LOCUS       NM_002160               8500 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens tenascin C (TNC), transcript variant 1, mRNA.
ACCESSION   NM_002160
VERSION     NM_002160.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8500)
  AUTHORS   Abirami,S., Adole,P.S. and Vinod,K.V.
  TITLE     Association of Tenascin-C Gene Polymorphisms with Risk of Acute
            Coronary Syndrome in South Indian Population: A Case-Control
            Genetic Association Study
  JOURNAL   Genet Test Mol Biomarkers 28 (3), 114-122 (2024)
   PUBMED   38471098
  REMARK    GeneRIF: Association of Tenascin-C Gene Polymorphisms with Risk of
            Acute Coronary Syndrome in South Indian Population: A Case-Control
            Genetic Association Study.
REFERENCE   2  (bases 1 to 8500)
  AUTHORS   Li,Y., Jiang,J., Wang,X., Cao,Y., Tang,L., Song,X., Huang,F.,
            Li,M., Chen,F., Wan,H. and Ye,S.
  TITLE     Engrailed 2 serves as a master regulator of the super-enhancer in
            the TNC gene locus in non-small cell lung cancer
  JOURNAL   Environ Toxicol 39 (3), 1442-1455 (2024)
   PUBMED   37987507
  REMARK    GeneRIF: Engrailed 2 serves as a master regulator of the
            super-enhancer in the TNC gene locus in non-small cell lung cancer.
REFERENCE   3  (bases 1 to 8500)
  AUTHORS   Yu,Y., Liang,C., Tang,Q., Shi,Y. and Shen,L.
  TITLE     Characteristics of n6-methyladenosine (m6A) regulators and role of
            FTO/TNC in scleroderma
  JOURNAL   Gene 894, 147989 (2024)
   PUBMED   37972699
  REMARK    GeneRIF: Characteristics of n6-methyladenosine (m6A) regulators and
            role of FTO/TNC in scleroderma.
REFERENCE   4  (bases 1 to 8500)
  AUTHORS   Zhang,H., Zhou,L., Wang,H., Gu,W., Li,Z., Sun,J., Wei,X. and
            Zheng,Y.
  TITLE     Tenascin-C-EGFR activation induces functional human satellite cell
            proliferation and promotes wound-healing of skeletal muscles via
            oleanic acid
  JOURNAL   Dev Biol 504, 86-97 (2023)
   PUBMED   37758009
  REMARK    GeneRIF: Tenascin-C-EGFR activation induces functional human
            satellite cell proliferation and promotes wound-healing of skeletal
            muscles via oleanic acid.
REFERENCE   5  (bases 1 to 8500)
  AUTHORS   Campos,A., Burgos-Ravanal,R., Lobos-Gonzalez,L., Huilcaman,R.,
            Gonzalez,M.F., Diaz,J., Verschae,A.C., Acevedo,J.P., Carrasco,M.,
            Sepulveda,F., Jeldes,E., Varas-Godoy,M., Leyton,L. and Quest,A.F.
  TITLE     Caveolin-1-dependent tenascin C inclusion in extracellular vesicles
            is required to promote breast cancer cell malignancy
  JOURNAL   Nanomedicine (Lond) 18 (23), 1651-1668 (2023)
   PUBMED   37929694
  REMARK    GeneRIF: Caveolin-1-dependent tenascin C inclusion in extracellular
            vesicles is required to promote breast cancer cell malignancy.
REFERENCE   6  (bases 1 to 8500)
  AUTHORS   White,D.M., Mikol,D.D., Espinosa,R., Weimer,B., Le Beau,M.M. and
            Stefansson,K.
  TITLE     Structure and chromosomal localization of the human gene for a
            brain form of prostaglandin D2 synthase
  JOURNAL   J Biol Chem 267 (32), 23202-23208 (1992)
   PUBMED   1385416
REFERENCE   7  (bases 1 to 8500)
  AUTHORS   Leahy,D.J., Hendrickson,W.A., Aukhil,I. and Erickson,H.P.
  TITLE     Structure of a fibronectin type III domain from tenascin phased by
            MAD analysis of the selenomethionyl protein
  JOURNAL   Science 258 (5084), 987-991 (1992)
   PUBMED   1279805
REFERENCE   8  (bases 1 to 8500)
  AUTHORS   Gulcher,J.R., Nies,D.E., Alexakos,M.J., Ravikant,N.A.,
            Sturgill,M.E., Marton,L.S. and Stefansson,K.
  TITLE     Structure of the human hexabrachion (tenascin) gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9438-9442 (1991)
   PUBMED   1719530
REFERENCE   9  (bases 1 to 8500)
  AUTHORS   Nies,D.E., Hemesath,T.J., Kim,J.H., Gulcher,J.R. and Stefansson,K.
  TITLE     The complete cDNA sequence of human hexabrachion (Tenascin). A
            multidomain protein containing unique epidermal growth factor
            repeats
  JOURNAL   J Biol Chem 266 (5), 2818-2823 (1991)
   PUBMED   1704365
REFERENCE   10 (bases 1 to 8500)
  AUTHORS   Siri,A., Carnemolla,B., Saginati,M., Leprini,A., Casari,G.,
            Baralle,F. and Zardi,L.
  TITLE     Human tenascin: primary structure, pre-mRNA splicing patterns and
            localization of the epitopes recognized by two monoclonal
            antibodies
  JOURNAL   Nucleic Acids Res 19 (3), 525-531 (1991)
   PUBMED   1707164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP279008.1, AK304015.1,
            X78565.1, AB210038.1, AI964017.1, BU860660.1, BX100095.1 and
            AI266750.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002160.3.
            
            Summary: This gene encodes an extracellular matrix protein with a
            spatially and temporally restricted tissue distribution. This
            protein is homohexameric with disulfide-linked subunits, and
            contains multiple EGF-like and fibronectin type-III domains. It is
            implicated in guidance of migrating neurons as well as axons during
            development, synaptic plasticity, and neuronal regeneration.
            [provided by RefSeq, Jul 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210038.1, X78565.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350763.9/ ENSP00000265131.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BP279008.1         385-388
            5-1927              AK304015.1         1-1923
            1928-3599           X78565.1           1929-3600
            3600-7548           AB210038.1         3576-7524
            7549-7846           AI964017.1         1-298               c
            7847-8017           BU860660.1         252-422
            8018-8433           BX100095.1         21-436
            8434-8500           AI266750.1         6-72                c
FEATURES             Location/Qualifiers
     source          1..8500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.1"
     gene            1..8500
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /note="tenascin C"
                     /db_xref="GeneID:3371"
                     /db_xref="HGNC:HGNC:5318"
                     /db_xref="MIM:187380"
     exon            1..176
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            177..769
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..6918
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hexabrachion (tenascin); cytotactin;
                     neuronectin; myotendinous antigen;
                     glioma-associated-extracellular matrix antigen; GP
                     150-225; deafness, autosomal dominant 56; tenascin-C
                     additional domain 1"
                     /codon_start=1
                     /product="tenascin isoform 1 precursor"
                     /protein_id="NP_002151.2"
                     /db_xref="CCDS:CCDS6811.1"
                     /db_xref="GeneID:3371"
                     /db_xref="HGNC:HGNC:5318"
                     /db_xref="MIM:187380"
                     /translation="MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEE
                     NQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTH
                     RINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPF
                     CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQ
                     LACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAG
                     DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEE
                     GFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRC
                     ECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCV
                     EGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNR
                     GLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSD
                     CHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVS
                     PPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQEL
                     EPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFE
                     TWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRV
                     TTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDEN
                     QYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWR
                     NGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDK
                     ESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQ
                     LPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWD
                     GLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYG
                     VIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADT
                     VEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNL
                     TVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGT
                     PYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFV
                     IQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTA
                     KEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAH
                     ISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMAS
                     ENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKP
                     LRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITL
                     LAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSA
                     TVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKG
                     FEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEIT
                     RTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQS
                     ETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQAL
                     NGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDM
                     TSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRV
                     DLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSA
                     ITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSN
                     FRNLEGRRKRA"
     exon            770..2179
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2443
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2559
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2716
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2986
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3172
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3262
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3526
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3799
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..4072
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4345
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4618
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4891
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4892..5164
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5437
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..5560
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5561..5704
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5705..5824
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5825..5968
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5969..6099
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6100..6232
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6233..6384
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6385..6481
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6482..6643
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6644..6807
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6808..8500
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7519..7524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /note="hexamer: AATAAA"
     polyA_site      7541
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /note="major polyA site"
     regulatory      8482..8487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
                     /note="hexamer: AATAGA"
     polyA_site      8500
                     /gene="TNC"
                     /gene_synonym="150-225; DFNA56; GMEM; GP; HXB; JI; TN;
                     TN-C"
ORIGIN      
        1 ggccacagcc tgcctactgt cacccgcctc tcccgcgcgc agatacacgc ccccgcctcc
       61 gtgggcacaa aggcagcgct gctggggaac tcgggggaac gcgcacgtgg gaaccgccgc
      121 agctccacac tccaggtact tcttccaagg acctaggtct ctcgcccatc ggaaagaaaa
      181 taattctttc aagaagatca gggacaactg atttgaagtc tactctgtgc ttctaaatcc
      241 ccaattctgc tgaaagtgag ataccctaga gccctagagc cccagcagca cccagccaaa
      301 cccacctcca ccatgggggc catgactcag ctgttggcag gtgtctttct tgctttcctt
      361 gccctcgcta ccgaaggtgg ggtcctcaag aaagtcatcc ggcacaagcg acagagtggg
      421 gtgaacgcca ccctgccaga agagaaccag ccagtggtgt ttaaccacgt ttacaacatc
      481 aagctgccag tgggatccca gtgttcggtg gatctggagt cagccagtgg ggagaaagac
      541 ctggcaccgc cttcagagcc cagcgaaagc tttcaggagc acacagtgga tggggaaaac
      601 cagattgtct tcacacatcg catcaacatc ccccgccggg cctgtggctg tgccgcagcc
      661 cctgatgtta aggagctgct gagcagactg gaggagctgg agaacctggt gtcttccctg
      721 agggagcaat gtactgcagg agcaggctgc tgtctccagc ctgccacagg ccgcttggac
      781 accaggccct tctgtagcgg tcggggcaac ttcagcactg aaggatgtgg ctgtgtctgc
      841 gaacctggct ggaaaggccc caactgctct gagcccgaat gtccaggcaa ctgtcacctt
      901 cgaggccggt gcattgatgg gcagtgcatc tgtgacgacg gcttcacggg cgaggactgc
      961 agccagctgg cttgccccag cgactgcaat gaccagggca agtgcgtaaa tggagtctgc
     1021 atctgtttcg aaggctacgc cggggctgac tgcagccgtg aaatctgccc agtgccctgc
     1081 agtgaggagc acggcacatg tgtagatggc ttgtgtgtgt gccacgatgg ctttgcaggc
     1141 gatgactgca acaagcctct gtgtctcaac aattgctaca accgtggacg atgcgtggag
     1201 aatgagtgcg tgtgtgatga gggtttcacg ggcgaagact gcagtgagct catctgcccc
     1261 aatgactgct tcgaccgggg ccgctgcatc aatggcacct gctactgcga agaaggcttc
     1321 acaggtgaag actgcgggaa acccacctgc ccacatgcct gccacaccca gggccggtgt
     1381 gaggaggggc agtgtgtatg tgatgagggc tttgccggtg tggactgcag cgagaagagg
     1441 tgtcctgctg actgtcacaa tcgtggccgc tgtgtagacg ggcggtgtga gtgtgatgat
     1501 ggtttcactg gagctgactg tggggagctc aagtgtccca atggctgcag tggccatggc
     1561 cgctgtgtca atgggcagtg tgtgtgtgat gagggctata ctggggagga ctgcagccag
     1621 ctacggtgcc ccaatgactg tcacagtcgg ggccgctgtg tcgagggcaa atgtgtatgt
     1681 gagcaaggct tcaagggcta tgactgcagt gacatgagct gccctaatga ctgtcaccag
     1741 cacggccgct gtgtgaatgg catgtgtgtt tgtgatgacg gctacacagg ggaagactgc
     1801 cgggatcgcc aatgccccag ggactgcagc aacaggggcc tctgtgtgga cggacagtgc
     1861 gtctgtgagg acggcttcac cggccctgac tgtgcagaac tctcctgtcc aaatgactgc
     1921 catggccagg gtcgctgtgt gaatgggcag tgcgtgtgcc atgaaggatt tatgggcaaa
     1981 gactgcaagg agcaaagatg tcccagtgac tgtcatggcc agggccgctg cgtggacggc
     2041 cagtgcatct gccacgaggg cttcacaggc ctggactgtg gccagcactc ctgccccagt
     2101 gactgcaaca acttaggaca atgcgtctcg ggccgctgca tctgcaacga gggctacagc
     2161 ggagaagact gctcagaggt gtctcctccc aaagacctcg ttgtgacaga agtgacggaa
     2221 gagacggtca acctggcctg ggacaatgag atgcgggtca cagagtacct tgtcgtgtac
     2281 acgcccaccc acgagggtgg tctggaaatg cagttccgtg tgcctgggga ccagacgtcc
     2341 accatcatcc aggagctgga gcctggtgtg gagtacttta tccgtgtatt tgccatcctg
     2401 gagaacaaga agagcattcc tgtcagcgcc agggtggcca cgtacttacc tgcacctgaa
     2461 ggcctgaaat tcaagtccat caaggagaca tctgtggaag tggagtggga tcctctagac
     2521 attgcttttg aaacctggga gatcatcttc cggaatatga ataaagaaga tgagggagag
     2581 atcaccaaaa gcctgaggag gccagagacc tcttaccggc aaactggtct agctcctggg
     2641 caagagtatg agatatctct gcacatagtg aaaaacaata cccggggccc tggcctgaag
     2701 agggtgacca ccacacgctt ggatgccccc agccagatcg aggtgaaaga tgtcacagac
     2761 accactgcct tgatcacctg gttcaagccc ctggctgaga tcgatggcat tgagctgacc
     2821 tacggcatca aagacgtgcc aggagaccgt accaccatcg atctcacaga ggacgagaac
     2881 cagtactcca tcgggaacct gaagcctgac actgagtacg aggtgtccct catctcccgc
     2941 agaggtgaca tgtcaagcaa cccagccaaa gagaccttca caacaggcct cgatgctccc
     3001 aggaatcttc gacgtgtttc ccagacagat aacagcatca ccctggaatg gaggaatggc
     3061 aaggcagcta ttgacagtta cagaattaag tatgccccca tctctggagg ggaccacgct
     3121 gaggttgatg ttccaaagag ccaacaagcc acaaccaaaa ccacactcac aggtctgagg
     3181 ccgggaactg aatatgggat tggagtttct gctgtgaagg aagacaagga gagcaatcca
     3241 gcgaccatca acgcagccac agagttggac acgcccaagg accttcaggt ttctgaaact
     3301 gcagagacca gcctgaccct gctctggaag acaccgttgg ccaaatttga ccgctaccgc
     3361 ctcaattaca gtctccccac aggccagtgg gtgggagtgc agcttccaag aaacaccact
     3421 tcctatgtcc tgagaggcct ggaaccagga caggagtaca atgtcctcct gacagccgag
     3481 aaaggcagac acaagagcaa gcccgcacgt gtgaaggcat ccactgaaca agcccctgag
     3541 ctggaaaacc tcaccgtgac tgaggttggc tgggatggcc tcagactcaa ctggaccgca
     3601 gctgaccagg cctatgagca ctttatcatt caggtgcagg aggccaacaa ggtggaggca
     3661 gctcggaacc tcaccgtgcc tggcagcctt cgggctgtgg acataccggg cctcaaggct
     3721 gctacgcctt atacagtctc catctatggg gtgatccagg gctatagaac accagtgctc
     3781 tctgctgagg cctccacagg ggaaactccc aatttgggag aggtcgtggt ggccgaggtg
     3841 ggctgggatg ccctcaaact caactggact gctccagaag gggcctatga gtactttttc
     3901 attcaggtgc aggaggctga cacagtagag gcagcccaga acctcaccgt cccaggagga
     3961 ctgaggtcca cagacctgcc tgggctcaaa gcagccactc attataccat caccatccgc
     4021 ggggtcactc aggacttcag cacaacccct ctctctgttg aagtcttgac agaggaggtt
     4081 ccagatatgg gaaacctcac agtgaccgag gttagctggg atgctctcag actgaactgg
     4141 accacgccag atggaaccta tgaccagttt actattcagg tccaggaggc tgaccaggtg
     4201 gaagaggctc acaatctcac ggttcctggc agcctgcgtt ccatggaaat cccaggcctc
     4261 agggctggca ctccttacac agtcaccctg cacggcgagg tcaggggcca cagcactcga
     4321 ccccttgctg tagaggtcgt cacagaggat ctcccacagc tgggagattt agccgtgtct
     4381 gaggttggct gggatggcct cagactcaac tggaccgcag ctgacaatgc ctatgagcac
     4441 tttgtcattc aggtgcagga ggtcaacaaa gtggaggcag cccagaacct cacgttgcct
     4501 ggcagcctca gggctgtgga catcccgggc ctcgaggctg ccacgcctta tagagtctcc
     4561 atctatgggg tgatccgggg ctatagaaca ccagtactct ctgctgaggc ctccacagcc
     4621 aaagaacctg aaattggaaa cttaaatgtt tctgacataa ctcccgagag cttcaatctc
     4681 tcctggatgg ctaccgatgg gatcttcgag acctttacca ttgaaattat tgattccaat
     4741 aggttgctgg agactgtgga atataatatc tctggtgctg aacgaactgc ccatatctca
     4801 gggctacccc ctagtactga ttttattgtc tacctctctg gacttgctcc cagcatccgg
     4861 accaaaacca tcagtgccac agccacgaca gaggccctgc cccttctgga aaacctaacc
     4921 atttccgaca ttaatcccta cgggttcaca gtttcctgga tggcatcgga gaatgccttt
     4981 gacagctttc tagtaacggt ggtggattct gggaagctgc tggaccccca ggaattcaca
     5041 ctttcaggaa cccagaggaa gctggagctt agaggcctca taactggcat tggctatgag
     5101 gttatggtct ctggcttcac ccaagggcat caaaccaagc ccttgagggc tgagattgtt
     5161 acagaagccg aaccggaagt tgacaacctt ctggtttcag atgccacccc agacggtttc
     5221 cgtctgtcct ggacagctga tgaaggggtc ttcgacaatt ttgttctcaa aatcagagat
     5281 accaaaaagc agtctgagcc actggaaata accctacttg cccccgaacg taccagggac
     5341 ataacaggtc tcagagaggc tactgaatac gaaattgaac tctatggaat aagcaaagga
     5401 aggcgatccc agacagtcag tgctatagca acaacagcca tgggctcccc aaaggaagtc
     5461 attttctcag acatcactga aaattcggct actgtcagct ggagggcacc cacagcccaa
     5521 gtggagagct tccggattac ctatgtgccc attacaggag gtacaccctc catggtaact
     5581 gtggacggaa ccaagactca gaccaggctg gtgaaactca tacctggcgt ggagtacctt
     5641 gtcagcatca tcgccatgaa gggctttgag gaaagtgaac ctgtctcagg gtcattcacc
     5701 acagctctgg atggcccatc tggcctggtg acagccaaca tcactgactc agaagccttg
     5761 gccaggtggc agccagccat tgccactgtg gacagttatg tcatctccta cacaggcgag
     5821 aaagtgccag aaattacacg cacggtgtcc gggaacacag tggagtatgc tctgaccgac
     5881 ctcgagcctg ccacggaata cacactgaga atctttgcag agaaagggcc ccagaagagc
     5941 tcaaccatca ctgccaagtt cacaacagac ctcgattctc caagagactt gactgctact
     6001 gaggttcagt cggaaactgc cctccttacc tggcgacccc cccgggcatc agtcaccggt
     6061 tacctgctgg tctatgaatc agtggatggc acagtcaagg aagtcattgt gggtccagat
     6121 accacctcct acagcctggc agacctgagc ccatccaccc actacacagc caagatccag
     6181 gcactcaatg ggcccctgag gagcaatatg atccagacca tcttcaccac aattggactc
     6241 ctgtacccct tccccaagga ctgctcccaa gcaatgctga atggagacac gacctctggc
     6301 ctctacacca tttatctgaa tggtgataag gctgaggcgc tggaagtctt ctgtgacatg
     6361 acctctgatg ggggtggatg gattgtgttc ctgagacgca aaaacggacg cgagaacttc
     6421 taccaaaact ggaaggcata tgctgctgga tttggggacc gcagagaaga attctggctt
     6481 gggctggaca acctgaacaa aatcacagcc caggggcagt acgagctccg ggtggacctg
     6541 cgggaccatg gggagacagc ctttgctgtc tatgacaagt tcagcgtggg agatgccaag
     6601 actcgctaca agctgaaggt ggaggggtac agtgggacag caggtgactc catggcctac
     6661 cacaatggca gatccttctc cacctttgac aaggacacag attcagccat caccaactgt
     6721 gctctgtcct acaaaggggc tttctggtac aggaactgtc accgtgtcaa cctgatgggg
     6781 agatatgggg acaataacca cagtcagggc gttaactggt tccactggaa gggccacgaa
     6841 cactcaatcc agtttgctga gatgaagctg agaccaagca acttcagaaa tcttgaaggc
     6901 aggcgcaaac gggcataaat tccagggacc actgggtgag agaggaataa ggcccagagc
     6961 gaggaaagga ttttaccaaa gcatcaatac aaccagccca accatcggtc cacacctggg
     7021 catttggtga gagtcaaagc tgaccatgga tccctggggc caacggcaac agcatgggcc
     7081 tcacctcctc tgtgatttct ttctttgcac caaagacatc agtctccaac atgtttctgt
     7141 tttgttgttt gattcagcaa aaatctccca gtgacaacat cgcaatagtt ttttacttct
     7201 cttaggtggc tctgggaatg ggagaggggt aggatgtaca ggggtagttt gttttagaac
     7261 cagccgtatt ttacatgaag ctgtataatt aattgtcatt atttttgtta gcaaagatta
     7321 aatgtgtcat tggaagccat cccttttttt acatttcata caacagaaac cagaaaagca
     7381 atactgtttc cattttaagg atatgattaa tattattaat ataataatga tgatgatgat
     7441 gatgaaaact aaggattttt caagagatct ttctttccaa aacatttctg gacagtacct
     7501 gattgtattt tttttttaaa taaaagcaca agtacttttg agtttgttat tttgctttga
     7561 attgttgagt ctgaatttca ccaaagccaa tcatttgaac aaagcgggga atgttgggat
     7621 aggaaaggta agtagggata gtggtcaagt gggaggggtg gaaaggagac taaagactgg
     7681 gagagaggga agcacttttt ttaaataaag ttgaacacac ttgggaaaag cttacaggcc
     7741 aggcctgtaa tcccaacact ttgggaggcc aaggtgggag gatagcttaa ccccaggagt
     7801 ttgagaccag cctgagcaac atagtgagaa cttgtctcta cagaaaaaaa aaaaaaaaaa
     7861 aatttaatta ggcaagcgtg gtagtgcgca cctgtcgtcc cagctactca ggaggctgag
     7921 gtaggaaaat cactggagcc caggagttag aggttacagt gagctatgat cacactactg
     7981 cactccagcc tgggcaacag agggagaccc tgtctctaaa taaaaaaaga aaagaaaaaa
     8041 aaagcttaca acttgagatt cagcatcttg ctcagtattt ccaagactaa tagattatgg
     8101 tttaaaagat gcttttatac tcattttcta atgcaactcc tagaaactct atgatatagt
     8161 tgaggtaagt attgttacca cacatgggct aagatcccca gaggcagact gcctgagttc
     8221 aattcttggc tccaccattc ccaagttccc taacctctct atgcctcagt ttcctcttct
     8281 gtaaagtagg gacactcata cttctcattt cagaacattt ttgtgaagaa taaattatgt
     8341 tatccatttg aggcccttag aatggtaccc ggtgtatatt aagtgctagt acatgttagc
     8401 tatcatcatt atcactttat atgagatgga ctggggttca tagaaaccca atgacttgat
     8461 tgtggctact actcaataaa taatagaatt tggatttaaa
//
