LOCUS       NM_030755               4025 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens thioredoxin related transmembrane protein 1 (TMX1),
            mRNA.
ACCESSION   NM_030755
VERSION     NM_030755.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4025)
  AUTHORS   Luo,N., Mei,Z., Zhang,Q., Tang,H., Wan,R., Deng,A., Zou,X. and
            Lv,C.
  TITLE     TMX family genes and their association with prognosis, immune
            infiltration, and chemotherapy in human pan-cancer
  JOURNAL   Aging (Albany NY) 15 (24), 15064-15083 (2023)
   PUBMED   38147024
  REMARK    GeneRIF: TMX family genes and their association with prognosis,
            immune infiltration, and chemotherapy in human pan-cancer.
            Erratum:[Aging (Albany NY). 2024 Jun 30;16(12):10666-10667. doi:
            10.18632/aging.205990.. PMID: 38967984]
REFERENCE   2  (bases 1 to 4025)
  AUTHORS   McLelland,G.L., Lopez-Osias,M., Verzijl,C.R.C., Ellenbroek,B.D.,
            Oliveira,R.A., Boon,N.J., Dekker,M., van den Hengel,L.G., Ali,R.,
            Janssen,H., Song,J.Y., Krimpenfort,P., van Zutphen,T., Jonker,J.W.
            and Brummelkamp,T.R.
  TITLE     Identification of an alternative triglyceride biosynthesis pathway
  JOURNAL   Nature 621 (7977), 171-178 (2023)
   PUBMED   37648867
REFERENCE   3  (bases 1 to 4025)
  AUTHORS   Gaspar,R.S. and Gibbins,J.M.
  TITLE     Thiol Isomerases Orchestrate Thrombosis and Hemostasis
  JOURNAL   Antioxid Redox Signal 35 (13), 1116-1133 (2021)
   PUBMED   33940944
  REMARK    GeneRIF: Thiol Isomerases Orchestrate Thrombosis and Hemostasis.
            Review article
REFERENCE   4  (bases 1 to 4025)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4025)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4025)
  AUTHORS   Lynes,E.M., Bui,M., Yap,M.C., Benson,M.D., Schneider,B.,
            Ellgaard,L., Berthiaume,L.G. and Simmen,T.
  TITLE     Palmitoylated TMX and calnexin target to the
            mitochondria-associated membrane
  JOURNAL   EMBO J 31 (2), 457-470 (2012)
   PUBMED   22045338
  REMARK    GeneRIF: TMX1 is enriched on the mitochondria-associated membrane.
            Targeting TMX to the MAM requires palmitoylation of two
            membrane-proximal cytosolic cysteines.
REFERENCE   7  (bases 1 to 4025)
  AUTHORS   Matsuo,Y., Masutani,H., Son,A., Kizaka-Kondoh,S. and Yodoi,J.
  TITLE     Physical and functional interaction of transmembrane
            thioredoxin-related protein with major histocompatibility complex
            class I heavy chain: redox-based protein quality control and its
            potential relevance to immune responses
  JOURNAL   Mol Biol Cell 20 (21), 4552-4562 (2009)
   PUBMED   19741092
  REMARK    GeneRIF: These results suggest a specific role for transmembrane
            thioredoxin-related protein TMX and its mechanism of action in
            redox-based ER quality control.
REFERENCE   8  (bases 1 to 4025)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4025)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 4025)
  AUTHORS   Matsuo,Y., Akiyama,N., Nakamura,H., Yodoi,J., Noda,M. and
            Kizaka-Kondoh,S.
  TITLE     Identification of a novel thioredoxin-related transmembrane protein
  JOURNAL   J Biol Chem 276 (13), 10032-10038 (2001)
   PUBMED   11152479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB048246.1, BC056874.1, AL591807.1 and BU754378.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030755.4.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal ER-signal sequence, a
            catalytically active thioredoxin domain, and one transmembrane
            domain. Unlike most members of this gene family, it lacks a
            C-terminal ER-retention sequence. The mature membrane-bound protein
            can both oxidize and reduce disulfide bonds and acts selectively on
            membrane-associated polypeptides. [provided by RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.138510.1,
                                           SRR1660805.46843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457354.7/ ENSP00000393316.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1041              AB048246.1         72-1112
            1042-2414           BC056874.1         1010-2382
            2415-3685           AL591807.1         66622-67892         c
            3686-4025           BU754378.1         16-355              c
FEATURES             Location/Qualifiers
     source          1..4025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4025
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="thioredoxin related transmembrane protein 1"
                     /db_xref="GeneID:81542"
                     /db_xref="HGNC:HGNC:15487"
                     /db_xref="MIM:610527"
     exon            1..198
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..889
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /EC_number="5.3.4.1"
                     /note="thioredoxin domain containing 1; protein disulfide
                     isomerase family A, member 11; protein disulfide-isomerase
                     TMX1; transmembrane Trx-related protein; thioredoxin
                     domain-containing protein 1"
                     /codon_start=1
                     /product="thioredoxin-related transmembrane protein 1
                     precursor"
                     /protein_id="NP_110382.3"
                     /db_xref="CCDS:CCDS41953.1"
                     /db_xref="GeneID:81542"
                     /db_xref="HGNC:HGNC:15487"
                     /db_xref="MIM:610527"
                     /translation="MAPSGSLAVPLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLE
                     GDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQPGLSGRFIITALPT
                     IYHCKDGEFRRYQGPRTKKDFINFISDKEWKSIEPVSSWFGPGSVLMSSMSALFQLSM
                     WIRTCHNYFIEDLGLPVWGSYTVFALATLFSGLLLGLCMIFVADCLCPSKRRRPQPYP
                     YPSKKLLSESAQPLKKVEEEQEADEEDVSEEEAESKEGTNKDFPQNAIRQRSLGPSLA
                     TDKS"
     exon            199..314
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..360
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..489
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..535
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..637
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..710
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..4025
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="major polyA site"
     regulatory      3894..3899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3916
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="hexamer: ATTAAA"
     regulatory      3991..3996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
     polyA_site      4025
                     /gene="TMX1"
                     /gene_synonym="PDIA11; TMX; TXNDC; TXNDC1"
ORIGIN      
        1 agtgggagct gcgaccgcgc tccctgtgag gtgggcaagc ggcgaaatgg cgccctccgg
       61 gagtcttgca gttcccctgg cagtcctggt gctgttgctt tggggtgctc cctggacgca
      121 cgggcggcgg agcaacgttc gcgtcatcac ggacgagaac tggagagaac tgctggaagg
      181 agactggatg atagaatttt atgccccgtg gtgccctgct tgtcaaaatc ttcaaccgga
      241 atgggaaagt tttgctgaat ggggagaaga tcttgaggtt aatattgcga aagtagatgt
      301 cacagagcag ccaggactga gtggacggtt tatcataact gctcttccta ctatttatca
      361 ttgtaaagat ggtgaattta ggcgctatca gggtccaagg actaagaagg acttcataaa
      421 ctttataagt gataaagagt ggaagagtat tgagcccgtt tcatcatggt ttggtccagg
      481 ttctgttctg atgagtagta tgtcagcact ctttcagcta tctatgtgga tcaggacttg
      541 ccataactac tttattgaag accttggatt gccagtgtgg ggatcatata ctgtttttgc
      601 tttagcaact ctgttttccg gactgttatt aggactctgt atgatatttg tggcagattg
      661 cctttgtcct tcaaaaaggc gcagaccaca gccgtaccca tacccttcaa aaaaattatt
      721 atcagaatct gcacaacctt tgaaaaaagt ggaggaggaa caagaggcgg atgaagaaga
      781 tgtttcagaa gaagaagctg aaagtaaaga aggaacaaac aaagactttc cacagaatgc
      841 cataagacaa cgctctctgg gtccatcatt ggccacagat aaatcctagt taaattttat
      901 agttatctta atattatgat tttgataaaa acagaagatt gatcattttg tttggtttga
      961 agtgaactgt gacttttttg aatattgcag ggttcagtct agattgtcat taaattgaag
     1021 agtctacatt cagaacataa aagcactagg tatacaagtt tgaaatatga tttaagcaca
     1081 gtatgatggt ttaaatagtt ctctaatttt tgaaaaatcg tgccaagcaa taagatttat
     1141 gtatatttgt ttaataataa cctatttcaa gtctgagttt tgaaaattta catttcccaa
     1201 gtattgcatt attgaggtat ttaagaagat tattttagag aaaaatattt ctcatttgat
     1261 ataatttttc tctgtttcac tgtgtgaaaa aaagaagata tttcccataa atgggaagtt
     1321 tgcccattgt ctcaagaaat gtgtatttca gtgacaattt cgtggtcttt ttagaggtat
     1381 attccaaaat ttccttgtat ttttaggtta tgcaactaat aaaaactacc ttacattaat
     1441 taattacagt tttctacaca tggtaataca ggatatgcta ctgatttagg aagtttttaa
     1501 gttcatggta ttctcttgat tccaacaaag tttgattttc tcttgtattt ttcttactta
     1561 ctatgggtta cattttttat ttttcaaatt ggatgataat ttcttggaaa cattttttat
     1621 gttttagtaa acagtatttt tttgttgttt caaactgaag tttactgaga gatccatcaa
     1681 attgaacaat ctgttgtaat ttaaaatttt ggccactttt ttcagatttt acatcattct
     1741 tgctgaactt caacttgaaa ttgttttttt ttttttttct ttttggatgt gaaggtgaac
     1801 attcctgatt tttgtctgat gtgaaaaagc cttggtattt tacattttga aaattcaaag
     1861 aagcttaata taaaagtttg cattctactc aggaaaaagc atcttcttgt atatgtctta
     1921 aatgtatttt tgtcctcata tacagaaagt tcttaattga ttttacagtc tgtaatgctt
     1981 gatgttttaa aataataaca tttttatatt ttttaaaaga caaacttcat attatcctgt
     2041 gttctttcct gactggtaat attgtgtggg atttcacagg taaaagtcag taggatggaa
     2101 cattttagtg tatttttact ccttaaagag ctagaataca tagttttcac cttaaaagaa
     2161 gggggaaaat cataaataca atgaatcaac tgaccattac gtagtagaca atttctgtaa
     2221 tgtccccttc tttctaggct ctgttgctgt gtgaatccat tagatttaca gtatcgtaat
     2281 atacaagttt tctttaaagc cctctccttt agaatttaaa atattgtacc attgaagagt
     2341 ttggatgtgt aacttgtgat gccttagaaa aatatcctaa gcacaaaata aacctttcta
     2401 accacttcat taaagctgaa gaccagtatg atttctggtt gctttttgaa ggtatgcttt
     2461 attactttgt atttaacgat gttcagatga gtagttgtgt gttcctatat atgtacttga
     2521 tatgtgtaat caaaagactg ccttcttttt ctattgagat gtttaaggac agtaatgctc
     2581 attaatcaag catttttttt ttttagtgtt ctagtatatg tgacatggcc aattttttta
     2641 ttagaaaata tgtgaccaga aagattctat agagtaaaaa atcaaagcaa aacaaaaacc
     2701 acaaaaagac ccctgtacta tagaaaatgt aaagttggct gaacagatag ggtcttgaaa
     2761 tttcaggaaa catataatct cacggttctt aaagattgtc actgtagaca tctgagtaat
     2821 taattttcag ttagtaacag gcttatagaa actttgggat tatttacaaa tggtttagga
     2881 aagaataagg tatagtaaaa gtaatatcct ggagaattct gggccaccta cccaccataa
     2941 tcaattcagc tgtactactg aagtattgta aaatctgatc tctagaggaa aatacagtat
     3001 tctaccttac gttgtgtaaa tacttaatga ttatcagaaa gactgaaaaa agttttaatg
     3061 aagaattctg gctacatcta acagctgcca tttaccaagt acctactgga gctttgttgt
     3121 tttcttgtat ttattaattt agtcctaatg acaactgcaa gacaggtaag cattgcacat
     3181 ctttcaggtg agtcagccca gaggtgtggt acaaataggt aaaatttgaa tctaattctt
     3241 gttccaaatc tttttttgtt tgtttttgtt tttgtttttt ttcttcagtg tgggtacatg
     3301 aaattcagca atctcttatt ttggtctttt tttttttttt gagacagagt ttcactcttg
     3361 ttgcccaggc tggagtgcaa tggcatgatc ttggctcact gcaacctcca cctcctgggt
     3421 tcaagcagtt cttctgcctc agcctcccaa gtagctggga ttacaggcat gtgccaccat
     3481 gcccggctat tattttggtc ttaaaatttc actcctgtca gaatgtagga gtgaataaat
     3541 gctattcata aataaccata attattcagt atttgcagtc tcgtgatgtt ggttattgca
     3601 taaagtaagt tattgcagta aatgatgctt tagaaagcaa ttttctctca tcagtttcgt
     3661 ccttattcag ccttacacaa aaaaaggcat agttctgggc ttaattgtga tgtaattaaa
     3721 attattgagt gaacattttg gctcatattt tatgacattg tagttcatcc ccatggtcaa
     3781 tttaaggtag agttcttaca atatattact ttcaatatag gtattttatt aataagaatt
     3841 tatttcagtt ggacttatta aatgagtggt tttgctgagt gtatgagtct ataaataaaa
     3901 ttttaattga acatcattgg agatttagat atgttggtac tgcttatcta gcaacttttg
     3961 tatttgtgaa accattaaaa ctagagtaac aataaattta agttggaatt ttggtaatat
     4021 gtaaa
//
