LOCUS       NM_014350               6976 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens TNF alpha induced protein 8 (TNFAIP8), transcript
            variant 1, mRNA.
ACCESSION   NM_014350
VERSION     NM_014350.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6976)
  AUTHORS   Liu,B., Si,W., Wei,B., Zhang,X. and Chen,P.
  TITLE     Tumor Necrosis Factor alpha-Induced Protein 8-Like 1 Binds to
            Protein Arginine Methyltransferase 1 to Suppress the Methylation of
            Signal Transducer and Activator of Transcription 3 and Cell Growth
            in Oral Squamous Cell Carcinoma
  JOURNAL   Am J Pathol 194 (6), 1126-1136 (2024)
   PUBMED   38432512
  REMARK    GeneRIF: Tumor Necrosis Factor alpha-Induced Protein 8-Like 1 Binds
            to Protein Arginine Methyltransferase 1 to Suppress the Methylation
            of Signal Transducer and Activator of Transcription 3 and Cell
            Growth in Oral Squamous Cell Carcinoma.
REFERENCE   2  (bases 1 to 6976)
  AUTHORS   Ji,Y., Xiong,L., Zhang,G., Xu,M., Qiu,W., Xiu,C., Kuang,G. and
            Rui,Y.
  TITLE     Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis
            by downregulating TNFAIP8 and promoting autophagy through LC3
            signaling
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111177 (2023)
   PUBMED   37948986
  REMARK    GeneRIF: Synovial fluid exosome-derived miR-182-5p alleviates
            osteoarthritis by downregulating TNFAIP8 and promoting autophagy
            through LC3 signaling.
REFERENCE   3  (bases 1 to 6976)
  AUTHORS   Liu,X., Liu,Z., Wang,C., Miao,J., Zhou,S., Ren,Q., Jia,N., Zhou,L.
            and Liu,Y.
  TITLE     Kidney tubular epithelial cells control interstitial fibroblast
            fate by releasing TNFAIP8-encapsulated exosomes
  JOURNAL   Cell Death Dis 14 (10), 672 (2023)
   PUBMED   37828075
  REMARK    GeneRIF: Kidney tubular epithelial cells control interstitial
            fibroblast fate by releasing TNFAIP8-encapsulated exosomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6976)
  AUTHORS   Li,M., Li,X., Goldsmith,J.R., Shi,S., Zhang,L., Zamani,A., Wan,L.,
            Sun,H., Li,T., Yu,J., Etwebi,Z., Bou-Dargham,M.J. and Chen,Y.H.
  TITLE     Decoupling tumor cell metastasis from growth by cellular pilot
            protein TNFAIP8
  JOURNAL   Oncogene 40 (46), 6456-6468 (2021)
   PUBMED   34608264
  REMARK    GeneRIF: Decoupling tumor cell metastasis from growth by cellular
            pilot protein TNFAIP8.
REFERENCE   5  (bases 1 to 6976)
  AUTHORS   Hua,J., Zhuang,G. and Qi,Z.
  TITLE     Current research status of TNFAIP8 in tumours and other
            inflammatory conditions (Review)
  JOURNAL   Int J Oncol 59 (1) (2021)
   PUBMED   34036374
  REMARK    GeneRIF: Current research status of TNFAIP8 in tumours and other
            inflammatory conditions (Review).
            Review article
REFERENCE   6  (bases 1 to 6976)
  AUTHORS   Dong,Q.Z., Zhao,Y., Liu,Y., Wang,Y., Zhang,P.X., Jiang,G.Y.,
            Dong,X.J., Cui,Q.Z. and Wang,E.H.
  TITLE     Overexpression of SCC-S2 correlates with lymph node metastasis and
            poor prognosis in patients with non-small-cell lung cancer
  JOURNAL   Cancer Sci 101 (6), 1562-1569 (2010)
   PUBMED   20398053
  REMARK    GeneRIF: SCC-S2 plays an important role in NSCLC and might be a
            useful therapeutic target of NSCLC.
REFERENCE   7  (bases 1 to 6976)
  AUTHORS   Zhang,L.J., Liu,X., Gafken,P.R., Kioussi,C. and Leid,M.
  TITLE     A chicken ovalbumin upstream promoter transcription factor I
            (COUP-TFI) complex represses expression of the gene encoding tumor
            necrosis factor alpha-induced protein 8 (TNFAIP8)
  JOURNAL   J Biol Chem 284 (10), 6156-6168 (2009)
   PUBMED   19112178
  REMARK    GeneRIF: A chicken ovalbumin upstream promoter transcription factor
            I (COUP-TFI) complex represses expression of the gene encoding
            tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
REFERENCE   8  (bases 1 to 6976)
  AUTHORS   Kumar,D., Gokhale,P., Broustas,C., Chakravarty,D., Ahmad,I. and
            Kasid,U.
  TITLE     Expression of SCC-S2, an antiapoptotic molecule, correlates with
            enhanced proliferation and tumorigenicity of MDA-MB 435 cells
  JOURNAL   Oncogene 23 (2), 612-616 (2004)
   PUBMED   14724590
  REMARK    GeneRIF: SCC-S2 is a novel oncogenic factor in cancer cells
REFERENCE   9  (bases 1 to 6976)
  AUTHORS   Kumar,D., Whiteside,T.L. and Kasid,U.
  TITLE     Identification of a novel tumor necrosis factor-alpha-inducible
            gene, SCC-S2, containing the consensus sequence of a death effector
            domain of fas-associated death domain-like interleukin-
            1beta-converting enzyme-inhibitory protein
  JOURNAL   J Biol Chem 275 (4), 2973-2978 (2000)
   PUBMED   10644768
REFERENCE   10 (bases 1 to 6976)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007014.1, CB241243.1 and AC035144.3.
            
            On Nov 22, 2018 this sequence version replaced NM_014350.3.
            
            Transcript Variant: This variant (1) encodes isoform a. Both
            variant 1 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA931467.1, SRR1803612.111858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504771.3/ ENSP00000422245.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1886              BC007014.1         165-2050
            1887-1892           CB241243.1         204-209
            1893-6976           AC035144.3         66838-71921
FEATURES             Location/Qualifiers
     source          1..6976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..6976
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="TNF alpha induced protein 8"
                     /db_xref="GeneID:25816"
                     /db_xref="HGNC:HGNC:17260"
                     /db_xref="MIM:612111"
     exon            1..103
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..669
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="isoform a is encoded by transcript variant 1;
                     TNF-induced protein GG2-1; NF-kappa-B-inducible
                     DED-containing protein; head and neck tumor and
                     metastasis-related protein; tumor necrosis factor, alpha
                     induced protein 8"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein 8
                     isoform a"
                     /protein_id="NP_055165.2"
                     /db_xref="CCDS:CCDS47258.1"
                     /db_xref="GeneID:25816"
                     /db_xref="HGNC:HGNC:17260"
                     /db_xref="MIM:612111"
                     /translation="MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLID
                     DTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKF
                     KKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFD
                     HFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI"
     exon            104..6976
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="hexamer: AGTAAA"
     polyA_site      1733
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="major polyA site"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="major polyA site"
     regulatory      6952..6957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
                     /note="hexamer: ATTAAA"
     polyA_site      6976
                     /gene="TNFAIP8"
                     /gene_synonym="GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2"
ORIGIN      
        1 gcagagcgaa cttgcggctc gtccgagtac atgtgagcgg taatcgcccc tgcagctggt
       61 tatcctgaca ttatgcactc cgaagcagaa gaatccaagg aagtggccac agatgtcttt
      121 aattccaaaa acctggccgt tcaggcacaa aagaagatct tgggtaaaat ggtgtccaaa
      181 tccatcgcca ccaccttaat agacgacaca agtagtgagg tgctggatga gctctacaga
      241 gtgaccaggg agtacaccca aaacaagaag gaggcagaga agatcatcaa gaacctcatc
      301 aagacagtca tcaagctggc cattctttat aggaataatc agtttaatca agatgagcta
      361 gcattgatgg agaaatttaa gaagaaagtt catcagcttg ctatgaccgt ggtcagtttc
      421 catcaggtgg attatacctt tgaccggaat gtgttatcca ggctgttaaa tgaatgcaga
      481 gagatgctgc accaaatcat tcagcgccac ctcactgcca agtcacatgg acgggttaat
      541 aatgtgtttg atcatttttc agattgtgaa tttttggctg ccttgtataa tccttttggg
      601 aattttaaac cccacttaca aaaactatgt gatggtatca acaaaatgtt ggatgaagag
      661 aacatatgag cacatgagtt aagattgtga ctgatcatga tttatttgaa gatggagcac
      721 tgctgattta tgaaggaaaa aagaagaatt ttctaaagat tacacatatt tcagaaagac
      781 tttacccaat tcagttgtca gacataatga tttatttgaa ggcttgtttt atttgaagaa
      841 aagcatattg ccaaaaattc tggttaaaag cttcctaacg ggtaacagac catgggagag
      901 atatgtggtt gggtaatgca aatgtagtta tacaaagaaa aatacagatg tctccagacc
      961 tgaggacttt ttaatagggc agttgttgtg ttggtggcac attggatatt tctaacatgt
     1021 acaaagctat gtattttgat ttactttcat ttcttgctat gtatatgtac ttttcttaaa
     1081 atgccaagaa ctttctcttg ctatcattgc tccttttgaa acaattcaat tttcatgtct
     1141 acagctgact gttttgttaa gattgagtca tcgacattca ggatttaagt ctgaggtagt
     1201 caaccctcag gaaaaaaaaa atggcttatc tgaaatcagt actgtggaaa tgaactatat
     1261 tagctattat gaataatgtc cagtataaga atatgcttct ggaattgagt tctcctttta
     1321 agtaccaatg atacttaaat ttctcagaaa tgtaatggtg tgtcattgcc ttgaaatgct
     1381 tgcttagggc ttcttttatg ttatcttaaa aagtgctggt gaattttcca ttttttacat
     1441 ccatttcaca tgtaagagac aaaaaagtct agattggtct tgatattgag ataataaaaa
     1501 gtaagtagca ttaagaaagg taacaatctt cattctacag atgaactcat tgaaacaatt
     1561 taggggaatg aggggcaaaa ggggagaaat actgctaaag aacatgagca taaaaatgcg
     1621 tgcgtttcag tgtttaagaa ggcttgataa agaatgtcac ttttttattt aactgataag
     1681 atttttgtta ttttttactt tgataagtaa accaaagaat atttgtattt caagcagttt
     1741 gtgtggtgtt tctatataat tttctgtgta taaataataa agtaggcatt tgtttatttt
     1801 gtaaaaaaga aatgaaaatc tgctggccag ctatgtcctc taggaaatga cagacccaac
     1861 caccagcaat aaacatttcc attgtcactg tgtctatgat tttttttttt ttttttttga
     1921 gtctcgctct gttgtttagg ctagaatgca gtggcatgat tttggctcac tgcaacctct
     1981 gcctcccagg ttcaagtgat tctcctgcct ctgcctccca agtagctggg attacaggca
     2041 tgcaccacca cacccagcta atttttgtat ttttagtcga gatggggttt caccatgttg
     2101 cccaggctgg tcttgaactc ctgacttcaa atgatctgcc tgcctcggcc tccgaaagtg
     2161 ttgggattac aggtgtgagc cactgtgcct atgatttagt gtactctctt gccttaaatt
     2221 tgcctgcctc ccagaatatt gacattaaaa taatagttta ccaggaaagg ttccacaact
     2281 aaaaattcca gaagttgaga tctgctctaa cccatttcag cctagagagg gtggtcagtt
     2341 tctctgacac cctcatttgc ttggctaaga caagcagcaa aggtgtagag tttcttcctg
     2401 tttgatatta aatcctgaca ctaagatttg aactgaaagt atcattctca cttcctagag
     2461 ccagtaggtg atcagtatat gctgtaacaa taacacagtg actacagaaa tgacccttct
     2521 agcttcataa cttgctaagt ggcttataaa tggaattcag cagccttcct tgaccagctg
     2581 ttttcctcac atgtgaaggc tgagaatgtg atggggggtg tgagctactg actggatgtg
     2641 ttctgttctc cagatctcaa acagcagagg tatgggaaac gaaagccctg ggcagtccat
     2701 ggatgcttct tgctcatctg tagctataga caggaccaac cagagagaga aaacgtacgg
     2761 agggagaaat ctggatctct ctggacacac tggatcatag ggttgtgcca gcaggctagc
     2821 aatcaaatgt gcatgggatt gggggagcaa tgcttcatct cccacagagg gaaggcagtg
     2881 aggagtagac cgaaggaggg aatcctgttt gctaccattt ctcagcattt tctggagggg
     2941 acccatctcc ttaccagtgc tgtgcctgaa aagcatgtct tggatcaggt ccaaagtcgt
     3001 gattagcaag ttcatttcta atacaatagg actccccttg agcatttagg gtggcaagga
     3061 gcgtgggagc tgggaagaat ccccacgtgc ttagggtaga taaatctgag ccgagttaat
     3121 actaatttgg ggatcctatg aaccttttta taaaatagta tctgttcacg ttttgaaaaa
     3181 aattgtgttg taattgattt tattttgtgc tggtggcttc tctgcaaaaa ttatgagtgg
     3241 atatgataag tggatgataa tactaatgga caactaacgc agagtagttt gtattatgtg
     3301 tcgggcacat taactcattt aattctgcca caatcttcac catcttatag ataaggaaac
     3361 taggggaata gaagttaagg aatttcctga ggtcacatgt gctcgaggtg tcccagccgg
     3421 aatatgtata aaatcttatt ttcacttaaa gatgatatgg ctaaaggcag tgctaggaac
     3481 atctttggct cagagaagcg tgggcagtat gctgctgaaa tggttcctca tatagtgaca
     3541 ttttaggcag tacctaagtc agcacaggtc tggcctgttc tctaaagatc tgtgtagatg
     3601 ttgtacaaag acatttttca aagttttcaa catgactcct actttggggg catcttgtgg
     3661 ctcagttttc tgtctcgtgg aacttcactt ctaggtgctc acaatgactt ttaacgttga
     3721 cttctgaggt gcagtgagct gctcccccac agctgtccct agcagtggtg ggttcagagc
     3781 atgacaaggc actcaatgtg cattcaccaa gagaagcaag gaagcagcag ttcagtactg
     3841 tgctccctag agtaggcacg gcatcagttt caaacttcaa cattattttc cagatttgga
     3901 ggctcaaaat atttgagcaa gttaagttaa gaaatagcct ttttctgatt attaggcctt
     3961 tcatatacaa ctcaaaatta gtttaagagt aaagcatggg gtgggtgcgg tggcttatgc
     4021 ttgtaagccc agaactttgg gaggcggagg tgggaggatc acttgaggtg aggagttcga
     4081 gaccagcctg gccaacgtgg tgaaacccca ctgctactaa aaatacacaa gattagccag
     4141 atgtggtggc aggcacctgt aatcccagct acttgggagg ctaaggcagg agaatcgctg
     4201 gaacctggga ggcagaggtt gcagtgagct gagattgtac cactgcactg cagcctgggc
     4261 aacaagaacg aaaccccgtc tcaaaaaaaa aaaaaaaaaa aaaaagcatg agttaagaac
     4321 tttgatcgta cagaaatatt gcgttttaaa ctcttatata atagtatgcc attcacaatt
     4381 atctggaaag ttctttttct cccaccatgt gaatacacac acacacacac acacacacac
     4441 aatttttaag cccccaaagg cttaaaatag tactttttgt ggtctgtacc ggtcagttgg
     4501 atttttacta agaattttaa tttatccttg agatacttga tgagtgtata taagcagttg
     4561 caatttagca tacaaaacct gacaaatggt aaataaaaga atatgtttat ccaaatgatg
     4621 aaatatttgt agtaaaaagt gctattcaat tgccaggaaa ttaaaatact ccagtaaaat
     4681 gaattaaatt agcatgttaa taagagtgat aatatttaaa agttttagtc aatcttgcat
     4741 ttccatactt gcattatcta aactagttga acttttcagt gttttacttg atatattgca
     4801 ttcttgagca ttaggcttct aggtgatttg ttaaactcat agcaggtttt agtacacagt
     4861 gctgtttatg acagaaaaaa ttttatccta cctctgaaat aattgtactt tctgtgattc
     4921 agataaaaac tttatagaaa ctccctaatg aaaatattga agcattaacc agaaaatgag
     4981 tcagcttttt gtttccaaaa tgatgcaaca ggaaaacctt taactactta taatcccgta
     5041 tagtcaccat caccacgaag tattgaaaat ctgttttctc ttttactaag tgtctgcacg
     5101 gtcacttatg tatacccaaa gccagaaaga tatttttatc tcagggaaat tccagaaatg
     5161 gaaacatttt tgtgtaatat tgattcattt ctgtctcacc aaagatgtgt tttccacgta
     5221 gcaaagaaca tcagccccac gttataggga acaagcgagt cccaaatcgt accatctgct
     5281 gagcactgag aaaggatatg gacaagtcag tcagcattca caattaagag aaaaacatct
     5341 gtgctttgga aaatgttctt caaggataga gaattgtgcc ctatgtccac caaatttgca
     5401 tgagatcttt ataagattag acagccagtg gataaggccc cttatctttc ttcatggatg
     5461 gctgaggaaa ttctccgcct tccctgacat cagctgcata actgtatttc tgcctcgtgg
     5521 aaataaagta gatgatcagg cacttgcggt ttgttcttaa tacaagaaag acaatttgat
     5581 ttttaaaagt tttgatttgt agaataatgt aagacaatat gtttctttct actttggttt
     5641 ttccattcaa aagcttacag atgaattcat tcgtttaaaa ctgccaggct gagtgcggtg
     5701 gctcatgcct gtaatcccaa cacttcggga gactgaggtg ggcggatcac ctgaggtcca
     5761 gagttcaaga ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaatt
     5821 agccgggtgc agtgccacat gcctgtaatc ccagctactt gggaggctga ggcaggagaa
     5881 ccacttgaac ccaggaggca gaggttgcag tgagccaaga ttacaccact gcactccagc
     5941 ctgggcaaca agagtgagac tttgtctcaa aaaaaaaaaa agaaactctg tctcgaagta
     6001 aataaataaa tttttaaaaa ccaacctgat gtgaagttga aacacaagac gcggaaataa
     6061 aaactcagag tataaatatc tatattgtta ccattatctg ggataattga tgatttataa
     6121 gaagctgagg tttcgtcttc ctagaaatgg acttttatta ggccagcaag aatgaccact
     6181 tagccattta aatgatttgt cagcatcttt tgctgctctc ttctaagacc attggttttc
     6241 actaaaggat aaatacctgc taagcaaatt ataaaatact ataagacatt taatctcctg
     6301 gaagaggact tgctgataat tggatcaaag ttccagcatt attgctcttt tcgaatcata
     6361 tggacttagt gttctcatga ccgaggagtc acatttttag cttgctaaaa tattcactgg
     6421 agaacatggt gaaatccacg agtggaaacg ttccatggta ttttcaaacg ccacgtgtca
     6481 ggaatttggc atgccttcct ctgggagagg cactggagtg tggccagatg gaacccagca
     6541 gggtacagag ggcatttgtg ggagcagtta ggaaaccagg acgtccagct tctgcctgcc
     6601 agggagctcg ctcatgttgt ctctgaaatt tgcataagag caattacctc atattctaat
     6661 tttaaagata caatttttaa agacatggaa ggctctgaga cctcctgaag gctattccta
     6721 tgtgaggtat tgtttacggg tggcctttca ctatttccaa atcagcgatg aaaagaagac
     6781 tgagtctaaa ataaatgaag caacagactt cagcagcctg agagaatttt gttcaattcc
     6841 agtctcctta aaaaaaaatc ggtttttgct ttcaatttag gaaaattgtt ttgggttgca
     6901 ttgttgaaag taatgatttc tagcagctac ttatgtataa tctcttaacc aattaaattc
     6961 tgaatctctt aaatca
//
