LOCUS       NM_012452               1391 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.
ACCESSION   NM_012452
VERSION     NM_012452.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Cumbo,C., Orsini,P., Tarantini,F., Anelli,L., Zagaria,A.,
            Tragni,V., Coccaro,N., Tota,G., Parciante,E., Conserva,M.R.,
            Redavid,I., Minervini,C.F., Minervini,A., Attolico,I., Gentile,M.,
            Pierri,C.L., Specchia,G., Musto,P. and Albano,F.
  TITLE     TNFRSF13B gene mutation in familial acute myeloid leukemia: A new
            piece in the complex scenario of hereditary predisposition?
  JOURNAL   Hematol Oncol 41 (5), 942-946 (2023)
   PUBMED   37534633
  REMARK    GeneRIF: TNFRSF13B gene mutation in familial acute myeloid
            leukemia: A new piece in the complex scenario of hereditary
            predisposition?
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   Fichtner,M.L., Rubsamen,H., Smolle,M., Schaller,J., Feederle,R.,
            Bultmann,A., Kumpfel,T., Schneider,P., Thaler,F.S. and Meinl,E.
  TITLE     Features of Isoforms of Human Soluble TACI
  JOURNAL   J Immunol 211 (2), 199-208 (2023)
   PUBMED   37272840
  REMARK    GeneRIF: Features of Isoforms of Human Soluble TACI.
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Tsiouma,G.K., Skoulakis,C.E., Lachanas,V.A., Sevdali,E.G.,
            Tsinti,G.N., Florou,Z.A., Petinaki,E.A. and Speletas,M.G.
  TITLE     TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis
            with Nasal Polyps
  JOURNAL   Am J Rhinol Allergy 37 (1), 74-77 (2023)
   PUBMED   36305039
  REMARK    GeneRIF: TNFRSF13B/TACI Mutations in Patients with Chronic
            Rhinosinusitis with Nasal Polyps.
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Fioredda,F., Beccaria,A., Turrini,E., Casartelli,P., Coviello,D.,
            Maffei,M., Lanciotti,M., Lupia,M., Terranova,P., Grossi,A.,
            Ceccherini,I., Miano,M. and Dufour,C.
  TITLE     TACI variants as underlying condition in autoimmune neutropenia:
            Description of four cases
  JOURNAL   Am J Hematol 97 (9), E328-E331 (2022)
   PUBMED   35686370
  REMARK    GeneRIF: TACI variants as underlying condition in autoimmune
            neutropenia: Description of four cases.
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Wong,D.P., Roy,N.K., Zhang,K., Anukanth,A., Asthana,A.,
            Shirkey-Son,N.J., Dunmire,S., Jones,B.J., Lahr,W.S., Webber,B.R.,
            Moriarity,B.S., Caimi,P. and Parameswaran,R.
  TITLE     A BAFF ligand-based CAR-T cell targeting three receptors and
            multiple B cell cancers
  JOURNAL   Nat Commun 13 (1), 217 (2022)
   PUBMED   35017485
  REMARK    GeneRIF: A BAFF ligand-based CAR-T cell targeting three receptors
            and multiple B cell cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1391)
  AUTHORS   Xia,X.Z., Treanor,J., Senaldi,G., Khare,S.D., Boone,T., Kelley,M.,
            Theill,L.E., Colombero,A., Solovyev,I., Lee,F., McCabe,S.,
            Elliott,R., Miner,K., Hawkins,N., Guo,J., Stolina,M., Yu,G.,
            Wang,J., Delaney,J., Meng,S.Y., Boyle,W.J. and Hsu,H.
  TITLE     TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis
            factor family member involved in B cell regulation
  JOURNAL   J Exp Med 192 (1), 137-143 (2000)
   PUBMED   10880535
REFERENCE   7  (bases 1 to 1391)
  AUTHORS   Yan,M., Marsters,S.A., Grewal,I.S., Wang,H., Ashkenazi,A. and
            Dixit,V.M.
  TITLE     Identification of a receptor for BLyS demonstrates a crucial role
            in humoral immunity
  JOURNAL   Nat Immunol 1 (1), 37-41 (2000)
   PUBMED   10881172
REFERENCE   8  (bases 1 to 1391)
  AUTHORS   Marsters,S.A., Yan,M., Pitti,R.M., Haas,P.E., Dixit,V.M. and
            Ashkenazi,A.
  TITLE     Interaction of the TNF homologues BLyS and APRIL with the TNF
            receptor homologues BCMA and TACI
  JOURNAL   Curr Biol 10 (13), 785-788 (2000)
   PUBMED   10898980
REFERENCE   9  (bases 1 to 1391)
  AUTHORS   Gross,J.A., Johnston,J., Mudri,S., Enselman,R., Dillon,S.R.,
            Madden,K., Xu,W., Parrish-Novak,J., Foster,D., Lofton-Day,C.,
            Moore,M., Littau,A., Grossman,A., Haugen,H., Foley,K., Blumberg,H.,
            Harrison,K., Kindsvogel,W. and Clegg,C.H.
  TITLE     TACI and BCMA are receptors for a TNF homologue implicated in
            B-cell autoimmune disease
  JOURNAL   Nature 404 (6781), 995-999 (2000)
   PUBMED   10801128
REFERENCE   10 (bases 1 to 1391)
  AUTHORS   von Bulow,G.U. and Bram,R.J.
  TITLE     NF-AT activation induced by a CAML-interacting member of the tumor
            necrosis factor receptor superfamily
  JOURNAL   Science 278 (5335), 138-141 (1997)
   PUBMED   9311921
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104024.8 and AL353996.3.
            
            On Aug 31, 2019 this sequence version replaced NM_012452.2.
            
            Summary: The protein encoded by this gene is a lymphocyte-specific
            member of the tumor necrosis factor (TNF) receptor superfamily. It
            interacts with calcium-modulator and cyclophilin ligand (CAML). The
            protein induces activation of the transcription factors NFAT, AP1,
            and NF-kappa-B and plays a crucial role in humoral immunity by
            interacting with a TNF ligand. This gene is located within the
            Smith-Magenis syndrome region on chromosome 17. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF023614.1, AK223453.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261652.7/ ENSP00000261652.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC104024.8         70370-70473
            105-242             AC104024.8         89905-90042
            243-488             AL353996.3         2686-2931
            489-674             AL353996.3         11158-11343
            675-1391            AL353996.3         11872-12588
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1391
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /note="TNF receptor superfamily member 13B"
                     /db_xref="GeneID:23495"
                     /db_xref="HGNC:HGNC:18153"
                     /db_xref="MIM:604907"
     exon            1..104
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..925
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /note="transmembrane activator and CAML interactor; tumor
                     necrosis factor receptor 13B"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 13B"
                     /protein_id="NP_036584.1"
                     /db_xref="CCDS:CCDS11181.1"
                     /db_xref="GeneID:23495"
                     /db_xref="HGNC:HGNC:18153"
                     /db_xref="MIM:604907"
                     /translation="MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLL
                     GTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAY
                     FCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQV
                     ALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGS
                     PVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPD
                     SGLGIVCVPAQEGGPGA"
     exon            105..242
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /inference="alignment:Splign:2.1.0"
     exon            243..488
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /inference="alignment:Splign:2.1.0"
     exon            489..674
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1391
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1146
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
     regulatory      1359..1364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /note="hexamer: AATAAA"
     polyA_site      1391
                     /gene="TNFRSF13B"
                     /gene_synonym="CD267; CVID; CVID2; IGAD2; RYZN; TACI;
                     TNFRSF14B"
                     /note="major polyA site"
ORIGIN      
        1 aagcactaat caaatctaag actagtaata agcatcctga gtaatgagtg gcctgggccg
       61 gagcaggcga ggtggccgga gccgtgtgga ccaggaggag cgctttccac agggcctgtg
      121 gacgggggtg gctatgagat cctgccccga agagcagtac tgggatcctc tgctgggtac
      181 ctgcatgtcc tgcaaaacca tttgcaacca tcagagccag cgcacctgtg cagccttctg
      241 caggtcactc agctgccgca aggagcaagg caagttctat gaccatctcc tgagggactg
      301 catcagctgt gcctccatct gtggacagca ccctaagcaa tgtgcatact tctgtgagaa
      361 caagctcagg agcccagtga accttccacc agagctcagg agacagcgga gtggagaagt
      421 tgaaaacaat tcagacaact cgggaaggta ccaaggattg gagcacagag gctcagaagc
      481 aagtccagct ctcccggggc tgaagctgag tgcagatcag gtggccctgg tctacagcac
      541 gctggggctc tgcctgtgtg ccgtcctctg ctgcttcctg gtggcggtgg cctgcttcct
      601 caagaagagg ggggatccct gctcctgcca gccccgctca aggccccgtc aaagtccggc
      661 caagtcttcc caggatcacg cgatggaagc cggcagccct gtgagcacat cccccgagcc
      721 agtggagacc tgcagcttct gcttccctga gtgcagggcg cccacgcagg agagcgcagt
      781 cacgcctggg acccccgacc ccacttgtgc tggaaggtgg gggtgccaca ccaggaccac
      841 agtcctgcag ccttgcccac acatcccaga cagtggcctt ggcattgtgt gtgtgcctgc
      901 ccaggagggg ggcccaggtg cataaatggg ggtcagggag ggaaaggagg agggagagag
      961 atggagagga ggggagagag aaagagaggt ggggagaggg gagagagata tgaggagaga
     1021 gagacagagg aggcagagag ggagagaaac agaggagaca gagagggaga gagagacaga
     1081 gggagagaga gacagagggg aagagaggca gagagggaaa gaggcagaga aggaaagaga
     1141 caggcagaga aggagagagg cagagaggga gagaggcaga gagggagaga ggcagagaga
     1201 cagagaggga gagagggaca gagagagata gagcaggagg tcggggcact ctgagtccca
     1261 gttcccagtg cagctgtagg tcgtcatcac ctaaccacac gtgcaataaa gtcctcgtgc
     1321 ctgctgctca cagcccccga gagcccctcc tcctggagaa taaaaccttt ggcagctgcc
     1381 cttcctcact g
//
