LOCUS       NM_001204848            1927 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens TNFAIP8L2-SCNM1 readthrough (TNFAIP8L2-SCNM1),
            transcript variant 1, mRNA.
ACCESSION   NM_001204848
VERSION     NM_001204848.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592424.13 and BG531092.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001204848.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring TNFAIP8L2 (tumor necrosis
            factor, alpha-induced protein 8-like 2) and SCNM1 (sodium channel
            modifier 1) genes on chromosome 1. The protein-coding read-through
            transcript variant encodes a protein that shares sequence identity
            with the downstream gene product but its N-terminal region is
            shorter due to alternate exon use relative to the downstream gene.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR999387.1, BG531092.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 79005, 79626
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL592424.13        50752-50766
            16-152              BG531092.1         2-138
            153-153             AL592424.13        61044-61044
            154-515             BG531092.1         140-501
            516-524             AL592424.13        62341-62349
            525-661             BG531092.1         512-648
            662-1927            AL592424.13        63134-64399
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1927
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /note="TNFAIP8L2-SCNM1 readthrough"
                     /db_xref="GeneID:100534012"
     exon            1..74
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..145
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..716
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /note="Sodium channel modifier 1"
                     /codon_start=1
                     /product="TNFAIP8L2-SCNM1 protein"
                     /protein_id="NP_001191777.1"
                     /db_xref="GeneID:100534012"
                     /translation="MLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKK
                     QPGKERKQNPKHQNELRREETKAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAP
                     GPSVSLSPMPPSEVKLQSGKISREPEPAAGPQAEESATVSAPAPMSPTRRRALDHYLT
                     LRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLPLD"
     exon            146..234
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..332
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..421
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..616
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1927
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      745..750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /note="hexamer: ATTACA"
     polyA_site      769
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /note="major polyA site"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="TNFAIP8L2-SCNM1"
                     /gene_synonym="SCNM1"
ORIGIN      
        1 acactaagtg aagcttctcc attctgtaag ctttccggga acatccaagg caagactggc
       61 acccagcaca gcagaaaaga agagtcgggg acctcctagc cagttacatt ccagaggatg
      121 aggcgctgat gcttcgggat ggacgctttg cttgtgccat ctgcccccat cgaccggtac
      181 tggacaccct ggccatgctg actgcccacc gtgcaggcaa gaaacatctg tccagcttgc
      241 agcttttcta tggcaagaag cagccgggaa aggaaagaaa gcagaatcca aaacatcaga
      301 atgaattgag aagggaagaa accaaagctg aggctcctct gctaactcag acacgactta
      361 tcacccagag tgctctgcac agagctcccc actataacag ttgctgccgc cggaagtaca
      421 gaccagaagc ccctggtccc tctgtctccc tttcccctat gccaccctca gaggtcaaac
      481 tccaaagtgg gaagatcagt agggaacctg aacctgcggc tggcccacag gccgaggagt
      541 cagcaactgt ctcagcccct gcacccatga gccccacaag aagacgagcc ctggaccatt
      601 atctcaccct tcgaagctct ggatggatcc cagatggacg aggtcgatgg gtaaaagatg
      661 aaaatgttga gtttgactct gatgaggagg aaccacctga tctccccttg gactgatacc
      721 cttttcccat tcattcacaa ataaattaca atgggtgctg agaacttaac tttccttaag
      781 tctggttcct tgttggatct caggatttca gatctgttca ttctcattcc aactactcct
      841 tgcctgcaag gtacacagct ctccacactc cttttttttt tttttttttt tttgaggcag
      901 agtctcgctc tatcgcccag gctggagtgc agtggcacga tctcggctca ctgcaagctc
      961 tgcctcccag gttcacgcct ttctcctgcc tcagcctcct gagtagctgg gactacaggc
     1021 gcccgccacc atgcccagct aattttttgt atttttagta gagacggggt ttcactgtgt
     1081 tagccaggat ggtctcgatc tcctgacctc gtgatccgcc cacctcggcc tcccaaagtg
     1141 ctgggattac aggcatgagc caccgcaccc agccacggct atccatactt ctaacccctc
     1201 ccccacctcc taccaaagcc atgccaagcg tcagctgcat cagcctggtg ccctattaat
     1261 aagactgtca aaaagaggtc tttgcccttc atgttgtctg cctgcttctc cactaccact
     1321 caaagtcctt tcccccttca aatcacataa ggactgcagg taggcactag ggggacctgg
     1381 ccacatctgg aaacagggct gtggctaagt tccctgtgaa agtagaagag tcaaaaggca
     1441 ttggcagggt tatggggaac accaagggag ggaacacccc cacctcctcc tagtaacctg
     1501 aacctccctg cctgctgatc cccagagtat aaataatccc ctggtgaact ggcagtaacc
     1561 cttgggggtt agcgccaaga ttctcacccc aaagcccaag gaaggaggca ggcaaaatgg
     1621 atagaagggc ttttatttac aggaaaggag gacagatgag gatttaagtg tccagtgctc
     1681 ccagcgctag ttggtaaagg gaaatgcagt gttatctctt cttttgctgg cgacctgtaa
     1741 aggagcaata ttaaacataa gtgtttgttc cagctcctgc tttctgcaaa ggcactcttc
     1801 tcctttccag tcccttagcc aaactcataa attggtagtg tcttaggcca ccttacaggc
     1861 ccatcccaca ttaacaaaac aaaacaagaa accacaccac aaataaaatt acgatacctc
     1921 taaacaa
//
