LOCUS       NM_016639                977 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TNF receptor superfamily member 12A (TNFRSF12A), mRNA.
ACCESSION   NM_016639
VERSION     NM_016639.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Zhao,M., Liu,A., Wu,J., Mo,L., Lu,F. and Wan,G.
  TITLE     Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of
            ischemic stroke via bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 103 (4), e36109 (2024)
   PUBMED   38277520
  REMARK    GeneRIF: Il1r2 and Tnfrsf12a in transcranial magnetic stimulation
            effect of ischemic stroke via bioinformatics analysis.
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Yang,M., Ge,H., Ji,S., Li,Y., Xu,L., Bi,Z. and Bu,B.
  TITLE     TWEAK and Fn14 are overexpressed in immune-mediated necrotizing
            myopathy: implications for muscle damage and repair
  JOURNAL   Rheumatology (Oxford) 62 (11), 3732-3741 (2023)
   PUBMED   36916753
  REMARK    GeneRIF: TWEAK and Fn14 are overexpressed in immune-mediated
            necrotizing myopathy: implications for muscle damage and repair.
            Erratum:[Rheumatology (Oxford). 2023 Nov 2;62(11):3770. doi:
            10.1093/rheumatology/kead200.. PMID: 37167527]
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Ruiz,B.I., Lowman,X.H., Yang,Y., Fan,Q., Wang,T., Wu,H., Hanse,E.A.
            and Kong,M.
  TITLE     Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone
            Modification and Prevents Cancer-Induced Cachexia
  JOURNAL   Genes (Basel) 14 (9), 1818 (2023)
   PUBMED   37761958
  REMARK    GeneRIF: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression
            via Histone Modification and Prevents Cancer-Induced Cachexia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Gu,J.J., Deng,C.C., Feng,Q.L., Liu,J., Zhu,D.H., Cheng,Q., Rong,Z.
            and Yang,B.
  TITLE     Relief of Extracellular Matrix Deposition Repression by
            Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids
  JOURNAL   J Invest Dermatol 143 (7), 1208-1219 (2023)
   PUBMED   36716919
  REMARK    GeneRIF: Relief of Extracellular Matrix Deposition Repression by
            Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids.
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Liang,T., Wu,X., Wang,L., Ni,Z., Fan,Y., Wu,P., Wang,H., Niu,Y. and
            Huang,H.
  TITLE     Clinical significance and diagnostic value of QPCT, SCEL and
            TNFRSF12A in papillary thyroid cancer
  JOURNAL   Pathol Res Pract 245, 154431 (2023)
   PUBMED   37060824
  REMARK    GeneRIF: Clinical significance and diagnostic value of QPCT, SCEL
            and TNFRSF12A in papillary thyroid cancer.
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Nakayama,M., Ishidoh,K., Kojima,Y., Harada,N., Kominami,E.,
            Okumura,K. and Yagita,H.
  TITLE     Fibroblast growth factor-inducible 14 mediates multiple pathways of
            TWEAK-induced cell death
  JOURNAL   J Immunol 170 (1), 341-348 (2003)
   PUBMED   12496418
  REMARK    GeneRIF: FN14 is the sole mediator of the multiple pathways of
            TWEAK-induced cell death in all TWEAK-sensitive tumor cell lines.
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Harada,N., Nakayama,M., Nakano,H., Fukuchi,Y., Yagita,H. and
            Okumura,K.
  TITLE     Pro-inflammatory effect of TWEAK/Fn14 interaction on human
            umbilical vein endothelial cells
  JOURNAL   Biochem Biophys Res Commun 299 (3), 488-493 (2002)
   PUBMED   12445828
  REMARK    GeneRIF: These results indicated that TWEAK could induce
            pro-inflammatory reactions via fibroblast growth factor-inducible
            14 (Fn14)on human umbilical vein endothelial cells.
REFERENCE   8  (bases 1 to 977)
  AUTHORS   Wiley,S.R., Cassiano,L., Lofton,T., Davis-Smith,T., Winkles,J.A.,
            Lindner,V., Liu,H., Daniel,T.O., Smith,C.A. and Fanslow,W.C.
  TITLE     A novel TNF receptor family member binds TWEAK and is implicated in
            angiogenesis
  JOURNAL   Immunity 15 (5), 837-846 (2001)
   PUBMED   11728344
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Feng,S.L., Guo,Y., Factor,V.M., Thorgeirsson,S.S., Bell,D.W.,
            Testa,J.R., Peifley,K.A. and Winkles,J.A.
  TITLE     The Fn14 immediate-early response gene is induced during liver
            regeneration and highly expressed in both human and murine
            hepatocellular carcinomas
  JOURNAL   Am J Pathol 156 (4), 1253-1261 (2000)
   PUBMED   10751351
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Meighan-Mantha,R.L., Hsu,D.K., Guo,Y., Brown,S.A., Feng,S.L.,
            Peifley,K.A., Alberts,G.F., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Richards,C.M. and Winkles,J.A.
  TITLE     The mitogen-inducible Fn14 gene encodes a type I transmembrane
            protein that modulates fibroblast adhesion and migration
  JOURNAL   J Biol Chem 274 (46), 33166-33176 (1999)
   PUBMED   10551889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC002718.2.
            
            On Jun 2, 2019 this sequence version replaced NM_016639.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002718.2, AF191148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326577.9/ ENSP00000326737.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-977               BC002718.2         28-1004
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..977
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /note="TNF receptor superfamily member 12A"
                     /db_xref="GeneID:51330"
                     /db_xref="HGNC:HGNC:18152"
                     /db_xref="MIM:605914"
     exon            1..124
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..420
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /note="type I transmembrane protein Fn14; tweak-receptor;
                     FGF-inducible 14; fibroblast growth factor-inducible
                     immediate-early response protein 14; tumor necrosis factor
                     receptor superfamily member 12A"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 12A precursor"
                     /protein_id="NP_057723.1"
                     /db_xref="CCDS:CCDS10489.1"
                     /db_xref="GeneID:51330"
                     /db_xref="HGNC:HGNC:18152"
                     /db_xref="MIM:605914"
                     /translation="MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSA
                     DLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWR
                     RCRRREKFTTPIEETGGEGCPAVALIQ"
     exon            125..229
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /inference="alignment:Splign:2.1.0"
     exon            230..364
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /inference="alignment:Splign:2.1.0"
     exon            365..977
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      954..959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="TNFRSF12A"
                     /gene_synonym="CD266; FN14; TWEAKR"
                     /note="major polyA site"
ORIGIN      
        1 gcagacagcg gcgggcgcag gacgtgcact atggctcggg gctcgctgcg ccggttgctg
       61 cggctcctcg tgctggggct ctggctggcg ttgctgcgct ccgtggccgg ggagcaagcg
      121 ccaggcaccg ccccctgctc ccgcggcagc tcctggagcg cggacctgga caagtgcatg
      181 gactgcgcgt cttgcagggc gcgaccgcac agcgacttct gcctgggctg cgctgcagca
      241 cctcctgccc ccttccggct gctttggccc atccttgggg gcgctctgag cctgaccttc
      301 gtgctggggc tgctttctgg ctttttggtc tggagacgat gccgcaggag agagaagttc
      361 accaccccca tagaggagac cggcggagag ggctgcccag ctgtggcgct gatccagtga
      421 caatgtgccc cctgccagcc ggggctcgcc cactcatcat tcattcatcc attctagagc
      481 cagtctctgc ctcccagacg cggcgggagc caagctcctc caaccacaag gggggtgggg
      541 ggcggtgaat cacctctgag gcctgggccc agggttcagg ggaaccttcc aaggtgtctg
      601 gttgccctgc ctctggctcc agaacagaaa gggagcctca cgctggctca cacaaaacag
      661 ctgacactga ctaaggaact gcagcatttg cacaggggag gggggtgccc tccttcctag
      721 aggccctggg ggccaggctg acttgggggg cagacttgac actaggcccc actcactcag
      781 atgtcctgaa attccaccac gggggtcacc ctggggggtt agggacctat ttttaacact
      841 agggggctgg cccactagga gggctggccc taagatacag acccccccaa ctccccaaag
      901 cggggaggag atatttattt tggggagagt ttggagggga gggagaattt attaataaaa
      961 gaatctttaa ctttaaa
//
