LOCUS       NM_006291               4683 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TNF alpha induced protein 2 (TNFAIP2), transcript
            variant 1, mRNA.
ACCESSION   NM_006291
VERSION     NM_006291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4683)
  AUTHORS   Lan,G., Wu,X., Zhao,A., Lan,J., Guo,Q., Wang,B., Shen,F., Yu,X.,
            Zhao,Y., Gao,R. and Xu,T.
  TITLE     The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in
            acute myeloid leukaemia
  JOURNAL   Aging (Albany NY) 16 (2), 1496-1515 (2024)
   PUBMED   38271140
  REMARK    GeneRIF: The miR-146b-3p/TNFAIP2 axis regulates cell
            differentiation in acute myeloid leukaemia.
REFERENCE   2  (bases 1 to 4683)
  AUTHORS   Xu,T., Yang,Y., Chen,Z., Wang,J., Wang,X., Zheng,Y., Wang,C.,
            Wang,Y., Zhu,Z., Ding,X., Zhou,J., Li,G., Zhang,H., Zhang,W., Wu,Y.
            and Song,X.
  TITLE     TNFAIP2 confers cisplatin resistance in head and neck squamous cell
            carcinoma via KEAP1/NRF2 signaling
  JOURNAL   J Exp Clin Cancer Res 42 (1), 190 (2023)
   PUBMED   37525222
  REMARK    GeneRIF: TNFAIP2 confers cisplatin resistance in head and neck
            squamous cell carcinoma via KEAP1/NRF2 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4683)
  AUTHORS   Lin,M.S., Zhong,H.Y., Yim,R.L., Chen,Q.Y., Du,H.L., He,H.Q.,
            Lin,K., Zhao,P., Gao,R., Gao,F. and Zhang,M.Y.
  TITLE     Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic
            value and immunological function in acute myeloid leukemia
  JOURNAL   BMC Cancer 22 (1), 1068 (2022)
   PUBMED   36243694
  REMARK    GeneRIF: Pan-cancer analysis of oncogenic TNFAIP2 identifying its
            prognostic value and immunological function in acute myeloid
            leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4683)
  AUTHORS   Yu,Y.L., Chen,M., Zhu,H., Zhuo,M.X., Chen,P., Mao,Y.J., Li,L.Y.,
            Zhao,Q., Wu,M. and Ye,M.
  TITLE     STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300
            to contribute to the pathogenesis of inflammatory bowel disease
  JOURNAL   Clin Epigenetics 13 (1), 127 (2021)
   PUBMED   34112215
  REMARK    GeneRIF: STAT1 epigenetically regulates LCP2 and TNFAIP2 by
            recruiting EP300 to contribute to the pathogenesis of inflammatory
            bowel disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4683)
  AUTHORS   Liao,G.R., Tseng,Y.Y., Tseng,C.Y., Huang,Y.P., Tsai,C.H., Liu,H.P.
            and Hsu,W.L.
  TITLE     K160 in the RNA-binding domain of the orf virus virulence factor
            OV20.0 is critical for its functions in counteracting host
            antiviral defense
  JOURNAL   FEBS Lett 595 (12), 1721-1733 (2021)
   PUBMED   33909294
REFERENCE   6  (bases 1 to 4683)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4683)
  AUTHORS   Canova,C., Hashibe,M., Simonato,L., Nelis,M., Metspalu,A.,
            Lagiou,P., Trichopoulos,D., Ahrens,W., Pigeot,I., Merletti,F.,
            Richiardi,L., Talamini,R., Barzan,L., Macfarlane,G.J.,
            Macfarlane,T.V., Holcatova,I., Bencko,V., Benhamou,S.,
            Bouchardy,C., Kjaerheim,K., Lowry,R., Agudo,A., Castellsague,X.,
            Conway,D.I., McKinney,P.A., Znaor,A., McCartan,B.E., Healy,C.M.,
            Marron,M. and Brennan,P.
  TITLE     Genetic associations of 115 polymorphisms with cancers of the upper
            aerodigestive tract across 10 European countries: the ARCAGE
            project
  JOURNAL   Cancer Res 69 (7), 2956-2965 (2009)
   PUBMED   19339270
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4683)
  AUTHORS   Rusiniak,M.E., Yu,M., Ross,D.T., Tolhurst,E.C. and Slack,J.L.
  TITLE     Identification of B94 (TNFAIP2) as a potential retinoic acid target
            gene in acute promyelocytic leukemia
  JOURNAL   Cancer Res 60 (7), 1824-1829 (2000)
   PUBMED   10766166
REFERENCE   9  (bases 1 to 4683)
  AUTHORS   Wolf,F.W., Sarma,V., Seldin,M., Drake,S., Suchard,S.J., Shao,H.,
            O'Shea,K.S. and Dixit,V.M.
  TITLE     B94, a primary response gene inducible by tumor necrosis
            factor-alpha, is expressed in developing hematopoietic tissues and
            the sperm acrosome
  JOURNAL   J Biol Chem 269 (5), 3633-3640 (1994)
   PUBMED   8106408
REFERENCE   10 (bases 1 to 4683)
  AUTHORS   Sarma,V., Wolf,F.W., Marks,R.M., Shows,T.B. and Dixit,V.M.
  TITLE     Cloning of a novel tumor necrosis factor-alpha-inducible primary
            response gene that is differentially expressed in development and
            capillary tube-like formation in vitro
  JOURNAL   J Immunol 148 (10), 3302-3312 (1992)
   PUBMED   1374453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161669.5.
            
            On Sep 23, 2019 this sequence version replaced NM_006291.3.
            
            Summary: This gene was identified as a gene whose expression can be
            induced by the tumor necrosis factor alpha (TNF) in umbilical vein
            endothelial cells. The expression of this gene was shown to be
            induced by retinoic acid in a cell line expressing a oncogenic
            version of the retinoic acid receptor alpha fusion protein, which
            suggested that this gene may be a retinoic acid target gene in
            acute promyelocytic leukemia. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M92357.1, DRR138517.191274.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000560869.6/ ENSP00000452634.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AL161669.5         116468-116958       c
            492-874             AL161669.5         113727-114109       c
            875-1499            AL161669.5         112790-113414       c
            1500-1614           AL161669.5         110565-110679       c
            1615-1737           AL161669.5         110295-110417       c
            1738-1838           AL161669.5         110004-110104       c
            1839-1937           AL161669.5         109269-109367       c
            1938-2061           AL161669.5         108657-108780       c
            2062-2184           AL161669.5         107547-107669       c
            2185-2340           AL161669.5         106902-107057       c
            2341-2462           AL161669.5         106616-106737       c
            2463-4683           AL161669.5         102980-105200       c
FEATURES             Location/Qualifiers
     source          1..4683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32"
     gene            1..4683
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /note="TNF alpha induced protein 2"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
     exon            1..491
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..874
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..2604
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst complex component 3-like 3; primary response gene
                     B94 protein; tumor necrosis factor, alpha induced protein
                     2"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein 2
                     isoform 1"
                     /protein_id="NP_006282.2"
                     /db_xref="CCDS:CCDS9979.1"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
                     /translation="MSEASSEDLVPPLEAGAAPYREEEEAAKKKKEKKKKSKGLANVF
                     CVFTKGKKKKGQPSSAEPEDAAGSRQGLDGPPPTVEELKAALERGQLEAARPLLALER
                     ELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVLRRPLEAPPERLRQALAVVAE
                     QEREDRQAAAAGPGTSGLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGAEVPESVFL
                     HLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVAQFELCERDTYM
                     LLLWVQNLYPNDIINSPKLVGELQGMGLGSLLPPRQIRLLEATFLSSEAANVRELMDR
                     ALELEARRWAEDVPPQRLDGHCHSELAIDIIQITSQAQAKAESITLDLGSQIKRVLLV
                     ELPAFLRSYQRAFNEFLERGKQLTNYRANVIANINNCLSFRMSMEQNWQVPQDTLSLL
                     LGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHTRWAAPVETLENIIATVDTRLPEFSE
                     LQGCFREELMEALHLHLVKEYIIQLSKGRLVLKTAEQQQQLAGYILANADTIQHFCTQ
                     HGSPATWLQPALPTLAEIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSN
                     SEVKRIRSILDVSMGAQEPSRPLFSLIKVG"
     exon            875..1499
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1614
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1737
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1838
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1937
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2061
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2184
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2340
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2462
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..4683
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /note="hexamer: TATAAA"
     polyA_site      4683
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggcc aggccgggac acggtaagtg acctccgctt ccacacgtcc attccccgcc
       61 gctccgcgcg gcttctcgcc cgcccctacc ccgaggccag gccggattcc ccgaggaaag
      121 agcctgtcgc cgcggcgggg acaggagggg gctggacgct tccagggaaa ctgaggccct
      181 ggcgcgccca gcgtccgcgc gtccgggcgc agaggggcca aggctggctg agggcccggg
      241 cctgccagag gcagggaggg cggggctggg gcaggcgcag gggtctcccc tccattacag
      301 cagaaaggcc ccaggtccgg cgtgactccc cggccgggcg acacaggccg agtcacttcc
      361 tcgcccgtgc ccgggtgtcc tcatcggggg atgggtgcgc cttccacatc ctgcccagga
      421 ctgaaggagc cgggcccagc gagctcccgg gaggtgtgtg gacatcagcc ctgacgggga
      481 aggcgagcca ggagcctgca ggcctgaacc agggtgatgc tgaagatgat gaccttcttc
      541 caaggcctct agagccatca gcctgtgcca ggcaccctcg acttgcctag aggcccccaa
      601 aagttgcagt ccacatcaga ggcagagtca gaggcctcca tgtcggaggc ctcctctgag
      661 gacctggtgc cacccctgga ggctggggca gccccatata gggaggagga agaggcggcg
      721 aagaagaaga aggagaagaa gaagaagtcc aaaggcctgg ccaatgtgtt ctgcgtcttc
      781 accaaaggga agaagaagaa gggtcagccc agctcagcgg agcccgagga cgcagccggg
      841 tccaggcagg ggctggatgg cccgcccccc acagtggagg agctgaaggc ggcgctggag
      901 cgcgggcagc tggaggcggc gcggccgctg ctggcgctgg agcgggagct ggcggcggcg
      961 gcggcggcgg gcggtgtgag cgaggaggag ctggtgcggc gccagagcaa ggtggaggcg
     1021 ctgtacgagc tgctgcgcga ccaggtgctg ggcgtgctgc ggcggccgct ggaggcgccg
     1081 cccgagcggc tgcgccaggc gctggccgtg gtggcggagc aggagcgcga ggaccgccag
     1141 gcggcggcgg cggggccggg gacctcgggg ctggcggcca cgcgcccgcg gcgctggctg
     1201 cagctgtggc ggcgcggcgt ggcggaggcg gccgaggagc gcatgggcca gcggccggcc
     1261 gcgggcgccg aggtccccga gagcgtcttt ctgcacttgg gccgcaccat gaaggaggac
     1321 ctggaggccg tggtggagcg gctgaagccg ctgttccccg ccgagttcgg cgtcgtggcg
     1381 gcctacgccg agagctacca ccagcacttc gcggcccacc tggccgccgt ggcgcagttc
     1441 gagctgtgcg agcgcgacac ctacatgctg ctgctctggg tgcagaacct ctaccccaat
     1501 gacatcatca acagccccaa gctggtgggt gagctgcagg gtatggggct cgggagcctc
     1561 ctgcccccca ggcagatccg actgctggag gccacattcc tgtccagtga ggcggccaat
     1621 gtgagggagt tgatggaccg agctctggag ctagaggcac ggcgctgggc tgaggatgtg
     1681 cctccccaga ggctggacgg ccactgccac agcgagctgg ccatcgacat catccagatc
     1741 acctcccagg cccaggccaa ggccgagagc atcacgctgg acttgggctc acagataaag
     1801 cgggtgctgc tggtggagct gcctgcgttc ctgaggagct accagcgcgc ctttaatgaa
     1861 tttctggaga gaggcaagca gctgacgaat tacagggcca atgttattgc caacatcaac
     1921 aactgcctgt ccttccggat gtccatggag cagaattggc aggtacccca ggacaccctg
     1981 agcctcctgc tgggccccct gggtgagctc aagagccacg gctttgacac cctgctccag
     2041 aacctgcatg aggacctgaa gccactgttc aagaggttca cgcacacccg ctgggcggcc
     2101 cctgtggaga ccctggaaaa catcatcgcc actgtagaca cgaggctgcc tgagttctca
     2161 gagctgcagg gctgtttccg ggaggagctc atggaggcct tgcacctgca cctggtgaag
     2221 gagtacatca tccaactcag caaggggcgc ctggtcctca agacggccga gcagcagcag
     2281 cagctggctg ggtacatcct ggccaatgct gacaccatcc agcacttctg cacccagcac
     2341 ggctccccgg cgacctggct gcagcctgct ctccctacgc tggccgagat cattcgcctg
     2401 caggacccca gtgccatcaa gattgaggtg gccacttatg ccacctgcta ccctgacttc
     2461 agcaaaggcc acctgagcgc tatcctggcc atcaagggga acctatccaa cagtgaggtc
     2521 aagcgcatcc ggagcatctt ggacgtcagc atgggggcgc aggagccctc ccggccccta
     2581 ttttccctta taaaggttgg ttagcttttc ctgtggcctg acctgcctgt gagtgcccag
     2641 caagccttgg gcacaccccg ctgggagctg ttaagagcag cgctggttct cggttcctcc
     2701 cgggtctcct gtgctctgat gctacttctg cctagccctg gcggaggtgc aggccctgtc
     2761 agctggaact ggacagacct tggtttgttt acatgtccga tgggggcagg agctcccatc
     2821 ctgggcagcc aaccaggcaa caccaaggac tctttgtaaa cgatagctga tcgtgtgcac
     2881 gcaaggaaag aaccaggagg gagagtgcag ccaggctcag ggatccccgg acacctctgt
     2941 ccagagcccc tccacagtcg gcctcatgac tgtcctcctc gtgggtgggg ccgagggccc
     3001 tcttcagctc tctggagaca ggggccgagc ctcacccatc tgccctctgc agcccagggc
     3061 cgccgtgagc gggattcagc aatggtggaa tggaagacag aactggaaga gaaagaagga
     3121 aaagatgagc tctcgtctgg caggggcttt tagggtcctg tggcgagctg tgagcaccgc
     3181 cagcattaga cgtcacatcc aggtggcccc acggccccta caggctggcc ctgcaatggg
     3241 gccctgagcc ctccctcttc atcccccaag gcctcaacta gagggtggtc ccccgagggc
     3301 ttggtgtcta ctaccgaagg gcccaagacc tcctgggtcc tctcaggctc ccccttcccc
     3361 aaggcaggga caggccctgg gggtgccacc gtgggccctg ccacccagaa gtctggctga
     3421 ggtctgggca ggggcagggc aagcttgacc tctcactgtt gaccctttgg cctctgtatt
     3481 tgtttcctat tgccgtgaca ggtttccaca aacttcgtgg atcaaaacga ggtcttccag
     3541 ttctgcgggt cagaaggctg acccggggct caaatctggg tgtcggcagt cctgcactcc
     3601 ttctggaggc tctaggggag aattcatttc tggccttttc atttttagag gctgaccgta
     3661 attcttgact tcaggctcct ccatcttcag agccagctgt gggtagttga atctttttcc
     3721 cgtcacctca ttgaggcctc ccctctcctg cctccctcca ccactttttt tttttttttt
     3781 ttgagacagg gtcttgctgt gttgcccagg ctggagtgca gtggcctggt catggcatca
     3841 aggctcactg cagcctggac ctcctggttc aagtgatcct cttgtctcag tcccctgaga
     3901 caatccccca cgcccagcta catatttttt gtggatacag ggtctcattc tgttgcctag
     3961 gcttgtctgg aactcctggg ctcaagggat cttgtagcct tagcctccta aagtgctggg
     4021 attataggca tgagtcactg tacccggcct gctctaccgc ttttaaggac gcttatgatc
     4081 acattgcgcc tacccagaga acccaggtcg tctttctatt ttcaggtcag ctgattagcc
     4141 accttagttc catctgcaac tttagttccc actggctgtg taacctaaca tagtcacagg
     4201 ctctggggac tgtcacgtgg acatctttgg gaggccgtta ttctgcccac cgcaccctcc
     4261 gttcatcccc tgccctgccg ggcacctcgc tctaccccag gaaaatgtga gctcgttttc
     4321 ctgctcggca tgtgctcccc ctaaggctct gctcctccct gggcctgaaa gttccttctc
     4381 agcctgagag ggggcccttc ggactcaggc atgactcagc ccggctgatg cctctgcagt
     4441 gctgagtcag gatttggggc cggctctctt gggtccgtcc ccttttccca ggtactgcct
     4501 tacaaagctg tggccaggaa gtggccggta taaaggatgc ccaaggtctt tgtacgtgtg
     4561 taggagttag cgtgtttgat attgttaata taataataat tattttttag agtactgctt
     4621 ttgtatgtat gttgaacagg atccaggttt ttatagcttg atataaaaca gaattcaaaa
     4681 gtg
//
