LOCUS       NM_003840               3535 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 10d (TNFRSF10D), mRNA.
ACCESSION   NM_003840
VERSION     NM_003840.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3535)
  AUTHORS   Ghosal,N., Tapadar,P., Biswas,D. and Pal,R.
  TITLE     ELF3 plays an important role in defining TRAIL sensitivity in
            breast cancer by modulating the expression of decoy receptor 2
            (DCR2)
  JOURNAL   Mol Biol Rep 51 (1), 671 (2024)
   PUBMED   38787503
  REMARK    GeneRIF: ELF3 plays an important role in defining TRAIL sensitivity
            in breast cancer by modulating the expression of decoy receptor 2
            (DCR2).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3535)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3535)
  AUTHORS   Madsen,S.D., Jones,S.H., Tucker,H.A., Giler,M.K., Muller,D.C.,
            Discher,C.T., Russell,K.C., Dobek,G.L., Sammarco,M.C., Bunnell,B.A.
            and O'Connor,K.C.
  TITLE     Survival of aging CD264+ and CD264- populations of human bone
            marrow mesenchymal stem cells is independent of colony-forming
            efficiency
  JOURNAL   Biotechnol Bioeng 117 (1), 223-237 (2020)
   PUBMED   31612990
  REMARK    GeneRIF: Survival of aging CD264(+) and CD264(-) populations of
            human bone marrow mesenchymal stem cells is independent of
            colony-forming efficiency.
REFERENCE   4  (bases 1 to 3535)
  AUTHORS   Heilmann,T., Vondung,F., Borzikowsky,C., Szymczak,S., Kruger,S.,
            Alkatout,I., Wenners,A., Bauer,M., Klapper,W., Rocken,C., Maass,N.,
            von Karstedt,S., Schem,C. and Trauzold,A.
  TITLE     Heterogeneous intracellular TRAIL-receptor distribution predicts
            poor outcome in breast cancer patients
  JOURNAL   J Mol Med (Berl) 97 (8), 1155-1167 (2019)
   PUBMED   31183506
  REMARK    GeneRIF: data suggest that the determination of intracellular
            co-expression patterns of TRAIL-R1, TRAIL-R2, and TRAIL-R4 provides
            an innovative and robust method for risk stratification in breast
            cancer patients beyond conventional prognostic markers.
REFERENCE   5  (bases 1 to 3535)
  AUTHORS   Chen,J., Chen,K.H., Wang,L.M., Zhang,W.W., Feng,L., Dai,H.Z. and
            He,Y.N.
  TITLE     High-dose HOOK effect in urinary DcR2 assay in patients with
            chronic kidney disease
  JOURNAL   Clin Biochem 58, 32-36 (2018)
   PUBMED   29879421
  REMARK    GeneRIF: The high-dose hook effect was apparent during ELISA
            testing of uDcR2 in chronic kidney disease (CKD) patients, yet
            dilution of the urine samples neutralized this effect. However, the
            use of a four-fold dilution of urine for uDcR2/cre testing may
            eliminate the high-dose hook effect and make it possible to
            effectively monitor the severity of TII in CKD patients.
REFERENCE   6  (bases 1 to 3535)
  AUTHORS   Zhang,X.D., Franco,A.V., Nguyen,T., Gray,C.P. and Hersey,P.
  TITLE     Differential localization and regulation of death and decoy
            receptors for TNF-related apoptosis-inducing ligand (TRAIL) in
            human melanoma cells
  JOURNAL   J Immunol 164 (8), 3961-3970 (2000)
   PUBMED   10754286
REFERENCE   7  (bases 1 to 3535)
  AUTHORS   Phillips,T.A., Ni,J., Pan,G., Ruben,S.M., Wei,Y.F., Pace,J.L. and
            Hunt,J.S.
  TITLE     TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications
            for immune privilege
  JOURNAL   J Immunol 162 (10), 6053-6059 (1999)
   PUBMED   10229846
REFERENCE   8  (bases 1 to 3535)
  AUTHORS   Pan,G., Ni,J., Yu,G., Wei,Y.F. and Dixit,V.M.
  TITLE     TRUNDD, a new member of the TRAIL receptor family that antagonizes
            TRAIL signalling
  JOURNAL   FEBS Lett 424 (1-2), 41-45 (1998)
   PUBMED   9537512
REFERENCE   9  (bases 1 to 3535)
  AUTHORS   Marsters,S.A., Sheridan,J.P., Pitti,R.M., Huang,A., Skubatch,M.,
            Baldwin,D., Yuan,J., Gurney,A., Goddard,A.D., Godowski,P. and
            Ashkenazi,A.
  TITLE     A novel receptor for Apo2L/TRAIL contains a truncated death domain
  JOURNAL   Curr Biol 7 (12), 1003-1006 (1997)
   PUBMED   9382840
REFERENCE   10 (bases 1 to 3535)
  AUTHORS   Degli-Esposti,M.A., Dougall,W.C., Smolak,P.J., Waugh,J.Y.,
            Smith,C.A. and Goodwin,R.G.
  TITLE     The novel receptor TRAIL-R4 induces NF-kappaB and protects against
            TRAIL-mediated apoptosis, yet retains an incomplete death domain
  JOURNAL   Immunity 7 (6), 813-820 (1997)
   PUBMED   9430226
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100861.2, AY358285.1,
            AF021233.1, BU199149.1 and AA743393.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003840.4.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor contains an extracellular
            TRAIL-binding domain, a transmembrane domain, and a truncated
            cytoplamic death domain. This receptor does not induce apoptosis,
            and has been shown to play an inhibitory role in TRAIL-induced cell
            apoptosis. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358285.1, SRR1660803.35943.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312584.4/ ENSP00000310263.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC100861.2         115239-115247
            10-1020             AY358285.1         1-1011
            1021-1346           AF021233.1         1008-1333
            1347-2837           AY358285.1         1338-2828
            2838-2855           BU199149.1         161-178
            2856-3527           AY358285.1         2847-3518
            3528-3535           AA743393.1         32-39               c
FEATURES             Location/Qualifiers
     source          1..3535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3535
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /note="TNF receptor superfamily member 10d"
                     /db_xref="GeneID:8793"
                     /db_xref="HGNC:HGNC:11907"
                     /db_xref="MIM:603614"
     exon            1..242
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1253
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /note="decoy receptor 2; TNF receptor-related receptor for
                     TRAIL; TRAIL receptor 4; TRAIL receptor with a truncated
                     death domain; tumor necrosis factor receptor superfamily,
                     member 10d, decoy with truncated death domain; tumor
                     necrosis factor receptor superfamily member 10d;
                     TNF-related apoptosis-inducing ligand receptor 4"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 10D precursor"
                     /protein_id="NP_003831.2"
                     /db_xref="CCDS:CCDS6038.1"
                     /db_xref="GeneID:8793"
                     /db_xref="HGNC:HGNC:11907"
                     /db_xref="MIM:603614"
                     /translation="MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFI
                     VAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEG
                     VDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRT
                     GCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVV
                     LVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNAR
                     NETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVP
                     VNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL"
     exon            243..348
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            349..462
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            463..574
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            575..828
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            829..860
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1046
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1119
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..3535
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /note="hexamer: AATAAA"
     polyA_site      3535
                     /gene="TNFRSF10D"
                     /gene_synonym="CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD"
                     /note="major polyA site"
ORIGIN      
        1 agtgtagctg cgagaacctt tgcacgcgca caaactacgg ggacgatttc tgattgattt
       61 ttggcgcttt cgatccaccc tcctcccttc tcatgggact ttggggacaa agcgtcccga
      121 ccgcctcgag cgctcgagca gggcgctatc caggagccag gacagcgtcg ggaaccagac
      181 catggctcct ggaccccaag atccttaagt tcgtcgtctt catcgtcgcg gttctgctgc
      241 cggtccgggt tgactctgcc accatccccc ggcaggacga agttccccag cagacagtgg
      301 ccccacagca acagaggcgc agcctcaagg aggaggagtg tccagcagga tctcatagat
      361 cagaatatac tggagcctgt aacccgtgca cagagggtgt ggattacacc attgcttcca
      421 acaatttgcc ttcttgcctg ctatgtacag tttgtaaatc aggtcaaaca aataaaagtt
      481 cctgtaccac gaccagagac accgtgtgtc agtgtgaaaa aggaagcttc caggataaaa
      541 actcccctga gatgtgccgg acgtgtagaa cagggtgtcc cagagggatg gtcaaggtca
      601 gtaattgtac gccccggagt gacatcaagt gcaaaaatga atcagctgcc agttccactg
      661 ggaaaacccc agcagcggag gagacagtga ccaccatcct ggggatgctt gcctctccct
      721 atcactacct tatcatcata gtggttttag tcatcatttt agctgtggtt gtggttggct
      781 tttcatgtcg gaagaaattc atttcttacc tcaaaggcat ctgctcaggt ggtggaggag
      841 gtcccgaacg tgtgcacaga gtccttttcc ggcggcgttc atgtccttca cgagttcctg
      901 gggcggagga caatgcccgc aacgagaccc tgagtaacag atacttgcag cccacccagg
      961 tctctgagca ggaaatccaa ggtcaggagc tggcagagct aacaggtgtg actgtagagt
     1021 tgccagagga gccacagcgt ctgctggaac aggcagaagc tgaagggtgt cagaggagga
     1081 ggctgctggt tccagtgaat gacgctgact ccgctgacat cagcaccttg ctggatgcct
     1141 cggcaacact ggaagaagga catgcaaagg aaacaattca ggaccaactg gtgggctccg
     1201 aaaagctctt ttatgaagaa gatgaggcag gctctgctac gtcctgcctg tgaaagaatc
     1261 tcttcaggaa accagagctt ccctcattta ccttttctcc tacaaaggga agcagcctgg
     1321 aagaaacagt ccagtacttg acccatgccc caacaaactc tactatccaa tatggggcag
     1381 cttaccaatg gtcctagaac tttgttaacg cacttggagt aatttttatg aaatactgcg
     1441 tgtgataagc aaacgggaga aatttatatc agattcttgg ctgcatagtt atacgattgt
     1501 gtattaaggg tcgttttagg ccacatgcgg tggctcatgc ctgtaatccc agcactttga
     1561 taggctgagg caggtggatt gcttgagctc gggagtttga gaccagcctc atcaacacag
     1621 tgaaactcca tctcaattta aaaagaaaaa aagtggtttt aggatgtcat tctttgcagt
     1681 tcttcatcat gagacaagtc tttttttctg cttcttatat tgcaagctcc atctctactg
     1741 gtgtgtgcat ttaatgacat ctaactacag atgccgcaca gccacaatgc tttgccttat
     1801 agttttttaa ctttagaacg ggattatctt gttattacct gtattttcag tttcggatat
     1861 ttttgactta atgatgagat tatcaagacg tagccctatg ctaagtcatg agcatatgga
     1921 cttacgaggg ttcgacttag agttttgagc tttaagatag gattattggg gcttaccccc
     1981 accttaatta gagaaacatt tatattgctt actactgtag gctgtacatc tcttttccga
     2041 tttttgtata atgatgtaaa catggaaaaa ctttaggaaa tgcacttatt aggctgttta
     2101 catgggttgc ctggatacaa atcagcagtc aaaaatgact aaaaatataa ctagtgacgg
     2161 agggagaaat cctccctctg tgggaggcac ttactgcatt ccagttctcc ctcctgcgcc
     2221 ctgagactgg accagggttt gatggctggc agcttctcaa ggggcagctt gtcttacttg
     2281 ttaattttag aggtatatag ccatatttat ttataaataa atatttattt atttatttat
     2341 aagtagatgt ttacatatgc ccaggatttt gaagagcctg gtatctttgg gaagccatgt
     2401 gtctggtttg tcgtgctggg acagtcatgg gactgcatct tccgacttgt ccacagcaga
     2461 tgaggacagt gagaattaag ttagatccga gactgcgaag agcttctctt tcaagcgcca
     2521 ttacagttga acgttagtga atcttgagcc tcatttgggc tcagggcaga gcaggtgttt
     2581 atctgccccg gcatctgcca tggcatcaag agggaagagt ggacggtgct tgggaatggt
     2641 gtgaaatggt tgccgactca ggcatggatg ggcccctctc gcttctggtg gtctgtgaac
     2701 tgagtccctg ggatgccttt tagggcagag attcctgagc tgcgttttag ggtacagatt
     2761 ccctgtttga ggagcttggc ccctctgtaa gcatctgact catctcagag atatcaattc
     2821 ttaaacactg tgacaacagg atctaaaatg gctgacacat ttgtccttgt gtcacgttcc
     2881 attattttat ttaaaaacct cagtaatcgt tttagcttct ttccagcaaa ctcttctcca
     2941 cagtagccca gtcgtggtag gataaattac ggatatagtc attctagggg tttcagtctt
     3001 ttccatctca aggcattgtg tgttttgttc cgggactggt ttggctggga caaagttaga
     3061 actgcctgaa gttcgcacat tcagattgtt gtgtccatgg agttttagga ggggatggcc
     3121 tttccggtct tcgcacttcc atcctctccc acttccatct ggcgtcccac accttgtccc
     3181 ctgcacttct ggatgacaca gggtgctgct gcctcctagt ctttgccttt gctgggcctt
     3241 ctgtgcagga gacttggtct caaagctcag agagagccag tccggtccca gctcctttgt
     3301 cccttcctca gaggccttcc ttgaagatgc atctagacta ccagccttat cagtgtttaa
     3361 gcttattcct ttaacataag cttcctgaca acatgaaatt gttggggttt tttggcgttg
     3421 gttgatttgt ttaggttttg ctttataccc gggccaaata gcacataaca cctggttata
     3481 tatgaaatac tcatatgttt atgaccaaaa taaatatgaa acctcatatt aaaaa
//
