LOCUS       NM_003841               1395 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 10c (TNFRSF10C), mRNA.
ACCESSION   NM_003841
VERSION     NM_003841.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Suehiro,Y., Tsuge,M., Kurihara,M., Uchida,T., Fujino,H., Ono,A.,
            Yamauchi,M., Naswa Makokha,G., Nakahara,T., Murakami,E.,
            Abe-Chayama,H., Kawaoka,T., Miki,D., Imamura,M., Aikata,H., Nelson
            Hayes,C., Fujita,T. and Chayama,K.
  TITLE     Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in
            Hepatocytes Resulting in Escape From Both Cell Apoptosis and
            Suppression of HBV Replication by TRAIL
  JOURNAL   J Infect Dis 227 (5), 686-695 (2023)
   PUBMED   35226068
  REMARK    GeneRIF: Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in
            Hepatocytes Resulting in Escape From Both Cell Apoptosis and
            Suppression of HBV Replication by TRAIL.
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Singh,D., Prasad,C.B., Biswas,D., Tewari,M., Kar,A.G., Ansari,M.A.,
            Singh,S. and Narayan,G.
  TITLE     TRAIL receptors are differentially regulated and clinically
            significant in gallbladder cancer
  JOURNAL   Pathology 52 (3), 348-358 (2020)
   PUBMED   32111400
  REMARK    GeneRIF: TRAIL receptors are differentially regulated and
            clinically significant in gallbladder cancer.
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Labovsky,V., Martinez,L.M., Davies,K.M., de Lujan Calcagno,M.,
            Garcia-Rivello,H., Wernicke,A., Feldman,L., Matas,A.,
            Giorello,M.B., Borzone,F.R., Choi,H., Howard,S.C. and
            Chasseing,N.A.
  TITLE     Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor
            epithelial cells of patients with early breast cancer
  JOURNAL   BMC Cancer 17 (1), 280 (2017)
   PUBMED   28420351
  REMARK    GeneRIF: High levels of TRAIL-R3 and CCR-2 expression in tumor
            epithelial cells identified patients with early breast cancer with
            poor outcomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Ruiz de Almodovar,C., Lopez-Rivas,A., Redondo,J.M. and Rodriguez,A.
  TITLE     Transcription initiation sites and promoter structure of the human
            TRAIL-R3 gene
  JOURNAL   FEBS Lett 531 (2), 304-308 (2002)
   PUBMED   12417331
  REMARK    GeneRIF: analysis of the transcription initiation sites and
            promoter structure of the TRAIL-R3 gene
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   MacFarlane,M., Ahmad,M., Srinivasula,S.M., Fernandes-Alnemri,T.,
            Cohen,G.M. and Alnemri,E.S.
  TITLE     Identification and molecular cloning of two novel receptors for the
            cytotoxic ligand TRAIL
  JOURNAL   J Biol Chem 272 (41), 25417-25420 (1997)
   PUBMED   9325248
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Degli-Esposti,M.A., Smolak,P.J., Walczak,H., Waugh,J., Huang,C.P.,
            DuBose,R.F., Goodwin,R.G. and Smith,C.A.
  TITLE     Cloning and characterization of TRAIL-R3, a novel member of the
            emerging TRAIL receptor family
  JOURNAL   J Exp Med 186 (7), 1165-1170 (1997)
   PUBMED   9314565
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M.,
            Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I.,
            Goddard,A.D., Godowski,P. and Ashkenazi,A.
  TITLE     Control of TRAIL-induced apoptosis by a family of signaling and
            decoy receptors
  JOURNAL   Science 277 (5327), 818-821 (1997)
   PUBMED   9242611
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107959.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_003841.4.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor contains an extracellular
            TRAIL-binding domain and a transmembrane domain, but no cytoplasmic
            death domain. This receptor is not capable of inducing apoptosis,
            and is thought to function as an antagonistic receptor that
            protects cells from TRAIL-induced apoptosis. This gene was found to
            be a p53-regulated DNA damage-inducible gene. The expression of
            this gene was detected in many normal tissues but not in most
            cancer cell lines, which may explain the specific sensitivity of
            cancer cells to the apoptosis-inducing activity of TRAIL. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses a downstream AUG start
            codon. This start codon has a strong Kozak signal and is restricted
            to human. An upstream start codon, which has a weak Kozak signal
            and is conserved in some other primates, is also present. The use
            of the upstream start codon would result in a protein that is 40 aa
            longer at the N-terminus. However, this would eliminate a signal
            peptide that is predicted for the shorter but not the longer
            N-terminus. PMID:9242611 shows experimental evidence for cleavage
            of a signal peptide following aa 25 from the downstream start, and
            this is also confirmed in PMID:15340161. Therefore, the downstream
            start codon is represented for this CCDS.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017852.1, AF014794.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000356864.4/
                                                ENSP00000349324.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC107959.8         165616-165876
            262-367             AC107959.8         174415-174520
            368-481             AC107959.8         177352-177465
            482-590             AC107959.8         178203-178311
            591-1395            AC107959.8         179336-180140
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1395
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /note="TNF receptor superfamily member 10c"
                     /db_xref="GeneID:8794"
                     /db_xref="HGNC:HGNC:11906"
                     /db_xref="MIM:603613"
     exon            1..261
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..981
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /note="decoy receptor 1; lymphocyte inhibitor of TRAIL;
                     antagonist decoy receptor for TRAIL/Apo-2L; cytotoxic
                     TRAIL receptor-3; decoy TRAIL receptor without death
                     domain; TNF-related apoptosis-inducing ligand receptor 3;
                     tumor necrosis factor receptor superfamily, member 10c,
                     decoy without an intracellular domain"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 10C precursor"
                     /protein_id="NP_003832.3"
                     /db_xref="CCDS:CCDS6037.1"
                     /db_xref="GeneID:8794"
                     /db_xref="HGNC:HGNC:11906"
                     /db_xref="MIM:603613"
                     /translation="MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQ
                     RHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCT
                     MTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVE
                     TPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPG
                     TPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV"
     exon            262..367
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /inference="alignment:Splign:2.1.0"
     exon            368..481
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /inference="alignment:Splign:2.1.0"
     exon            482..590
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1395
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1122
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /note="major polyA site"
     polyA_site      1395
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtgcag ctgtgggaac ctctccacgc gcacgaactc agccaacgat ttctgataga
       61 tttttgggag tttgaccaga gatgcaaggg gtgaaggagc gcttcctacc gttagggaac
      121 tctggggaca gagcgccccg gccgcctgat ggccgaggca gggtgcgacc caggacccag
      181 gacggcgtcg ggaaccatac catggcccgg atccccaaga ccctaaagtt cgtcgtcgtc
      241 atcgtcgcgg tcctgctgcc agtcctagct tactctgcca ccactgcccg gcaggaggaa
      301 gttccccagc agacagtggc cccacagcaa cagaggcaca gcttcaaggg ggaggagtgt
      361 ccagcaggat ctcatagatc agaacatact ggagcctgta acccgtgcac agagggtgtg
      421 gattacacca acgcttccaa caatgaacct tcttgcttcc catgtacagt ttgtaaatca
      481 gatcaaaaac ataaaagttc ctgcaccatg accagagaca cagtgtgtca gtgtaaagaa
      541 ggcaccttcc ggaatgaaaa ctccccagag atgtgccgga agtgtagcag gtgccctagt
      601 ggggaagtcc aagtcagtaa ttgtacgtcc tgggatgata tccagtgtgt tgaagaattt
      661 ggtgccaatg ccactgtgga aaccccagct gctgaagaga caatgaacac cagcccgggg
      721 actcctgccc cagctgctga agagacaatg aacaccagcc cggggactcc tgccccagct
      781 gctgaagaga caatgaccac cagcccgggg actcctgccc cagctgctga agagacaatg
      841 accaccagcc cggggactcc tgccccagct gctgaagaga caatgatcac cagcccgggg
      901 actcctgcct cttctcatta cctctcatgc accatcgtag ggatcatagt tctaattgtg
      961 cttctgattg tgtttgtttg aaagacttca ctgtggaaga aattccttcc ttacctgaaa
     1021 ggttcaggta ggcgctggct gagggcgggg ggcgctggac actctctgcc ctgcctccct
     1081 ctgctgtgtt cccacagaca gaaacgcctg cccctgcccc aagtcctggt gtctccagcc
     1141 tggctctatc ttcctccttg tgatcgtccc atccccacat cccgtgcacc ccccaggacc
     1201 ctggtctcat cagtccctct cctggagctg ggggtccaca catctcccag ccaagtccaa
     1261 gagggcaggg ccagttcctc ccatcttcag gcccagccag gcagggggca gtcggctcct
     1321 caactgggtg acaagggtga ggatgagaag tggtcacggg atttattcag ccttggtcag
     1381 agcagaacac agaga
//
