LOCUS       NM_004195               1083 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 18 (TNFRSF18),
            transcript variant 1, mRNA.
ACCESSION   NM_004195
VERSION     NM_004195.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Rakke,Y.S., Campos Carrascosa,L., van Beek,A.A., de Ruiter,V., van
            Gemerden,R.S., Doukas,M., Doornebosch,P.G., Vermaas,M., Ter
            Borg,S., van der Harst,E., Coene,P.P.L.O., Kliffen,M.,
            Grunhagen,D.J., Verhoef,C., IJzermans,J.N.M., Kwekkeboom,J. and
            Sprengers,D.
  TITLE     GITR Ligation Improves Anti-PD1-Mediated Restoration of Human
            MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (1), 77-97 (2023)
   PUBMED   36155259
  REMARK    GeneRIF: GITR Ligation Improves Anti-PD1-Mediated Restoration of
            Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Loick,S.M., Frohlich,A., Gabrielpillai,J., Franzen,A., Vogt,T.J.,
            Dietrich,J., Wiek,C., Scheckenbach,K., Strieth,S., Landsberg,J. and
            Dietrich,D.
  TITLE     DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR
            (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma
            Correlates With HPV Status, Mutational Load, an Interferon-gamma
            Signature, Signatures of Immune Infiltrates, and Survival
  JOURNAL   J Immunother 45 (4), 194-206 (2022)
   PUBMED   34908008
  REMARK    GeneRIF: DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and
            GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma
            Correlates With HPV Status, Mutational Load, an Interferon-gamma
            Signature, Signatures of Immune Infiltrates, and Survival.
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Ming,S., Yin,H., Li,X., Gong,S., Zhang,G. and Wu,Y.
  TITLE     GITR Promotes the Polarization of TFH-Like Cells in Helicobacter
            pylori-Positive Gastritis
  JOURNAL   Front Immunol 12, 736269 (2021)
   PUBMED   34589088
  REMARK    GeneRIF: GITR Promotes the Polarization of TFH-Like Cells in
            Helicobacter pylori-Positive Gastritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Bosmans,L.A., Shami,A., Atzler,D., Weber,C., Goncalves,I. and
            Lutgens,E.
  TITLE     Glucocorticoid induced TNF receptor family-related protein (GITR) -
            A novel driver of atherosclerosis
  JOURNAL   Vascul Pharmacol 139, 106884 (2021)
   PUBMED   34102305
  REMARK    GeneRIF: Glucocorticoid induced TNF receptor family-related protein
            (GITR) - A novel driver of atherosclerosis.
            Review article
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Wang,F., Chau,B., West,S.M., Kimberlin,C.R., Cao,F., Schwarz,F.,
            Aguilar,B., Han,M., Morishige,W., Bee,C., Dollinger,G., Rajpal,A.
            and Strop,P.
  TITLE     Structures of mouse and human GITR-GITRL complexes reveal unique
            TNF superfamily interactions
  JOURNAL   Nat Commun 12 (1), 1378 (2021)
   PUBMED   33654081
  REMARK    GeneRIF: Structures of mouse and human GITR-GITRL complexes reveal
            unique TNF superfamily interactions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Shimizu,J., Yamazaki,S., Takahashi,T., Ishida,Y. and Sakaguchi,S.
  TITLE     Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks
            immunological self-tolerance
  JOURNAL   Nat Immunol 3 (2), 135-142 (2002)
   PUBMED   11812990
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Nocentini,G., Ronchetti,S., Bartoli,A., Spinicelli,S., Delfino,D.,
            Brunetti,L., Migliorati,G. and Riccardi,C.
  TITLE     Identification of three novel mRNA splice variants of GITR
  JOURNAL   Cell Death Differ 7 (4), 408-410 (2000)
   PUBMED   10836847
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Kwon,B., Yu,K.Y., Ni,J., Yu,G.L., Jang,I.K., Kim,Y.J., Xing,L.,
            Liu,D., Wang,S.X. and Kwon,B.S.
  TITLE     Identification of a novel activation-inducible protein of the tumor
            necrosis factor receptor superfamily and its ligand
  JOURNAL   J Biol Chem 274 (10), 6056-6061 (1999)
   PUBMED   10037686
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Gurney,A.L., Marsters,S.A., Huang,R.M., Pitti,R.M., Mark,D.T.,
            Baldwin,D.T., Gray,A.M., Dowd,A.D., Brush,A.D., Heldens,A.D.,
            Schow,A.D., Goddard,A.D., Wood,W.I., Baker,K.P., Godowski,P.J. and
            Ashkenazi,A.
  TITLE     Identification of a new member of the tumor necrosis factor family
            and its receptor, a human ortholog of mouse GITR
  JOURNAL   Curr Biol 9 (4), 215-218 (1999)
   PUBMED   10074428
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Nocentini,G., Giunchi,L., Ronchetti,S., Krausz,L.T., Bartoli,A.,
            Moraca,R., Migliorati,G. and Riccardi,C.
  TITLE     A new member of the tumor necrosis factor/nerve growth factor
            receptor family inhibits T cell receptor-induced apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6216-6221 (1997)
   PUBMED   9177197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162741.44, AY358877.1 and
            AF241229.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004195.2.
            
            Summary: This gene encodes a member of the TNF-receptor
            superfamily. The encoded receptor has been shown to have increased
            expression upon T-cell activation, and it is thought to play a key
            role in dominant immunological self-tolerance maintained by
            CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also
            suggest the role of this receptor is in the regulation of
            CD3-driven T-cell activation and programmed cell death. Three
            alternatively spliced transcript variants of this gene encoding
            distinct isoforms have been reported. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It contains an extra coding segment, which leads to a
            frame shift, compared to variant 2. The resulting preotein (isoform
            1) contains a distinct and shorter C-terminus, as compared to
            isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.154915.1,
                                           SRR1163658.352830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379268.7/ ENSP00000368570.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL162741.44        16497-16704         c
            209-909             AY358877.1         308-1008
            910-1083            AF241229.1         678-851
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..1083
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /note="TNF receptor superfamily member 18"
                     /db_xref="GeneID:8784"
                     /db_xref="HGNC:HGNC:11914"
                     /db_xref="MIM:603905"
     exon            1..208
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..747
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TNF receptor superfamily activation-inducible
                     protein; glucocorticoid-induced TNFR-related protein;
                     activation-inducible TNFR family receptor; tumor necrosis
                     factor receptor superfamily member 18"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 18 isoform 1 precursor"
                     /protein_id="NP_004186.1"
                     /db_xref="CCDS:CCDS10.1"
                     /db_xref="GeneID:8784"
                     /db_xref="HGNC:HGNC:11914"
                     /db_xref="MIM:603905"
                     /translation="MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTG
                     TDARCCRVHTTRCCRDYPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQS
                     QGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPA
                     EPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSC
                     QFPEEERGERSAEEKGRLGDLWV"
     exon            209..331
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /inference="alignment:Splign:2.1.0"
     exon            332..419
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /inference="alignment:Splign:2.1.0"
     exon            420..622
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1083
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /note="hexamer: AATAAA"
     polyA_site      1083
                     /gene="TNFRSF18"
                     /gene_synonym="AITR; CD357; ENERGEN; GITR; GITR-D"
                     /note="major polyA site"
ORIGIN      
        1 gtgggctctt gaaacccgag catggcacag cacggggcga tgggcgcgtt tcgggccctg
       61 tgcggcctgg cgctgctgtg cgcgctcagc ctgggtcagc gccccaccgg gggtcccggg
      121 tgcggccctg ggcgcctcct gcttgggacg ggaacggacg cgcgctgctg ccgggttcac
      181 acgacgcgct gctgccgcga ttacccgggc gaggagtgct gttccgagtg ggactgcatg
      241 tgtgtccagc ctgaattcca ctgcggagac ccttgctgca cgacctgccg gcaccaccct
      301 tgtcccccag gccagggggt acagtcccag gggaaattca gttttggctt ccagtgtatc
      361 gactgtgcct cggggacctt ctccgggggc cacgaaggcc actgcaaacc ttggacagac
      421 tgcacccagt tcgggtttct cactgtgttc cctgggaaca agacccacaa cgctgtgtgc
      481 gtcccagggt ccccgccggc agagccgctt gggtggctga ccgtcgtcct cctggccgtg
      541 gccgcctgcg tcctcctcct gacctcggcc cagcttggac tgcacatctg gcagctgagg
      601 agtcagtgca tgtggccccg agagacccag ctgctgctgg aggtgccgcc gtcgaccgaa
      661 gacgccagaa gctgccagtt ccccgaggaa gagcggggcg agcgatcggc agaggagaag
      721 gggcggctgg gagacctgtg ggtgtgagcc tggccgtcct ccggggccac cgaccgcagc
      781 cagcccctcc ccaggagctc cccaggccgc aggggctctg cgttctgctc tgggccgggc
      841 cctgctcccc tggcagcaga agtgggtgca ggaaggtggc agtgaccagc gccctggacc
      901 atgcagttcg gcggccgcgg ctgggccctg caggagggag agagagacac agtcatggcc
      961 cccttcctcc cttgctggcc ctgatggggt ggggtcttag gacgggaggc tgtgtccgtg
     1021 ggtgtgcagt gcccagcacg ggacccggct gcaggggacc ttcaataaac acttgtccag
     1081 tga
//
