LOCUS       NM_152362               3816 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens TNF alpha induced protein 8 like 1 (TNFAIP8L1),
            transcript variant 2, mRNA.
ACCESSION   NM_152362
VERSION     NM_152362.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Sun,J., Zhang,X., Zhu,B., Chen,Y. and Wang,H.
  TITLE     A pan-cancer analysis of TNFAIP8L1 in human tumors
  JOURNAL   Medicine (Baltimore) 102 (49), e36291 (2023)
   PUBMED   38065896
  REMARK    GeneRIF: A pan-cancer analysis of TNFAIP8L1 in human tumors.
REFERENCE   2  (bases 1 to 3816)
  AUTHORS   Wang,Z., Sun,L., Liu,S. and Jiang,H.
  TITLE     TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing
            Wnt/beta-catenin signaling
  JOURNAL   Clin Transl Oncol 25 (5), 1332-1339 (2023)
   PUBMED   36495466
  REMARK    GeneRIF: TIPE1 inhibits the growth of Ewing's sarcoma cells by
            suppressing Wnt/beta-catenin signaling.
REFERENCE   3  (bases 1 to 3816)
  AUTHORS   Yang,M., Zhang,Y., Liu,G., Zhao,Z., Li,J., Yang,L., Liu,K., Hu,W.,
            Lou,Y., Jiang,J., Liu,Q. and Zhao,P.
  TITLE     TIPE1 inhibits osteosarcoma tumorigenesis and progression by
            regulating PRMT1 mediated STAT3 arginine methylation
  JOURNAL   Cell Death Dis 13 (9), 815 (2022)
   PUBMED   36151091
  REMARK    GeneRIF: TIPE1 inhibits osteosarcoma tumorigenesis and progression
            by regulating PRMT1 mediated STAT3 arginine methylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3816)
  AUTHORS   Cheng,Y., Bai,F., Ren,X., Sun,R., Guo,X., Liu,W., Wang,B., Yang,Y.,
            Zhang,X., Xu,Y., Li,C., Yang,X., Gao,L., Ma,C., Li,X. and Liang,X.
  TITLE     Phosphoinositide-Binding Protein TIPE1 Promotes Alternative
            Activation of Macrophages and Tumor Progression via
            PIP3/Akt/TGFbeta Axis
  JOURNAL   Cancer Res 82 (8), 1603-1616 (2022)
   PUBMED   35135809
  REMARK    GeneRIF: Phosphoinositide-Binding Protein TIPE1 Promotes
            Alternative Activation of Macrophages and Tumor Progression via
            PIP3/Akt/TGFbeta Axis.
REFERENCE   5  (bases 1 to 3816)
  AUTHORS   Bordoloi,D., Padmavathi,G., Banik,K., Devi,K.A., Harsha,C.,
            Girisa,S., Buhrmann,C., Shakibaei,M. and Kunnumakkara,A.B.
  TITLE     Human tumor necrosis factor alpha-induced protein eight-like 1
            exhibited potent anti-tumor effect through modulation of
            proliferation, survival, migration and invasion of lung cancer
            cells
  JOURNAL   Mol Cell Biochem 476 (9), 3303-3318 (2021)
   PUBMED   33895911
  REMARK    GeneRIF: Human tumor necrosis factor alpha-induced protein
            eight-like 1 exhibited potent anti-tumor effect through modulation
            of proliferation, survival, migration and invasion of lung cancer
            cells.
REFERENCE   6  (bases 1 to 3816)
  AUTHORS   Liu,W., Chen,Y., Xie,H., Guo,Y., Ren,D., Li,Y., Jing,X., Li,D.,
            Wang,X., Zhao,M., Zhu,T., Wang,Z., Wei,X., Gao,F., Wang,X., Liu,S.,
            Zhang,Y. and Yi,F.
  TITLE     TIPE1 suppresses invasion and migration through down-regulating
            Wnt/beta-catenin pathway in gastric cancer
  JOURNAL   J Cell Mol Med 22 (2), 1103-1117 (2018)
   PUBMED   28994231
  REMARK    GeneRIF: the levels of TIPE1 were significantly reduced and
            inversely correlated with differentiation status and distant
            metastasis in primary gastric cancer tissues.
REFERENCE   7  (bases 1 to 3816)
  AUTHORS   Zhang,Z., Liang,X., Gao,L., Ma,H., Liu,X., Pan,Y., Yan,W., Shan,H.,
            Wang,Z., Chen,Y.H. and Ma,C.
  TITLE     TIPE1 induces apoptosis by negatively regulating Rac1 activation in
            hepatocellular carcinoma cells
  JOURNAL   Oncogene 34 (20), 2566-2574 (2015)
   PUBMED   25043299
  REMARK    GeneRIF: TIPE1 induced apoptosis in HCC cells by negatively
            regulating Rac1 pathway
REFERENCE   8  (bases 1 to 3816)
  AUTHORS   Ha,J.Y., Kim,J.S., Kang,Y.H., Bok,E., Kim,Y.S. and Son,J.H.
  TITLE     Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through
            activation of TSC2 in a Parkinson's disease model
  JOURNAL   J Neurochem 129 (3), 527-538 (2014)
   PUBMED   24444419
  REMARK    GeneRIF: oxidative stress induces Tnfaip8 l1/Oxi-beta, which
            results in increased autophagy by its exclusive binding with FBXW5
            to stabilize TSC2
REFERENCE   9  (bases 1 to 3816)
  AUTHORS   Lou,Y. and Liu,S.
  TITLE     The TIPE (TNFAIP8) family in inflammation, immunity, and cancer
  JOURNAL   Mol Immunol 49 (1-2), 4-7 (2011)
   PUBMED   21924498
  REMARK    Review article
REFERENCE   10 (bases 1 to 3816)
  AUTHORS   Cui,J., Zhang,G., Hao,C., Wang,Y., Lou,Y., Zhang,W., Wang,J. and
            Liu,S.
  TITLE     The expression of TIPE1 in murine tissues and human cell lines
  JOURNAL   Mol Immunol 48 (12-13), 1548-1555 (2011)
   PUBMED   21600655
  REMARK    GeneRIF: high levels of TIPE1 (TNFAIP8-like 1) mRNA were detected
            in most human carcinoma cell lines, especially in cells transformed
            with viral genomes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX282702.1 and AC005339.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152362.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.874435.1, BC017672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327473.9/ ENSP00000331827.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               BX282702.1         2-535
            535-3816            AC005339.1         19532-22813
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3816
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /note="TNF alpha induced protein 8 like 1"
                     /db_xref="GeneID:126282"
                     /db_xref="HGNC:HGNC:28279"
                     /db_xref="MIM:615869"
     exon            1..114
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..3816
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..678
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     protein 1; TNFAIP8-like protein 1; TNF alpha-induced
                     protein 8-like protein 1; oxy-beta; oxidative
                     stress-regulated gene-beta; tumor necrosis factor, alpha
                     induced protein 8 like 1"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 1"
                     /protein_id="NP_689575.2"
                     /db_xref="CCDS:CCDS12132.1"
                     /db_xref="GeneID:126282"
                     /db_xref="HGNC:HGNC:28279"
                     /db_xref="MIM:615869"
                     /translation="MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYR
                     ATREFTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAV
                     SFHQVDFTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALY
                     GPAEPYRSHLRRICEGLGRMLDEGSL"
     regulatory      3753..3758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /note="hexamer: ATTAAA"
     polyA_site      3772
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /note="major polyA site"
     regulatory      3793..3798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
                     /note="hexamer: AATAAA"
     polyA_site      3816
                     /gene="TNFAIP8L1"
                     /gene_synonym="TIPE1"
ORIGIN      
        1 ggccccggcc ccggctccgg cgctgctccc accgccgcgg caacggcccc ggcccacgga
       61 ggcggctgga cggacccccg acggttggac gtacggactc tgcttcgaga gtaggccatg
      121 gacaccttca gcaccaagag cctggctctg caggcgcaga agaagctcct gagtaagatg
      181 gcgtccaagg cagtggtggc cgtgctggtg gatgacacca gcagtgaggt gctggatgag
      241 ctgtaccgcg ccaccaggga gttcacgcgc agccgcaagg aggcccagaa gatgctcaag
      301 aacctggtca aggtggccct gaagctggga ctgctgctgc gtggggacca gctgggcggt
      361 gaggagctgg cgctgctgcg gcgcttccgc caccgggcgc gctgcctggc catgacggcc
      421 gtcagcttcc accaggtgga cttcaccttc gaccggcgcg tgctggccgc cgggctgctc
      481 gagtgccgcg acctgctgca ccaggccgtg ggtccccacc tgaccgccaa gtcccacggc
      541 cgcatcaacc acgtgttcgg ccacctagcc gactgcgact tcctggctgc gctctacggc
      601 cccgccgagc cctaccgctc ccacctgcgc aggatctgcg agggcctggg ccggatgctg
      661 gacgagggca gcctctgaac cccggcgccg cccaaccgcg cccctcgcgc cttttggggc
      721 tctcctgctg ggcgcgggtg gggtttgtgg gtttttttcc acctcttttc tcccaatcgg
      781 actccggcca aactccccta gacagatggg tgacctgtct cctttgagag gatgctgagg
      841 catctgtagc agctgtttca aacaccaatg tcacctctcc tcctggcccc cgcccaatgg
      901 ggagaggaat ttggggccct actctgggga ccacctttca cccgtttgta ctttctgggc
      961 cacgccgacc cctgggtcgc ttgatgtaaa agccaaaagc tgctgcctcc cacttggatc
     1021 atgtcgcctg ggattttcat ccctcgcaca aggactacgg gttcacacgg tgaactgggg
     1081 gaagggaagt gttagggggc aagtcgcggc accccccctt ccataaactc acgtcctaac
     1141 ccccaggacc tcagaagatg atctgatttg gaaataggat cattacagat ggaattagtt
     1201 cagatgatct catcttggag tagggtgggc cccaattcaa ggactggggt ccttaaaaaa
     1261 agggggcctg gggcagggcg cggtggctca cgcctgtaat cccagcactt tgagaggctg
     1321 aggcgggcgg atcacgaggt caggagatcg agaccatcct ggctaacacg gtgaaacccc
     1381 atctctactg aaaatacaaa aaattagctg ggcatggtgg cacatgcctg tagtcccagc
     1441 tactcgggag gctgaggcag gataatcact tgaaccagga ggaggaggtt gcagtgagcc
     1501 gagattgtgc cactgcactc cagcctgggt gacagagcaa gactctgtct caaaaaaaga
     1561 agcgggggag tgggggattg aggccacgtg cagtggctca ctactctaat tccagcactt
     1621 tgggaggccg aggcaggaag attgcttgaa ctcagaagtt caagaccagt ctgggcaaca
     1681 tggtgagacc ctcgtctcta caaaaaaaaa attatcgtgg tgggccgggc gtggtggctc
     1741 acacctgtaa tcccagcact ttgggaggct gaggcgggca gatcacaagg tcaagagatc
     1801 gagaccatcc tggccaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagccg
     1861 ggcatggtgt tgcgtgcctg tagtcccagc tacttgggag gctgaggcag gagaatcgct
     1921 tgaacctggg aggcgcaggt tgcagggagg cggaggttgc agtgagccga gattgcacca
     1981 ctgcacttca gcctggtgac agagcgagac tcgtctcaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaagtgac tgtggtggtg cacacgtata atcccagcta cttgagagat gacgagggaa
     2101 gatcacttga gcccaggagt taagaggctg cagtgaccga tgatcatgcc actgcactcc
     2161 agcttgggtg agagtgggac tctgtcttag aaagaaaaaa aaaagtattt ggacacagac
     2221 atgcatgcaa ggaaggccaa tgatgccggc caccaccagg agctgggaga ggcccagggc
     2281 agatcccctt cagccttgga gggacctagc cctggccaca ccttcatctc agacttgcgg
     2341 cccagagaac tgaatgagaa taaatgtgcg tgaagcccct cagtccacag gatgtggtac
     2401 tggaagcccc cactcaagaa ggctccagtg aatgctggca cgttcagcca ggatgcctcc
     2461 gtgaagctgg agacctctgc cctgggtcgg gaggggaaac tgctccaatc cagggactgc
     2521 cacatgggag gggacggagc gtgcccacct cccaggggtg aggggggacc cacctgagat
     2581 gtgtgcacat tttatttatt tattgttttg agacaaagtc tcgctgtgtc acccaggctg
     2641 gagtgcagtg gtgaaatctc ggctcattgc agccccttcc ttccaggctc aagtgatcct
     2701 cccacctcag ccccgggtag ctgggactac aggtgtgcac gagcacaccc ggctaatctt
     2761 tgtatttttt gtagacagaa ggtctcacca tgttgcccag gatggtctcg aactcctggg
     2821 ctcaagcgac ctacctacct cggcctcaca aagtgtgcac attgtaatat cgtgatttca
     2881 tatttggaga atcagcaacc aaccagccaa ccatgttgct tttataagac agagctgaga
     2941 aagcaaagct tggctgtcgt cttggctctg gtaccaccca cgagatgcgg gcgattctca
     3001 gctcagggcg tggaggcgtg gtgtggggga gtctatttgc catttttgtt tgtcagcagg
     3061 gggcaggggt tctcaaagat tgcaaaatgc tgctgcaggt caggaaggtt attttgggtg
     3121 cctgtggggg aggtgaaaca aggtcccatg actgttttgc agaaccttgt ctgtggaggg
     3181 tagaggttgc ggcaggggcc tgtgggcctt acttggtgag aaggtaggtc tagctggctc
     3241 cattcagtat ttgagacatt tggaatttgt ctgcatttaa aaccaagaga tcacacacac
     3301 ctgtctggat ttggagtttc tcttgaaaac tcgccagtcc ggccgtctga gcctgcactg
     3361 acgcctggtg aagctgtgca ggggccgccc ctctcccttt caccacagtc ctctccactc
     3421 cctttcgcct ctccctggcc tgctgcactc actgatagga aattctgacc ccagactcgg
     3481 agcagccttc ccgtggttcg gtttttgctt ccgcgaaaaa gccaaaggcc ttggccagag
     3541 agccagctgt tcctacctct accccacgct tccaaggcaa ccttctccac ttatcttagg
     3601 ccgagagaca gctcttcaag aacgtacatg gatcctgatt ttctcacgaa gtcccgatgg
     3661 aaccctgtgc tgttgagaca tcagtgtgta aaactctctg tgtccctgtt gggctgtcca
     3721 gacagtctgg actcttgtaa atttgagatt taattaaagg aaacaaacca aataggactg
     3781 cggaacaatt taaataaaag cacacaccag cctggg
//
