LOCUS       NM_001192                891 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.
ACCESSION   NM_001192
VERSION     NM_001192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 891)
  AUTHORS   Tryggestad,S.S., Roseth,I.A., Aass,K.R., Orning,N.E.H., Mjelle,R.,
            Hella,H. and Standal,T.
  TITLE     Toll-like receptor signaling in multiple myeloma cells promotes the
            expression of pro-survival genes B-cell lymphoma 2 and MYC and
            modulates the expression of B-cell maturation antigen
  JOURNAL   Front Immunol 15, 1393906 (2024)
   PUBMED   38911853
  REMARK    GeneRIF: Toll-like receptor signaling in multiple myeloma cells
            promotes the expression of pro-survival genes B-cell lymphoma 2 and
            MYC and modulates the expression of B-cell maturation antigen.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 891)
  AUTHORS   Lu,Q., Li,H., Wu,Z., Zhu,Z., Zhang,Z., Yang,D. and Tong,A.
  TITLE     BCMA/CD47-directed universal CAR-T cells exhibit excellent
            antitumor activity in multiple myeloma
  JOURNAL   J Nanobiotechnology 22 (1), 279 (2024)
   PUBMED   38783333
  REMARK    GeneRIF: BCMA/CD47-directed universal CAR-T cells exhibit excellent
            antitumor activity in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 891)
  AUTHORS   He,M., Jiang,W., Li,X., Liu,H., Ren,H. and Lin,Y.
  TITLE     25-hydroxycholesterol promotes proliferation and metastasis of lung
            adenocarcinoma cells by regulating ERbeta/TNFRSF17 axis
  JOURNAL   BMC Cancer 24 (1), 505 (2024)
   PUBMED   38649856
  REMARK    GeneRIF: 25-hydroxycholesterol promotes proliferation and
            metastasis of lung adenocarcinoma cells by regulating
            ERbeta/TNFRSF17 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 891)
  AUTHORS   Wiedemann,A., Szita,V.R., Horvath,R., Szederjesi,A., Sebo,A.,
            Toth,A.D., Masszi,T. and Varga,G.
  TITLE     Soluble B-cell maturation antigen as a monitoring marker for
            multiple myeloma
  JOURNAL   Pathol Oncol Res 29, 1611171 (2023)
   PUBMED   37188125
  REMARK    GeneRIF: Soluble B-cell maturation antigen as a monitoring marker
            for multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 891)
  AUTHORS   Sriram,H., Kunjachan,F., Khanka,T., Gawai,S., Ghogale,S.,
            Deshpande,N., Girase,K., Patil,J., Chatterjee,G., Rajpal,S.,
            Patkar,N.V., Bagal,B., Jain,H., Sengar,M., Hasan,S.K., Khattry,N.,
            Subramanian,P.G., Gujral,S. and Tembhare,P.R.
  TITLE     Expression levels and patterns of B-cell maturation antigen in
            newly diagnosed and relapsed multiple myeloma patients from Indian
            subcontinent
  JOURNAL   Cytometry B Clin Cytom 102 (6), 462-470 (2022)
   PUBMED   36346307
  REMARK    GeneRIF: Expression levels and patterns of B-cell maturation
            antigen in newly diagnosed and relapsed multiple myeloma patients
            from Indian subcontinent.
REFERENCE   6  (bases 1 to 891)
  AUTHORS   Gross,J.A., Johnston,J., Mudri,S., Enselman,R., Dillon,S.R.,
            Madden,K., Xu,W., Parrish-Novak,J., Foster,D., Lofton-Day,C.,
            Moore,M., Littau,A., Grossman,A., Haugen,H., Foley,K., Blumberg,H.,
            Harrison,K., Kindsvogel,W. and Clegg,C.H.
  TITLE     TACI and BCMA are receptors for a TNF homologue implicated in
            B-cell autoimmune disease
  JOURNAL   Nature 404 (6781), 995-999 (2000)
   PUBMED   10801128
REFERENCE   7  (bases 1 to 891)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 891)
  AUTHORS   Gras,M.P., Laabi,Y., Linares-Cruz,G., Blondel,M.O., Rigaut,J.P.,
            Brouet,J.C., Leca,G., Haguenauer-Tsapis,R. and Tsapis,A.
  TITLE     BCMAp: an integral membrane protein in the Golgi apparatus of human
            mature B lymphocytes
  JOURNAL   Int Immunol 7 (7), 1093-1106 (1995)
   PUBMED   8527407
REFERENCE   9  (bases 1 to 891)
  AUTHORS   Laabi,Y., Gras,M.P., Brouet,J.C., Berger,R., Larsen,C.J. and
            Tsapis,A.
  TITLE     The BCMA gene, preferentially expressed during B lymphoid
            maturation, is bidirectionally transcribed
  JOURNAL   Nucleic Acids Res 22 (7), 1147-1154 (1994)
   PUBMED   8165126
REFERENCE   10 (bases 1 to 891)
  AUTHORS   Laabi,Y., Gras,M.P., Carbonnel,F., Brouet,J.C., Berger,R.,
            Larsen,C.J. and Tsapis,A.
  TITLE     A new gene, BCM, on chromosome 16 is fused to the interleukin 2
            gene by a t(4;16)(q26;p13) translocation in a malignant T cell
            lymphoma
  JOURNAL   EMBO J 11 (11), 3897-3904 (1992)
   PUBMED   1396583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007216.2.
            
            On Nov 26, 2018 this sequence version replaced NM_001192.2.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is preferentially expressed
            in mature B lymphocytes, and may be important for B cell
            development and autoimmune response. This receptor has been shown
            to specifically bind to the tumor necrosis factor (ligand)
            superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to
            NF-kappaB and MAPK8/JNK activation. This receptor also binds to
            various TRAF family members, and thus may transduce signals for
            cell survival and proliferation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.304475.1, BC058291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000053243.6/ ENSP00000053243.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC007216.2         62237-62481         c
            246-392             AC007216.2         61350-61496         c
            393-891             AC007216.2         59623-60121         c
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..891
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /note="TNF receptor superfamily member 17"
                     /db_xref="GeneID:608"
                     /db_xref="HGNC:HGNC:11913"
                     /db_xref="MIM:109545"
     exon            1..245
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..670
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /note="B-cell maturation factor; B cell maturation
                     antigen; B-cell maturation protein"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 17"
                     /protein_id="NP_001183.2"
                     /db_xref="CCDS:CCDS10552.1"
                     /db_xref="GeneID:608"
                     /db_xref="HGNC:HGNC:11913"
                     /db_xref="MIM:109545"
                     /translation="MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNAS
                     VTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANI
                     DLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTK
                     TNDYCKSLPAALSATEIEKSISAR"
     exon            246..392
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /inference="alignment:Splign:2.1.0"
     exon            393..891
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /note="hexamer: ATTAAA"
     polyA_site      891
                     /gene="TNFRSF17"
                     /gene_synonym="BCM; BCMA; CD269; TNFRSF13A"
                     /note="major polyA site"
ORIGIN      
        1 attgttctca acattctagc tgctcttgct gcatttgctc tggaattctt gtagagatat
       61 tacttgtcct tccaggctgt tctttctgta gctcccttgt tttctttttg tgatcatgtt
      121 gcagatggct gggcagtgct cccaaaatga atattttgac agtttgttgc atgcttgcat
      181 accttgtcaa cttcgatgtt cttctaatac tcctcctcta acatgtcagc gttattgtaa
      241 tgcaagtgtg accaattcag tgaaaggaac gaatgcgatt ctctggacct gtttgggact
      301 gagcttaata atttctttgg cagttttcgt gctaatgttt ttgctaagga agataaactc
      361 tgaaccatta aaggacgagt ttaaaaacac aggatcaggt ctcctgggca tggctaacat
      421 tgacctggaa aagagcagga ctggtgatga aattattctt ccgagaggcc tcgagtacac
      481 ggtggaagaa tgcacctgtg aagactgcat caagagcaaa ccgaaggtcg actctgacca
      541 ttgctttcca ctcccagcta tggaggaagg cgcaaccatt cttgtcacca cgaaaacgaa
      601 tgactattgc aagagcctgc cagctgcttt gagtgctacg gagatagaga aatcaatttc
      661 tgctaggtaa ttaaccattt cgactcgagc agtgccactt taaaaatctt ttgtcagaat
      721 agatgatgtg tcagatctct ttaggatgac tgtatttttc agttgccgat acagcttttt
      781 gtcctctaac tgtggaaact ctttatgtta gatatatttc tctaggttac tgttgggagc
      841 ttaatggtag aaacttcctt ggtttcatga ttaaactctt ttttttcctg a
//
