LOCUS       NM_007115               1422 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.
ACCESSION   NM_007115
VERSION     NM_007115.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Verma,S., Moreno,I.Y., Prinholato da Silva,C., Sun,M., Cheng,X.,
            Gesteira,T.F. and Coulson-Thomas,V.J.
  TITLE     Endogenous TSG-6 modulates corneal inflammation following chemical
            injury
  JOURNAL   Ocul Surf 32, 26-38 (2024)
   PUBMED   38151073
  REMARK    GeneRIF: Endogenous TSG-6 modulates corneal inflammation following
            chemical injury.
REFERENCE   2  (bases 1 to 1422)
  AUTHORS   Chen,H., Wu,Y., Jiang,Y., Chen,Z. and Zheng,T.
  TITLE     DKC1 aggravates gastric cancer cell migration and invasion through
            up-regulating the expression of TNFAIP6
  JOURNAL   Funct Integr Genomics 24 (2), 38 (2024)
   PUBMED   38376551
  REMARK    GeneRIF: DKC1 aggravates gastric cancer cell migration and invasion
            through up-regulating the expression of TNFAIP6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1422)
  AUTHORS   Lee,R.H., Boregowda,S.V., Shigemoto-Kuroda,T., Bae,E., Haga,C.L.,
            Abbery,C.A., Bayless,K.J., Haskell,A., Gregory,C.A., Ortiz,L.A. and
            Phinney,D.G.
  TITLE     TWIST1 and TSG6 are coordinately regulated and function as potency
            biomarkers in human MSCs
  JOURNAL   Sci Adv 9 (45), eadi2387 (2023)
   PUBMED   37948519
  REMARK    GeneRIF: TWIST1 and TSG6 are coordinately regulated and function as
            potency biomarkers in human MSCs.
REFERENCE   4  (bases 1 to 1422)
  AUTHORS   Payet,M., Septembre-Malaterre,A., Gasque,P. and Guillot,X.
  TITLE     Human Synovial Mesenchymal Stem Cells Expressed Immunoregulatory
            Factors IDO and TSG6 in a Context of Arthritis Mediated by
            Alphaviruses
  JOURNAL   Int J Mol Sci 24 (21), 15932 (2023)
   PUBMED   37958918
  REMARK    GeneRIF: Human Synovial Mesenchymal Stem Cells Expressed
            Immunoregulatory Factors IDO and TSG6 in a Context of Arthritis
            Mediated by Alphaviruses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1422)
  AUTHORS   Kohda,D., Morton,C.J., Parkar,A.A., Hatanaka,H., Inagaki,F.M.,
            Campbell,I.D. and Day,A.J.
  TITLE     Solution structure of the link module: a hyaluronan-binding domain
            involved in extracellular matrix stability and cell migration
  JOURNAL   Cell 86 (5), 767-775 (1996)
   PUBMED   8797823
REFERENCE   6  (bases 1 to 1422)
  AUTHORS   Wisniewski,H.G., Hua,J.C., Poppers,D.M., Naime,D., Vilcek,J. and
            Cronstein,B.N.
  TITLE     TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by
            inter-alpha-inhibitor and exerts a strong anti-inflammatory effect
            in vivo
  JOURNAL   J Immunol 156 (4), 1609-1615 (1996)
   PUBMED   8568267
REFERENCE   7  (bases 1 to 1422)
  AUTHORS   Klampfer,L., Lee,T.H., Hsu,W., Vilcek,J. and Chen-Kiang,S.
  TITLE     NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6
            gene by tumor necrosis factor alpha and interleukin-1
  JOURNAL   Mol Cell Biol 14 (10), 6561-6569 (1994)
   PUBMED   7935377
REFERENCE   8  (bases 1 to 1422)
  AUTHORS   Wisniewski,H.G., Burgess,W.H., Oppenheim,J.D. and Vilcek,J.
  TITLE     TSG-6, an arthritis-associated hyaluronan binding protein, forms a
            stable complex with the serum protein inter-alpha-inhibitor
  JOURNAL   Biochemistry 33 (23), 7423-7429 (1994)
   PUBMED   7516184
REFERENCE   9  (bases 1 to 1422)
  AUTHORS   Lee,T.H., Klampfer,L., Shows,T.B. and Vilcek,J.
  TITLE     Transcriptional regulation of TSG6, a tumor necrosis factor- and
            interleukin-1-inducible primary response gene coding for a secreted
            hyaluronan-binding protein
  JOURNAL   J Biol Chem 268 (9), 6154-6160 (1993)
   PUBMED   8454591
REFERENCE   10 (bases 1 to 1422)
  AUTHORS   Lee,T.H., Wisniewski,H.G. and Vilcek,J.
  TITLE     A novel secretory tumor necrosis factor-inducible protein (TSG-6)
            is a member of the family of hyaluronate binding proteins, closely
            related to the adhesion receptor CD44
  JOURNAL   J Cell Biol 116 (2), 545-557 (1992)
   PUBMED   1730767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU102580.1, BC030205.1 and
            AC009311.3.
            
            On Nov 23, 2018 this sequence version replaced NM_007115.3.
            
            Summary: The protein encoded by this gene is a secretory protein
            that contains a hyaluronan-binding domain, and thus is a member of
            the hyaluronan-binding protein family. The hyaluronan-binding
            domain is known to be involved in extracellular matrix stability
            and cell migration. This protein has been shown to form a stable
            complex with inter-alpha-inhibitor (I alpha I), and thus enhance
            the serine protease inhibitory activity of I alpha I, which is
            important in the protease network associated with inflammation.
            This gene can be induced by proinflammatory cytokines such as tumor
            necrosis factor alpha and interleukin-1. Enhanced levels of this
            protein are found in the synovial fluid of patients with
            osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.73644.1,
                                           SRR5189652.124369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243347.5/ ENSP00000243347.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AU102580.1         1-31
            32-920              BC030205.1         1-889
            921-921             AC009311.3         118353-118353
            922-1422            BC030205.1         890-1390
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..1422
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /note="TNF alpha induced protein 6"
                     /db_xref="GeneID:7130"
                     /db_xref="HGNC:HGNC:11898"
                     /db_xref="MIM:600410"
     exon            1..169
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..909
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /note="tumor necrosis factor alpha-inducible protein 6;
                     hyaluronate-binding protein; tumor necrosis
                     factor-stimulated gene-6 protein; tumor necrosis
                     factor-inducible gene 6 protein; TNF-stimulated gene 6
                     protein; tumor necrosis factor, alpha induced protein 6"
                     /codon_start=1
                     /product="tumor necrosis factor-inducible gene 6 protein
                     precursor"
                     /protein_id="NP_009046.2"
                     /db_xref="CCDS:CCDS2193.1"
                     /db_xref="GeneID:7130"
                     /db_xref="HGNC:HGNC:11898"
                     /db_xref="MIM:600410"
                     /translation="MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARS
                     GKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPN
                     CGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQI
                     CYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDI
                     ISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSH
                     L"
     exon            170..307
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     exon            308..469
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     exon            470..698
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     exon            699..739
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1422
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /note="hexamer: AATAAA"
     polyA_site      1422
                     /gene="TNFAIP6"
                     /gene_synonym="TSG-6; TSG6"
                     /note="major polyA site"
ORIGIN      
        1 agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc
       61 actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact
      121 caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc
      181 ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag
      241 gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga
      301 aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc
      361 attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc
      421 cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt
      481 ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac
      541 gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg
      601 agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata
      661 tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca
      721 gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg
      781 acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa
      841 ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc
      901 cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt
      961 ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa
     1021 agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa
     1081 cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt
     1141 cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa
     1201 ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata
     1261 aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata
     1321 ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg
     1381 tcattttcat aaatattgtt gcaataaata tccttgaaca ca
//
