LOCUS       NM_001270508            4665 bp    mRNA    linear   PRI 30-DEC-2024
DEFINITION  Homo sapiens TNF alpha induced protein 3 (TNFAIP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001270508
VERSION     NM_001270508.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4665)
  AUTHORS   Wang,C., Huang,C., Li,Y., Bai,J., Zhao,K., Fang,Z. and Chen,J.
  TITLE     Hepatitis B surface antigen impairs TLR4 signaling by upregulating
            A20 expression in monocytes
  JOURNAL   Microbiol Spectr 12 (10), e0090924 (2024)
   PUBMED   39248482
  REMARK    GeneRIF: Hepatitis B surface antigen impairs TLR4 signaling by
            upregulating A20 expression in monocytes.
REFERENCE   2  (bases 1 to 4665)
  AUTHORS   Ning,F., Wang,H., Liang,Z. and Lan,J.
  TITLE     TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma
            Progression by Promoting Autophagy through TLR4/MyD88/NF-kappaB
            Signaling Pathway
  JOURNAL   Discov Med 36 (187), 1627-1640 (2024)
   PUBMED   39190378
  REMARK    GeneRIF: TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell
            Lymphoma Progression by Promoting Autophagy through
            TLR4/MyD88/NF-kappaB Signaling Pathway.
REFERENCE   3  (bases 1 to 4665)
  AUTHORS   Kommer,A., Meineck,M., Classen,P. and Weinmann-Menke,J.
  TITLE     A20 in Kidney Transplantation and Autoimmunity
  JOURNAL   Int J Mol Sci 25 (12), 6628 (2024)
   PUBMED   38928333
  REMARK    GeneRIF: A20 in Kidney Transplantation and Autoimmunity.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4665)
  AUTHORS   Ha,N.T., Trang,D.T., Nhat,P.V., Huong,P.T., Giang,N.H., Mao,C.V.,
            Binh,V.D., Vuong,N.B. and Xuan,N.T.
  TITLE     A20 promoted the phagocytosis of lymphoma cells by dendritic cells
            from activated B-cell-like non-Hodgkin lymphoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 1-9 (2024)
   PUBMED   38814241
  REMARK    GeneRIF: A20 promoted the phagocytosis of lymphoma cells by
            dendritic cells from activated B-cell-like non-Hodgkin lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4665)
  AUTHORS   Hua,X., Hongbing,R., Juan,X., Jizan,L. and Beibei,Y.
  TITLE     Dysregulation of TNF-induced protein 3 and CCAAT/enhancer-binding
            protein beta in alveolar macrophages: Implications for systemic
            sclerosis-associated interstitial lung disease
  JOURNAL   Int J Rheum Dis 27 (5), e15174 (2024)
   PUBMED   38720423
  REMARK    GeneRIF: Dysregulation of TNF-induced protein 3 and
            CCAAT/enhancer-binding protein beta in alveolar macrophages:
            Implications for systemic sclerosis-associated interstitial lung
            disease.
REFERENCE   6  (bases 1 to 4665)
  AUTHORS   Cooper,J.T., Stroka,D.M., Brostjan,C., Palmetshofer,A., Bach,F.H.
            and Ferran,C.
  TITLE     A20 blocks endothelial cell activation through a
            NF-kappaB-dependent mechanism
  JOURNAL   J Biol Chem 271 (30), 18068-18073 (1996)
   PUBMED   8663499
REFERENCE   7  (bases 1 to 4665)
  AUTHORS   Song,H.Y., Rothe,M. and Goeddel,D.V.
  TITLE     The tumor necrosis factor-inducible zinc finger protein A20
            interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6721-6725 (1996)
   PUBMED   8692885
REFERENCE   8  (bases 1 to 4665)
  AUTHORS   Deuitch,N.T., Schwartz,D.M. and Aksentijevich,I.
  TITLE     Haploinsufficiency of A20
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39715316
REFERENCE   9  (bases 1 to 4665)
  AUTHORS   Opipari,A.W. Jr., Boguski,M.S. and Dixit,V.M.
  TITLE     The A20 cDNA induced by tumor necrosis factor alpha encodes a novel
            type of zinc finger protein
  JOURNAL   J Biol Chem 265 (25), 14705-14708 (1990)
   PUBMED   2118515
REFERENCE   10 (bases 1 to 4665)
  AUTHORS   Dixit,V.M., Green,S., Sarma,V., Holzman,L.B., Wolf,F.W.,
            O'Rourke,K., Ward,P.A., Prochownik,E.V. and Marks,R.M.
  TITLE     Tumor necrosis factor-alpha induction of novel gene products in
            human endothelial cells including a macrophage-specific chemotaxin
  JOURNAL   J Biol Chem 265 (5), 2973-2978 (1990)
   PUBMED   2406243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY009939.1, M59465.1 and
            CB528739.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001270508.1.
            
            Summary: This gene was identified as a gene whose expression is
            rapidly induced by the tumor necrosis factor (TNF). The protein
            encoded by this gene is a zinc finger protein and ubiqitin-editing
            enzyme, and has been shown to inhibit NF-kappa B activation as well
            as TNF-mediated apoptosis. The encoded protein, which has both
            ubiquitin ligase and deubiquitinase activities, is involved in the
            cytokine-mediated immune and inflammatory responses. Several
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.119981.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612899.5/ ENSP00000481570.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               HY009939.1         130-506
            378-4401            M59465.1           145-4168
            4402-4665           CB528739.1         18-281              c
FEATURES             Location/Qualifiers
     source          1..4665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..4665
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /note="TNF alpha induced protein 3"
                     /db_xref="GeneID:7128"
                     /db_xref="HGNC:HGNC:11896"
                     /db_xref="MIM:191163"
     exon            1..284
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..594
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2672
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /EC_number="3.4.19.12"
                     /note="tumor necrosis factor inducible protein A20; zinc
                     finger protein A20; OTU domain-containing protein 7C;
                     putative DNA-binding protein A20; tumor necrosis factor,
                     alpha induced protein 3"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein 3"
                     /protein_id="NP_001257437.1"
                     /db_xref="CCDS:CCDS5187.1"
                     /db_xref="GeneID:7128"
                     /db_xref="HGNC:HGNC:11896"
                     /db_xref="MIM:191163"
                     /translation="MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMH
                     RYTLEMFRTCQFCPQFREIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGN
                     CLMHATSQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYD
                     TRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSL
                     ESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLV
                     NRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEAN
                     LPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPMEPSVPQLSLMDVKCETPNC
                     PFFMSVNTQPLCHECSERRQKNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNP
                     EESTGGPHSAPPTAPSPFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHNARQLHASH
                     APDHTRHLDPGKCQACLQDVTRTFNGICSTCFKRTTAEASSSLSTSLPPSCHQRSKSD
                     PSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGDRTGTSKCRKAGCVYFGTPENKGFC
                     TLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGRECGTLGSTMFEGYCQKCFIEAQ
                     NQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARASCKNILACRSEELCMECQHPN
                     QRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFKQMYG"
     exon            595..785
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..933
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1104
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1285
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2205
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2387
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..4665
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4640..4645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /note="hexamer: ATTAAA"
     regulatory      4647..4652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /note="hexamer: AATAAA"
     polyA_site      4660
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /note="major polyA site"
     polyA_site      4665
                     /gene="TNFAIP3"
                     /gene_synonym="A20; AIFBL1; AISBL; OTUD7C; TNFA1P2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtctgca gtcttcgtgg cgggccaagc gagcttggag cccgcggggg cggagcggtg
       61 agagcggccg ccaagagaga tcacaccccc agccgaccct gccagcgagc gagcccgacc
      121 ccaggcgtcc atggagcgtc gcctccgccc ggtccctgcc ccgacccccg cctgcggcgc
      181 gctcctgcct tgaccaggac ttgggacttt gcgaaaggat cgcggggccc ggagaggtaa
      241 ccgccgcgcc tcccggagag gtaaccgccg cgcctcccgg agaggtgttg gagagcacaa
      301 tggctgaaca agtccttcct caggctttgt atttgagcaa tatgcggaaa gctgtgaaga
      361 tacgggagag aactccagaa gacattttta aacctactaa tgggatcatt catcatttta
      421 aaaccatgca ccgatacaca ctggaaatgt tcagaacttg ccagttttgt cctcagtttc
      481 gggagatcat ccacaaagcc ctcatcgaca gaaacatcca ggccaccctg gaaagccaga
      541 agaaactcaa ctggtgtcga gaagtccgga agcttgtggc gctgaaaacg aacggtgacg
      601 gcaattgcct catgcatgcc acttctcagt acatgtgggg cgttcaggac acagacttgg
      661 tactgaggaa ggcgctgttc agcacgctca aggaaacaga cacacgcaac tttaaattcc
      721 gctggcaact ggagtctctc aaatctcagg aatttgttga aacggggctt tgctatgata
      781 ctcggaactg gaatgatgaa tgggacaatc ttatcaaaat ggcttccaca gacacaccca
      841 tggcccgaag tggacttcag tacaactcac tggaagaaat acacatattt gtcctttgca
      901 acatcctcag aaggccaatc attgtcattt cagacaaaat gctaagaagt ttggaatcag
      961 gttccaattt cgcccctttg aaagtgggtg gaatttactt gcctctccac tggcctgccc
     1021 aggaatgcta cagatacccc attgttctcg gctatgacag ccatcatttt gtacccttgg
     1081 tgaccctgaa ggacagtggg cctgaaatcc gagctgttcc acttgttaac agagaccggg
     1141 gaagatttga agacttaaaa gttcactttt tgacagatcc tgaaaatgag atgaaggaga
     1201 agctcttaaa agagtactta atggtgatag aaatccccgt ccaaggctgg gaccatggca
     1261 caactcatct catcaatgcc gcaaagttgg atgaagctaa cttaccaaaa gaaatcaatc
     1321 tggtagatga ttactttgaa cttgttcagc atgagtacaa gaaatggcag gaaaacagcg
     1381 agcaggggag gagagagggg cacgcccaga atcccatgga accttccgtg ccccagcttt
     1441 ctctcatgga tgtaaaatgt gaaacgccca actgcccctt cttcatgtct gtgaacaccc
     1501 agcctttatg ccatgagtgc tcagagaggc ggcaaaagaa tcaaaacaaa ctcccaaagc
     1561 tgaactccaa gccgggccct gaggggctcc ctggcatggc gctcggggcc tctcggggag
     1621 aagcctatga gcccttggcg tggaaccctg aggagtccac tggggggcct cattcggccc
     1681 caccgacagc acccagccct tttctgttca gtgagaccac tgccatgaag tgcaggagcc
     1741 ccggctgccc cttcacactg aatgtgcagc acaacggatt ttgtgaacgt tgccacaacg
     1801 cccggcaact tcacgccagc cacgccccag accacacaag gcacttggat cccgggaagt
     1861 gccaagcctg cctccaggat gttaccagga catttaatgg gatctgcagt acttgcttca
     1921 aaaggactac agcagaggcc tcctccagcc tcagcaccag cctccctcct tcctgtcacc
     1981 agcgttccaa gtcagatccc tcgcggctcg tccggagccc ctccccgcat tcttgccaca
     2041 gagctggaaa cgacgcccct gctggctgcc tgtctcaagc tgcacggact cctggggaca
     2101 ggacggggac gagcaagtgc agaaaagccg gctgcgtgta ttttgggact ccagaaaaca
     2161 agggcttttg cacactgtgt ttcatcgagt acagagaaaa caaacatttt gctgctgcct
     2221 cagggaaagt cagtcccaca gcgtccaggt tccagaacac cattccgtgc ctggggaggg
     2281 aatgcggcac ccttggaagc accatgtttg aaggatactg ccagaagtgt ttcattgaag
     2341 ctcagaatca gagatttcat gaggccaaaa ggacagaaga gcaactgaga tcgagccagc
     2401 gcagagatgt gcctcgaacc acacaaagca cctcaaggcc caagtgcgcc cgggcctcct
     2461 gcaagaacat cctggcctgc cgcagcgagg agctctgcat ggagtgtcag catcccaacc
     2521 agaggatggg ccctggggcc caccggggtg agcctgcccc cgaagacccc cccaagcagc
     2581 gttgccgggc ccccgcctgt gatcattttg gcaatgccaa gtgcaacggc tactgcaacg
     2641 aatgctttca gttcaagcag atgtatggct aaccggaaac aggtgggtca cctcctgcaa
     2701 gaagtggggc ctcgagctgt cagtcatcat ggtgctatcc tctgaacccc tcagctgcca
     2761 ctgcaacagt gggcttaagg gtgtctgagc aggagaggaa agataagctc ttcgtggtgc
     2821 ccacgatgct caggtttggt aacccgggag tgttcccagg tggccttaga aagcaaagct
     2881 tgtaactggc aagggatgat gtcagattca gcccaaggtt cctcctctcc taccaagcag
     2941 gaggccagga acttctttgg acttggaagg tgtgcgggga ctggccgagg cccctgcacc
     3001 ctgcgcatca ggactgcttc atcgtcttgg ctgagaaagg gaaaagacac acaagtcgcg
     3061 tgggttggag aagccagagc cattccacct cccctccccc agcatctctc agagatgtga
     3121 agccagatcc tcatggcagc gaggccctct gcaagaagct caaggaagct cagggaaaat
     3181 ggacgtattc agagagtgtt tgtagttcat ggtttttccc tacctgcccg gttcctttcc
     3241 tgaggacccg gcagaaatgc agaaccatcc atggactgtg attctgaggc tgctgagact
     3301 gaacatgttc acattgacag aaaaacaagc tgctctttat aatatgcacc ttttaaaaaa
     3361 ttagaatatt ttactgggaa gacgtgtaac tctttgggtt attactgtct ttacttctaa
     3421 agaagttagc ttgaactgag gagtaaaagt gtgtacatat ataatatacc cttacattat
     3481 gtatgaggga tttttttaaa ttatattgaa atgctgccct agaagtacaa taggaaggct
     3541 aaataataat aacctgtttt ctggttgttg ttggggcatg agcttgtgta tacactgctt
     3601 gcataaactc aaccagctgc ctttttaaag ggagctctag tcctttttgt gtaattcact
     3661 ttatttattt tattacaaac ttcaagatta tttaagtgaa gatatttctt cagctctggg
     3721 gaaaatgcca cagtgttctc ctgagagaac atccttgctt tgagtcaggc tgtgggcaag
     3781 ttcctgacca cagggagtaa attggcctct ttgatacact tttgcttgcc tccccaggaa
     3841 agaaggaatt gcatccaagg tatacataca tattcatcga tgtttcgtgc ttctccttat
     3901 gaaactccag ctatgtaata aaaaactata ctctgtgttc tgttaatgcc tctgagtgtc
     3961 ctacctcctt ggagatgaga tagggaagga gcagggatga gactggcaat ggtcacaggg
     4021 aaagatgtgg ccttttgtga tggttttatt ttctgttaac actgtgtcct gggggggctg
     4081 ggaagtcccc tgcatcccat ggtaccctgg tattgggaca gcaaaagcca gtaaccatga
     4141 gtatgaggaa atctctttct gttgctggct tacagtttct ctgtgtgctt tgtggttgct
     4201 gtcatatttg ctctagaaga aaaaaaaaaa aggaggggaa atgcattttc cccagagata
     4261 aaggctgcca ttttgggggt ctgtacttat ggcctgaaaa tatttgtgat ccataactct
     4321 acacagcctt tactcatact attaggcaca ctttcccctt agagccccct aagtttttcc
     4381 cagacgaatc tttataattt ctttccaaag ataccaaata aacttcagtg ttttcatcta
     4441 attctcttaa agttgatatc ttaatatttt gtgttgatca ttatttccat tcttaatgtg
     4501 aaaaaaagta attatttata cttattataa aaagtatttg aaatttgcac atttaattgt
     4561 ccctaataga aagccaccta ttctttgttg gatttcttca agtttttcta aataaatgta
     4621 acttttcaca agagtcaaca ttaaaaaata aattatttaa gaaca
//
