LOCUS       NM_024575               1158 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens TNF alpha induced protein 8 like 2 (TNFAIP8L2), mRNA.
ACCESSION   NM_024575
VERSION     NM_024575.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1158)
  AUTHORS   Tang,Z., Zhang,D., Yao,C., Jiang,M., Wang,C., Chen,Z., Yu,H.,
            Xue,C., Liu,Y., Shi,Y., Zhang,L., Wang,X. and Wei,Z.
  TITLE     TIPE2 inhibits the migration and invasion of epithelial ovarian
            cancer cells by targeting Smad2 to reverse TGF-beta1-induced EMT
  JOURNAL   FASEB J 38 (17), e70045 (2024)
   PUBMED   39259551
  REMARK    GeneRIF: TIPE2 inhibits the migration and invasion of epithelial
            ovarian cancer cells by targeting Smad2 to reverse
            TGF-beta1-induced EMT.
REFERENCE   2  (bases 1 to 1158)
  AUTHORS   Ming,T., Liu,H., Yuan,M., Tian,J., Fang,Q., Liu,Y., Kong,Q.,
            Wang,Q., Song,X., Xia,Z. and Wu,X.
  TITLE     The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling
  JOURNAL   Biochem Pharmacol 227, 116418 (2024)
   PUBMED   38996928
  REMARK    GeneRIF: The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling.
REFERENCE   3  (bases 1 to 1158)
  AUTHORS   Li,J., He,X., Liu,F., Zheng,X. and Jiang,J.
  TITLE     Tumor Necrosis Factor-alpha-Induced Protein-8-like 2 Transfected
            Adipose-Derived Stem Cells Regulated the Dysfunction of
            Monocrotaline Pyrrole-Induced Pulmonary Arterial Smooth Muscle
            Cells and Pulmonary Arterial Endothelial Cells
  JOURNAL   J Cardiovasc Pharmacol 83 (1), 73-85 (2024)
   PUBMED   38180455
  REMARK    GeneRIF: Tumor Necrosis Factor-alpha-Induced Protein-8-like 2
            Transfected Adipose-Derived Stem Cells Regulated the Dysfunction of
            Monocrotaline Pyrrole-Induced Pulmonary Arterial Smooth Muscle
            Cells and Pulmonary Arterial Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1158)
  AUTHORS   Chen,H., Pei,M., Shin,S.W., Moon,S., Nam,W. and Zheng,Z.
  TITLE     Implication of TIPE2 Expression on the Malignant Transformation of
            Oral Leukoplakia
  JOURNAL   Anticancer Res 43 (11), 4937-4946 (2023)
   PUBMED   37909982
  REMARK    GeneRIF: Implication of TIPE2 Expression on the Malignant
            Transformation of Oral Leukoplakia.
REFERENCE   5  (bases 1 to 1158)
  AUTHORS   Yuan,M., Jing,G., Kong,Q., Ming,T., Zuo,J., Wang,Q., Feng,Y.,
            Liu,W., Wu,X. and Xia,Z.
  TITLE     TIPE2 ameliorates neuroinflammation and cognitive impairment in
            sepsis-associated encephalopathy through regulating
            RhoA/ROCK2-NF-kappaB signaling pathway
  JOURNAL   Biochem Pharmacol 217, 115816 (2023)
   PUBMED   37748665
  REMARK    GeneRIF: TIPE2 ameliorates neuroinflammation and cognitive
            impairment in sepsis-associated encephalopathy through regulating
            RhoA/ROCK2-NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 1158)
  AUTHORS   Gus-Brautbar,Y., Johnson,D., Zhang,L., Sun,H., Wang,P., Zhang,S.,
            Zhang,L. and Chen,Y.H.
  TITLE     The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras
  JOURNAL   Mol Cell 45 (5), 610-618 (2012)
   PUBMED   22326055
  REMARK    GeneRIF: TIPE2 is an inhibitor of both inflammation and cancer, and
            a potential drug target for inflammatory and neoplastic diseases.
REFERENCE   7  (bases 1 to 1158)
  AUTHORS   Lou,Y. and Liu,S.
  TITLE     The TIPE (TNFAIP8) family in inflammation, immunity, and cancer
  JOURNAL   Mol Immunol 49 (1-2), 4-7 (2011)
   PUBMED   21924498
  REMARK    Review article
REFERENCE   8  (bases 1 to 1158)
  AUTHORS   Xi,W., Hu,Y., Liu,Y., Zhang,J., Wang,L., Lou,Y., Qu,Z., Cui,J.,
            Zhang,G., Liang,X., Ma,C., Gao,C., Chen,Y. and Liu,S.
  TITLE     Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in
            humans and mice
  JOURNAL   Mol Immunol 48 (9-10), 1203-1208 (2011)
   PUBMED   21466895
  REMARK    GeneRIF: These results indicate that TIPE2 plays an important role
            in taming Hepatitis B virus-induced hepatic inflammation.
REFERENCE   9  (bases 1 to 1158)
  AUTHORS   Zhang,L., Shi,Y., Wang,Y., Zhu,F., Wang,Q., Ma,C., Chen,Y.H. and
            Zhang,L.
  TITLE     The unique expression profile of human TIPE2 suggests new functions
            beyond its role in immune regulation
  JOURNAL   Mol Immunol 48 (9-10), 1209-1215 (2011)
   PUBMED   21459448
  REMARK    GeneRIF: The unique expressional profile of human TIPE2 suggests
            new functions beyond controlling innate and adaptive immunity.
REFERENCE   10 (bases 1 to 1158)
  AUTHORS   Zhang,G., Hao,C., Lou,Y., Xi,W., Wang,X., Wang,Y., Qu,Z., Guo,C.,
            Chen,Y., Zhang,Y. and Liu,S.
  TITLE     Tissue-specific expression of TIPE2 provides insights into its
            function
  JOURNAL   Mol Immunol 47 (15), 2435-2442 (2010)
   PUBMED   20663561
  REMARK    GeneRIF: High levels of TIPE2 were detected in monocyte/macrophage
            derived cell lines and ovarian adenocarcinoma cells, but not
            detectable or weakly expressed in most human carcinoma cell lines.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI833715.1 and BC063014.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024575.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.44626.1,
                                           SRR1163657.284552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368910.4/ ENSP00000357906.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BI833715.1         21-48
            29-1158             BC063014.1         1-1130
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1158
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /note="TNF alpha induced protein 8 like 2"
                     /db_xref="GeneID:79626"
                     /db_xref="HGNC:HGNC:26277"
                     /db_xref="MIM:612112"
     exon            1..74
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..1158
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..661
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     protein 2; inflammation factor 20; TNFAIP8-like protein 2;
                     inflammation factor protein 20; TNF alpha-induced protein
                     8-like protein 2; tumor necrosis factor, alpha induced
                     protein 8 like 2"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 2"
                     /protein_id="NP_078851.2"
                     /db_xref="CCDS:CCDS985.1"
                     /db_xref="GeneID:79626"
                     /db_xref="HGNC:HGNC:26277"
                     /db_xref="MIM:612112"
                     /translation="MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYR
                     VSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTAL
                     SFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALY
                     GPDFTQHLGKICDGLRKLLDEGKL"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="TNFAIP8L2"
                     /gene_synonym="TIPE2"
                     /note="major polyA site"
ORIGIN      
        1 acactaagtg aagcttctcc attctgtaag ctttccggga acatccaagg caagactggc
       61 acccagcaca gcagtgactg accacatacc ccactctcca ggacccatgg agtccttcag
      121 ctcaaagagc ctggcactgc aagcagagaa gaagctactg agtaagatgg cgggtcgctc
      181 tgtggctcat ctcttcatag atgagacaag cagtgaggtg ctagatgagc tctaccgtgt
      241 gtccaaggag tacacgcaca gccggcccca ggcccagcgc gtgatcaagg acctgatcaa
      301 agtggccatc aaggtggctg tgctgcaccg caatggctcc tttggcccca gtgagctggc
      361 cctggctacc cgctttcgcc agaagctgcg gcagggtgcc atgacggcac ttagctttgg
      421 tgaggtagac ttcaccttcg aggctgctgt tctggctggc ctgctgaccg agtgccggga
      481 tgtgctgcta gagttggtgg aacaccacct cacgcccaag tcacatggcc gcatccgcca
      541 cgtgtttgat cacttctctg acccaggtct gctcacggcc ctctatgggc ctgacttcac
      601 tcagcacctt ggcaagatct gtgacggact caggaagctg ctagacgaag ggaagctctg
      661 agagccctga gcctagcaca ttccaccttg acaaaatggt tgactgagaa aacacagata
      721 atgggcttcc taaccctgct cacctggcac taacactttt caatcttcag gcttcattcc
      781 ttcccaagag tgcttttgac tctgagacca gcccaccccc aaacagctag tggagaagga
      841 gcaatgctga ggggtgaggc ctctctccca ctccagcccc aggacaggaa acagaactgc
      901 ctgaaaaagg tgaagtgaaa cttggatctc tatttctccc ataagggact tctgaaacag
      961 ggaagccccc tcccatgtga accaaggaaa ggaggcacag cccagagaac ccctttgggg
     1021 atactaaaga cagaagaggg gaaggtggcc cttagagaca gagcttggac agatgccaga
     1081 ggctctgttc cagagtgcag gaagaagggg ctagggcagg ggagattctc ataggggaaa
     1141 taaaactact aaaatatg
//
