LOCUS       NM_003844               2690 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TNF receptor superfamily member 10a (TNFRSF10A), mRNA.
ACCESSION   NM_003844
VERSION     NM_003844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Kiraly,P., Zupan,A., Matjasic,A. and Mekjavic,P.J.
  TITLE     Associations of Single-Nucleotide Polymorphisms in Slovenian
            Patients with Acute Central Serous Chorioretinopathy
  JOURNAL   Genes (Basel) 13 (1), 55 (2021)
   PUBMED   35052395
  REMARK    GeneRIF: Associations of Single-Nucleotide Polymorphisms in
            Slovenian Patients with Acute Central Serous Chorioretinopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Greenlee,J.D., Lopez-Cavestany,M., Ortiz-Otero,N., Liu,K.,
            Subramanian,T., Cagir,B. and King,M.R.
  TITLE     Oxaliplatin resistance in colorectal cancer enhances TRAIL
            sensitivity via death receptor 4 upregulation and lipid raft
            localization
  JOURNAL   Elife 10, e67750 (2021)
   PUBMED   34342264
  REMARK    GeneRIF: Oxaliplatin resistance in colorectal cancer enhances TRAIL
            sensitivity via death receptor 4 upregulation and lipid raft
            localization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Watanabe,A., Miyake,K., Akahane,K., Goi,K., Kagami,K., Yagita,H.
            and Inukai,T.
  TITLE     Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL
            Resistance in Childhood B-Cell Precursor Acute Lymphoblastic
            Leukemia
  JOURNAL   Genes (Basel) 12 (6), 864 (2021)
   PUBMED   34198757
  REMARK    GeneRIF: Epigenetic Modification of Death Receptor Genes for TRAIL
            and TRAIL Resistance in Childhood B-Cell Precursor Acute
            Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Khorshied,M., Soliman,N., Khorshid,O. and Bakr,S.
  TITLE     Genetic variations in tumor ecrosis factor related
            apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the
            susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt
  JOURNAL   Cancer Biomark 32 (4), 451-458 (2021)
   PUBMED   34275891
  REMARK    GeneRIF: Genetic variations in tumor ecrosis factor related
            apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the
            susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt.
            Erratum:[Cancer Biomark. 2022;33(2):275. doi: 10.3233/CBM-209786..
            PMID: 35068443]
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Schneider,P., Bodmer,J.L., Thome,M., Hofmann,K., Holler,N. and
            Tschopp,J.
  TITLE     Characterization of two receptors for TRAIL
  JOURNAL   FEBS Lett 416 (3), 329-334 (1997)
   PUBMED   9373179
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   MacFarlane,M., Ahmad,M., Srinivasula,S.M., Fernandes-Alnemri,T.,
            Cohen,G.M. and Alnemri,E.S.
  TITLE     Identification and molecular cloning of two novel receptors for the
            cytotoxic ligand TRAIL
  JOURNAL   J Biol Chem 272 (41), 25417-25420 (1997)
   PUBMED   9325248
REFERENCE   8  (bases 1 to 2690)
  AUTHORS   Walczak,H., Degli-Esposti,M.A., Johnson,R.S., Smolak,P.J.,
            Waugh,J.Y., Boiani,N., Timour,M.S., Gerhart,M.J., Schooley,K.A.,
            Smith,C.A., Goodwin,R.G. and Rauch,C.T.
  TITLE     TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
  JOURNAL   EMBO J 16 (17), 5386-5397 (1997)
   PUBMED   9311998
REFERENCE   9  (bases 1 to 2690)
  AUTHORS   Pan,G., O'Rourke,K., Chinnaiyan,A.M., Gentz,R., Ebner,R., Ni,J. and
            Dixit,V.M.
  TITLE     The receptor for the cytotoxic ligand TRAIL
  JOURNAL   Science 276 (5309), 111-113 (1997)
   PUBMED   9082980
REFERENCE   10 (bases 1 to 2690)
  AUTHORS   Fleury,S., Thibodeau,J., Croteau,G., Labrecque,N., Aronson,H.E.,
            Cantin,C., Long,E.O. and Sekaly,R.P.
  TITLE     HLA-DR polymorphism affects the interaction with CD4
  JOURNAL   J Exp Med 182 (3), 733-741 (1995)
   PUBMED   7650480
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012866.1, CN423254.1 and
            AC100861.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003844.3.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is activated by tumor
            necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL),
            and thus transduces cell death signal and induces cell apoptosis.
            Studies with FADD-deficient mice suggested that FADD, a death
            domain containing adaptor protein, is required for the apoptosis
            mediated by this protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.404726.1,
                                           SRR6380201.98557.17 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221132.8/ ENSP00000221132.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              BC012866.1         25-1386
            1363-1368           CN423254.1         33-38
            1369-1685           BC012866.1         1393-1709
            1686-2690           AC100861.2         87810-88814
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..2690
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /note="TNF receptor superfamily member 10a"
                     /db_xref="GeneID:8797"
                     /db_xref="HGNC:HGNC:11904"
                     /db_xref="MIM:603611"
     exon            1..347
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1448
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /note="death receptor 4; cytotoxic TRAIL receptor;
                     TRAIL-R1; TRAIL receptor 1; TNF-related apoptosis-inducing
                     ligand receptor 1; tumor necrosis factor receptor
                     superfamily, member 10a"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 10A"
                     /protein_id="NP_003835.3"
                     /db_xref="CCDS:CCDS6039.1"
                     /db_xref="GeneID:8797"
                     /db_xref="HGNC:HGNC:11904"
                     /db_xref="MIM:603611"
                     /translation="MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGR
                     IEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQ
                     VVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNN
                     LFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKV
                     KDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMD
                     RVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEA
                     QCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKN
                     EIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVD
                     SGKFIYLEDGTGSAVSLE"
     exon            348..444
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..558
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..670
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..744
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..840
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..872
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1055
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1128
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..2690
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2561..2566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2585
                     /gene="TNFRSF10A"
                     /gene_synonym="APO2; CD261; DR4; TRAILR-1; TRAILR1"
                     /note="major polyA site"
ORIGIN      
        1 gtcatagcca agcacgctgc ttcttggatt gacctggcag gatggcgcca ccaccagcta
       61 gagtacatct aggtgcgttc ctggcagtga ctccgaatcc cgggagcgca gcgagtggga
      121 cagaggcagc cgcggccaca cccagcaaag tgtggggctc ttccgcgggg aggattgaac
      181 cacgaggcgg gggccgagga gcgctcccta cctccatggg acagcacgga cccagtgccc
      241 gggcccgggc agggcgcgcc ccaggaccca ggccggcgcg ggaagccagc cctcggctcc
      301 gggtccacaa gaccttcaag tttgtcgtcg tcggggtcct gctgcaggtc gtacctagct
      361 cagctgcaac catcaaactt catgatcaat caattggcac acagcaatgg gaacatagcc
      421 ctttgggaga gttgtgtcca ccaggatctc atagatcaga acatcctgga gcctgtaacc
      481 ggtgcacaga gggtgtgggt tacaccaatg cttccaacaa tttgtttgct tgcctcccat
      541 gtacagcttg taaatcagat gaagaagaga gaagtccctg caccacgacc aggaacacag
      601 catgtcagtg caaaccagga actttccgga atgacaattc tgctgagatg tgccggaagt
      661 gcagcagagg gtgccccaga gggatggtca aggtcaagga ttgtacgccc tggagtgaca
      721 tcgagtgtgt ccacaaagaa tcaggcaatg gacataatat atgggtgatt ttggttgtga
      781 ctttggttgt tccgttgctg ttggtggctg tgctgattgt ctgttgttgc atcggctcag
      841 gttgtggagg ggaccccaag tgcatggaca gggtgtgttt ctggcgcttg ggtctcctac
      901 gagggcctgg ggctgaggac aatgctcaca acgagattct gagcaacgca gactcgctgt
      961 ccactttcgt ctctgagcag caaatggaaa gccaggagcc ggcagatttg acaggtgtca
     1021 ctgtacagtc cccaggggag gcacagtgtc tgctgggacc ggcagaagct gaagggtctc
     1081 agaggaggag gctgctggtt ccagcaaatg gtgctgaccc cactgagact ctgatgctgt
     1141 tctttgacaa gtttgcaaac atcgtgccct ttgactcctg ggaccagctc atgaggcagc
     1201 tggacctcac gaaaaatgag atcgatgtgg tcagagctgg tacagcaggc ccaggggatg
     1261 ccttgtatgc aatgctgatg aaatgggtca acaaaactgg acggaacgcc tcgatccaca
     1321 ccctgctgga tgccttggag aggatggaag agagacatgc aagagagaag attcaggacc
     1381 tcttggtgga ctctggaaag ttcatctact tagaagatgg cacaggctct gccgtgtcct
     1441 tggagtgaaa gactcttttt accagaggtt tcctcttagg tgttaggagt taatacatat
     1501 taggtttttt ttttttttaa catgtataca aagtaaattc ttagccaggt gtagtggctc
     1561 atgcctgtaa tcccagcact ttgggaggct gaggcgggtg gatcacttga ggtcagaagt
     1621 tcaagaccag cctgaccaac atcgtgaaat gccgtcttta caaaaaaata caaaaattaa
     1681 ctggatgtga tggtgtgtgc atatattctc ggctactcgg gaggctgagg caggagaatc
     1741 acttgaaccc acgaggcagt gagctgagat tgcaccactg cactccagcc tgggacacag
     1801 agcaagactc tgtctcaaga taaaataaaa taaacttgaa agaattattg cccgactgag
     1861 gctcacatgc caaaggaaaa tctggttctc ccctgagctg gcctccgtgt gtttccttat
     1921 catggtggtc aattggaggt gttaatttga atggattaag gaacacctag aacactggta
     1981 aggcattatt tctgggacat tatttctggg catgtcttcg agggtgtttc cagaggggat
     2041 tggcatgcga tcgggtggac tgagtggaaa agacctaccc ttaatttggg ggggcaccgt
     2101 ccgacagact ggggagcaag atagaagaaa acaaaaaaaa aaggaaaagc aaatccatct
     2161 gatctcctgg agctgggaca ctcttctgcc tgtggacatc agagtctagg atttctagcc
     2221 cttggactcc agggcataca ccagtggcct cccgaaggat ctaaggattt tggccttgaa
     2281 ctaagaatta caccatcggc ttccctgggt cttaggtttt tgggctggat taagtcctgc
     2341 ttccagcatt tcagggtctc tgctgtgcag atggcctgtt gtggaacttc tcaacctcca
     2401 ttatcagatg cattaattcc tccaataagt cccatttcat atatagtcat ttaccccaca
     2461 acatttcagt caagggaaca gcatataaga tggtggccgt ccagtaagct aaggttaatt
     2521 tattaattat ttaatttatt taccttgagt tcaagtcaca attaaagtac atataccttt
     2581 ggaaatttgg acttttgtat ataaaagtac ttttttttgg cgggggcagt gggcagctct
     2641 catcctaaac aaatgtgtta tttggtacct atgcaaagat ttggttaaaa
//
