LOCUS       NM_003842               3998 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B),
            transcript variant 1, mRNA.
ACCESSION   NM_003842
VERSION     NM_003842.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Chen,J., Li,L., Huangfu,L., Du,H., Ji,X., Xing,X. and Ji,J.
  TITLE     Death receptor 5 promotes tumor progression in gastric cancer
  JOURNAL   FEBS Open Bio 13 (12), 2375-2388 (2023)
   PUBMED   37879960
  REMARK    GeneRIF: Death receptor 5 promotes tumor progression in gastric
            cancer.
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Kuang,N., Shu,B., Yang,F., Li,S. and Zhang,M.
  TITLE     TRAIL or TRAIL-R2 as a Predictive Biomarker for Mortality or
            Cardiovascular Events: A Systematic Review and Meta-analysis
  JOURNAL   J Cardiovasc Pharmacol 81 (5), 348-354 (2023)
   PUBMED   36888983
  REMARK    GeneRIF: TRAIL or TRAIL-R2 as a Predictive Biomarker for Mortality
            or Cardiovascular Events: A Systematic Review and Meta-analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Dai,M., Yan,L., Yu,H., Chen,C. and Xie,Y.
  TITLE     TNFRSF10B is involved in motor dysfunction in Parkinson's disease
            by regulating exosomal alpha-synuclein secretion from microglia
  JOURNAL   J Chem Neuroanat 129, 102249 (2023)
   PUBMED   36791922
  REMARK    GeneRIF: TNFRSF10B is involved in motor dysfunction in Parkinson's
            disease by regulating exosomal alpha-synuclein secretion from
            microglia.
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Woo,S.M., Kim,S., Seo,S.U., Kim,S., Park,J.W., Kim,G., Choi,Y.R.,
            Hur,K. and Kwon,T.K.
  TITLE     Inhibition of USP1 enhances anticancer drugs-induced cancer cell
            death through downregulation of survivin and miR-216a-5p-mediated
            upregulation of DR5
  JOURNAL   Cell Death Dis 13 (9), 821 (2022)
   PUBMED   36153316
  REMARK    GeneRIF: Inhibition of USP1 enhances anticancer drugs-induced
            cancer cell death through downregulation of survivin and
            miR-216a-5p-mediated upregulation of DR5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Mora-Molina,R. and Lopez-Rivas,A.
  TITLE     Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon
            Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer
  JOURNAL   Int J Mol Sci 23 (16), 8987 (2022)
   PUBMED   36012252
  REMARK    GeneRIF: Restoring TRAILR2/DR5-Mediated Activation of Apoptosis
            upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in
            Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Walczak,H., Degli-Esposti,M.A., Johnson,R.S., Smolak,P.J.,
            Waugh,J.Y., Boiani,N., Timour,M.S., Gerhart,M.J., Schooley,K.A.,
            Smith,C.A., Goodwin,R.G. and Rauch,C.T.
  TITLE     TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
  JOURNAL   EMBO J 16 (17), 5386-5397 (1997)
   PUBMED   9311998
REFERENCE   7  (bases 1 to 3998)
  AUTHORS   Screaton,G.R., Mongkolsapaya,J., Xu,X.N., Cowper,A.E.,
            McMichael,A.J. and Bell,J.I.
  TITLE     TRICK2, a new alternatively spliced receptor that transduces the
            cytotoxic signal from TRAIL
  JOURNAL   Curr Biol 7 (9), 693-696 (1997)
   PUBMED   9285725
REFERENCE   8  (bases 1 to 3998)
  AUTHORS   Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M.,
            Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I.,
            Goddard,A.D., Godowski,P. and Ashkenazi,A.
  TITLE     Control of TRAIL-induced apoptosis by a family of signaling and
            decoy receptors
  JOURNAL   Science 277 (5327), 818-821 (1997)
   PUBMED   9242611
REFERENCE   9  (bases 1 to 3998)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
REFERENCE   10 (bases 1 to 3998)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Raymond Dalgleish. The reference sequence was
            derived from DA738472.1, DA889488.1, BC001281.1, CX870630.1,
            BX537617.1 and AC107959.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003842.4.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily, and contains an intracellular death
            domain. This receptor can be activated by tumor necrosis
            factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L),
            and transduces an apoptosis signal. Studies with FADD-deficient
            mice suggested that FADD, a death domain containing adaptor
            protein, is required for the apoptosis mediated by this protein.
            Two transcript variants encoding different isoforms and one
            non-coding transcript have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016266.1, SRR1803611.27807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276431.9/ ENSP00000276431.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               DA738472.1         157-387
            232-562             DA889488.1         232-562
            563-708             BC001281.1         573-718
            709-1471            CX870630.1         77-839
            1472-3108           BX537617.1         733-2369
            3109-3998           AC107959.8         82828-83717         c
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3998
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="TNF receptor superfamily member 10b"
                     /db_xref="GeneID:8795"
                     /db_xref="HGNC:HGNC:11905"
                     /db_xref="MIM:603612"
     exon            1..281
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1460
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; death receptor 5; apoptosis inducing receptor
                     TRAIL-R2; apoptosis inducing protein TRICK2A/2B; tumor
                     necrosis factor receptor-like protein ZTNFR9; death domain
                     containing receptor for TRAIL/Apo-2L; cytotoxic TRAIL
                     receptor-2; p53-regulated DNA damage-inducible cell death
                     receptor(killer); Fas-like protein; TNF-related
                     apoptosis-inducing ligand receptor 2; tumor necrosis
                     factor receptor superfamily, member 10b; tumor necrosis
                     factor receptor superfamily member 10B"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 10B isoform 1 precursor"
                     /protein_id="NP_003833.4"
                     /db_xref="CCDS:CCDS6035.1"
                     /db_xref="GeneID:8795"
                     /db_xref="HGNC:HGNC:11905"
                     /db_xref="MIM:603612"
                     /translation="MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAA
                     VLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQD
                     YSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGC
                     PRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGV
                     TVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIV
                     SILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDP
                     TETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNK
                     TGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS"
     exon            282..387
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            388..501
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            502..613
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            614..885
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            886..917
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1073
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1146
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..3998
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3973..3978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="hexamer: ATTAAA"
     polyA_site      3998
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="major polyA site"
ORIGIN      
        1 agcctggaca cataaatcag cacgcggccg gagaaccccg caatctctgc gcccacaaaa
       61 tacaccgacg atgcccgatc tactttaagg gctgaaaccc acgggcctga gagactataa
      121 gagcgttccc taccgccatg gaacaacggg gacagaacgc cccggccgct tcgggggccc
      181 ggaaaaggca cggcccagga cccagggagg cgcggggagc caggcctggg ccccgggtcc
      241 ccaagaccct tgtgctcgtt gtcgccgcgg tcctgctgtt ggtctcagct gagtctgctc
      301 tgatcaccca acaagaccta gctccccagc agagagcggc cccacaacaa aagaggtcca
      361 gcccctcaga gggattgtgt ccacctggac accatatctc agaagacggt agagattgca
      421 tctcctgcaa atatggacag gactatagca ctcactggaa tgacctcctt ttctgcttgc
      481 gctgcaccag gtgtgattca ggtgaagtgg agctaagtcc ctgcaccacg accagaaaca
      541 cagtgtgtca gtgcgaagaa ggcaccttcc gggaagaaga ttctcctgag atgtgccgga
      601 agtgccgcac agggtgtccc agagggatgg tcaaggtcgg tgattgtaca ccctggagtg
      661 acatcgaatg tgtccacaaa gaatcaggta caaagcacag tggggaagtc ccagctgtgg
      721 aggagacggt gacctccagc ccagggactc ctgcctctcc ctgttctctc tcaggcatca
      781 tcataggagt cacagttgca gccgtagtct tgattgtggc tgtgtttgtt tgcaagtctt
      841 tactgtggaa gaaagtcctt ccttacctga aaggcatctg ctcaggtggt ggtggggacc
      901 ctgagcgtgt ggacagaagc tcacaacgac ctggggctga ggacaatgtc ctcaatgaga
      961 tcgtgagtat cttgcagccc acccaggtcc ctgagcagga aatggaagtc caggagccag
     1021 cagagccaac aggtgtcaac atgttgtccc ccggggagtc agagcatctg ctggaaccgg
     1081 cagaagctga aaggtctcag aggaggaggc tgctggttcc agcaaatgaa ggtgatccca
     1141 ctgagactct gagacagtgc ttcgatgact ttgcagactt ggtgcccttt gactcctggg
     1201 agccgctcat gaggaagttg ggcctcatgg acaatgagat aaaggtggct aaagctgagg
     1261 cagcgggcca cagggacacc ttgtacacga tgctgataaa gtgggtcaac aaaaccgggc
     1321 gagatgcctc tgtccacacc ctgctggatg ccttggagac gctgggagag agacttgcca
     1381 agcagaagat tgaggaccac ttgttgagct ctggaaagtt catgtatcta gaaggtaatg
     1441 cagactctgc catgtcctaa gtgtgattct cttcaggaag tcagaccttc cctggtttac
     1501 cttttttctg gaaaaagccc aactggactc cagtcagtag gaaagtgcca caattgtcac
     1561 atgaccggta ctggaagaaa ctctcccatc caacatcacc cagtggatgg aacatcctgt
     1621 aacttttcac tgcacttggc attattttta taagctgaat gtgataataa ggacactatg
     1681 gaaatgtctg gatcattccg tttgtgcgta ctttgagatt tggtttggga tgtcattgtt
     1741 ttcacagcac ttttttatcc taatgtaaat gctttattta tttatttggg ctacattgta
     1801 agatccatct acacagtcgt tgtccgactt cacttgatac tatatgatat gaaccttttt
     1861 tgggtggggg gtgcggggca gttcactctg tctcccaggc tggagtgcaa tggtgcaatc
     1921 ttggctcact atagccttga cctctcaggc tcaagcgatt ctcccacctc agccatccaa
     1981 atagctggga ccacaggtgt gcaccaccac gcccggctaa ttttttgtat tttgtctaga
     2041 tataggggct ctctatgttg ctcagggtgg tctcgaattc ctggactcaa gcagtctgcc
     2101 cacctcagac tcccaaagcg gtggaattag aggcgtgagc ccccatgctt ggccttacct
     2161 ttctactttt ataattctgt atgttattat tttatgaaca tgaagaaact ttagtaaatg
     2221 tacttgttta catagttatg tgaatagatt agataaacat aaaaggagga gacatacaat
     2281 gggggaagaa gaagaagtcc cctgtaagat gtcactgtct gggttccagc cctccctcag
     2341 atgtactttg gcttcaatga ttggcaactt ctacaggggc cagtcttttg aactggacaa
     2401 ccttacaagt atatgagtat tatttatagg tagttgttta catatgagtc gggaccaaag
     2461 agaactggat ccacgtgaag tcctgtgtgt ggctggtccc tacctgggca gtctcatttg
     2521 cacccatagc ccccatctat ggacaggctg ggacagaggc agatgggtta gatcacacat
     2581 aacaataggg tctatgtcat atcccaagtg aacttgagcc ctgtttgggc tcaggagata
     2641 gaagacaaaa tctgtctccc acgtctgcca tggcatcaag ggggaagagt agatggtgct
     2701 tgagaatggt gtgaaatggt tgccatctca ggagtagatg gcccggctca cttctggtta
     2761 tctgtcaccc tgagcccatg agctgccttt tagggtacag attgcctact tgaggacctt
     2821 ggccgctctg taagcatctg actcatctca gaaatgtcaa ttcttaaaca ctgtggcaac
     2881 aggacctaga atggctgacg cattaaggtt ttcttcttgt gtcctgttct attattgttt
     2941 taagacctca gtaaccattt cagcctcttt ccagcaaacc cttctccata gtatttcagt
     3001 catggaagga tcatttatgc aggtagtcat tccaggagtt tttggtcttt tctgtctcaa
     3061 ggcattgtgt gttttgttcc gggactggtt tgggtgggac aaagttagaa ttgcctgaag
     3121 atcacacatt cagactgttg tgtctgtgga gttttaggag tggggggtga cctttctggt
     3181 ctttgcactt ccatcctctc ccacttccat ctggcatccc acgcgttgtc ccctgcactt
     3241 ctggaaggca cagggtgctg ctgcctcctg gtctttgcct ttgctgggcc ttctgtgcag
     3301 gacgctcagc ctcagggctc agaaggtgcc agtccggtcc caggtccctt gtcccttcca
     3361 cagaggcctt cctagaagat gcatctagag tgtcagcctt atcagtgttt aagatttttc
     3421 ttttattttt aatttttttg agacagaatc tcactctctc gcccaggctg gagtgcaacg
     3481 gtacgatctt ggctcagtgc aacctccgcc tcctgggttc aagcgattct cgtgcctcag
     3541 cctccggagt agctgggatt gcaggcaccc gccaccacgc ctggctaatt tttgtatttt
     3601 tagtagagac ggggtttcac catgttggtc aggctggtct cgaactcctg acctcaggtg
     3661 atccaccttg gcctccgaaa gtgctgggat tacaggcgtg agccaccagc caggccaagc
     3721 tattctttta aagtaagctt cctgacgaca tgaaataatt gggggttttg ttgtttagtt
     3781 acattaggct ttgctatatc cccaggccaa atagcatgtg acacaggaca gccatagtat
     3841 agtgtgtcac tcgtggttgg tgtcctttca tgcttctgcc ctgtcaaagg tccctatttg
     3901 aaatgtgtta taatacaaac aaggaagcac attgtgtaca aaatacttat gtatttatga
     3961 atccatgacc aaattaaata tgaaacctta tataaaaa
//
