LOCUS       NP_003832                259 aa            linear   PRI 30-APR-2025
DEFINITION  tumor necrosis factor receptor superfamily member 10C precursor
            [Homo sapiens].
ACCESSION   NP_003832
VERSION     NP_003832.3
DBSOURCE    REFSEQ: accession NM_003841.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 259)
  AUTHORS   Suehiro,Y., Tsuge,M., Kurihara,M., Uchida,T., Fujino,H., Ono,A.,
            Yamauchi,M., Naswa Makokha,G., Nakahara,T., Murakami,E.,
            Abe-Chayama,H., Kawaoka,T., Miki,D., Imamura,M., Aikata,H., Nelson
            Hayes,C., Fujita,T. and Chayama,K.
  TITLE     Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in
            Hepatocytes Resulting in Escape From Both Cell Apoptosis and
            Suppression of HBV Replication by TRAIL
  JOURNAL   J Infect Dis 227 (5), 686-695 (2023)
   PUBMED   35226068
  REMARK    GeneRIF: Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in
            Hepatocytes Resulting in Escape From Both Cell Apoptosis and
            Suppression of HBV Replication by TRAIL.
REFERENCE   2  (residues 1 to 259)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 259)
  AUTHORS   Singh,D., Prasad,C.B., Biswas,D., Tewari,M., Kar,A.G., Ansari,M.A.,
            Singh,S. and Narayan,G.
  TITLE     TRAIL receptors are differentially regulated and clinically
            significant in gallbladder cancer
  JOURNAL   Pathology 52 (3), 348-358 (2020)
   PUBMED   32111400
  REMARK    GeneRIF: TRAIL receptors are differentially regulated and
            clinically significant in gallbladder cancer.
REFERENCE   4  (residues 1 to 259)
  AUTHORS   Labovsky,V., Martinez,L.M., Davies,K.M., de Lujan Calcagno,M.,
            Garcia-Rivello,H., Wernicke,A., Feldman,L., Matas,A.,
            Giorello,M.B., Borzone,F.R., Choi,H., Howard,S.C. and
            Chasseing,N.A.
  TITLE     Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor
            epithelial cells of patients with early breast cancer
  JOURNAL   BMC Cancer 17 (1), 280 (2017)
   PUBMED   28420351
  REMARK    GeneRIF: High levels of TRAIL-R3 and CCR-2 expression in tumor
            epithelial cells identified patients with early breast cancer with
            poor outcomes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 259)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (residues 1 to 259)
  AUTHORS   Ruiz de Almodovar,C., Lopez-Rivas,A., Redondo,J.M. and Rodriguez,A.
  TITLE     Transcription initiation sites and promoter structure of the human
            TRAIL-R3 gene
  JOURNAL   FEBS Lett 531 (2), 304-308 (2002)
   PUBMED   12417331
  REMARK    GeneRIF: analysis of the transcription initiation sites and
            promoter structure of the TRAIL-R3 gene
REFERENCE   7  (residues 1 to 259)
  AUTHORS   MacFarlane,M., Ahmad,M., Srinivasula,S.M., Fernandes-Alnemri,T.,
            Cohen,G.M. and Alnemri,E.S.
  TITLE     Identification and molecular cloning of two novel receptors for the
            cytotoxic ligand TRAIL
  JOURNAL   J Biol Chem 272 (41), 25417-25420 (1997)
   PUBMED   9325248
REFERENCE   8  (residues 1 to 259)
  AUTHORS   Degli-Esposti,M.A., Smolak,P.J., Walczak,H., Waugh,J., Huang,C.P.,
            DuBose,R.F., Goodwin,R.G. and Smith,C.A.
  TITLE     Cloning and characterization of TRAIL-R3, a novel member of the
            emerging TRAIL receptor family
  JOURNAL   J Exp Med 186 (7), 1165-1170 (1997)
   PUBMED   9314565
REFERENCE   9  (residues 1 to 259)
  AUTHORS   Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M.,
            Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I.,
            Goddard,A.D., Godowski,P. and Ashkenazi,A.
  TITLE     Control of TRAIL-induced apoptosis by a family of signaling and
            decoy receptors
  JOURNAL   Science 277 (5327), 818-821 (1997)
   PUBMED   9242611
REFERENCE   10 (residues 1 to 259)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107959.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NP_003832.2.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor contains an extracellular
            TRAIL-binding domain and a transmembrane domain, but no cytoplasmic
            death domain. This receptor is not capable of inducing apoptosis,
            and is thought to function as an antagonistic receptor that
            protects cells from TRAIL-induced apoptosis. This gene was found to
            be a p53-regulated DNA damage-inducible gene. The expression of
            this gene was detected in many normal tissues but not in most
            cancer cell lines, which may explain the specific sensitivity of
            cancer cells to the apoptosis-inducing activity of TRAIL. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses a downstream AUG start
            codon. This start codon has a strong Kozak signal and is restricted
            to human. An upstream start codon, which has a weak Kozak signal
            and is conserved in some other primates, is also present. The use
            of the upstream start codon would result in a protein that is 40 aa
            longer at the N-terminus. However, this would eliminate a signal
            peptide that is predicted for the shorter but not the longer
            N-terminus. PMID:9242611 shows experimental evidence for cleavage
            of a signal peptide following aa 25 from the downstream start, and
            this is also confirmed in PMID:15340161. Therefore, the downstream
            start codon is represented for this CCDS.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017852.1, AF014794.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000356864.4/
                                                ENSP00000349324.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     Protein         1..259
                     /product="tumor necrosis factor receptor superfamily
                     member 10C precursor"
                     /note="decoy receptor 1; lymphocyte inhibitor of TRAIL;
                     antagonist decoy receptor for TRAIL/Apo-2L; cytotoxic
                     TRAIL receptor-3; decoy TRAIL receptor without death
                     domain; TNF-related apoptosis-inducing ligand receptor 3;
                     tumor necrosis factor receptor superfamily, member 10c,
                     decoy without an intracellular domain"
                     /calculated_mol_wt=24683
     sig_peptide     1..25
                     /note="/evidence=ECO:0000269|PubMed:15340161,
                     ECO:0000269|PubMed:9242611; propagated from
                     UniProtKB/Swiss-Prot (O14798.3)"
                     /calculated_mol_wt=2742
     mat_peptide     26..236
                     /product="Tumor necrosis factor receptor superfamily
                     member 10C. /id=PRO_0000034582"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
                     /calculated_mol_wt=22199
     Region          29..66
                     /region_name="TNFR-Cys 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     Region          30..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     Region          50..150
                     /region_name="TNFRSF10"
                     /note="Tumor necrosis factor receptor superfamily member
                     10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5),
                     TNFRSF10C (DcR1) and TNFRSF10D (DcR2); cd10580"
                     /db_xref="CDD:276906"
     Site            order(50..52,59,61,78..79,81..84,86..87,126,146)
                     /site_type="other"
                     /note="Antibody binding [polypeptide binding]"
                     /db_xref="CDD:276906"
     Region          50..66
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276906"
     Region          69..109
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276906"
     Region          69..109
                     /region_name="TNFR-Cys 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     Site            77
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (high mannose) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O14798.3)"
     Site            order(84,87,92,123..127)
                     /site_type="other"
                     /note="polypeptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276906"
     Region          110..149
                     /region_name="TNFR-Cys 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     Region          111..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276906"
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (high mannose) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O14798.3)"
     Site            156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (high mannose) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O14798.3)"
     Region          160..224
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     Region          163..>232
                     /region_name="PRK11907"
                     /note="bifunctional 2',3'-cyclic-nucleotide
                     2'-phosphodiesterase/3'-nucleotidase"
                     /db_xref="CDD:237019"
     Region          222..236
                     /region_name="TAPE 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O14798.3)"
     CDS             1..259
                     /gene="TNFRSF10C"
                     /gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
                     TRAILR3; TRID"
                     /coded_by="NM_003841.5:202..981"
                     /db_xref="CCDS:CCDS6037.1"
                     /db_xref="GeneID:8794"
                     /db_xref="HGNC:HGNC:11906"
                     /db_xref="MIM:603613"
ORIGIN      
        1 maripktlkf vvvivavllp vlaysattar qeevpqqtva pqqqrhsfkg eecpagshrs
       61 ehtgacnpct egvdytnasn nepscfpctv cksdqkhkss ctmtrdtvcq ckegtfrnen
      121 spemcrkcsr cpsgevqvsn ctswddiqcv eefganatve tpaaeetmnt spgtpapaae
      181 etmntspgtp apaaeetmtt spgtpapaae etmttspgtp apaaeetmit spgtpasshy
      241 lsctivgiiv livllivfv
//
