LOCUS       NM_003839               8148 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 11a (TNFRSF11A),
            transcript variant 1, mRNA.
ACCESSION   NM_003839
VERSION     NM_003839.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8148)
  AUTHORS   Papatheodorou,V., Gerodimos,C., Dimitrakopoulos,A., Lada,E.,
            Tektonidou,M.G., Germenis,A., Sfikakis,P.P. and Laskari,K.
  TITLE     TNFRSF11A variants contribute to systemic autoinflammatory
            diseases: A case series of 12 patients
  JOURNAL   Semin Arthritis Rheum 68, 152505 (2024)
   PUBMED   39003954
  REMARK    GeneRIF: TNFRSF11A variants contribute to systemic autoinflammatory
            diseases: A case series of 12 patients.
REFERENCE   2  (bases 1 to 8148)
  AUTHORS   Ortega,M.A., Jimenez-Alvarez,L., Fraile-Martinez,O.,
            Garcia-Montero,C., De Leon-Oliva,D., Toledo-Lobo,M.D.V.,
            Palacios,E., Granado,P., Esteban,A., Guijarro,L.G., Pekarek,L.,
            Asunsolo,A., Lopez-Gonzalez,L., Bujan,J., Garcia-Honduvilla,N.,
            Alvarez-Mon,M., Saez,M.A. and Diaz-Pedrero,R.
  TITLE     Elevated tissue expression of RANKL and RANK is associated with
            poorer survival rates in pancreatic cancer patients
  JOURNAL   Histol Histopathol 39 (9), 1133-1140 (2024)
   PUBMED   38230588
  REMARK    GeneRIF: Elevated tissue expression of RANKL and RANK is associated
            with poorer survival rates in pancreatic cancer patients.
REFERENCE   3  (bases 1 to 8148)
  AUTHORS   Pfeuffer,L., Siegert,V., Frede,J., Rieger,L., Trozzo,R., de Andrade
            Kratzig,N., Ring,S., Sarhadi,S., Beck,N., Niedermeier,S.,
            Abril-Gil,M., Elbahloul,M., Remke,M., Steiger,K., Eichner,R.,
            Jellusova,J., Rad,R., Bassermann,F., Winter,C., Ruland,J. and
            Buchner,M.
  TITLE     B-cell intrinsic RANK signaling cooperates with TCL1 to induce
            lineage-dependent B-cell transformation
  JOURNAL   Blood Cancer J 14 (1), 151 (2024)
   PUBMED   39198400
  REMARK    GeneRIF: B-cell intrinsic RANK signaling cooperates with TCL1 to
            induce lineage-dependent B-cell transformation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8148)
  AUTHORS   Zhang,Y., Liang,J., Liu,P., Wang,Q., Liu,L. and Zhao,H.
  TITLE     The RANK/RANKL/OPG system and tumor bone metastasis: Potential
            mechanisms and therapeutic strategies
  JOURNAL   Front Endocrinol (Lausanne) 13, 1063815 (2022)
   PUBMED   36589815
  REMARK    GeneRIF: The RANK/RANKL/OPG system and tumor bone metastasis:
            Potential mechanisms and therapeutic strategies.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8148)
  AUTHORS   Guerrini,M.M., Sobacchi,C., Cassani,B., Abinun,M., Kilic,S.S.,
            Pangrazio,A., Moratto,D., Mazzolari,E., Clayton-Smith,J.,
            Orchard,P., Coxon,F.P., Helfrich,M.H., Crockett,J.C., Mellis,D.,
            Vellodi,A., Tezcan,I., Notarangelo,L.D., Rogers,M.J., Vezzoni,P.,
            Villa,A. and Frattini,A.
  TITLE     Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due
            to TNFRSF11A (RANK) mutations
  JOURNAL   Am J Hum Genet 83 (1), 64-76 (2008)
   PUBMED   18606301
  REMARK    GeneRIF: Osteoclast-poor osteopetrosis with agammaglobulinemia due
            to TNFRSF11A (RANK) mutation is reported.
REFERENCE   6  (bases 1 to 8148)
  AUTHORS   Hughes,A.E., Ralston,S.H., Marken,J., Bell,C., MacPherson,H.,
            Wallace,R.G., van Hul,W., Whyte,M.P., Nakatsuka,K., Hovy,L. and
            Anderson,D.M.
  TITLE     Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause
            familial expansile osteolysis
  JOURNAL   Nat Genet 24 (1), 45-48 (2000)
   PUBMED   10615125
REFERENCE   7  (bases 1 to 8148)
  AUTHORS   Haslam,S.I., Van Hul,W., Morales-Piga,A., Balemans,W.,
            San-Millan,J.L., Nakatsuka,K., Willems,P., Haites,N.E. and
            Ralston,S.H.
  TITLE     Paget's disease of bone: evidence for a susceptibility locus on
            chromosome 18q and for genetic heterogeneity
  JOURNAL   J Bone Miner Res 13 (6), 911-917 (1998)
   PUBMED   9626621
REFERENCE   8  (bases 1 to 8148)
  AUTHORS   Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
            Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
            Galibert,L.
  TITLE     A homologue of the TNF receptor and its ligand enhance T-cell
            growth and dendritic-cell function
  JOURNAL   Nature 390 (6656), 175-179 (1997)
   PUBMED   9367155
REFERENCE   9  (bases 1 to 8148)
  AUTHORS   Cody,J.D., Singer,F.R., Roodman,G.D., Otterund,B., Lewis,T.B.,
            Leppert,M. and Leach,R.J.
  TITLE     Genetic linkage of Paget disease of the bone to chromosome 18q
  JOURNAL   Am J Hum Genet 61 (5), 1117-1122 (1997)
   PUBMED   9345096
REFERENCE   10 (bases 1 to 8148)
  AUTHORS   Hughes,A.E., Shearman,A.M., Weber,J.L., Barr,R.J., Wallace,R.G.,
            Osterberg,P.H., Nevin,N.C. and Mollan,R.A.
  TITLE     Genetic linkage of familial expansile osteolysis to chromosome 18q
  JOURNAL   Hum Mol Genet 3 (2), 359-361 (1994)
   PUBMED   7911698
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB209762.1, AC100843.2,
            AF018253.1 and DA403964.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003839.3.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptors can interact with various
            TRAF family proteins, through which this receptor induces the
            activation of NF-kappa B and MAPK8/JNK. This receptor and its
            ligand are important regulators of the interaction between T cells
            and dendritic cells. This receptor is also an essential mediator
            for osteoclast and lymph node development. Mutations at this locus
            have been associated with familial expansile osteolysis, autosomal
            recessive osteopetrosis, and Paget disease of bone. Alternatively
            spliced transcript variants have been described for this locus.
            [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF018253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586569.3/ ENSP00000465500.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AB209762.1         24-27
            5-5                 AC100843.2         131537-131537       c
            6-975               AF018253.1         1-970
            976-976             AC100843.2         88001-88001         c
            977-2213            AF018253.1         972-2208
            2214-4519           AB209762.1         1286-3591
            4520-4570           DA403964.1         478-528
            4571-8148           AC100843.2         65563-69140         c
FEATURES             Location/Qualifiers
     source          1..8148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..8148
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="TNF receptor superfamily member 11a"
                     /db_xref="GeneID:8792"
                     /db_xref="HGNC:HGNC:11908"
                     /db_xref="MIM:603499"
     exon            1..118
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1894
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; loss of heterozygosity, 18, chromosomal region
                     1; Paget disease of bone 2; tumor necrosis factor receptor
                     superfamily member 11a; receptor activator of nuclear
                     factor-kappa B; osteoclast differentiation factor
                     receptor; receptor activator of NF-KB; familial expansile
                     osteolysis; tumor necrosis factor receptor superfamily,
                     member 11a, NFKB activator; TRANCE receptor"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11A isoform 1 precursor"
                     /protein_id="NP_003830.1"
                     /db_xref="CCDS:CCDS11980.1"
                     /db_xref="GeneID:8792"
                     /db_xref="HGNC:HGNC:11908"
                     /db_xref="MIM:603499"
                     /translation="MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLG
                     RCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVV
                     AGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFS
                     DAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILL
                     LFASVALVAAIIFGVCYRKKGKALTANLWHWINEACGRLSGDKESSGDSCVSTHTANF
                     GQQGACEGVLLLTLEEKTFPEDMCYPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTE
                     IEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPGSKSTPPFSEPLEVGENDSLSQCFTG
                     TQSTVGSESCNCTEPLCRTDWTPMSSENYLQKEVDSGHCPHWAASPSPNWADVCTGCR
                     NPPGEDCEPLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAG
                     AGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPM
                     GRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA"
     exon            119..200
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            201..326
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            327..470
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            471..564
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            565..659
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            660..773
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            774..826
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1610
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..8148
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4489..4494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="hexamer: AATACA"
     polyA_site      4522
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="major polyA site"
     regulatory      4961..4966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="hexamer: AATAAA"
     polyA_site      4990
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
     regulatory      8130..8135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
                     /note="hexamer: AATAAA"
     polyA_site      8148
                     /gene="TNFRSF11A"
                     /gene_synonym="CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7;
                     OSTS; PDB2; RANK; TRANCE-R; TRANCER"
ORIGIN      
        1 agaggccgct gaggccgcgg cgcccgccag cctgtcccgc gccatggccc cgcgcgcccg
       61 gcggcgccgc ccgctgttcg cgctgctgct gctctgcgcg ctgctcgccc ggctgcaggt
      121 ggctttgcag atcgctcctc catgtaccag tgagaagcat tatgagcatc tgggacggtg
      181 ctgtaacaaa tgtgaaccag gaaagtacat gtcttctaaa tgcactacta cctctgacag
      241 tgtatgtctg ccctgtggcc cggatgaata cttggatagc tggaatgaag aagataaatg
      301 cttgctgcat aaagtttgtg atacaggcaa ggccctggtg gccgtggtcg ccggcaacag
      361 cacgaccccc cggcgctgcg cgtgcacggc tgggtaccac tggagccagg actgcgagtg
      421 ctgccgccgc aacaccgagt gcgcgccggg cctgggcgcc cagcacccgt tgcagctcaa
      481 caaggacaca gtgtgcaaac cttgccttgc aggctacttc tctgatgcct tttcctccac
      541 ggacaaatgc agaccctgga ccaactgtac cttccttgga aagagagtag aacatcatgg
      601 gacagagaaa tccgatgcgg tttgcagttc ttctctgcca gctagaaaac caccaaatga
      661 accccatgtt tacttgcccg gtttaataat tctgcttctc ttcgcgtctg tggccctggt
      721 ggctgccatc atctttggcg tttgctatag gaaaaaaggg aaagcactca cagctaattt
      781 gtggcactgg atcaatgagg cttgtggccg cctaagtgga gataaggagt cctcaggtga
      841 cagttgtgtc agtacacaca cggcaaactt tggtcagcag ggagcatgtg aaggtgtctt
      901 actgctgact ctggaggaga agacatttcc agaagatatg tgctacccag atcaaggtgg
      961 tgtctgtcag ggcacatgtg taggaggtgg tccctacgca caaggcgaag atgccaggat
     1021 gctctcattg gtcagcaaga ccgagataga ggaagacagc ttcagacaga tgcccacaga
     1081 agatgaatac atggacaggc cctcccagcc cacagaccag ttactgttcc tcactgagcc
     1141 tggaagcaaa tccacacctc ctttctctga acccctggag gtgggggaga atgacagttt
     1201 aagccagtgc ttcacgggga cacagagcac agtgggttca gaaagctgca actgcactga
     1261 gcccctgtgc aggactgatt ggactcccat gtcctctgaa aactacttgc aaaaagaggt
     1321 ggacagtggc cattgcccgc actgggcagc cagccccagc cccaactggg cagatgtctg
     1381 cacaggctgc cggaaccctc ctggggagga ctgtgaaccc ctcgtgggtt ccccaaaacg
     1441 tggacccttg ccccagtgcg cctatggcat gggccttccc cctgaagaag aagccagcag
     1501 gacggaggcc agagaccagc ccgaggatgg ggctgatggg aggctcccaa gctcagcgag
     1561 ggcaggtgcc gggtctggaa gctcccctgg tggccagtcc cctgcatctg gaaatgtgac
     1621 tggaaacagt aactccacgt tcatctccag cgggcaggtg atgaacttca agggcgacat
     1681 catcgtggtc tacgtcagcc agacctcgca ggagggcgcg gcggcggctg cggagcccat
     1741 gggccgcccg gtgcaggagg agaccctggc gcgccgagac tccttcgcgg ggaacggccc
     1801 gcgcttcccg gacccgtgcg gcggccccga ggggctgcgg gagccggaga aggcctcgag
     1861 gccggtgcag gagcaaggcg gggccaaggc ttgagcgccc cccatggctg ggagcccgaa
     1921 gctcggagcc agggctcgcg agggcagcac cgcagcctct gccccagccc cggccaccca
     1981 gggatcgatc ggtacagtcg aggaagacca cccggcattc tctgcccact ttgccttcca
     2041 ggaaatgggc ttttcaggaa gtgaattgat gaggactgtc cccatgccca cggatgctca
     2101 gcagcccgcc gcactggggc agatgtctcc cctgccactc ctcaaactcg cagcagtaat
     2161 ttgtggcact atgacagcta tttttatgac tatcctgttc tgtggggggg ggggtctgtt
     2221 ttccccccat atttgtattc cttttcataa cttttcttga tatctttcct ccctcttttt
     2281 taatgtaaag gttttctcaa aaattctcct aaaggtgagg gtctctttct tttctctttt
     2341 cctttttttt ttcttttttt ggcaacctgg ctctggccca ggctagagtg cagtggtgcg
     2401 attatagccc ggtgcagcct ctaactcctg ggctcaagca atccaagtga tcctcccacc
     2461 tcaaccttcg gagtagctgg gatcacagct gcaggccacg cccagcttcc tccccccgac
     2521 tcccccccca gagacacggt cccaccatgt tacccagcct ggtctcaaac tccccagcta
     2581 aagcagtcct ccagcctcgg cctcccaaag tactgggatt acaggcgtga gcccccacgc
     2641 tggcctgctt tacgtatttt cttttgtgcc cctgctcaca gtgttttaga gatggctttc
     2701 ccagtgtgtg ttcattgtaa acacttttgg gaaagggcta aacatgtgag gcctggagat
     2761 agttgctaag ttgctaggaa catgtggtgg gactttcata ttctgaaaaa tgttctatat
     2821 tctcattttt ctaaaagaaa gaaaaaagga aacccgattt atttctcctg aatcttttta
     2881 agtttgtgtc gttccttaag cagaactaag ctcagtatgt gaccttaccc gctaggtggt
     2941 taatttatcc atgctggcag aggcactcag gtacttggta agcaaatttc taaaactcca
     3001 agttgctgca gcttggcatt cttcttattc tagaggtctc tctggaaaag atggagaaaa
     3061 tgaacaggac atggggctcc tggaaagaaa gggcccggga agttcaagga agaataaagt
     3121 tgaaatttta atttgcattt tttttgtcta gataagaata gcgtgaatag atcctctttt
     3181 attcgtaaat aatcgtgcat ctgtgggtta gccttgtaga agtggaaaac attccatttt
     3241 ccaatgcatt taaatgtaaa gccaaatctg catgttgtga atttaagaaa acttattatc
     3301 ctaaaggtgc ctttctcttg gcatcatccc gcttgtgaga agcctagagg acgctccagg
     3361 tggaaggaaa tcccctgggt ggttttatct tttgttaccc agtgagcact ggttccccgc
     3421 aaatactggg gaaaagcaaa aatacacaag caagttaaaa ttaattttgc acatctggga
     3481 ggttataaaa gaaagcacta atagtagtca ctgcccagac tttactggcc acaaatgccc
     3541 agctgaagag catgactgtg gatcactggt ttttccctcc tgctggaaat gctggggtgg
     3601 tagcggtcga ttaggatttt cagtggagaa gcacaggaca gttctgtaat ttatgggact
     3661 ccttagccaa cataaagaac tgcaggaaat aactgcacag ccaggaggat ccgttggtgg
     3721 gaatttaccg tcattcctgc ccttttattt aacatcatcc acagagagat gttatacaaa
     3781 tggaggaaac cattatacct tttgatatgg aatatattac agagttacag ttcacaaagt
     3841 agaatgctga gctgaaaacc cgagtttctg ctgtgactgt catctcactg agcacttcgc
     3901 ttttctttgc ttttattttt tccttctata aaaaggcaat aatgataatt tataatagtt
     3961 tccctaccca gagatattag aagtatgcta cagtgaatgt taaagtacct tgagatcctt
     4021 aaatcaaagg tgctatatac ataagtaaga ctctactttc agaaaaaggt aatattattt
     4081 cctgcactga tccctactaa ttctatattg atccaaaggc aactcaatgc taaaaaatgt
     4141 atagaaaata taagtctgtg tctgtgtact gtagagatgt atgtgacaag tgtaaacaaa
     4201 atgaactgaa gcagtaatga acagttatta gggggaacat gataaagaga ttatattaag
     4261 cttatgtttc accataaaat cctttttatg gcttactaaa accgagctca ctgtaaaatc
     4321 atgatccaac ttattgctaa tctttatgat atgcttattc ctaatcttta tggtatggtg
     4381 tcaaccgttc atttgtatct tattgctcat tccctggacc acagactagg gacagaaaat
     4441 acttgcttta ataatatata tgctgttgat ttcacaaaaa tttattaaaa tacagcctgg
     4501 gtacccagtg aaagagctga aatggaaatg gagtatcatg tttcctactc acattttact
     4561 cagctgtcgg aaggaagaat gaatttctca agagcagttt gaatgtgtta gatcagaacc
     4621 ttcatgtggt ggggaaaatg ggattatttc agtgtaacaa accacccaaa gacttagtgg
     4681 cttaaaatag tcaccattgg ccaggcacag cggttcatgc ctcccagtgc tttgggaggc
     4741 caaggcagga ggatcacttg aggacagtag ttagagatca aactgggcaa tggagtgaga
     4801 cctcgtctct acaaaaaata caaaacttat ctgggcacgg tggtgtgcac ctgcagtcct
     4861 ggctactcag gaggctgagg caggaggatg cttgagtcca ggagttcaag gttactgtga
     4921 gctttgattg ggtcagtgca ctccagtgta aaaaaacaaa aataaaaacc accacttatt
     4981 tagctcccaa ttctatgggt tggatcagct tgggtggttc ttcaggcctg gtccctcctg
     5041 gcctggtttg cttacccatt tacaatgacc cggctagttg gccgggccag gctgtgtgct
     5101 ctccacctgt ctcccatcct tccagccacc tagctgggca tgctctcatg gtggtgtcga
     5161 gcctgagaac aagcagaaac ctgccaggct tcttgaggcc taggctctaa ctggcatgct
     5221 gtcacttctg ccacattctg tgggccaaag caggtcacaa aggcagccca gatccaaggg
     5281 atgggggagc agcatatccc cccatgggaa gagttgcgga atgagagggt agggggtgga
     5341 cacacagagg ggaagatggc ccccttgcca tctgtccacc acagggcact gcgtggagta
     5401 aaatgctgca gagaagagtg cattctggga aaaaaagagg aacatatccc agcccctaac
     5461 cagtgagtag ctccttctct ggtgattgaa ttcccttaat gcacagcact atagattccc
     5521 acaatgaaag ggacacccac gttcatattt aagtgctgtg tcaaaattct ttccagagcc
     5581 aaatataggt gatttgggaa ttgagcctac tgtactgctt ccacattcct ttggcacaga
     5641 aaactgaaaa gtcacaactt ctaaaatcaa gaaaactggt gagatacctt ggggtagaga
     5701 aacctgcata taaacagata aaagatcgag tgttcaccct tcacctcagc tcaacaaaca
     5761 aactcttgtt acgattatac aagggtgagc ttgagcaaag gtgctgtctt tggtggaaga
     5821 aacgtagttt tgagttgttt gctctttgac agtctctgat ggcatgtgag tctggtgcat
     5881 tgctgtgggc tgcgctgggc acaagttgca taacccgctt ttggaagagg agacaaagca
     5941 ttcaaagccc taaacactct gttggtgaat catcatgttt attgagtgtg cttttagtgg
     6001 cagggccctg agcacctggg aaaggagatg aggagcgctg gagggttcgg agcagagaag
     6061 acgagacaat gctctgctcc aagcgccaga ggaggcttct gggaaggggc tgtctgtgga
     6121 atttctgacc cccagagccc tgctggtgaa gtcttgcaac cactaaagct ttgccagaga
     6181 agaggaggga cctgacactg ggcagtggcg gtgccagcag tgagcacagg cggggtctag
     6241 gtgggatcac tgaagccaag ccaagtggtg cagggggagc cgccctggac caacaccccc
     6301 atggctgccc cactgcggaa ctgcctactg cggcaaaaca atcctatgtc ccccaaggtt
     6361 tcaacaaaga ggaggaccga ataaatgtcc cagtgggcag gcacacccac aagacttgct
     6421 gctcctcctg acccacccgc atggctctgc acagctgtga gtccagtttt ctctcttcct
     6481 acctccctct tacccagtta tcctgacccc agggtgaggt tgaaactcat gctaggctaa
     6541 catctctttc cttcatccca ttcataaaac tggcatacag gaatgtttta aaaaaatctt
     6601 taagattacc aggagtataa aagttaaaat gacaaaatta caggcctgtt accagatctt
     6661 cgtactaacc aaggagctgg tgacactacc ctcttccctg tgtgatagaa aatgcagacg
     6721 ttttgcaggc agacctggtt catgactcag cgctgtgact tgtggactta tcttgtgcag
     6781 ctacatcact tcttagcctt gttttcaaca tgcgtaagca gaaggtacta atattagtct
     6841 ttagggctgg tttgaggatg acgtgagatg agagacaacc aagcactcac tggcagttcc
     6901 tagaagattc cagtagtaga gatctgactg tcctacacta ctttccctcc ctgtctctga
     6961 cacttgttca ttcctgggct caggagccat ctcagtcatc atgtcggacc acgtaactat
     7021 aaccaagctc tgctgcccac ctgggacacc ttcccactct ttgcaactag gtcggaggga
     7081 cgcaccttct ccacagttga caggactgtt atggttgacc caaaagttgt catcttctga
     7141 catgacacac tgagggaagt agacttaccc aatataactt cacattatac tgtcttaaaa
     7201 gactatgatt aaaatgggca tcagtgtagg caacatgtag ggcgcaaaga atagccagat
     7261 gtgaaggttg aaaggctatg tgggctagtt tgtcatggta ttcctggtgc ctctccccgt
     7321 ttgggaagaa taacacattg accaccggct cagaggaggt ggcattatag gtccaggccc
     7381 cttcaggagg gcactggagt caatgaaagc ttttgctctc acccaggctc ttggtttctc
     7441 acgggcaggg gtagcccagg aaacaaaggc tgtatagact ttaagtcgtg agaaaaacga
     7501 cattcttatg gtgaggctct tagagactgt ctccatttaa gcagcagcag taaaacatct
     7561 taccctaaaa tgaagaagca aatccatttt tattggcttt tatagcctct ctctttcaat
     7621 gacaaagaaa ccattaaaat gaatgtttaa agttcttaga agagctttct ctaaatattt
     7681 actctgtcag tggaaaaata aacatttttt acatcgggtc tattgagttt gttatataca
     7741 gtaaaattca ccctttttag atatatagtt ttatgagttt taacaaaaat acatagttgt
     7801 gtaaccacca ccatcacaat caagatatag aatatttcaa catcccaaag ttcccatttc
     7861 ccttttcagt caatcccttc cccactaccc ctagcccctg gcaaccatta tctgttctct
     7921 cttcccatag tttcaccttt tccaatttgt cgtgtagagt tacacagctc atagccattt
     7981 gagtctggct tctttccaca taatgtcctt gagatccatc ggtgggtaca ccagtagttc
     8041 catttttttt ctgagtagta gtccattgta tggatgtact gcggtttatt caccaacata
     8101 tgggttcttt cctgtttggg gagattacaa ataaagctac tataaaaa
//
