LOCUS       NM_052945               3923 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 13C (TNFRSF13C), mRNA.
ACCESSION   NM_052945
VERSION     NM_052945.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Sagrero-Fabela,N., Ortiz-Lazareno,P.C., Salazar-Camarena,D.C.,
            Cruz,A., Cerpa-Cruz,S., Munoz-Valle,J.F., Marin-Rosales,M.,
            Alvarez-Gomez,J.A. and Palafox-Sanchez,C.A.
  TITLE     BAFFR expression in circulating T follicular helper
            (CD4+CXCR5+PD-1+) and T peripheral helper (CD4+CXCR5-PD-1+) cells
            in systemic lupus erythematosus
  JOURNAL   Lupus 32 (9), 1093-1104 (2023)
   PUBMED   37460408
  REMARK    GeneRIF: BAFFR expression in circulating T follicular helper
            (CD4[+]CXCR5[+]PD-1[+]) and T peripheral helper
            (CD4[+]CXCR5[-]PD-1[+]) cells in systemic lupus erythematosus.
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Shimojima,Y., Kishida,D., Ichikawa,T., Takamatsu,R., Nomura,S. and
            Sekijima,Y.
  TITLE     Features of BAFF and APRIL receptors on circulating B cells in
            antineutrophil cytoplasmic antibody-associated vasculitis
  JOURNAL   Clin Exp Immunol 213 (1), 125-137 (2023)
   PUBMED   36794867
  REMARK    GeneRIF: Features of BAFF and APRIL receptors on circulating B
            cells in antineutrophil cytoplasmic antibody-associated vasculitis.
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Block,V., Sevdali,E., Recher,M., Abolhassani,H., Hammarstrom,L.,
            Smulski,C.R., Baronio,M., Plebani,A., Proietti,M., Speletas,M.,
            Warnatz,K., Voll,R.E., Lougaris,V., Schneider,P. and Eibel,H.
  TITLE     CVID-Associated B Cell Activating Factor Receptor Variants Change
            Receptor Oligomerization, Ligand Binding, and Signaling Responses
  JOURNAL   J Clin Immunol 43 (2), 391-405 (2023)
   PUBMED   36308663
  REMARK    GeneRIF: CVID-Associated B Cell Activating Factor Receptor Variants
            Change Receptor Oligomerization, Ligand Binding, and Signaling
            Responses.
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Sevdali,E., Block,V., Lataretu,M., Li,H., Smulski,C.R., Briem,J.S.,
            Heitz,Y., Fischer,B., Ramirez,N.J., Grimbacher,B., Jack,H.M.,
            Voll,R.E., Holzer,M., Schneider,P. and Eibel,H.
  TITLE     BAFFR activates PI3K/AKT signaling in human naive but not in
            switched memory B cells through direct interactions with B cell
            antigen receptors
  JOURNAL   Cell Rep 39 (13), 111019 (2022)
   PUBMED   35767961
  REMARK    GeneRIF: BAFFR activates PI3K/AKT signaling in human naive but not
            in switched memory B cells through direct interactions with B cell
            antigen receptors.
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Neys,S.F.H., Verstappen,G.M., Bootsma,H., Kroese,F.G.M.,
            Hendriks,R.W. and Corneth,O.B.J.
  TITLE     Decreased BAFF Receptor Expression and Unaltered B Cell Receptor
            Signaling in Circulating B Cells from Primary Sjogren's Syndrome
            Patients at Diagnosis
  JOURNAL   Int J Mol Sci 23 (9), 5101 (2022)
   PUBMED   35563492
  REMARK    GeneRIF: Decreased BAFF Receptor Expression and Unaltered B Cell
            Receptor Signaling in Circulating B Cells from Primary Sjogren's
            Syndrome Patients at Diagnosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Rolink,A.G. and Melchers,F.
  TITLE     BAFFled B cells survive and thrive: roles of BAFF in B-cell
            development
  JOURNAL   Curr Opin Immunol 14 (2), 266-275 (2002)
   PUBMED   11869903
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Laabi,Y., Egle,A. and Strasser,A.
  TITLE     TNF cytokine family: more BAFF-ling complexities
  JOURNAL   Curr Biol 11 (24), R1013-R1016 (2001)
   PUBMED   11747837
  REMARK    Review article
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Yan,M., Brady,J.R., Chan,B., Lee,W.P., Hsu,B., Harless,S.,
            Cancro,M., Grewal,I.S. and Dixit,V.M.
  TITLE     Identification of a novel receptor for B lymphocyte stimulator that
            is mutated in a mouse strain with severe B cell deficiency
  JOURNAL   Curr Biol 11 (19), 1547-1552 (2001)
   PUBMED   11591325
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Thompson,J.S., Bixler,S.A., Qian,F., Vora,K., Scott,M.L.,
            Cachero,T.G., Hession,C., Schneider,P., Sizing,I.D., Mullen,C.,
            Strauch,K., Zafari,M., Benjamin,C.D., Tschopp,J., Browning,J.L. and
            Ambrose,C.
  TITLE     BAFF-R, a newly identified TNF receptor that specifically interacts
            with BAFF
  JOURNAL   Science 293 (5537), 2108-2111 (2001)
   PUBMED   11509692
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Schneider,P., MacKay,F., Steiner,V., Hofmann,K., Bodmer,J.L.,
            Holler,N., Ambrose,C., Lawton,P., Bixler,S., Acha-Orbea,H.,
            Valmori,D., Romero,P., Werner-Favre,C., Zubler,R.H., Browning,J.L.
            and Tschopp,J.
  TITLE     BAFF, a novel ligand of the tumor necrosis factor family,
            stimulates B cell growth
  JOURNAL   J Exp Med 189 (11), 1747-1756 (1999)
   PUBMED   10359578
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z99716.4.
            
            On Feb 4, 2020 this sequence version replaced NM_052945.3.
            
            Summary: B cell-activating factor (BAFF) enhances B-cell survival
            in vitro and is a regulator of the peripheral B-cell population.
            Overexpression of Baff in mice results in mature B-cell hyperplasia
            and symptoms of systemic lupus erythematosus (SLE). Also, some SLE
            patients have increased levels of BAFF in serum. Therefore, it has
            been proposed that abnormally high levels of BAFF may contribute to
            the pathogenesis of autoimmune diseases by enhancing the survival
            of autoreactive B cells. The protein encoded by this gene is a
            receptor for BAFF and is a type III transmembrane protein
            containing a single extracellular cysteine-rich domain. It is
            thought that this receptor is the principal receptor required for
            BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF373846.1, BC105123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291232.5/ ENSP00000291232.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               Z99716.4           69878-70046         c
            170-400             Z99716.4           69341-69571         c
            401-3923            Z99716.4           65272-68794         c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3923
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /note="TNF receptor superfamily member 13C"
                     /db_xref="GeneID:115650"
                     /db_xref="HGNC:HGNC:17755"
                     /db_xref="MIM:606269"
     exon            1..169
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..588
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /note="BAFF receptor; B cell-activating factor receptor;
                     BLyS receptor 3"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 13C"
                     /protein_id="NP_443177.1"
                     /db_xref="CCDS:CCDS14024.1"
                     /db_xref="GeneID:115650"
                     /db_xref="HGNC:HGNC:17755"
                     /db_xref="MIM:606269"
                     /translation="MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPK
                     PAGASSPAPRTALQPQESVGAGAGEAALPLPGLLFGAPALLGLALVLALVLVGLVSWR
                     RRQRRLRGASSAEAPDGDKDAPEPLDKVIILSPGISDATAPAWPPPGEDPGTTPPGHS
                     VPVPATELGSTELVTTKTAGPEQQ"
     exon            170..400
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /inference="alignment:Splign:2.1.0"
     exon            401..3923
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3842
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /note="major polyA site"
     polyA_site      3862
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
     regulatory      3902..3907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /note="hexamer: AATAAA"
     polyA_site      3923
                     /gene="TNFRSF13C"
                     /gene_synonym="BAFF-R; BAFFR; BROMIX; CD268; CVID4;
                     prolixin"
                     /note="major polyA site"
ORIGIN      
        1 agtccccgca gcttgtgcgg cggcgtcggc accatgaggc gagggccccg gagcctgcgg
       61 ggcagggacg cgccagcccc cacgccctgc gtcccggccg agtgcttcga cctgctggtc
      121 cgccactgcg tggcctgcgg gctcctgcgc acgccgcggc cgaaaccggc cggggccagc
      181 agccctgcgc ccaggacggc gctgcagccg caggagtcgg tgggcgcggg ggccggcgag
      241 gcggcgctgc ccctgcccgg gctgctcttt ggcgcccccg cgctgctggg cctggcactg
      301 gtcctggcgc tggtcctggt gggtctggtg agctggaggc ggcgacagcg gcggcttcgc
      361 ggcgcgtcct ccgcagaggc ccccgacgga gacaaggacg ccccagagcc cctggacaag
      421 gtcatcattc tgtctccggg aatctctgat gccacagctc ctgcctggcc tcctcctggg
      481 gaagacccag gaaccacccc acctggccac agtgtccctg tgccagccac agagctgggc
      541 tccactgaac tggtgaccac caagacggcc ggccctgagc aacaatagca gggagccggc
      601 aggaggtggc ccctgccctc cctctggacc cccagccagg ggcttggaaa tcaaattcag
      661 ctcttcactc cagcatgcac atgccctctt tctgggacca ggctaactct gcagaagcac
      721 agacactaca gaccacagca ttcagccccc atggagtttg gtgtgcttgc ctttggcttc
      781 agacctcacc atctttgaca gcccttgaag gtggtagccc agctcctgtt cctgtgcctt
      841 caaaaggctg gggcactatg agtaaaagac cgcttttaaa atggggaagg caccattaag
      901 ccaaaatgaa tctgaaaaaa gaccaagtgg gaggatgcct aatttgtagt tgggtggttt
      961 tttgtgtttg tttgattttt tttttttttt tttttttttt tttttgagac gagtcttgct
     1021 ctgtcgccag gctggagtac agtggcgcga tctcgcctca ctgtaacctc cgactccttg
     1081 gttcaagtga ttctcctgcc tcagcctccc gaatagctgg gattacaggc acgcaccacc
     1141 acagccagct aatttttgta tttttagtag agacgggatt tcaccatgtt ggccaggatg
     1201 gtctcgatct cctgacctcg tgatccgccc tgctcggcct cccaaagtgc tgggattaca
     1261 ggcatgagcc accatgcccg gccttgtttt gtgttttggt tttttttgag acagggtctt
     1321 gctgtatcac gcaggctgga gtgcaacgat gggtccccag ctaattgcag cctgggctca
     1381 agcaatcttt ctgcttcagc ctcctgagta ggtgggacta caggtgctcc accttgccca
     1441 gctaattttt tttttttttt tttttttgag acagagtctc gctctgtcgc ctaggctgga
     1501 gtgcagtgac gcaatttcgg ctcacttcaa gctccgcctc ctgggttcac accattctcc
     1561 tgcctgagcc tcctgagtag ctgggactat aggcgcccgc catcacgccc ggctaatttt
     1621 ttttgtattt ttagtagaga cggggtgtca ccgtattagc caggatggtc tcgatctcct
     1681 gacctcgtga tccgcccgcc tcagcctccc aaagtgctag gattacaggc gtgagccacc
     1741 gtggctggcc tttttttttt tttaaagaca gggtctcggt atgttgccca ggccagtctc
     1801 aaactcctgg cctcaggcag tcctccccga agggctggga ttataggcag gaggcgccgg
     1861 gcctggcctc tatttcttta atacctgccc tcagagccgt cctgctttta aactgatgca
     1921 aatggcagca gtgaataatc aattcatggg ttcgcttgct ttgggattta gtacaagatt
     1981 attttaagaa ataacaaagg agaaaagatt gagctggatt ttgctgattc tcaggtatct
     2041 gtaccccagg gtcaaccctg agattggccc aatctgccag aacctaagat gccattttga
     2101 ccccagtggc agcttccaga gccacaagcc tgcatttggg aggaggtgcg cagcctccag
     2161 ggctggactc caaactcgag ctgaaggaac atgctggcag gtagctctct cagggtccac
     2221 ctggggttcc agctgctcca agacacagca catttagcca taaacatgga agggctggga
     2281 cctacaggag gctcctttgt gtagaggcca gggcaggcgt gtgaccttga accaggtgga
     2341 catgaggtcc cttgaactcc cttctctctc tggcttgttc ccctgaagca ctggcccccc
     2401 agtgctgggc ttatttggcc atcctgtgcc agccccctgg tcacccaccg tcacagtgga
     2461 agctgctccc tcctcttaca atggtgttcc ttgctctggg gtctggggac aagaccatct
     2521 ctttccactc ctggacgaca ctgtgcactc agtcagccgc ctcctacctg ccctcctgca
     2581 cagggtcaga acctcctgac ctggacttcg ccctgggcag cttccttgga acttgttgca
     2641 gcttagcatc tttggaaggg agcactggac taggagtcag aaggtggagt tctgggtgct
     2701 gttttcccac tcttgggccc tgggcatgtt ctgttctgtg catcagatgt tttctgcctg
     2761 cctccccctg agctgccacc agagccacct gtagacccct gcttctcctg cccctcctgt
     2821 cccttgccag gcctctggac tcagtgcttc ctgtcccaag gacctgttgt gtgcccagct
     2881 tggaagacag tggccactca catccaggtc tctgcctggc tatttgctcc atgaacccat
     2941 ctcagatgcc cctgccccca gggagccagg tgacagggtg aggtcaagtg acaagcagta
     3001 ggtgtgggag aggtttggtg gggtcaggcc cacatgggcc cagccatcca ctccccttcc
     3061 atctggagtt gggggagtct gagctgctcc tggccacccc atctgcccca ccccatcttt
     3121 tcctggccac cccagctccc accccatctt ctcctggcca ccccatctcc caccccatct
     3181 tctcttgaca ccccatctcc caccccatct tctcctggcc accccatctc ccaccccatc
     3241 ttctcctggc caccccatct tctcctggcc accccatctc ccccacccca tcttctcctg
     3301 gacaccccca tctcccaccc catcttttgc tacagccagg gttagctcag caggtgaaaa
     3361 ccccgagggt gggtgaaacc cctctggggc tcagacatgc aaaccttggg catctctctg
     3421 tcccagctgg ccccgccagc cggtaggaag tttcccctga gttctcagtt ttttcttctg
     3481 aaaaatgagg ggttgtatgc aaggttctcc tcctggcctg tggtccccag agaagggcag
     3541 gaaggaacct tagataattc tcatatgcat ttaacagacg aggaaactga gacccagagc
     3601 cgtcacatca atacctcatt tgatcttcat aagagcacct ggaggagggg ggtggggtgt
     3661 ttgtgtttgt ttaaattttt ttttgtgaaa aaaatgaaga taggcatttt gtagacaatc
     3721 tggaagttct ggaccggaat ccatgatgta gtcagggaag aaatgacccg tgtccagtaa
     3781 ccccaggcct cgagtgtgtg gtgtattttt ctacataatt gtaatcattc tatacataca
     3841 aattcatgtc ttgaccatca tattaatatt tggtaagttt ctctctcttt agagactcca
     3901 caataaagtt ttcaacatgg taa
//
