LOCUS       NM_021137               3570 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.
ACCESSION   NM_021137
VERSION     NM_021137.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3570)
  AUTHORS   Lv,D., Chen,Y., Tang,L., Tian,Y., Ren,D., Jian,N. and Shen,T.
  TITLE     HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an
            Inflammatory Response in Renal Cell Carcinoma Cells
  JOURNAL   In Vivo 38 (3), 1094-1103 (2024)
   PUBMED   38688591
  REMARK    GeneRIF: HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to
            Promote an Inflammatory Response in Renal Cell Carcinoma Cells.
REFERENCE   2  (bases 1 to 3570)
  AUTHORS   Wang,W., Gao,W., Gong,P., Song,W., Bu,X., Hou,J., Zhang,L. and
            Zhao,B.
  TITLE     Neuronal-specific TNFAIP1 ablation attenuates postoperative
            cognitive dysfunction via targeting SNAP25 for K48-linked
            ubiquitination
  JOURNAL   Cell Commun Signal 21 (1), 356 (2023)
   PUBMED   38102610
  REMARK    GeneRIF: Neuronal-specific TNFAIP1 ablation attenuates
            postoperative cognitive dysfunction via targeting SNAP25 for
            K48-linked ubiquitination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3570)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 3570)
  AUTHORS   Tang,X., Tangkham,T., Aljahdali,B., Lee,S., Su,M. and Dibart,S.
  TITLE     The role of TNF-alpha induced protein 1 in the activation of
            pro-apoptotic proteins
  JOURNAL   Hum Cell 34 (4), 1123-1129 (2021)
   PUBMED   33909263
  REMARK    GeneRIF: The role of TNF-alpha induced protein 1 in the activation
            of pro-apoptotic proteins.
REFERENCE   5  (bases 1 to 3570)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3570)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   7  (bases 1 to 3570)
  AUTHORS   Pandey,A., Shao,H., Marks,R.M., Polverini,P.J. and Dixit,V.M.
  TITLE     Role of B61, the ligand for the Eck receptor tyrosine kinase, in
            TNF-alpha-induced angiogenesis
  JOURNAL   Science 268 (5210), 567-569 (1995)
   PUBMED   7536959
REFERENCE   8  (bases 1 to 3570)
  AUTHORS   Wolf,F.W., Marks,R.M., Sarma,V., Byers,M.G., Katz,R.W., Shows,T.B.
            and Dixit,V.M.
  TITLE     Characterization of a novel tumor necrosis factor-alpha-induced
            endothelial primary response gene
  JOURNAL   J Biol Chem 267 (2), 1317-1326 (1992)
   PUBMED   1370465
REFERENCE   9  (bases 1 to 3570)
  AUTHORS   Holzman,L.B., Marks,R.M. and Dixit,V.M.
  TITLE     A novel immediate-early response gene of endothelium is induced by
            cytokines and encodes a secreted protein
  JOURNAL   Mol Cell Biol 10 (11), 5830-5838 (1990)
   PUBMED   2233719
REFERENCE   10 (bases 1 to 3570)
  AUTHORS   Dixit,V.M., Green,S., Sarma,V., Holzman,L.B., Wolf,F.W.,
            O'Rourke,K., Ward,P.A., Prochownik,E.V. and Marks,R.M.
  TITLE     Tumor necrosis factor-alpha induction of novel gene products in
            human endothelial cells including a macrophage-specific chemotaxin
  JOURNAL   J Biol Chem 265 (5), 2973-2978 (1990)
   PUBMED   2406243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003694.2.
            
            On Nov 22, 2018 this sequence version replaced NM_021137.4.
            
            Summary: This gene was identified as a gene whose expression can be
            induced by the tumor necrosis factor alpha (TNF) in umbilical vein
            endothelial cells. Studies of a similar gene in mouse suggest that
            the expression of this gene is developmentally regulated in a
            tissue-specific manner. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003694.2, SRR1803611.75799.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226225.7/ ENSP00000226225.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1482              BC003694.2         2-1483
            1483-1896           BC003694.2         1485-1898
            1897-3570           BC003694.2         1900-3573
FEATURES             Location/Qualifiers
     source          1..3570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3570
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /note="TNF alpha induced protein 1"
                     /db_xref="GeneID:7126"
                     /db_xref="HGNC:HGNC:11894"
                     /db_xref="MIM:191161"
     exon            1..96
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..415
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1161
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /note="BTB/POZ domain-containing protein TNFAIP1; tumor
                     necrosis factor, alpha-induced protein 1 (endothelial);
                     tumor necrosis factor, alpha induced protein 1"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 2"
                     /protein_id="NP_066960.1"
                     /db_xref="CCDS:CCDS11227.1"
                     /db_xref="GeneID:7126"
                     /db_xref="HGNC:HGNC:11894"
                     /db_xref="MIM:191161"
                     /translation="MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVR
                     ALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIK
                     ELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKL
                     LYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGR
                     KLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQ
                     ASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD"
     exon            416..585
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..675
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..728
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..924
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..3570
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3549..3554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /note="hexamer: AATAAA"
     polyA_site      3570
                     /gene="TNFAIP1"
                     /gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
                     /note="major polyA site"
ORIGIN      
        1 acagcttggg actgctgagg ggcaggcggc tgcaggctag gggcggctcg gagtccgctg
       61 gccacccagc tgagaggaga ggcgcccccg gggacgcact gagattatga ggctctggcc
      121 tccactggcc actcactcgt gaccctttcc accacggcgg agccttccaa gcctacctcc
      181 tgccgtgtgg tgatctacct gcagcgggag atgtcggggg acacctgcct gtgcccagcc
      241 tcaggggcca agcccaagct cagtggcttc aagggaggag ggttgggcaa caagtatgtc
      301 cagctcaacg tgggcggctc tctgtactac accactgtgc gggccctgac ccgccacgac
      361 accatgctca aggccatgtt cagtgggcgc atggaggtgc tgaccgacaa agaaggctgg
      421 atcctcatag accgttgtgg aaagcacttt ggcaccattt tgaattacct ccgagatgac
      481 accatcaccc tccctcagaa ccggcaagaa atcaaggaat tgatggctga agcaaagtat
      541 tacctcatcc aggggctggt gaatatgtgc cagagtgccc tgcaggacaa gaaggactcc
      601 taccagcctg tgtgcaacat ccccatcatc acatccctaa aggaggagga gcggctcatc
      661 gaatcctcca ccaagcccgt ggtgaagctg ctgtacaaca gaagcaacaa caagtattcc
      721 tacaccagca actctgacga ccacctgctg aaaaacatcg agctgtttga caagctctcc
      781 ctgcgcttca acggccgcgt gctcttcatc aaggatgtca ttggtgacga gatctgctgc
      841 tggtcctttt atggccaggg ccgtaagctg gcagaggtgt gctgtacctc catcgtgtat
      901 gccacggaga agaagcagac caaggtggaa ttcccagagg cccgaatcta tgaggagaca
      961 ctcaacgtcc tactctatga gactccccgc gtccccgaca actccttgtt ggaggccaca
     1021 agccgtagcc gcagccaggc ttcccccagt gaagatgagg agacctttga actgcgggac
     1081 cgtgtccgcc gcatccacgt caagcgctac agcacttacg atgaccggca gctcggccac
     1141 cagtctaccc atcgcgactg accagaccct cagggagtca gggcacggga ggccctatct
     1201 cccatcctgt ggaacccgcc ccattggcca ccccatgctg ctgctgcctg ggtctctgct
     1261 ctagcaccca gaggcatgac aggccctgct cagaggtcag agggtctggg cagaggaggg
     1321 accacattcc cctgccttgc ccctgagcac ttctggagac tgcgtcctgt cctatctgct
     1381 caccatcacc cttcctgccc gacggagctg cttctgctcc ctggggcata tggactgacc
     1441 cacctcctgc tgagaacctt cccctaggcc ctgtgcagaa ggctactgcc ccttaggcct
     1501 cagctggggg aaaggcagtt ctggtgctgt agaggccctg gtgcagaaag tgggacgtct
     1561 tttttcctaa ggtgtttaag cacaggcttg ataagtttgg tttttaaaaa ataatctagg
     1621 aaatgaataa ttctaaatct agtaatgagg aaactgagca tttcttttgc cctccagggt
     1681 gccaagaccc tacatatgac agaacccttg gcccttctcc atgcctgtgg gatctgtttc
     1741 tttaaagcac tttgtactgt tattcaggag gttgataatc tccttgaccc atgtctttct
     1801 accctaatcc ccacttccct gcagaatcaa tctgagggag gggataaaga ggaagcaata
     1861 aaaaaaaaac atccgacaga gcagctctgg ctttgcagcc tggccagcag ctcagagtgc
     1921 accgaggagg gaaggatggc taagctggga ccggcagtcc tcacagggtg cctgtgagaa
     1981 aggacatttt acccccacat catagtcaca tcactgactc ctaggtctag cacgactgct
     2041 ctttgtgatt ctcttgagta cccttggctt ccagccatgc tgtcctcaca tacggtaaag
     2101 ccaaagagct gtcacatggg ccagaaacat gagccacggc aggaagaccg tggagcccgt
     2161 gggcactgca tggtgttggc tggcatgccc atcagctgag gacagcaaac tcccagcagc
     2221 ccctacagag gtggcacatg cttggccaca catctactcc ctgcccacac catctatgct
     2281 cttggttggt gctggctggg atggcggttc tgcccagtgg tgtctctgag cgcgggatga
     2341 caggagcaac cgaagcaccc tgaaggcctt cactccttgt tgggtaactc agccatggag
     2401 atgccaagca ctagccagga ggtgagttcc tctttagggc tttggttttc attccttttt
     2461 gtttggcttg gccaaaccag aattcagctt atctgaatta ttttccaaag gaatgctgtc
     2521 agggagggac tgttctgcca gcctaacaaa gcaacgtagc cacgtatagt acccactttc
     2581 tgctctttgg agagaacaca ggttatcaag ttcatctctc ttgactactc ttatgatagc
     2641 tgatgccaca gagcctatgg gcaaatgcca gacccagggt tagacacaag gacctgaagt
     2701 gacatgacgg cgggacaggg gaaatgtgac tttctaatta ggcattttat gttagtcaca
     2761 gtcttgaatg tataaacagc actaagactc tcaggtcagg taccttggtg atcagctact
     2821 agttcttcca gccctcattg aggtaacaag ataaagacaa atccacttct ttggccaaat
     2881 tcaggctttg gctttatgac tttcccacag agactggaat gcgtcagcct gagaccactg
     2941 gcctattttc tcagctgccc tcttgaggtc ctttaacact caaattccca gctccccact
     3001 gaggtgttgt gatgcttgcc ttttgacctc cccatcccct ttagtccctg cttactactt
     3061 tgacattcac atcctcagtg tctcagtctt ttttgccgag aaagcacagt agtctgggac
     3121 tgggcattta tcttctctga ctgaaaatct ctccttggtc ttaaggaaaa tactaacatt
     3181 gaactcactg acatgatctt agcttcttta atcagacttt gtgacttaaa agtttggggg
     3241 ttttctttga aagtttccag ccctattcag aaagcaactc ttggctgtgt gcatttttca
     3301 actccaagca gcccaggggt aagtaaacaa agtatggatg aaggtcagat tttcttgtca
     3361 gtttctgaga aacctggcag cctgctgtta acaacacagg ccagtattgg gttttattga
     3421 atttggtatg tgaccaaggt cggcctaaag gatggcgcag gtcctgggca ggaaagaatt
     3481 tttcctttat cacataactg taatatttgg ttgctcagca taagtgatgg aagcaaacac
     3541 taatttctaa taaaattgtg ttaaactcaa
//
