LOCUS       NM_003820               1702 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 14 (TNFRSF14),
            transcript variant 1, mRNA.
ACCESSION   NM_003820
VERSION     NM_003820.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Guruprasad,P., Carturan,A., Zhang,Y., Cho,J.H., Kumashie,K.G.,
            Patel,R.P., Kim,K.H., Lee,J.S., Lee,Y., Kim,J.H., Chung,J.,
            Joshi,A., Cohen,I., Shestov,M., Ghilardi,G., Harris,J.,
            Pajarillo,R., Angelos,M., Lee,Y.G., Liu,S., Rodriguez,J., Wang,M.,
            Ballard,H.J., Gupta,A., Ugwuanyi,O.H., Hong,S.J.A.,
            Bochi-Layec,A.C., Sauter,C.T., Chen,L., Paruzzo,L., Kammerman,S.,
            Shestova,O., Liu,D., Vella,L.A., Schuster,S.J., Svoboda,J.,
            Porazzi,P. and Ruella,M.
  TITLE     The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
  JOURNAL   Nat Immunol 25 (6), 1020-1032 (2024)
   PUBMED   38831106
  REMARK    GeneRIF: The BTLA-HVEM axis restricts CAR T cell efficacy in
            cancer.
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Kanai,S., Fujiwara,H., Mizuno,S., Kishikawa,T., Nakatsuka,T.,
            Hamada,T., Tanaka,M., Arita,J., Nakai,Y., Isayama,H., Kasuga,M.,
            Tateishi,R., Tateishi,K., Ushiku,T., Hasegawa,K., Koike,K. and
            Fujishiro,M.
  TITLE     Increased expression of TNFRSF14 and LIGHT in biliary epithelial
            cells of patients with primary sclerosing cholangitis
  JOURNAL   Dig Liver Dis 56 (2), 305-311 (2024)
   PUBMED   37722959
  REMARK    GeneRIF: Increased expression of TNFRSF14 and LIGHT in biliary
            epithelial cells of patients with primary sclerosing cholangitis.
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Liu,Z., Li,Z., Yan,G., Lin,C., Luo,Y., Ye,Y., Zeng,X. and Yao,J.
  TITLE     MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis
            by binding HVEM and activating NF-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 121, 110494 (2023)
   PUBMED   37331297
  REMARK    GeneRIF: MIF promotes Th17 cell differentiation in Hashimoto's
            thyroiditis by binding HVEM and activating NF-kappaB signaling
            pathway.
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Del Rio,M.L., de Juan,C.Y., Roncador,G., Caleiras,E.,
            Alvarez-Esteban,R., Perez-Simon,J.A. and Rodriguez-Barbosa,J.I.
  TITLE     Genetic deletion of HVEM in a leukemia B cell line promotes a
            preferential increase of PD-1- stem cell-like T cells over PD-1+ T
            cells curbing tumor progression
  JOURNAL   Front Immunol 14, 1113858 (2023)
   PUBMED   37033927
  REMARK    GeneRIF: Genetic deletion of HVEM in a leukemia B cell line
            promotes a preferential increase of PD-1[-] stem cell-like T cells
            over PD-1[+] T cells curbing tumor progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Cheng,T.Y., Liu,Y.J., Yan,H., Xi,Y.B., Duan,L.Q., Wang,Y.,
            Zhang,T.T., Gu,Y.M., Wang,X.D., Wu,C.X. and Gao,S.
  TITLE     Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of
            Tumor Cells via ERK1/2
  JOURNAL   Cells 11 (24), 4021 (2022)
   PUBMED   36552785
  REMARK    GeneRIF: Tumor Cell-Intrinsic BTLA Receptor Inhibits the
            Proliferation of Tumor Cells via ERK1/2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Steinberg,M.W., Cheung,T.C. and Ware,C.F.
  TITLE     The signaling networks of the herpesvirus entry mediator (TNFRSF14)
            in immune regulation
  JOURNAL   Immunol Rev 244 (1), 169-187 (2011)
   PUBMED   22017438
  REMARK    Review article
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Kwon,B.S., Tan,K.B., Ni,J., Oh,K.O., Lee,Z.H., Kim,K.K., Kim,Y.J.,
            Wang,S., Gentz,R., Yu,G.L., Harrop,J., Lyn,S.D., Silverman,C.,
            Porter,T.G., Truneh,A. and Young,P.R.
  TITLE     A newly identified member of the tumor necrosis factor receptor
            superfamily with a wide tissue distribution and involvement in
            lymphocyte activation
  JOURNAL   J Biol Chem 272 (22), 14272-14276 (1997)
   PUBMED   9162061
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Marsters,S.A., Ayres,T.M., Skubatch,M., Gray,C.L., Rothe,M. and
            Ashkenazi,A.
  TITLE     Herpesvirus entry mediator, a member of the tumor necrosis factor
            receptor (TNFR) family, interacts with members of the
            TNFR-associated factor family and activates the transcription
            factors NF-kappaB and AP-1
  JOURNAL   J Biol Chem 272 (22), 14029-14032 (1997)
   PUBMED   9162022
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Hsu,H., Solovyev,I., Colombero,A., Elliott,R., Kelley,M. and
            Boyle,W.J.
  TITLE     ATAR, a novel tumor necrosis factor receptor family member, signals
            through TRAF2 and TRAF5
  JOURNAL   J Biol Chem 272 (21), 13471-13474 (1997)
   PUBMED   9153189
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Montgomery,R.I., Warner,M.S., Lum,B.J. and Spear,P.G.
  TITLE     Herpes simplex virus-1 entry into cells mediated by a novel member
            of the TNF/NGF receptor family
  JOURNAL   Cell 87 (3), 427-436 (1996)
   PUBMED   8898196
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC383433.1, U70321.1 and
            CD366981.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_003820.3.
            
            Summary: This gene encodes a member of the TNF (tumor necrosis
            factor) receptor superfamily. The encoded protein functions in
            signal transduction pathways that activate inflammatory and
            inhibitory T-cell immune response. It binds herpes simplex virus
            (HSV) viral envelope glycoprotein D (gD), mediating its entry into
            cells. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70321.1, U81232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355716.5/ ENSP00000347948.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               DC383433.1         7-350
            345-1218            U70321.1           344-1217
            1219-1702           CD366981.1         16-499              c
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1702
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /note="TNF receptor superfamily member 14"
                     /db_xref="GeneID:8764"
                     /db_xref="HGNC:HGNC:11912"
                     /db_xref="MIM:602746"
     exon            1..363
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1146
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tumor necrosis factor receptor-like gene2;
                     CD40-like protein; herpes virus entry mediator A; tumor
                     necrosis factor receptor superfamily, member 14
                     (herpesvirus entry mediator); tumor necrosis factor
                     receptor superfamily member 14"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 14 isoform 1 precursor"
                     /protein_id="NP_003811.2"
                     /db_xref="CCDS:CCDS44046.1"
                     /db_xref="GeneID:8764"
                     /db_xref="HGNC:HGNC:11912"
                     /db_xref="MIM:602746"
                     /translation="MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKE
                     DEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPA
                     MGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDT
                     LCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCST
                     VGLIICVKRRKPRGDVVKVIVSVQRKRQEAEGEATVIEALQAPPDVTTVAVEETIPSF
                     TGRSPNH"
     exon            364..472
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..598
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..754
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            755..845
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..988
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1020
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1702
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1622
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
     polyA_site      1702
                     /gene="TNFRSF14"
                     /gene_synonym="ATAR; CD270; HVEA; HVEM; LIGHTR; TR2"
                     /note="major polyA site"
ORIGIN      
        1 ataccggccc ttcccctcgg ctttgcctgg acagctcctg cctcccgcag ggcccacctg
       61 tgtcccccag cgccgctcca cccagcaggc ctgagcccct ctctgctgcc agacaccccc
      121 tgctgcccac tctcctgctg ctcgggttct gaggcacagc ttgtcacacc gaggcggatt
      181 ctctttctct ttctctttct cttctggccc acagccgcag caatggcgct gagttcctct
      241 gctggagttc atcctgctag ctgggttccc gagctgccgg tctgagcctg aggcatggag
      301 cctcctggag actgggggcc tcctccctgg agatccaccc ccaaaaccga cgtcttgagg
      361 ctggtgctgt atctcacctt cctgggagcc ccctgctacg ccccagctct gccgtcctgc
      421 aaggaggacg agtacccagt gggctccgag tgctgcccca agtgcagtcc aggttatcgt
      481 gtgaaggagg cctgcgggga gctgacgggc acagtgtgtg aaccctgccc tccaggcacc
      541 tacattgccc acctcaatgg cctaagcaag tgtctgcagt gccaaatgtg tgacccagcc
      601 atgggcctgc gcgcgagccg gaactgctcc aggacagaga acgccgtgtg tggctgcagc
      661 ccaggccact tctgcatcgt ccaggacggg gaccactgcg ccgcgtgccg cgcttacgcc
      721 acctccagcc cgggccagag ggtgcagaag ggaggcaccg agagtcagga caccctgtgt
      781 cagaactgcc ccccggggac cttctctccc aatgggaccc tggaggaatg tcagcaccag
      841 accaagtgca gctggctggt gacgaaggcc ggagctggga ccagcagctc ccactgggta
      901 tggtggtttc tctcagggag cctcgtcatc gtcattgttt gctccacagt tggcctaatc
      961 atatgtgtga aaagaagaaa gccaaggggt gatgtagtca aggtgatcgt ctccgtccag
     1021 cggaaaagac aggaggcaga aggtgaggcc acagtcattg aggccctgca ggcccctccg
     1081 gacgtcacca cggtggccgt ggaggagaca ataccctcat tcacggggag gagcccaaac
     1141 cactgaccca cagactctgc accccgacgc cagagatacc tggagcgacg gctgctgaaa
     1201 gaggctgtcc acctggcgga accaccggag cccggaggct tgggggctcc gccctgggct
     1261 ggcttccgtc tcctccagtg gagggagagg tggggcccct gctggggtag agctggggac
     1321 gccacgtgcc attcccatgg gccagtgagg gcctggggcc tctgttctgc tgtggcctga
     1381 gctccccaga gtcctgagga ggagcgccag ttgcccctcg ctcacagacc acacacccag
     1441 ccctcctggg ccagcccaga gggcccttca gaccccagct gtctgcgcgt ctgactcttg
     1501 tggcctcagc aggacaggcc ccgggcactg cctcacagcc aaggctggac tgggttggct
     1561 gcagtgtggt gtttagtgga taccacatcg gaagtgattt tctaaattgg atttgaattc
     1621 ggctcctgtt ttctatttgt catgaaacag tgtatttggg gagatgctgt gggaggatgt
     1681 aaatatcttg tttctcctca aa
//
