LOCUS       NM_001311175            2206 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens TNF alpha induced protein 8 like 3 (TNFAIP8L3),
            transcript variant 2, mRNA.
ACCESSION   NM_001311175 XM_005254367
VERSION     NM_001311175.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Zong,Z., Tang,G., Guo,Y. and Kong,F.
  TITLE     Down-regulated expression of TIPE3 inhibits malignant progression
            of non-small cell lung cancer via Wnt signaling
  JOURNAL   Exp Cell Res 439 (2), 114093 (2024)
   PUBMED   38759744
  REMARK    GeneRIF: Down-regulated expression of TIPE3 inhibits malignant
            progression of non-small cell lung cancer via Wnt signaling.
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Xia,H.B., Zhu,X.D., Zhu,Y. and Xu,A.M.
  TITLE     Comprehensive analysis of the prognostic and immunological roles of
            TIPE3 in Colon Cancer
  JOURNAL   Asian J Surg 47 (3), 1530-1532 (2024)
   PUBMED   38071098
  REMARK    GeneRIF: Comprehensive analysis of the prognostic and immunological
            roles of TIPE3 in Colon Cancer.
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Chen,W., Chen,X., Wang,L., Yang,R., Zhang,W., Zhang,S., Xia,J.,
            Cheng,B., Wu,T. and Ren,X.
  TITLE     TIPE3 represses head and neck squamous cell carcinoma progression
            via triggering PGAM5 mediated mitochondria dysfunction
  JOURNAL   Cell Death Dis 14 (4), 251 (2023)
   PUBMED   37024453
  REMARK    GeneRIF: TIPE3 represses head and neck squamous cell carcinoma
            progression via triggering PGAM5 mediated mitochondria dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2206)
  AUTHORS   Song,J., Yang,Q., Xiong,H., Gu,X., Chen,M., Zhou,C. and Cai,Y.
  TITLE     TIPE3 protects mice from lipopolysaccharide-induced acute lung
            injury
  JOURNAL   Transpl Immunol 77, 101799 (2023)
   PUBMED   36842565
  REMARK    GeneRIF: TIPE3 protects mice from lipopolysaccharide-induced acute
            lung injury.
REFERENCE   5  (bases 1 to 2206)
  AUTHORS   Xu,Y., Zhu,Y., Xia,H., Wang,Y., Li,L., Wan,H., Zhang,S., Xu,A.,
            Wang,L., Gong,J. and Zhang,P.
  TITLE     Tumor necrosis factor-alpha-inducible protein 8-like protein 3
            (TIPE3): a novel prognostic factor in colorectal cancer
  JOURNAL   BMC Cancer 23 (1), 131 (2023)
   PUBMED   36755222
  REMARK    GeneRIF: Tumor necrosis factor-alpha-inducible protein 8-like
            protein 3 (TIPE3): a novel prognostic factor in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2206)
  AUTHORS   Antony,P., Baby,B. and Vijayan,R.
  TITLE     Molecular insights into the binding of phosphoinositides to the TH
            domain region of TIPE proteins
  JOURNAL   J Mol Model 22 (11), 272 (2016)
   PUBMED   27783229
  REMARK    GeneRIF: Further MD simulations confirmed the dynamic stability of
            these lipids in the TH domain. This computational analysis thus
            provides insight into the binding mode of phospholipids in the TH
            domain of the TIPE family of proteins.
REFERENCE   7  (bases 1 to 2206)
  AUTHORS   Cui,J., Hao,C., Zhang,W., Shao,J., Zhang,N., Zhang,G. and Liu,S.
  TITLE     Identical expression profiling of human and murine TIPE3 protein
            reveals links to its functions
  JOURNAL   J Histochem Cytochem 63 (3), 206-216 (2015)
   PUBMED   25479791
  REMARK    GeneRIF: TIPE3 protein is highly expressed in most human carcinoma
            cell lines. These results suggest that TIPE3 may play important
            roles in carcinogenesis and cell secretion.
REFERENCE   8  (bases 1 to 2206)
  AUTHORS   Fayngerts,S.A., Wu,J., Oxley,C.L., Liu,X., Vourekas,A.,
            Cathopoulis,T., Wang,Z., Cui,J., Liu,S., Sun,H., Lemmon,M.A.,
            Zhang,L., Shi,Y. and Chen,Y.H.
  TITLE     TIPE3 is the transfer protein of lipid second messengers that
            promote cancer
  JOURNAL   Cancer Cell 26 (4), 465-478 (2014)
   PUBMED   25242044
  REMARK    GeneRIF: human cancers have markedly upregulated TIPE3 expression.
            Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3
            expression enhances it in vivo
REFERENCE   9  (bases 1 to 2206)
  AUTHORS   Lou,Y. and Liu,S.
  TITLE     The TIPE (TNFAIP8) family in inflammation, immunity, and cancer
  JOURNAL   Mol Immunol 49 (1-2), 4-7 (2011)
   PUBMED   21924498
  REMARK    Review article
REFERENCE   10 (bases 1 to 2206)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073964.3, HY052681.1, AK123281.1 and CA447540.1.
            
            On May 17, 2019 this sequence version replaced NM_001311175.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. It encodes isoform
            2, which has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: A downstream start codon is represented in this
            variant based on transcript data, conservation and data in PMID:
            25242044 that pertains to the mouse ortholog.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123281.1, SRR1803616.178725.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000637513.2/ ENSP00000489743.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC073964.3         104647-104847       c
            202-217             HY052681.1         1-16
            218-2203            AK123281.1         1-1986
            2204-2206           CA447540.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..2206
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /note="TNF alpha induced protein 8 like 3"
                     /db_xref="GeneID:388121"
                     /db_xref="HGNC:HGNC:20620"
                     /db_xref="MIM:616438"
     exon            1..363
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..926
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /note="isoform 2 is encoded by transcript variant 2; tumor
                     necrosis factor alpha-induced protein 8-like protein 3;
                     TNFAIP8-like protein 3; TNF alpha-induced protein 8-like
                     protein 3; tumor necrosis factor, alpha induced protein 8
                     like 3"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 3 isoform 2"
                     /protein_id="NP_001298104.1"
                     /db_xref="CCDS:CCDS81881.1"
                     /db_xref="GeneID:388121"
                     /db_xref="HGNC:HGNC:20620"
                     /db_xref="MIM:616438"
                     /translation="MDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTV
                     ANMLIDDTSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEEL
                     VIVEKFRKKLNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGR
                     INHVFNHFADVEFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL"
     exon            364..2206
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /note="hexamer: AATAAA"
     polyA_site      2206
                     /gene="TNFAIP8L3"
                     /gene_synonym="TIPE3"
                     /note="major polyA site"
ORIGIN      
        1 gccggacgct cgggctcctc ggcgctcgcg cctcccctcc ctcctcccgg ctgtctcccg
       61 gagcgcccca ccctccgccc tgcgctcgcc tcgcgcgcag gcaccggccg gcgggcgcgg
      121 ggagcggggc gcggcggcgc tcgcctctgc ggagccgccc cctggccgct gccgccgcgc
      181 accgcccagc ccgcgccgcc cgcgccgccc gggctccagc cgccccgctg tccgccctga
      241 gtgcgccgcg gctgcccgag cgccccgcag acgggcgggt ggccgtggac gcccagccag
      301 cagcccgcag catggattcg gattccgggg agcagagcga gggcgagccc gtgaccgccg
      361 caggtcctga tgtttttagt tcaaagagtc ttgcgcttca agcccagaag aagattctga
      421 gcaaaatagc cagcaaaact gtggccaaca tgttgattga tgacaccagc agcgagatct
      481 ttgatgagct ctacaaagtc accaaagagc acacacacaa caagaaggaa gcccacaaga
      541 tcatgaaaga cttaatcaag gtggcgatca aaatcgggat cctctaccgg aacaaccagt
      601 ttagccaaga ggagctggtt attgtggaga agttccggaa gaagctgaac cagaccgcca
      661 tgaccattgt cagcttctat gaggtggaat acaccttcga taggaacgtg ctctccaatc
      721 tcctgcatga gtgcaaggac ctggtgcatg aactggtgca gcggcacctg acgcccagga
      781 cccacgggcg catcaaccac gtctttaacc actttgccga tgtggagttc ctctccaccc
      841 tctatagtct ggatggagac tgtaggccca acctcaagag gatttgtgaa ggaatcaata
      901 agttgctaga tgagaaagtc ctttaaatgc cttccctcct actggacttt gctgctttaa
      961 agttacagca ctcaaccatg atctgggtga gaatcaagaa cataagcaga aacccttgtc
     1021 aaagatgtcc atgttctttc ctgttcatcc ctctgatgct gattctgatg ctgaactgag
     1081 ctcaggtgtg tttttcttcc aagctttcta gcaaggtttc tacttaaaat cacctgtgtg
     1141 caagcccaaa ggacatttca tctattctaa gcagaaaggc tgttttgttc attacagtga
     1201 gtgctgttca tctcatggag tgggaggagc actaaaccag gagacagagg acatggattt
     1261 ggtttccagc ttaaccagtt aggactctgt cctctgcatt ctggaaccat gatgcctgcc
     1321 tgcctgcctc acagggctgt tgtgaggacc agatgagatg atgtatgttc atacttttgg
     1381 aatctctaat ttaaagtctt aatattttgt cttctgagtg tgaggggata aacctggatg
     1441 tagactatta agcagcatag gagaaaagaa caatagaatc taatggactg ggtttgcaat
     1501 ctctctctaa atgcactgct tcagacaaag tgaaatccaa aggtgtgaaa aagtatagct
     1561 gcaaattgga aaaatgtgtt tcaagagtcg tctttttggc caggcatggt ggctcacacc
     1621 tgtaatccca gcactttggg aggccgaggt gggcagattg cctgaggtcc ggagttcaag
     1681 atcagcctgg ccaacatgat gaaaccctat ctctactaaa attacaaaaa ttagccaggc
     1741 gtggtggtac acgcctgtaa tcccagctac tcaggaggct gaggcaggag aattgtttga
     1801 acctgggaga tggaggctgc agtgagctga gatcacgcca ctgtactcca gcctgggcaa
     1861 cagagcaaga ctctgtctct aaaaaataat aataataata ataatttttt taaaaagagg
     1921 tgtttttgag gtcttagatg ttcaggttga tgatcctgca gagggaaact ttccatgggg
     1981 gggtggggag agagagtttt ccatccacaa tatagaaaca gagaagcact gtgctccctc
     2041 tgcaggacca gccttccctt atctaagggg catggagctc agggaggctt tattccatat
     2101 gcacgggaga atcaggcaga atgaacccct acccatcttt cttggctttt cagtcatttt
     2161 gtgctgtttt ctctggttca ttaataaatt gaaactgccc tccaaa
//
