function.
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Montoya-Buelna,M., Alvarado-Navarro,A., Munoz-Valle,J.F.,
            Lopez-Roa,R.I., Guerrero-Velazquez,C. and Fafutis-Morris,M.
  TITLE     Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B
            genes with lepromatous leprosy in Western Mexican patients
  JOURNAL   J Infect Dev Ctries 18 (5), 770-778 (2024)
   PUBMED   38865403
  REMARK    GeneRIF: Association of polymorphisms in the TNFA, TNFRSF1A and
            TNFRSF1B genes with lepromatous leprosy in Western Mexican
            patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   da Silva,P.B., Romao-Veiga,M., Ribeiro-Vasques,V.R., Peracoli,J.C.,
            Peracoli,M.T.S. and Amaral,L.M.
  TITLE     Progesterone modulates TNF receptors expression by Jurkat cells
            cultured with plasma from pregnant women with preeclampsia
  JOURNAL   Int Immunopharmacol 130, 111701 (2024)
   PUBMED   38382266
  REMARK    GeneRIF: Progesterone modulates TNF receptors expression by Jurkat
            cells cultured with plasma from pregnant women with preeclampsia.
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Liphaus,B.L., Silva,S.C., Palmeira,P., Silva,C.A.,
            Goldenstein-Schainberg,C. and Carneiro-Sampaio,M.
  TITLE     Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and
            TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus
            patients: relations with disease activity, nephritis, and
            neuropsychiatric involvement
  JOURNAL   Front Immunol 15, 1327255 (2024)
   PUBMED   38562920
  REMARK    GeneRIF: Reduced expressions of apoptosis-related proteins TRAIL,
            Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus
            erythematosus patients: relations with disease activity, nephritis,
            and neuropsychiatric involvement.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   McDermott,M.F., Aksentijevich,I., Galon,J., McDermott,E.M.,
            Ogunkolade,B.W., Centola,M., Mansfield,E., Gadina,M., Karenko,L.,
            Pettersson,T., McCarthy,J., Frucht,D.M., Aringer,M., Torosyan,Y.,
            Teppo,A.M., Wilson,M., Karaarslan,H.M., Wan,Y., Todd,I., Wood,G.,
            Schlimgen,R., Kumarajeewa,T.R., Cooper,S.M., Vella,J.P., Amos,C.I.,
            Mulley,J., Quane,K.A., Molloy,M.G., Ranki,A., Powell,R.J.,
            Hitman,G.A., O'Shea,J.J. and Kastner,D.L.
  TITLE     Germline mutations in the extracellular domains of the 55 kDa TNF
            receptor, TNFR1, define a family of dominantly inherited
            autoinflammatory syndromes
  JOURNAL   Cell 97 (1), 133-144 (1999)
   PUBMED   10199409
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Deuitch,N., Cudrici,C., Ombrello,A. and Aksentijevich,I.
  TITLE     TNF Receptor-Associated Periodic Fever Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36375008
REFERENCE   7  (bases 1 to 2171)
  AUTHORS   Zhang,X.M., Weber,I. and Chen,M.J.
  TITLE     Site-directed mutational analysis of human tumor necrosis
            factor-alpha receptor binding site and structure-functional
            relationship
  JOURNAL   J Biol Chem 267 (33), 24069-24075 (1992)
   PUBMED   1331108
REFERENCE   8  (bases 1 to 2171)
  AUTHORS   Fuchs,P., Strehl,S., Dworzak,M., Himmler,A. and Ambros,P.F.
  TITLE     Structure of the human TNF receptor 1 (p60) gene (TNFR1) and
            localization to chromosome 12p13 [corrected]
  JOURNAL   Genomics 13 (1), 219-224 (1992)
   PUBMED   1315717
  REMARK    Erratum:[Genomics 1992 Aug;13(4):1384]
REFERENCE   9  (bases 1 to 2171)
  AUTHORS   Derre,J., Kemper,O., Cherif,D., Nophar,Y., Berger,R. and Wallach,D.
  TITLE     The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is
            localized on band 12p13
  JOURNAL   Hum Genet 87 (2), 231-233 (1991)
   PUBMED   1648547
REFERENCE   10 (bases 1 to 2171)
  AUTHORS   Belokrylov,G.A. and Zhitnukhin,Iu.L.
  TITLE     [Effect of antibodies to rat and human cerebral cortex and white
            matter on heterologous T- and B-cells]
  JOURNAL   Zh Mikrobiol Epidemiol Immunobiol (9), 66-70 (1976)
   PUBMED   1087798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315509.1, M63121.1 and
            BC010140.2.
            
            On Aug 31, 2019 this sequence version replaced NM_001065.3.
            
            Summary: This gene encodes a member of the TNF receptor superfamily
            of proteins. The encoded receptor is found in membrane-bound and
            soluble forms that interact with membrane-bound and soluble forms,
            respectively, of its ligand, tumor necrosis factor alpha. Binding
            of membrane-bound tumor necrosis factor alpha to the membrane-bound
            receptor induces receptor trimerization and activation, which plays
            a role in cell survival, apoptosis, and inflammation. Proteolytic
            processing of the encoded receptor results in release of the
            soluble form of the receptor, which can interact with free tumor
            necrosis factor alpha to inhibit inflammation. Mutations in this
            gene underlie tumor necrosis factor receptor-associated periodic
            syndrome (TRAPS), characterized by fever, abdominal pain and other
            features. Mutations in this gene may also be associated with
            multiple sclerosis in human patients. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58286.1, M63121.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000162749.7/ ENSP00000162749.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1024              AK315509.1         39-1062
            1025-2168           M63121.1           969-2112
            2169-2171           BC010140.2         2137-2139
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2171
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /note="TNF receptor superfamily member 1A"
                     /db_xref="GeneID:7132"
                     /db_xref="HGNC:HGNC:11916"
                     /db_xref="MIM:191190"
     exon            1..301
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1630
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tumor necrosis factor-alpha receptor; tumor
                     necrosis factor binding protein 1; tumor necrosis factor
                     receptor type 1; TNF-R1; TNF-RI; TNFR-I; tumor necrosis
                     factor receptor superfamily member 1A"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 1A isoform 1 precursor"
                     /protein_id="NP_001056.1"
                     /db_xref="CCDS:CCDS8542.1"
                     /db_xref="GeneID:7132"
                     /db_xref="HGNC:HGNC:11916"
                     /db_xref="MIM:191190"
                     /translation="MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVC
                     PQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSC
                     SKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQE
                     KQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVI
                     FFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPT
                     PGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPI
                     PNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQN
                     GRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPA
                     PSLLR"
     exon            302..455
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            456..584
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            585..734
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            735..813
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            814..887
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1001
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1030
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1319
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..2171
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /note="hexamer: ACTAAA"
     polyA_site      2171
                     /gene="TNFRSF1A"
                     /gene_synonym="CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R;
                     TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60"
                     /note="major polyA site"
ORIGIN      
        1 actcttcccc tcccaccttc tctcccctcc tctctgcttt aattttctca gaattctctg
       61 gactgaggct ccagttctgg cctttggggt tcaagatcac tgggaccagg ccgtgatctc
      121 tatgcccgag tctcaaccct caactgtcac cccaaggcac ttgggacgtc ctggacagac
      181 cgagtcccgg gaagccccag cactgccgct gccacactgc cctgagccca aatgggggag
      241 tgagaggcca tagctgtctg gcatgggcct ctccaccgtg cctgacctgc tgctgccact
      301 ggtgctcctg gagctgttgg tgggaatata cccctcaggg gttattggac tggtccctca
      361 cctaggggac agggagaaga gagatagtgt gtgtccccaa ggaaaatata tccaccctca
      421 aaataattcg atttgctgta ccaagtgcca caaaggaacc tacttgtaca atgactgtcc
      481 aggcccgggg caggatacgg actgcaggga gtgtgagagc ggctccttca ccgcttcaga
      541 aaaccacctc agacactgcc tcagctgctc caaatgccga aaggaaatgg gtcaggtgga
      601 gatctcttct tgcacagtgg accgggacac cgtgtgtggc tgcaggaaga accagtaccg
      661 gcattattgg agtgaaaacc ttttccagtg cttcaattgc agcctctgcc tcaatgggac
      721 cgtgcacctc tcctgccagg agaaacagaa caccgtgtgc acctgccatg caggtttctt
      781 tctaagagaa aacgagtgtg tctcctgtag taactgtaag aaaagcctgg agtgcacgaa
      841 gttgtgccta ccccagattg agaatgttaa gggcactgag gactcaggca ccacagtgct
      901 gttgcccctg gtcattttct ttggtctttg ccttttatcc ctcctcttca ttggtttaat
      961 gtatcgctac caacggtgga agtccaagct ctactccatt gtttgtggga aatcgacacc
     1021 tgaaaaagag ggggagcttg aaggaactac tactaagccc ctggccccaa acccaagctt
     1081 cagtcccact ccaggcttca cccccaccct gggcttcagt cccgtgccca gttccacctt
     1141 cacctccagc tccacctata cccccggtga ctgtcccaac tttgcggctc cccgcagaga
     1201 ggtggcacca ccctatcagg gggctgaccc catccttgcg acagccctcg cctccgaccc
     1261 catccccaac ccccttcaga agtgggagga cagcgcccac aagccacaga gcctagacac
     1321 tgatgacccc gcgacgctgt acgccgtggt ggagaacgtg cccccgttgc gctggaagga
     1381 attcgtgcgg cgcctagggc tgagcgacca cgagatcgat cggctggagc tgcagaacgg
     1441 gcgctgcctg cgcgaggcgc aatacagcat gctggcgacc tggaggcggc gcacgccgcg
     1501 gcgcgaggcc acgctggagc tgctgggacg cgtgctccgc gacatggacc tgctgggctg
     1561 cctggaggac atcgaggagg cgctttgcgg ccccgccgcc ctcccgcccg cgcccagtct
     1621 tctcagatga ggctgcgccc ctgcgggcag ctctaaggac cgtcctgcga gatcgccttc
     1681 caaccccact tttttctgga aaggaggggt cctgcagggg caagcaggag ctagcagccg
     1741 cctacttggt gctaacccct cgatgtacat agcttttctc agctgcctgc gcgccgccga
     1801 cagtcagcgc tgtgcgcgcg gagagaggtg cgccgtgggc tcaagagcct gagtgggtgg
     1861 tttgcgagga tgagggacgc tatgcctcat gcccgttttg ggtgtcctca ccagcaaggc
     1921 tgctcggggg cccctggttc gtccctgagc ctttttcaca gtgcataagc agtttttttt
     1981 gtttttgttt tgttttgttt tgtttttaaa tcaatcatgt tacactaata gaaacttggc
     2041 actcctgtgc cctctgcctg gacaagcaca tagcaagctg aactgtccta aggcaggggc
     2101 gagcacggaa caatggggcc ttcagctgga gctgtggact tttgtacata cactaaaatt
     2161 ctgaagttaa a
//
