LOCUS       NM_002546               2087 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 11b (TNFRSF11B), mRNA.
ACCESSION   NM_002546
VERSION     NM_002546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Lyu,Z., Chan,Y.T., Lu,Y., Fung Lam,T., Wu,X., Wu,J., Xu,L.,
            Yang,W., Zhang,C., Lidan Zhong,L. and Wang,N.
  TITLE     Osteoprotegerin mediates adipogenesis in obesity
  JOURNAL   J Adv Res 62, 245-255 (2024)
   PUBMED   38906326
  REMARK    GeneRIF: Osteoprotegerin mediates adipogenesis in obesity.
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Soliman,E., Ohrndorf,S., Zehairy,M., Matrawy,K., Alhadidy,A. and
            Abdelati,A.
  TITLE     Osteopontin, osteoprotegerin and musculoskeletal ultrasound
            findings in first-degree relatives of rheumatoid arthritis:
            potential markers of preclinical disease
  JOURNAL   BMC Musculoskelet Disord 25 (1), 195 (2024)
   PUBMED   38443806
  REMARK    GeneRIF: Osteopontin, osteoprotegerin and musculoskeletal
            ultrasound findings in first-degree relatives of rheumatoid
            arthritis: potential markers of preclinical disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Suh,S.H., Oh,T.R., Choi,H.S., Kim,C.S., Bae,E.H., Ma,S.K., Oh,K.H.,
            Lee,K.B., Jeong,J.C., Jung,J.Y. and Kim,S.W.
  CONSRTM   Korean Cohort Study for Outcomes in Patients With Chronic Kidney
            Disease (KNOW-CKD) Investigators
  TITLE     Circulating osteoprotegerin levels and cardiovascular outcomes in
            patients with pre-dialysis chronic kidney disease: results from the
            KNOW-CKD study
  JOURNAL   Sci Rep 14 (1), 4136 (2024)
   PUBMED   38374135
  REMARK    GeneRIF: Circulating osteoprotegerin levels and cardiovascular
            outcomes in patients with pre-dialysis chronic kidney disease:
            results from the KNOW-CKD study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Kulik-Rechberger,B. and Kozlowska,M.
  TITLE     Osteoprotegerin and receptor activator of the nuclear factor kappa
            B ligand (RANKL) in healthy pubertal girls - relationships with
            physical growth and classical bone turnover markers
  JOURNAL   J Physiol Pharmacol 75 (1) (2024)
   PUBMED   38583439
  REMARK    GeneRIF: Osteoprotegerin and receptor activator of the nuclear
            factor kappa B ligand (RANKL) in healthy pubertal girls -
            relationships with physical growth and classical bone turnover
            markers.
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Hirata,W., Itatani,Y., Masui,H., Kawada,K., Mizuno,R., Yamamoto,T.,
            Okamoto,T., Ogawa,R., Inamoto,S., Maekawa,H., Okamura,R.,
            Kiyasu,Y., Hanada,K., Okamoto,M., Nishikawa,Y., Sugimoto,N.,
            Tamura,T., Hatano,E., Sakai,Y. and Obama,K.
  TITLE     Downregulation of osteoprotegerin in colorectal cancer cells
            promotes liver metastasis via activating tumor-associated
            macrophage
  JOURNAL   Sci Rep 13 (1), 22217 (2023)
   PUBMED   38097649
  REMARK    GeneRIF: Downregulation of osteoprotegerin in colorectal cancer
            cells promotes liver metastasis via activating tumor-associated
            macrophage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Tomoyasu,A., Goto,M., Fujise,N., Mochizuki,S., Yasuda,H.,
            Morinaga,T., Tsuda,E. and Higashio,K.
  TITLE     Characterization of monomeric and homodimeric forms of
            osteoclastogenesis inhibitory factor
  JOURNAL   Biochem Biophys Res Commun 245 (2), 382-387 (1998)
   PUBMED   9571159
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Yamaguchi,K., Kinosaki,M., Goto,M., Kobayashi,F., Tsuda,E.,
            Morinaga,T. and Higashio,K.
  TITLE     Characterization of structural domains of human osteoclastogenesis
            inhibitory factor
  JOURNAL   J Biol Chem 273 (9), 5117-5123 (1998)
   PUBMED   9478964
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Tan,K.B., Harrop,J., Reddy,M., Young,P., Terrett,J., Emery,J.,
            Moore,G. and Truneh,A.
  TITLE     Characterization of a novel TNF-like ligand and recently described
            TNF ligand and TNF receptor superfamily genes and their
            constitutive and inducible expression in hematopoietic and
            non-hematopoietic cells
  JOURNAL   Gene 204 (1-2), 35-46 (1997)
   PUBMED   9434163
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Tsuda,E., Goto,M., Mochizuki,S., Yano,K., Kobayashi,F., Morinaga,T.
            and Higashio,K.
  TITLE     Isolation of a novel cytokine from human fibroblasts that
            specifically inhibits osteoclastogenesis
  JOURNAL   Biochem Biophys Res Commun 234 (1), 137-142 (1997)
   PUBMED   9168977
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R. and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA477521.1, AK223155.1 and
            CK903484.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002546.3.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This protein is an osteoblast-secreted
            decoy receptor that functions as a negative regulator of bone
            resorption. This protein specifically binds to its ligand,
            osteoprotegerin ligand, both of which are key extracellular
            regulators of osteoclast development. Studies of the mouse
            counterpart also suggest that this protein and its ligand play a
            role in lymph-node organogenesis and vascular calcification.
            Alternatively spliced transcript variants of this gene have been
            reported, but their full length nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.31131.1, AK223155.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297350.9/ ENSP00000297350.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               DA477521.1         260-579
            321-2056            AK223155.1         319-2054
            2057-2087           CK903484.1         9-39                c
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..2087
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /note="TNF receptor superfamily member 11b"
                     /db_xref="GeneID:4982"
                     /db_xref="HGNC:HGNC:11909"
                     /db_xref="MIM:602643"
     exon            1..94
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1270
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /note="osteoprotegerin; osteoclastogenesis inhibitory
                     factor; tumor necrosis factor receptor superfamily, member
                     11b; tumor necrosis factor receptor superfamily member
                     11B"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11B precursor"
                     /protein_id="NP_002537.3"
                     /db_xref="CCDS:CCDS6326.1"
                     /db_xref="GeneID:4982"
                     /db_xref="HGNC:HGNC:11909"
                     /db_xref="MIM:602643"
                     /translation="MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKC
                     PPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHN
                     RVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPC
                     RKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPN
                     WLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDL
                     CENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRI
                     KNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQ
                     VQSVKISCL"
     exon            95..464
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..656
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..881
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..2087
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2087
                     /gene="TNFRSF11B"
                     /gene_synonym="OCIF; OPG; PDB5; TR1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgcac cggagcgctc gcccagccgc cgcctccaag cccctgaggt ttccggggac
       61 cacaatgaac aacttgctgt gctgcgcgct cgtgtttctg gacatctcca ttaagtggac
      121 cacccaggaa acgtttcctc caaagtacct tcattatgac gaagaaacct ctcatcagct
      181 gttgtgtgac aaatgtcctc ctggtaccta cctaaaacaa cactgtacag caaagtggaa
      241 gaccgtgtgc gccccttgcc ctgaccacta ctacacagac agctggcaca ccagtgacga
      301 gtgtctatac tgcagccccg tgtgcaagga gctgcagtac gtcaagcagg agtgcaatcg
      361 cacccacaac cgcgtgtgcg aatgcaagga agggcgctac cttgagatag agttctgctt
      421 gaaacatagg agctgccctc ctggatttgg agtggtgcaa gctggaaccc cagagcgaaa
      481 tacagtttgc aaaagatgtc cagatgggtt cttctcaaat gagacgtcat ctaaagcacc
      541 ctgtagaaaa cacacaaatt gcagtgtctt tggtctcctg ctaactcaga aaggaaatgc
      601 aacacacgac aacatatgtt ccggaaacag tgaatcaact caaaaatgtg gaatagatgt
      661 taccctgtgt gaggaggcat tcttcaggtt tgctgttcct acaaagttta cgcctaactg
      721 gcttagtgtc ttggtagaca atttgcctgg caccaaagta aacgcagaga gtgtagagag
      781 gataaaacgg caacacagct cacaagaaca gactttccag ctgctgaagt tatggaaaca
      841 tcaaaacaaa gaccaagata tagtcaagaa gatcatccaa gatattgacc tctgtgaaaa
      901 cagcgtgcag cggcacattg gacatgctaa cctcaccttc gagcagcttc gtagcttgat
      961 ggaaagctta ccgggaaaga aagtgggagc agaagacatt gaaaaaacaa taaaggcatg
     1021 caaacccagt gaccagatcc tgaagctgct cagtttgtgg cgaataaaaa atggcgacca
     1081 agacaccttg aagggcctaa tgcacgcact aaagcactca aagacgtacc actttcccaa
     1141 aactgtcact cagagtctaa agaagaccat caggttcctt cacagcttca caatgtacaa
     1201 attgtatcag aagttatttt tagaaatgat aggtaaccag gtccaatcag taaaaataag
     1261 ctgcttataa ctggaaatgg ccattgagct gtttcctcac aattggcgag atcccatgga
     1321 tgagtaaact gtttctcagg cacttgaggc tttcagtgat atctttctca ttaccagtga
     1381 ctaattttgc cacagggtac taaaagaaac tatgatgtgg agaaaggact aacatctcct
     1441 ccaataaacc ccaaatggtt aatccaactg tcagatctgg atcgttatct actgactata
     1501 ttttccctta ttactgcttg cagtaattca actggaaatt aaaaaaaaaa aactagactc
     1561 cattgtgcct tactaaatat gggaatgtct aacttaaata gctttgagat ttcagctatg
     1621 ctagaggctt ttattagaaa gccatatttt tttctgtaaa agttactaat atatctgtaa
     1681 cactattaca gtattgctat ttatattcat tcagatataa gatttgtaca tattatcatc
     1741 ctataaagaa acggtatgac ttaattttag aaagaaaatt atattctgtt tattatgaca
     1801 aatgaaagag aaaatatata tttttaatgg aaagtttgta gcatttttct aataggtact
     1861 gccatatttt tctgtgtgga gtatttttat aattttatct gtataagctg taatatcatt
     1921 ttatagaaaa tgcattattt agtcaattgt ttaatgttgg aaaacatatg aaatataaat
     1981 tatctgaata ttagatgctc tgagaaattg aatgtacctt atttaaaaga ttttatggtt
     2041 ttataactat ataaatgaca ttattaaagt tttcaaatta tttttta
//
