LOCUS       NM_148957               4438 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 19 (TNFRSF19),
            transcript variant 2, mRNA.
ACCESSION   NM_148957
VERSION     NM_148957.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Zuo,X., Wang,X., Ma,T., Chen,S., Cao,P., Cheng,H., Yang,N., Han,X.,
            Gao,W., Liu,X. and Sun,Y.
  TITLE     TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer
            Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 22 (3), 227-239 (2024)
   PUBMED   38047807
  REMARK    GeneRIF: TNFRSF19 within the 13q12.12 Risk Locus Functions as a
            Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin
            Signaling.
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Zhu,W., Tan,L., Ma,T., Yin,Z. and Gao,J.
  TITLE     Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer
            via binding with hnRNPA1 and stabilizing TROY expression
  JOURNAL   Dig Liver Dis 54 (11), 1573-1582 (2022)
   PUBMED   35354542
  REMARK    GeneRIF: Long noncoding RNA SNHG8 promotes chemoresistance in
            gastric cancer via binding with hnRNPA1 and stabilizing TROY
            expression.
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Wong,A.M., Ding,X., Wong,A.M., Xu,M., Zhang,L., Leung,H.H.,
            Chan,A.W., Song,Q.X., Kwong,J., Chan,L.K., Man,M., He,M., Chen,J.,
            Zhang,Z., You,W., Lau,C., Yu,A., Wei,Y., Yuan,Y., Lai,P.B.,
            Zhao,J., Man,K., Yu,J., Kahn,M. and Wong,N.
  TITLE     Unique molecular characteristics of NAFLD-associated liver cancer
            accentuate beta-catenin/TNFRSF19-mediated immune evasion
  JOURNAL   J Hepatol 77 (2), 410-423 (2022)
   PUBMED   35351523
  REMARK    GeneRIF: Unique molecular characteristics of NAFLD-associated liver
            cancer accentuate beta-catenin/TNFRSF19-mediated immune evasion.
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Kretzschmar,K., Boonekamp,K.E., Bleijs,M., Asra,P., Koomen,M.,
            Chuva de Sousa Lopes,S.M., Giovannone,B. and Clevers,H.
  TITLE     Troy/Tnfrsf19 marks epidermal cells that govern interfollicular
            epidermal renewal and cornification
  JOURNAL   Stem Cell Reports 16 (9), 2379-2394 (2021)
   PUBMED   34358453
  REMARK    GeneRIF: Troy/Tnfrsf19 marks epidermal cells that govern
            interfollicular epidermal renewal and cornification.
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Ding,Z., Kloss,J.M., Tuncali,S., Tran,N.L. and Loftus,J.C.
  TITLE     TROY signals through JAK1-STAT3 to promote glioblastoma cell
            migration and resistance
  JOURNAL   Neoplasia 22 (9), 352-364 (2020)
   PUBMED   32629176
  REMARK    GeneRIF: TROY signals through JAK1-STAT3 to promote glioblastoma
            cell migration and resistance.
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Spanjaard,R.A., Whren,K.M., Graves,C. and Bhawan,J.
  TITLE     Tumor necrosis factor receptor superfamily member TROY is a novel
            melanoma biomarker and potential therapeutic target
  JOURNAL   Int J Cancer 120 (6), 1304-1310 (2007)
   PUBMED   17187358
  REMARK    GeneRIF: TROY regulates melanoma growth.
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Cho,S.M., Kim,J., Ryu,H.J., Kim,J.J., Kim,H.H., Park,J.H.,
            Kim,H.T., Kim,K.H., Cho,H.Y., Oh,B., Park,C., Kimm,K., Jo,I.,
            Lee,J.E., Shin,H.D. and Lee,J.K.
  TITLE     Identification of single nucleotide polymorphisms in the tumor
            necrosis factor (TNF) and TNF receptor superfamily in the Korean
            population
  JOURNAL   Hum Immunol 65 (7), 710-718 (2004)
   PUBMED   15301860
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
            Nishikawa,S. and Inoue,J.
  TITLE     TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
   PUBMED   12060722
REFERENCE   9  (bases 1 to 4438)
  AUTHORS   Kojima,T., Morikawa,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Senba,E. and Kitamura,T.
  TITLE     TROY, a newly identified member of the tumor necrosis factor
            receptor superfamily, exhibits a homology with Edar and is
            expressed in embryonic skin and hair follicles
  JOURNAL   J Biol Chem 275 (27), 20742-20747 (2000)
   PUBMED   10764796
REFERENCE   10 (bases 1 to 4438)
  AUTHORS   Eby,M.T., Jasmin,A., Kumar,A., Sharma,K. and Chaudhary,P.M.
  TITLE     TAJ, a novel member of the tumor necrosis factor receptor family,
            activates the c-Jun N-terminal kinase pathway and mediates
            caspase-independent cell death
  JOURNAL   J Biol Chem 275 (20), 15336-15342 (2000)
   PUBMED   10809768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA192370.1, BC047321.1,
            AY358888.1, BM801444.1, BF968836.1 and BF971156.1.
            
            On Jun 2, 2019 this sequence version replaced NM_148957.3.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is highly expressed during
            embryonic development. It has been shown to interact with TRAF
            family members, and to activate JNK signaling pathway when
            overexpressed in cells. This receptor is capable of inducing
            apoptosis by a caspase-independent mechanism, and it is thought to
            play an essential role in embryonic development. Alternatively
            spliced transcript variants encoding distinct isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also known as TRADEalpha)
            differs in both UTR's and the 3' coding region, compared to variant
            1. The encoded isoform (2) is shorter and has a distinct
            C-terminus, compared to isoform (1). Variants 2 and 3 encode the
            same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.128071.1, BC047321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248484.9/ ENSP00000248484.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               DA192370.1         43-214
            173-2857            BC047321.1         1-2685
            2858-3157           AY358888.1         2571-2870
            3158-3373           BM801444.1         253-468
            3374-3892           BF968836.1         1-519
            3893-4438           BF971156.1         1-546
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..4438
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /note="TNF receptor superfamily member 19"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
     exon            1..437
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            438..540
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1725
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; toxicity and JNK inducer; tumor necrosis factor
                     receptor superfamily member 19"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform 2 precursor"
                     /protein_id="NP_683760.1"
                     /db_xref="CCDS:CCDS9301.1"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
                     /translation="MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRSG
                     NCVPCNQCGPGMELSKECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQ
                     KANCSATSDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIAS
                     TASSPRDTALAAVICSALATVLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSEL
                     SCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAAS
                     LQARNAGPAGEMVPTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDI
                     HSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYNNTLVESASTQDAL
                     TMRSQLDQESGAVIHPATQTSLQEA"
     exon            541..651
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            652..830
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            831..916
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1081
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1207
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1310
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1716
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..4438
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4413..4418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /note="hexamer: AATAAA"
     polyA_site      4438
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /note="major polyA site"
ORIGIN      
        1 actaggaaaa gcttccaaca cacagtccac aacacagctt gggaaccaaa aaagctacag
       61 atccagccac tcagcccaag catgggagaa ctaccagcat tgcctcattg caaaaaagag
      121 gaggaaaaca acgtgatcca tgtttaacaa aagagtctgt ggactaggag gtgggagggt
      181 aactacctgc tgaaagtgaa ctttctttga tatccatgca tatatataaa ctcagccctg
      241 cctttgatgt tcagcaactg attcactgat cagattacag gcatttcatc tccctgctcg
      301 tctgcctttg atctgcatgg ttaattttat tttcctggat ttgaagtttc gtctgggctt
      361 gtgctgacat acatttttgg gaaggtagaa gcatttggca cagaagtgct gccaggagaa
      421 actaagttgc tgaacggaac tctccaacaa taaatacatt tgataagaaa gatggcttta
      481 aaagtgctac tagaacaaga gaaaacgttt ttcactcttt tagtattact aggctatttg
      541 tcatgtaaag tgacttgtga atcaggagac tgtagacagc aagaattcag ggatcggtct
      601 ggaaactgtg ttccctgcaa ccagtgtggg ccaggcatgg agttgtctaa ggaatgtggc
      661 ttcggctatg gggaggatgc acagtgtgtg acgtgccggc tgcacaggtt caaggaggac
      721 tggggcttcc agaaatgcaa gccctgtctg gactgcgcag tggtgaaccg ctttcagaag
      781 gcaaattgtt cagccaccag tgatgccatc tgcggggact gcttgccagg attttatagg
      841 aagacgaaac ttgtcggctt tcaagacatg gagtgtgtgc cttgtggaga ccctcctcct
      901 ccttacgaac cgcactgtgc cagcaaggtc aacctcgtga agatcgcgtc cacggcctcc
      961 agcccacggg acacggcgct ggctgccgtt atctgcagcg ctctggccac cgtcctgctg
     1021 gccctgctca tcctctgtgt catctattgt aagagacagt ttatggagaa gaaacccagc
     1081 tggtctctgc ggtcacagga cattcagtac aacggctctg agctgtcgtg ttttgacaga
     1141 cctcagctcc acgaatatgc ccacagagcc tgctgccagt gccgccgtga ctcagtgcag
     1201 acctgcgggc cggtgcgctt gctcccatcc atgtgctgtg aggaggcctg cagccccaac
     1261 ccggcgactc ttggttgtgg ggtgcattct gcagccagtc ttcaggcaag aaacgcaggc
     1321 ccagccgggg agatggtgcc gactttcttc ggatccctca cgcagtccat ctgtggcgag
     1381 ttttcagatg cctggcctct gatgcagaat cccatgggtg gtgacaacat ctctttttgt
     1441 gactcttatc ctgaactcac tggagaagac attcattctc tcaatccaga acttgaaagc
     1501 tcaacgtctt tggattcaaa tagcagtcaa gatttggttg gtggggctgt tccagtccag
     1561 tctcattctg aaaactttac agcagctact gatttatcta gatataacaa cacactggta
     1621 gaatcagcat caactcagga tgcactaact atgagaagcc agctagatca ggagagtggt
     1681 gctgtcatcc acccagccac tcagacgtcc ctccaggaag cttaaagaac ctgcttcttt
     1741 ctgcagtaga agcgtgtgct ggaacccaaa gagtactcct ttgttaggct tatggactga
     1801 gcagtctgga ccttgcatgg cttctggggc aaaaataaat ctgaaccaaa ctgacggcat
     1861 ttgaagcctt tcagccagtt gcttctgagc cagaccagct gtaagctgaa acctcaatga
     1921 ataacaagaa aagactccag gccgactcat gatactctgc atctttccta catgagaagc
     1981 ttctctgcca caaaagtgac ttcaaagacg gatgggttga gctggcagcc tatgagattg
     2041 tggacatata acaagaaaca gaaatgccct catgcttatt ttcatggtga ttgtggtttt
     2101 acaagactga agacccagag tatacttttt ctttccagaa ataatttcat accgcctatg
     2161 aaatatcaga taaattacct tagcttttat gtagaatggg ttcaaaagtg agtgtttcta
     2221 tttgagaagg acactttttc atcatctaaa ctgattcgca taggtggtta gaatggccct
     2281 catattgcct gcctaaatct tgggtttatt agatgaagtt tactgaatca gaggaatcag
     2341 acagaggagg atagctcttt ccagaatcca cacttctgac ctcagcctcg gtctcatgaa
     2401 cacccgctga tctcaggaga acacctgggc tagggaatgt ggtcgagaaa gggcagccca
     2461 ttgcccagaa ttaacacata ttgtagagac ttgtatgcaa aggttggcat atttatatga
     2521 aaattagttg ctatagaaac atttgttgca tctgtccctc tgcctgagct tagaaggtta
     2581 tagaaaaagg gtatttataa acataaatga ccttttactt gcattgtatc ttatactaaa
     2641 ggctttagaa attacaacat atcaggttcc cctactactg aagtagcctt ccgtgagaac
     2701 acaccacatg ttaggactag aagaaaatgc acaatttgta ggggtttgga tgaagcagct
     2761 gtaactgccc tagtgtagtt tgaccaggac attgtcgtgc tccttccaat tgtgtaagat
     2821 tagttagcac atcatctcct actttagcca tccggtgttg gatttaagag gacggtgctt
     2881 ctttctatta aagtgctcca tcccctacca tctacacatt agcattgtct ctagagctaa
     2941 gacagaaatt aaccccgttc agtcacaaag cagggaatgg ttcatttact cttaatcttt
     3001 atgccctgga gaagacctac ttgaacaggg catatttttt agacttctga acatcagtat
     3061 gttcgagggt actatgatat tttggtttgg aattgccctg cccaagtcac tgtcttttaa
     3121 cttttaaact gaatattaaa atgtatctgt ctttcctagt atgtttttat cttctcatgt
     3181 attatccatg gttttctctg tttgtgacag attagtaaaa tttaatgagc cctctttctt
     3241 gtggccgttt ctccatagtt ttaggttttg atatgtgttt actagcttgc ctgtgtctgg
     3301 tacatctcat gacctcaatt ccctcacctg aaataggaaa tgagaatgtt tcattgtagc
     3361 cccaagcggt catgtcaacc tagtgcctag tcataattaa ttgacttttc ctgtattact
     3421 tcttttttta agtataaacc aatgatcctt tggtagtcaa gaactcttag gaacattgcc
     3481 ttttggacat gtaaaatatt taggatttga ccacacaatg gctatgaaaa tgcaagtagt
     3541 ttcctcgcgt gacctcacca tgattcacat acgtgccact gtttgaaatc tggtctgttt
     3601 gcatttctgt tatgacagag agatgatgtt tgcatttctg ttatgacaga gagatgatga
     3661 aagtaggcag ggctgtgttc ctttgtgtag cctgtatata ttttccatat gtagagccct
     3721 gattaacttc aaggacaaac actggctgga gaaagccaga ctgatgggaa tgagactttg
     3781 gccaaaaatc ccaaaacatc attttcaatc agtagagaag tgcttagggt tgaaaattga
     3841 tttcatttgc tactgaattt ggtaaatcct gggtaacttt tatcaagatg aagacatttt
     3901 accctaccta ctctagaaat atacaacaat gttatatttt acactccttg gaaacatttg
     3961 aggaaaaaaa tgcaatttgc acttcacttt gttggaatat cccatagcac tcaataaact
     4021 cagctgctag agtgccgatg tcaggagggc tgtgtcgggt aatgcgtgtg gctgaatggg
     4081 cataaccact gtggcttctt gtgctgcaga agctcgttga caagactgag gaggatttca
     4141 agagcaacca agtaaagtca tgaattttct aattttgtgt atatggaata tatttttaaa
     4201 tagagatttt tctactttag ataatgtgtt aatattgcta ttacctaggt taagcactat
     4261 tgtctgtgct agtaagaaaa agaaaggaaa accatcattg ctttatagta gcttatatca
     4321 atttagattt catcattact attttgcata ctggaattta taaatgtgta aattatcatt
     4381 ttcttagttt tgtaatacct tttttatttg tgaataaaat tatcacctgg tattctta
//
